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| 1 | Role of the receptor for advanced glycation end products in hepatic fibrosis显示文摘AIM:To study the role of advanced glycation end products(AGE)and their specifi c receptor(RAGE)in the pathogenesis of liver fi brogenesis.METHODS:In vitro RAGE expression and extracellular matrix-related gene expression in both rat and human hepatic stellate cells(HSC)were measured after stimulation with the two RAGE ligands,advanced glycation end product-bovine serum albumin(AGE-BSA)and Nε-(carboxymethyl)lysine(CML)-BSA,or with tumor necrosis factor-α(TNF-α).In vivo RAGE expression was examined in models of hepatic fi brosis induced by bile duct ligation or thioacetamide.The effects of AGE-BSA and CML-BSA on HSC proliferation,signal transduction and profi brogenic gene expression were studied in vitro.RESULTS:In hepatic fibrosis,RAGE expression was enhanced in activated HSC,and also in endothelial cells,inflammatory cells and activated bile duct epithelia.HSC expressed RAGE which was upregulated after stimulation with AGE-BSA,CML-BSA,and TNF-α.RAGE stimulation with AGE-BSA and CML-BSA did not alter HSC proliferation,apoptosis,fibrogenic signal transduction and fibrosis-or fibrolysis-related gene expression,except for marginal upregulation of procollagen α1(Ⅰ)mRNA by AGE-BSA.CONCLUSION:Despite upregulation of RAGE in activated HSC,RAGE stimulation by AGE does not alter their fibrogenic activation.Therefore,RAGE does not contribute directly to hepatic fibrogenesis. | Christina Lohwasser Daniel Neureiter Yury Popov Michael Bauer Detlef Schuppan | 2009 | World Journal of Gastroenterology2009，15，46： | 13 |
| 2 | Epigenetics and pancreatic cancer:Pathophysiology and novel treatment aspects显示文摘An improvement in pancreatic cancer treatment represents an urgent medical goal.Late diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal overall prognosis that has remained unchanged during the past decades.Increasing knowledge about the molecular pathogenesis of the disease has shown that genetic alterations,such as mutations of K-ras,and especially epigenetic dysregulation of tumor-associated genes,such as silencing of the tumor suppressor p16ink4a,are hallmarks of pancreatic cancer.Here,we describe genes that are commonly affected by epigenetic dysregulation in pancreatic cancer via DNA methylation,histone acetylation or miRNA(microRNA)expression,and review the implications on pancreatic cancer biology such as epithelial-mesenchymal transition,morphological pattern formation,or cancer stem cell regulation during carcinogenesis from PanIN(pancreatic intraepithelial lesions)to invasive cancer and resistance development.Epigenetic drugs,such as DNA methyltransferases or histone deactylase inhibitors,have shown promising preclinical results in pancreatic cancer and are currently in early phases of clinical development.Combinations of epigenetic drugs with established cytotoxic drugs or targeted therapies are promising approaches to improve the poor response and survival rate of pancreatic cancer patients. | Daniel Neureiter Tarkan Jger Matthias Ocker Tobias Kiesslich | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 3 | Differential role of Hedgehog signaling in human pancreatic(patho-)physiology:An up to date review显示文摘Since the discovery of the Hedgehog(Hh)pathway in drosophila melanogaster,our knowledge of the role of Hh in embryonic development,inflammation,and cancerogenesis in humans has dramatically increased over the last decades.This is the case especially concerning the pancreas,however,real therapeutic breakthroughs are missing until now.In general,Hh signaling is essential for pancreatic organogenesis,development,and tissue maturation.In the case of acute pancreatitis,Hh has a protective role,whereas in chronic pancreatitis,Hh interacts with pancreatic stellate cells,leading to destructive parenchym fibrosis and atrophy,as well as to irregular tissue remodeling with potency of initiating cancerogenesis.In vitro and in situ analysis of Hh in pancreatic cancer revealed that the Hh pathway participates in the development of pancreatic precursor lesions and ductal adenocarcinoma including critical interactions with the tumor microenvironment.The application of specific inhibitors of components of the Hh pathway is currently subject of ongoing clinical trials(phases 1 and 2).Furthermore,a combination of Hh pathway inhibitors and established chemotherapeutic drugs could also represent a promising therapeutic approach.In this review,we give a structured survey of the role of the Hh pathway in pancreatic development,pancreatitis,pancreatic carcinogenesis and pancreatic cancer as well as an overview of current clinical trials concerning Hh pathway inhibitors and pancreas cancer. | Eckhard Klieser Stefan Swierczynski Christian Mayr Tarkan Jager Johanna Schmidt Daniel Neureiter Tobias Kiesslich Romana Illig | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 5 |
| 4 | Hepatocellular carcinoma: Therapeutic advances in signaling,epigenetic and immune targets显示文摘Hepatocellular carcinoma(HCC)remains a global medical burden with rising incidence due to chronic viral hepatitis and non-alcoholic fatty liver diseases.Treatment of advanced disease stages is still unsatisfying.Besides first and second generation tyrosine kinase inhibitors,immune checkpoint inhibitors have become central for the treatment of HCC.New modalities like epigenetic therapy using histone deacetylase inhibitors(HDACi)and cell therapy approaches with chimeric antigen receptor T cells(CAR-T cells)are currently under investigation in clinical trials.Development of such novel drugs is closely linked to the availability and improvement of novel preclinical and animal models and the identification of predictive biomarkers.The current status of treatment options for advanced HCC,emerging novel therapeutic approaches and different preclinical models for HCC drug discovery and development are reviewed here. | Daniel Neureiter Sebastian Stintzing Tobias Kiesslich Matthias Ocker | 2019 | World Journal of Gastroenterology2019，25，25： | 4 |
| 5 | Pancreatic cancer cells surviving gemcitabine treatment express markersof stem cell differentiation and epithelial-mesenchymal transition显示文摘 | Karl Quint Manuel Tonigold Pietro Di Fazio Roberta Montalbano Susanne Lingelbach Felix Rückert Beate Alinger Matthias Ocker Daniel Neureiter | 2012 | International Journal of Oncology2012，，6： | 2 |
| 6 | GERD—Barrett—Adenocarcinoma: Do We Have Suitable Prognostic and Predictive Molecular Markers?显示文摘 | Romana Illig Eckhard Klieser Tobias Kiesslich Daniel Neureiter P. Marco Fisichella | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 7 | Uptake and phototoxicity of meso-tetrahydroxyphenyl chlorine are highly variable in human hiiiary tract cancer cell lines and correlate with markers of differentiation and proliferation 显示文摘 | KIESSLICH T NEUREITER D ALINGER B | 2010 | Photochem Photobiol Sci2010，9，5： | 1 |
| 8 | Activation of tumor-specific T lymphocytes by radio-frequency ablation of the VX2 hepatoma in rabbits显示文摘 | Wissniowski TT Hansler J Neureiter D | 2003 | Cancer Res2003，63，19： | 1 |
| 9 | De-differentiated chondrosarcoma is not a 'de-differentiated' chondrosarcoma显示文摘 | Aigner T Dertinger S Neureiter D | 1998 | Histopathology1998，33，： | 1 |
| 10 | Late manifestation of Indian childhood cirrhosis in a 3-year-old German girl显示文摘 | Trollmann R Neureiter D Lang T | 1999 | Eur J Pediatr1999，158，5： | 1 |
| 11 | CD40-CD154 expression in calcified and non-calcified coronary lesions of patients with chronic renal failure显示文摘 | NEUREITER D NONNAST-DANIEL B | 2006 | Atherosclerosis2006，01，： | 1 |
| 12 | Detoxification of wood hydrolysates with wood charcoal for increasing the fermentability of hydrolysates显示文摘 | Hisashi Miyafuji Herbert Danner Markus Neureiter | 2003 | Enz Microb Technol2003，32，： | 1 |
| 13 | The receptorfor advanced glycation end products is highly expressed inthe skin and upregulated by advanced glycation end prod-ucts and tumor necrosis factor-alpha显示文摘 | Lohwasser C Neureiter D Weigle B | 2006 | J Invest Derma-tol2006，126，2： | 1 |
| 14 | Dilute acid hydrolysis of presscakes from silage and grass to recover hemicellulose-derived sugars显示文摘 | M. Neureiter H. Danner S. Frühauf S. Kromus C. Thomasser R. Braun M. Narodoslawsky | 2003 | Bioresource Technology2003，，1： | 1 |
| 15 | Detoxification of wood hydrolysates with wood charcoal for increasing the fermentability of hydrolysates显示文摘 | MIYAFUJI H DANNER H NEUREITER M | 2003 | Enzyme and Microbial Technology2003，32，： | 1 |
| 16 | Apoptosis cell death is not a widespread phenomenon in normal aging and osteoarthritis human aricular knee eartilage显示文摘 | Aigner T Hennel M Neureiter D | 2001 | Arth-ritis Rheum2001，44，6： | 1 |
| 17 | De--differentiated chondrosarcoma is not a 'de--differentiated' chondrosarcoma显示文摘 | Aigner T Derringer S Neureiter D | 1998 | Histopathology1998，33，1： | 1 |
| 18 | Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage 显示文摘 | Hemmel M Neureiter D | 2001 | Arthritis Rheum2001，44，6： | 1 |
| 19 | Atherosclerosis and vascular calcification in chronic renal failure显示文摘 | Campean V Neureiter D Varga I | 2005 | Kidney Blood Press Res2005，28，56： | 1 |
| 20 | Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer cells显示文摘 | Wachter J Neureiter D Alinger B | 2012 | Int J Biol Sci2012，8，1： | 1 |
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