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| 1 | Role of the receptor for advanced glycation end products in hepatic fibrosis显示文摘AIM:To study the role of advanced glycation end products(AGE)and their specifi c receptor(RAGE)in the pathogenesis of liver fi brogenesis.METHODS:In vitro RAGE expression and extracellular matrix-related gene expression in both rat and human hepatic stellate cells(HSC)were measured after stimulation with the two RAGE ligands,advanced glycation end product-bovine serum albumin(AGE-BSA)and Nε-(carboxymethyl)lysine(CML)-BSA,or with tumor necrosis factor-α(TNF-α).In vivo RAGE expression was examined in models of hepatic fi brosis induced by bile duct ligation or thioacetamide.The effects of AGE-BSA and CML-BSA on HSC proliferation,signal transduction and profi brogenic gene expression were studied in vitro.RESULTS:In hepatic fibrosis,RAGE expression was enhanced in activated HSC,and also in endothelial cells,inflammatory cells and activated bile duct epithelia.HSC expressed RAGE which was upregulated after stimulation with AGE-BSA,CML-BSA,and TNF-α.RAGE stimulation with AGE-BSA and CML-BSA did not alter HSC proliferation,apoptosis,fibrogenic signal transduction and fibrosis-or fibrolysis-related gene expression,except for marginal upregulation of procollagen α1(Ⅰ)mRNA by AGE-BSA.CONCLUSION:Despite upregulation of RAGE in activated HSC,RAGE stimulation by AGE does not alter their fibrogenic activation.Therefore,RAGE does not contribute directly to hepatic fibrogenesis. | Christina Lohwasser Daniel Neureiter Yury Popov Michael Bauer Detlef Schuppan | 2009 | World Journal of Gastroenterology2009，15，46： | 13 |
| 2 | Epigenetics and pancreatic cancer:Pathophysiology and novel treatment aspects显示文摘An improvement in pancreatic cancer treatment represents an urgent medical goal.Late diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal overall prognosis that has remained unchanged during the past decades.Increasing knowledge about the molecular pathogenesis of the disease has shown that genetic alterations,such as mutations of K-ras,and especially epigenetic dysregulation of tumor-associated genes,such as silencing of the tumor suppressor p16ink4a,are hallmarks of pancreatic cancer.Here,we describe genes that are commonly affected by epigenetic dysregulation in pancreatic cancer via DNA methylation,histone acetylation or miRNA(microRNA)expression,and review the implications on pancreatic cancer biology such as epithelial-mesenchymal transition,morphological pattern formation,or cancer stem cell regulation during carcinogenesis from PanIN(pancreatic intraepithelial lesions)to invasive cancer and resistance development.Epigenetic drugs,such as DNA methyltransferases or histone deactylase inhibitors,have shown promising preclinical results in pancreatic cancer and are currently in early phases of clinical development.Combinations of epigenetic drugs with established cytotoxic drugs or targeted therapies are promising approaches to improve the poor response and survival rate of pancreatic cancer patients. | Daniel Neureiter Tarkan Jger Matthias Ocker Tobias Kiesslich | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 3 | Differential role of Hedgehog signaling in human pancreatic(patho-)physiology:An up to date review显示文摘Since the discovery of the Hedgehog(Hh)pathway in drosophila melanogaster,our knowledge of the role of Hh in embryonic development,inflammation,and cancerogenesis in humans has dramatically increased over the last decades.This is the case especially concerning the pancreas,however,real therapeutic breakthroughs are missing until now.In general,Hh signaling is essential for pancreatic organogenesis,development,and tissue maturation.In the case of acute pancreatitis,Hh has a protective role,whereas in chronic pancreatitis,Hh interacts with pancreatic stellate cells,leading to destructive parenchym fibrosis and atrophy,as well as to irregular tissue remodeling with potency of initiating cancerogenesis.In vitro and in situ analysis of Hh in pancreatic cancer revealed that the Hh pathway participates in the development of pancreatic precursor lesions and ductal adenocarcinoma including critical interactions with the tumor microenvironment.The application of specific inhibitors of components of the Hh pathway is currently subject of ongoing clinical trials(phases 1 and 2).Furthermore,a combination of Hh pathway inhibitors and established chemotherapeutic drugs could also represent a promising therapeutic approach.In this review,we give a structured survey of the role of the Hh pathway in pancreatic development,pancreatitis,pancreatic carcinogenesis and pancreatic cancer as well as an overview of current clinical trials concerning Hh pathway inhibitors and pancreas cancer. | Eckhard Klieser Stefan Swierczynski Christian Mayr Tarkan Jager Johanna Schmidt Daniel Neureiter Tobias Kiesslich Romana Illig | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 5 |
| 4 | Hepatocellular carcinoma: Therapeutic advances in signaling,epigenetic and immune targets显示文摘Hepatocellular carcinoma(HCC)remains a global medical burden with rising incidence due to chronic viral hepatitis and non-alcoholic fatty liver diseases.Treatment of advanced disease stages is still unsatisfying.Besides first and second generation tyrosine kinase inhibitors,immune checkpoint inhibitors have become central for the treatment of HCC.New modalities like epigenetic therapy using histone deacetylase inhibitors(HDACi)and cell therapy approaches with chimeric antigen receptor T cells(CAR-T cells)are currently under investigation in clinical trials.Development of such novel drugs is closely linked to the availability and improvement of novel preclinical and animal models and the identification of predictive biomarkers.The current status of treatment options for advanced HCC,emerging novel therapeutic approaches and different preclinical models for HCC drug discovery and development are reviewed here. | Daniel Neureiter Sebastian Stintzing Tobias Kiesslich Matthias Ocker | 2019 | World Journal of Gastroenterology2019，25，25： | 4 |
| 5 | Pancreatic cancer cells surviving gemcitabine treatment express markersof stem cell differentiation and epithelial-mesenchymal transition显示文摘 | Karl Quint Manuel Tonigold Pietro Di Fazio Roberta Montalbano Susanne Lingelbach Felix Rückert Beate Alinger Matthias Ocker Daniel Neureiter | 2012 | International Journal of Oncology2012，，6： | 2 |
| 6 | GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers?显示文摘 | Romana Illig Eckhard Klieser Tobias Kiesslich Daniel Neureiter P. Marco Fisichella | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 7 | The pan?deacetylase inhibitor panobinostat modulates the expressionof epithelial?mesenchymal transition markers in hepatocellular carcinoma models显示文摘 | Pietro Di Fazio Roberta Montalbano Karl Quint Beate Alinger Ralf Kemmerling Tobias Kiesslich Matthias Ocker Daniel Neureiter | 2013 | Oncology Letters2013，，1： | 1 |
| 8 | Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases显示文摘 | Stefan Swierczynski Eckhard Klieser Romana Illig Beate Alinger-Scharinger Tobias Kiesslich Daniel Neureiter | 2015 | Expert Opinion on Biological Therapy2015，，5： | 1 |
| 9 | Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man显示文摘 | Alexander Jais Elisa Einwallner Omar Sharif Klaus Gossens Tess Tsai-Hsiu Lu Selma M. Soyal David Medgyesi Daniel Neureiter Jamile Paier-Pourani Kevin Dalgaard J. Catharina Duvigneau Josefine Lindroos Christensen Thea-Christin Zapf Sabine Amann Simona Salu | 2014 | Cell2014，，： | 1 |
| 10 | Cellular plasticity of trans- and dedifferentiation markers in humanhepatoma cells in vitro and in vivo显示文摘 | Samir Jabari Matthias Meissnitzer Karl Quint Susanne Gahr Till Wissniowski Eckhart Hahn Daniel Neureiter Matthias Ocker | 2009 | International Journal of Oncology2009，，： | 1 |
| 11 | Different capabilities of morphological pattern formation and its association with the expression of differentiation markers in a xenograft model of human pancreatic cancer cell lines显示文摘 | Daniel Neureiter Steffen Zopf Arno Dimmler Sebastian Stintzing Eckhart G. Hahn Thomas Kirchner Christoph Herold Matthias Ocker | 2005 | Pancreatology . 2005 (4-5)2005，，： | 1 |
| 12 | Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines显示文摘 | Pietro Di Fazio Roberta Montalbano Daniel Neureiter Beate Alinger Ansgar Schmidt Anna Lena Merkel Karl Quint Matthias Ocker | 2012 | Experimental Cell Research2012，，15： | 1 |
| 13 | Intrathoracic major duodenal papilla with transhiatal herniation of the pancreas and duodenum:A case report and review of the literature显示文摘Transhiatal herniation of the pancreas is an extremely rare condition.In the published literature we found only eleven cases reported in the period of 1958 to 2011.A coincidental hiatal herniation of the duodenum is described in two cases only.To our knowledge,we report the first case with a hiatal herniation of the complete duodenum and proximal pancreas presenting an intrathoracic major duodenal papilla with consecutive intrahepatic and extrahepatic cholestasis.A 72-yearold Caucasian woman was admitted to our department with a hiatal hernia grade Ⅳ for further evaluation.According to our recommendation of surgical hernia repair soon after the diagnosis of a transhiatal herniation of the proximal pancreas and entire duodenum,we had to respect the declared intention of the patient for a conservative procedure.So we were forced to wait for surgical repair within an emergency situation complicated by a myocardial infarction and reduced general condition.We discuss the therapeutic decision making process and a complete literature review of this rare entity. | Tarkan Jger Daniel Neureiter Clemens Nawara Adam Dinnewitzer Dietmar fner Wolfram Lamadé | 2013 | World Journal of Gastrointestinal Surgery2013，5，6： | 1 |
| 14 | The role of polycomb repressive complexes in biliary tract cancer显示文摘 | Christian Mayr Daniel Neureiter Andrej Wagner Martin Pichler Tobias Kiesslich | 2015 | Expert Opinion on Therapeutic Targets2015，，： | 1 |
| 15 | Cytotoxic effects of chemokine receptor 4 inhibition by AMD3100 in biliarytract cancer cells: Potential drug synergism with gemcitabine显示文摘 | Christian Mayr Daniel Neureiter Martin Pichler Frieder Berr Andrej Wagner Tobias Kiesslich Konrad Namberger | 2015 | Molecular Medicine Reports2015，，： | 1 |
| 16 | Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines显示文摘 | Pietro Di Fazio Roberta Montalbano Daniel Neureiter Beate Alinger Ansgar Schmidt Anna Lena Merkel Karl Quint Matthias Ocker | 2012 | Experimental Cell Research2012，，15： | 1 |
| 17 | Comprehensive analysis of alterations in the miRNome in response to photodynamic treatment显示文摘 | Doris Bach Julia Fuereder Michael Karbiener Marcel Scheideler Anna Lena Ress Daniel Neureiter Ralf Kemmerling Otto Dietze Markus Wiederstein Frieder Berr Kristjan Plaetzer Tobias Kiesslich Martin Pichler | 2013 | Journal of Photochemistry & Photobiology B: Biology2013，，： | 1 |
| 18 | Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy显示文摘In the last years, our knowledge of the pathogenesis in acute and chronic pancreatitis(AP/CP) as well as in pancreatic cancerogenesis has significantly diversified. Nevertheless, the medicinal therapeutic options are still limited and therapeutic success and patient outcome are poor. Epigenetic deregulation of gene expression is known to contribute to development and progression of AP and CP as well as of pancreatic cancer. Therefore, the selective inhibition of aberrantly active epigenetic regulators can be an effective option for future thera-pies. Histone deacetylases(HDACs) are enzymes that remove an acetyl group from histone tails, thereby causing chromatin compaction and repression of transcri-ption. In this review we present an overview of the currently available literature addressing the role of HDACs in the pancreas and in pancreatic diseases. In pancreatic cancerogenesis, HDACs play a role in the important process of epithelial-mesenchymal-transition, ubiquitin-proteasome pathway and, hypoxia-inducible-factor-1-angiogenesis. Finally, we focus on HDACs as potential therapeutic targets by summarizing currently available histone deacetylase inhibitors. | Eckhard Klieser Stefan Swierczynski Christian Mayr Johanna Schmidt Daniel Neureiter Tobias Kiesslich Romana Illig | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 1 |
| 19 | Biliary tract cancer stem cells-translational options and challenges显示文摘Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells-the cancer stem cells-possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological intervention with cancer stem cells is an intensively investigated and promising research field. The involvement of cancer stem cells in biliary tract cancer is likely as a number of studies demonstrated their existence and the obvious clinical relevance of several established cancer stem cell markers in biliary tract cancer models and tissues. In the present article, we review and discuss the currently available literature addressing the role of putative cancer stem cells in biliary tract cancer as well as the connection between known contributors of biliary tract tumorigenesis such as oncogenic signaling pathways, micro-RNAs and the tumor microenvironment with cancer stem cells. | Christian Mayr Matthias Ocker Markus Ritter Martin Pichler Daniel Neureiter Tobias Kiesslich | 2017 | World Journal of Gastroenterology2017，23，14： | 0 |
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