|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 砷酸盐的溶解度及其稳定性随pH值的变化显示文摘本文讨论了铁、钙和钡的砷酸盐在水环境中的溶解度与稳定性 ,着重分析了砷酸盐在水中发生不一致性溶解与稳定性的关系 .同时藉助PHREEQC程序 ,探讨了砷酸铁溶解时 ,其溶解度、砷的存在形式与pH值的关系 ,以及共存的氢氧化铁对稳定性的影响 ,并作出了Ca As 水和Ba As 水体系的lg[As] | 朱义年 张学洪 解庆林 陈余道 王敦球 Broder Merkel | 2003 | 环境化学2003，22，5： | 35 |
| 2 | 利妥昔单抗治疗重度ANCA相关性血管炎与常规免疫抑制剂疗效相同显示文摘新英格兰医学杂志2013年8月发表了美国学者的研究结果,18个月的单疗程利妥昔单抗治疗重度抗中性粒细胞胞浆抗体(antineutrophilcytoplasmicantibody,ANCA)相关性血管炎,与常规免疫抑制剂环磷酰胺联合硫唑嘌呤的疗效相同。 | Specks U Merkel PA Seo P 王建中 | 2013 | 中华肾病研究电子杂志2013，2，5： | 33 |
| 3 | 武汉市区第四系含水层地下水有机污染敏感性研究显示文摘在详细调查武汉市水文地质条件和地下水污染现状的基础上 ,获得了高精度的武汉市水环境中微量有机污染物的组成数据 .所检测出的有机组分达 3 0余种 ,以苯及相关苯系物为主 ,污染程度较高的地下水主要分布在人口密集区和工业、商业区 .应用改进的DRASTIC模型———地下水污染敏感性评价模型 ,在GIS平台上 ,编制了武汉市区地下水污染敏感性分区图 .根据其评价结果 ,建议集中对那些敏感性相对较高的区域采取有效的环保措施 。 | 王焰新 李义连 付素蓉 蔡鹤生 Broder Merkel Dana Ihm | 2002 | 地球科学(中国地质大学学报)2002，27，5： | 27 |
| 4 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 5 | 直肠癌切除术后吻合口漏与患者长期预后的关系显示文摘目的 :探讨吻合口漏与直肠癌术后局部复发和生存率的关系。方法 :对 1978年~ 1996年行直肠癌前切除术的 814例患者进行随访 ,并对发生与未发生吻合口漏患者的预后进行了单因素和多因素分析。结果 :814例中 89例 (10 .9% )发生了吻合口漏。经过Kaplan Meier生存曲线分析 ,患者总体 5a局部复发率是 13.6 %。多因素分析显示吻合口漏是影响肿瘤局部复发的独立危险因素 (相对危险度为 1.7,P =0 .0 4 18) ,也是影响肿瘤相关生存率的独立危险因素 (相对危险度为 1.6 ,P =0 .0 172 )。结论 :吻合口漏是影响直肠癌患者术后局部复发率和肿瘤相关生存率的危险因素。 | 王文跃 Susanne Merkel Paul Hermanek Werner Hohenberger | 2001 | 中日友好医院学报2001，15，6： | 6 |
| 6 | Covert hepatic encephalopathy: Agreement and predictive validity of different indices显示文摘AIM:To investigate the agreement and prognosticvalue of different measures of covert hepatic encephalopathy(CHE).METHODS:One-hundred-and-thirty-two cirrhotic outpatients underwent electroencephalography(EEG),paper-and-pencil psychometry(PHES)and critical flicker frequency,scored on the original/modified(CFFo/CFFm)thresholds.Eighty-four patients underwent Dopplerultrasound to diagnose/exclude portal-systemic shunt.Seventy-nine were followed-up for 11±7 mo in relation to the occurrence of hepatic encephalopathy(HE)-related hospitalisations.RESULTS:On the day of study,36%had gradeⅠHE,42%abnormal EEG,33%abnormal PHES and 31/21%abnormal CFFo/CFFm.Significant associations were observed between combinations of test abnormalities;however,agreement was poor(Cohen’sκ<0.4).The prevalence of EEG,PHES and CFFo/CFFm abnormalities was significantly higher in patients with gradeⅠovert HE.The prevalence of EEG and CFFm abnormalities was higher in patients with shunt.The prevalence of EEG abnormalities was significantly higher in patients with a history of HE.During follow-up,10 patients died,10were transplanted and 29 had HE-related hospitalisations.GradeⅠHE(P=0.004),abnormal EEG(P=0.008)and abnormal PHES(P=0.04)at baseline all predicted the subsequent occurrence of HE;CFF did not.CONCLUSION:CHE diagnosis probably requires a combination of clinical,neurophysiological and neuropsychological indices. | Sara Montagnese Esmeralda Balistreri Sami Schiff Michele De Rui Paolo Angeli Giacomo Zanus Umberto Cillo Giancarlo Bombonato Massimo Bolognesi David Sacerdoti Angelo Gatta Carlo Merkel Piero Amodio | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 7 | Incidence and natural history of small esophageal varices in cirrhotic patients显示文摘 | Manuela Merli Giorgia Nicolini Stefania Angeloni Vittorio Rinaldi Adriano De Santis Carlo Merkel Adolfo Francesco Attili Oliviero Riggio | 2002 | Journal of Hepatology2002，，3： | 4 |
| 8 | 电池部分放电后析气量低的新型锌粉显示文摘用于碱性锌锰电池的锌粉在投产前都必须测定析气量,通常将使用的锌粉制成LR14 电池,采用2Ω恒电阻连续放电4 .5h 后在70 ℃下贮存7d ,如果锌粉释放出的气体量不高于负极集流体端部密封圈防爆孔开启压力的10 % ~20 % ,则该锌粉就可以使用。然而,有些合金锌粉在电池部分放电( 如放电40min) 后析气量剧增,为了研究锌粉的析气行为,我们测试了不同规格电池和锌粉在电池部分放电后的析气量,结果显示,Grillo 公司研制的一种新型锌粉在电池部分放电后析气量非常低,文章讨论了该锌粉的析气量和放电行为。 | Wolfgang Glaeser Sigrid Kunzel-Keune Petra Merkel Grillo-Werke AG,Werk Goslar (D-38644 Goslar, Germany) | 1999 | 电池工业1999，4，4： | 3 |
| 9 | The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression显示文摘 | Thomas Derrien Rory Johnson Giovanni Bussotti Andrea Tanzer Sarah Djebali Hagen Tilgner Gregory Guernec David Martin Angelika Merkel David G. Knowles Julien Lagarde Lavanya Veeravalli Xiaoan Ruan Yijun Ruan Timo Lassmann Piero Carninci James B. Brown Leon | 2012 | Genome Research2012，，9： | 3 |
| 10 | Resectability of pancreatic adenocarcinoma: assessment using multidetector-row computed tomography with multiplanar reformations显示文摘 | Elena Manak Susanne Merkel Peter Klein Thomas Papadopoulos Werner A. Bautz Ulrich Baum | 2009 | Abdominal Imaging2009，，1： | 3 |
| 11 | 致密含气砂岩的综合岩石物理模型研究显示文摘位于落基山脉的致密含气砂岩储层的岩性比较复杂,含有云母、长石、碳酸盐岩等成分。且泥岩是伊利石、蒙脱石、高岭石和绿泥石的混合物。大多数测井仪器响应都来源于岩石基质,这就造成了致密含气砂岩的测井响应非常复杂且很难确定。核磁共振仪测井响应值主要来自流体,岩石基质对其影响很小。综合核磁共振测井(用于测量流体组分)和裸眼井测井(用于测量骨架组分)可以得到致密含气砂岩的岩石物理模型。在大多数的岩石物理模型中,必须知道Rw、m、n及总孔隙度(PHIT)、粘土体积(VCLAy)和阳离子交换量(CEC)才能计算Sw。致密砂岩的胶结指数m和饱和度指数n的岩心分析是非常困难的,同时也是非常费时的。这是因为1)不可能在不破坏岩石骨架的基础上清洗烘干岩心;2)由于渗透率很低使得测量的饱和度范围很小。因为在这些储层中100%含水的层段不常见,Pickett交会图分析认为得到的胶结指数m和Rw值往往是错误的。而且,有一个值得注意的事实是在给定的致密含气地层中不同的砂岩中地层水矿化度会发生变化。利用产出水来确定Rw是不准确的,因为它已被产出气中凝析的低矿化度水所污染。
对于一个包括NMR测井的完整的测井系列,通常可以算出地层条件下的胶结指数m和饱和度指数n(有时包括Rw)。通过实例可以证明NMR测量对于我们的分析是必要的,并介绍了NMR测井如何与其它裸眼井测井资料结合起来确定孔隙度一饱和度模型。对于任何一个模型,都可以用NMR岩心资料结果进行检验和校正。 | Richard Merkel 刘延梅(译) 张晋言(校) 谢关宝(校) | 2007 | 测井与射孔2007，10，3： | 2 |
| 12 | Numerical Simulation of the Mechanical Properties of Sintered and Bonded Perforated Hollow Sphere Structures (PHSS)显示文摘This paper investigated the uniaxial mechanical properties of a new type of hollow sphere structures. For this new type, the sphere shell was perforated by several holes in order to open the inner sphere volume and surface. The mechanical properties, i.e. elastic properties and initial yield stress of perforated hollow sphere structures (PHSS) in a primitive cubic arrangement were numerically evaluated for different hole diameters and different joining techniques of the hollow spheres. The results are compared to classical configurations without perforation. | Andreas chsner Seyed Mohammad Hossein Hosseini Markus Merkel | 2010 | Journal of Materials Science & Technology2010，26，8： | 2 |
| 13 | Outcome of Operative Therapy of Hepatic Metastatic Stomach Carcinoma: A Retrospective Analysis显示文摘 | Claus Schildberg R. Croner S. Merkel V. Schellerer V. Müller S. Yedibela W. Hohenberger G. Peros A. Perrakis | 2012 | World Journal of Surgery2012，，4： | 2 |
| 14 | Pathogenesis and management of hepatorenal syndrome in patients with cirrhosis显示文摘 | Paolo Angeli Carlo Merkel | 2008 | Journal of Hepatology2008，，： | 2 |
| 15 | 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides显示文摘 | J. C. Jennette R. J. Falk P. A. Bacon N. Basu M. C. Cid F. Ferrario L. F. Flores‐Suarez W. L. Gross L. Guillevin E. C. Hagen G. S. Hoffman D. R. Jayne C. G. M. Kallenberg P. Lamprecht C. A. Langford R. A. Luqmani A. D. Mahr E. L. Matteson P. A. Merkel S. | 2012 | Arthritis & Rheumatism2012，，1： | 2 |
| 16 | Process parameters and their effect on grafting reactions in core/shell latexes显示文摘 | MERKEL M DIMONIE V EL-AASSER M | 1987 | Journal of Polymer Science (Part A): Polymer Chemistry1987，25，7： | 1 |
| 17 | Gasvolumetrische bestimmung der amidosulfons(a)ure,H2NSO3H显示文摘 | MEUWESEN A MERKEL H | 1940 | Zeitschrift für anorganische und allgemeine Chemie1940，244，1： | 1 |
| 18 | Fibroblast growth factor, epidermal growth factor, and platelet derived growth factor-BB stimulate proliferation of clonally derived porcine myogenic satellite cells显示文摘 | Doumit M E Cook D R Merkel R A | 1993 | J Cell Physiol1993，157，： | 1 |
| 19 | A placebo-controlled clini- cal trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis显示文摘 | MERKEL C MARIN R ANGELI P | 2004 | Gastroenterology2004，127，： | 1 |
| 20 | Wnt signaling in- duces gene expression of factors associated with bone destruction in lung and breast cancer显示文摘 | Johnson R W Merkel A R Page J M | 2014 | Clin Exp Metastasis2014，31，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员