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| 1 | Role of abnormal lipid metabolism in development,progression,diagnosis and therapy of pancreatic cancer显示文摘There is growing evidence that metabolic alterations play an important role in cancer development and progression.The metabolism of cancer cells is reprogrammed in order to support their rapid proliferation.Elevated fatty acid synthesis is one of the most important aberrations of cancer cell metabolism.An enhancement of fatty acids synthesis is required both for carcinogenesis and cancer cell survival,as inhibition of key lipogenic enzymes slows down the growth of tumor cells and impairs their survival.Based on the data that serum fatty acid synthase(FASN),also known as oncoantigen 519,is elevated in patients with certain types of cancer,its serum level was proposed as a marker of neoplasia.This review aims to demonstrate the changes in lipid metabolism and other metabolic processes associated with lipid metabolism in pancreatic ductal adenocarcinoma(PDAC),the most common pancreatic neoplasm,characterized by high mortality.We also addressed the influence of some oncogenic factors and tumor suppressors on pancreatic cancer cell metabolism.Additionally the review discusses the potential role of elevated lipid synthesis in diagnosis and treatment of pancreatic cancer.In particular,FASN is a viable candidate for indicator of pathologic state,marker of neoplasia,as well as,pharmacological treatment target in pancreatic cancer.Recent research showed that,in addition to lipogenesis,certain cancer cells can use fatty acids from circulation,derived from diet(chylomicrons),synthesized in liver,or released from adipose tissue for their growth.Thus,the interactions between de novo lipogenesis and uptake of fatty acids from circulation by PDAC cells require further investigation. | Julian Swierczynski Areta Hebanowska Tomasz Sledzinski | 2014 | World Journal of Gastroenterology2014，20，9： | 16 |
| 2 | Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome显示文摘Clinical studies have indicated that circulating bile acid(BA) concentrations increase following bariatric surgery, especially following malabsorptive procedures such as Roux-en-Y gastric bypasses(RYGB). Moreover, total circulating BA concentrations in patients following RYGB are positively correlated with serum glucagonlike peptide-1 concentrations and inversely correlated with postprandial glucose concentrations. Overall, these data suggest that the increased circulating BA concentrations following bariatric surgery- independently of calorie restriction and body-weight loss- could contribute, at least in part, to improvements in insulin sensitivity, incretin hormone secretion, and postprandial glycemia, leading to the remission of type-2 diabetes(T2DM). In humans, the primary and secondary BA pool size is dependent on the rate of biosynthesis and the enterohepatic circulation of BAs, as well as on the gut microbiota, which play a crucial role in BA biotransformation. Moreover, BAs and gut microbiota are closely integrated and affect each other. Thus, the alterations in bile flow that result from anatomical changes caused by bariatric surgery and changes in gutmicrobiome may influence circulating BA concentrations and could subsequently contribute to T2 DM remission following RYGB. Research data coming largely from animal and cell culture models suggest that BAs can contribute, via nuclear farnezoid X receptor(FXR) and membrane G-protein-receptor(TGR-5), to beneficial effects on glucose metabolism. It is therefore likely that FXR, TGR-5, and BAs play a similar role in glucose metabolism following bariatric surgery in humans. The objective of this review is to discuss in detail the results of published studies that show how bariatric surgery affects glucose metabolism and subsequently T2 DM remission. | Lukasz Kaska Tomasz Sledzinski Agnieszka Chomiczewska Agnieszka Dettlaff-Pokora Julian Swierczynski | 2016 | World Journal of Gastroenterology2016，22，39： | 11 |
| 3 | Differential role of Hedgehog signaling in human pancreatic(patho-)physiology:An up to date review显示文摘Since the discovery of the Hedgehog(Hh)pathway in drosophila melanogaster,our knowledge of the role of Hh in embryonic development,inflammation,and cancerogenesis in humans has dramatically increased over the last decades.This is the case especially concerning the pancreas,however,real therapeutic breakthroughs are missing until now.In general,Hh signaling is essential for pancreatic organogenesis,development,and tissue maturation.In the case of acute pancreatitis,Hh has a protective role,whereas in chronic pancreatitis,Hh interacts with pancreatic stellate cells,leading to destructive parenchym fibrosis and atrophy,as well as to irregular tissue remodeling with potency of initiating cancerogenesis.In vitro and in situ analysis of Hh in pancreatic cancer revealed that the Hh pathway participates in the development of pancreatic precursor lesions and ductal adenocarcinoma including critical interactions with the tumor microenvironment.The application of specific inhibitors of components of the Hh pathway is currently subject of ongoing clinical trials(phases 1 and 2).Furthermore,a combination of Hh pathway inhibitors and established chemotherapeutic drugs could also represent a promising therapeutic approach.In this review,we give a structured survey of the role of the Hh pathway in pancreatic development,pancreatitis,pancreatic carcinogenesis and pancreatic cancer as well as an overview of current clinical trials concerning Hh pathway inhibitors and pancreas cancer. | Eckhard Klieser Stefan Swierczynski Christian Mayr Tarkan Jager Johanna Schmidt Daniel Neureiter Tobias Kiesslich Romana Illig | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 5 |
| 4 | Decreased serum essential and aromatic amino acids in patients with chronic pancreatitis显示文摘AIM:To investigate the influence of chronic pancreatitis(CP) on serum concentrations of amino acids.METHODS:Thirty-five male patients with alcoholic CP and 21 healthy male subjects were examined.Serum concentrations of amino acids were assayed by ionpair high-performance liquid chromatography with mass detection.RESULTS:Serum glutamate concentration was increased in CP patients as compared to controls.In contrast,serum concentrations of glutamine,histidine,tyrosine,proline,tryptophan and threonine were significantly decreased in CP patients.A trend towards decreasing concentrations of serum lysine,alanine,methionine and valine as well as for total serum amino acids was observed.The sum of aromatic and the sum of essential amino acid concentrations were significantly lower in CP patients than in controls.CONCLUSION:CP leads to decreased serum concentrations of several amino acids,such as essential and aromatic serum amino acids,most likely due to decreased exocrine function. | Krystian Adrych Marian Smoczynski Magdalena Stojek Tomasz Sledzinski Ewa Slominska Elzbieta Goyke Ryszard Tomasz Smolenski Julian Swierczynski | 2010 | World Journal of Gastroenterology2010，16，35： | 3 |
| 5 | Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis显示文摘AIM: To examine circulating growth factor concentrations in patients with acute pancreatitis(AP) and chronic pancreatitis(CP), and walled-off pancreatic necrosis(WOPN). METHODS: Forty patients with mild AP, 40 patients with alcoholic CP, 33 patients with WOPN and 40 healthy subjects were examined. Serum concentrations of platelet derived growth factor BB(PDGF-BB), transforming growth factor β-1(TGFβ-1), chemerin and high-mobility group box chromosomal protein 1(HMBG1) were assayed by enzyme linked immunosorbent assay.RESULTS: Patients with mild AP and those with WOPN had significantly lower serum levels of PDGF-BB compared to healthy subjects(4.0 ± 0.61 ng/mL vs 6.2 ± 0.76 ng/mL, P = 0.027, and 1.60 ± 0.31 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001, respectively), while CP was associated with higher serum levels of PDGF-BB(12 ± 1.3 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001). Circulating TGFβ-1 and chemerin levels were elevated in CP patients(57 ± 3.6 ng/mL vs 39 ± 3.6 ng/mL, P < 0.001 and 73 ± 7.2 ng/mL vs 48 ± 2.3 ng/mL, P < 0.001, respectively), but not in patients with AP and WOPN. No significant changes in serum HMBG1 levels were found either in patients with AP, WOPN or CP. CONCLUSION: The serum levels of some growth factors and cytokines differ significantly in AP, WOPN and CP. These data suggest that selected growth factors and cytokines may be considered as potential diagnostic biomarkers in patients with pancreatic diseases. | Magdalena Stojek Krystian Adrych Lukasz Rojek Marian Smoczynski Tomasz Sledzinski Sylwia Szrok Julian Swierczynski | 2014 | World Journal of Gastroenterology2014，20，36： | 2 |
| 6 | Advance in low voltage circuit breaker modeling 显示文摘 | SWIERCZYNSKI B GONZALEA J J TEULET P | 2004 | Appl Phys2004，37，4： | 1 |
| 7 | Enhanced glycerol 3-phosphate dehydrogenase activity in adipose tissue of obese humans显示文摘 | Swierczynski J Zabrocka L Goyke E | 2003 | Mol Cell Bioehem2003，254，： | 1 |
| 8 | Tissue- specific effect of refeeding after short- and long-term caloric restriction on malic enzyme gene expression in rat tissues 显示文摘 | Stetmanska E Korczynska J Swierczynski J | 2004 | Department Biochem2004，51，： | 1 |
| 9 | Study of steam reforming of toluene used as model compound of tar produced by biomass gasification显示文摘 | Swierczynski D Courson C Kiennemann A | 2008 | Chemical Engineering and Processing: Process Intensification2008，47，3： | 1 |
| 10 | Late Neolithic Mondsee Culture in Austria: living on lakes and living with flood risk?显示文摘 | T. Swierczynski S. Lauterbach P. Dulski A. Brauer | 2013 | Climate of the Past2013，，4： | 1 |
| 11 | Comparative studies on NADP-linked dehydrogenasee in some tissues of fish and crustaceans显示文摘 | Skorkowski EF Aleksandrowicz Z Swierczynski J | 1980 | Comp Biochem Physiol1980，65，： | 1 |
| 12 | Layered Single Stage Driving System for Plane Liners 显示文摘 | Swierczynski R Tyl J Wlodarczyk E | 1985 | J Tech Phys1985，25，2： | 1 |
| 13 | The respiration and calcium content of heart mitochondria from rats with vitamin D-induced cardionecrosis显示文摘 | Zydowo M M Swierczynski J Nagel G | 1985 | Biochem J1985，226，1： | 1 |
| 14 | Potential role of high serum leptin concentration in age-related decrease of fatty acid synthase gene expression in rat white adipose tissue显示文摘 | Nogalska A Swierczynski J | 2004 | Exp Gerontol2004，39，1： | 1 |
| 15 | Corynebacterium diphtheriae empl Jys specific minor pilins to target human pharyngeal epithelial cells 显示文摘 | Mandlik A Swierczynski A Das A | 2007 | Mol Microbiol2007，64，1： | 1 |
| 16 | The age-related differences in obese and fatty acid synthase gene expression in white adipose tissue of rat显示文摘 | Nogalska A Swierczynski J | 2001 | Biochimica et Biophysica Acta2001，1553，： | 1 |
| 17 | Purines, lactate and phosphate release from child and adult heart during cardioplgic arrest显示文摘 | Swierczynski J Narkiewicz M | 1990 | Clin Chim Acta1990，192，： | 1 |
| 18 | Tissue-specific effect of reseeding after short-and long-term caloric restriction on malice enzyme gene expression in rat tissues显示文摘 | Stelmanska E Korczynska J Swierczynski J | 2004 | Department of Biochemistry2004，51，3： | 1 |
| 19 | Advance in low voltage circuit breaker modeling显示文摘 | SWIERCZYNSKI B GONZALEA J J TEULET P | 2004 | Journal of Physics D: Applied Physics2004，37，4： | 1 |
| 20 | Steam reforming of tar from a biomass gasification process over Ni/olivine catalyst using toluene as a model compound 显示文摘 | SWIERCZYNSKI D LIBS S COURSON C KIENNEMANN A | 2007 | Appl Catal B: Environ2007，74，34： | 1 |
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