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| 1 | Gastric cancer: Current status of lymph node dissection显示文摘D2 procedure has been accepted in Far East as the standard treatment for both early(EGC) and advanced gastric cancer(AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials(RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council(MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recur-rence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC. | Maurizio Degiuli Giovanni De Manzoni Alberto Di Leo Domenico D'Ugo Erica Galasso Daniele Marrelli Roberto Petrioli Karol Polom Franco Roviello Francesco Santullo Mario Morino | 2016 | World Journal of Gastroenterology2016，22，10： | 29 |
| 2 | Role of Helicobacter pylori infection on nutrition and metabolism显示文摘Helicobacter pylori(H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome. | Francesco Franceschi Tortora Annalisa Di Rienzo Teresa D'Angelo Giovanna Gianluca Ianiro Scaldaferri Franco Gerardi Viviana Tesori Valentina Lopetuso Loris Riccardo Gasbarrini Antonio | 2014 | World Journal of Gastroenterology2014，20，36： | 11 |
| 3 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 4 | The meaning of tissue and serum HCV RNA quantitation in hepatitis C recurrence after liver transplantation: A retrospective study显示文摘 | Francesco Vasuri Maria Cristina Morelli Elisa Gruppioni Michelangelo Fiorentino Giorgio Ercolani Matteo Cescon Antonio Daniele Pinna Walter Franco Grigioni Antonia D’Errico-Grigioni | 2013 | Digestive and Liver Disease2013，，6： | 3 |
| 5 | A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver Resection显示文摘 | Jean–Charles Nault Aurélien De Reyniès Augusto Villanueva Julien Calderaro Sandra Rebouissou Gabrielle Couchy Thomas Decaens Dominique Franco Sandrine Imbeaud Francis Rousseau Daniel Azoulay Jean Saric Jean–Frédéric Blanc Charles Balabaud Paulette Bioulac | 2013 | Gastroenterology2013，，1： | 3 |
| 6 | Serum α-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status显示文摘 | Franco Trevisani Paola Emanuela D’Intino Antonio Maria Morselli-Labate Giuseppe Mazzella Esterita Accogli Paolo Caraceni Marco Domenicali Stefania De Notariis Enrico Roda Mauro Bernardi | 2001 | Journal of Hepatology2001，，4： | 3 |
| 7 | Clinical significance of glycated hemoglobin in the acute phase of ST elevation myocardial infarction显示文摘In population-based studies,including diabetic and nondiabetic cohorts,glycated hemoglobin A1c(HbA1c) has been reported as an independent predictor of allcause and cardiovascular disease mortality.Data on the prognostic role of HbA1c in patients with acute myocardial infarction(MI) are not univocal since they stem from studies which mainly differ in patients' selection criteria,therapy(thrombolysis vs mechanical revascularization) and number consistency.The present review is focused on available evidence on the prognostic significance of HbA1c measured in the acute phase in patients with ST-elevation myocardial infarction(STEMI) submitted to primary percutaneous coronary intervention(PCI).We furthermore highlighted the role of HbA1c as a screening tool for glucose intolerance in patients with STEMI.According to available evidence,in contemporary cohorts of STEMI patients submitted to mechanical revascularization,HbA1c does not seem to be associated with short and long term mortality rates.However,HbA1c may represent a screening tool for glucose intolerance from the early phase on in STEMI patients.On a pragmatic ground,an HbA1c testhas several advantages over fasting plasma glucose or an oral glucose tolerance test in an acute setting.The test can be performed in the non-fasting state and reflects average glucose concentration over the preceding 2-3 mo.We therefore proposed an algorithm based on pragmatic grounds which could be applied in STEMI patients without known diabetes in order to detect glucose intolerance abnormalities from the early phase.The main advantage of this algorithm is that it may help in tailoring the follow-up program,by helping in identifying patients at risk for the development of glucose intolerance after MI.Further validation of this algorithm in prospective studies may be required in the contemporary STEMI population to resolve some of these uncertainties around HbA1c screening cutoff points. | Chiara Lazzeri Serafina Valente Marco Chiostri Maria Grazia D'Alfonso Gian Franco Gensini | 2014 | World Journal of Cardiology2014，6，4： | 2 |
| 8 | Colorectal stenting as a bridge to surgery reduces morbidity and mortality in left-sided malignant obstruction: a predictive risk score-based comparative study显示文摘 | Vincenzo Cennamo Carmelo Luigiano Gianpiero Manes Rocco Maurizio Zagari Luca Ansaloni Carlo Fabbri Liza Ceroni Fausto Catena Antonio Daniele Pinna Lorenzo Fuccio Alessandro Mussetto Tino Casetti Federico Coccolini Nicola D’Imperio Franco Bazzoli | 2012 | Digestive and Liver Disease2012，，6： | 2 |
| 9 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 10 | Emerging role of capecitabine in gastric cancer 显示文摘 | Comella P Franco L Pharm D | 2009 | Pharmacotherapy2009，29，3： | 1 |
| 11 | Resection of hepatocellular carcinoma显示文摘 | Franco D Usatoff V | 2001 | Hepatogastroenterology2001，48，： | 1 |
| 12 | PCNA in the testis of the frog, Rana esculenta; A molecular marker of the mitotic testicular epithelium proliferation显示文摘 | Paolo C Franco R Fulgione D | 2000 | General and Comparative Endocrinology2000，119，： | 1 |
| 13 | Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium 显示文摘 | Ao M Franco OE Park D | 2007 | Cancer Res2007，67，： | 1 |
| 14 | Portal hypertension af- ter bile duct obstruction: effect of bile diversion on portal pressure in the rat显示文摘 | Franco D Gigou M Szekely AM | 1979 | Arch Surg1979，114，9： | 1 |
| 15 | Ge- netic identification of lamniform and earcharhiniform sharks using multiplex - PCR 显示文摘 | Mendonca F F Hashimoto D T De - Franco B | 2010 | Conser- Genet Re- sour2010，2，1： | 1 |
| 16 | Full laparoscopic total pancreatectomy with and without spleen and pylorus preservation: a feasibility report显示文摘 | Bernard Dallemagne Antonio Talvane Torres Oliveira Croider Franco Lacerda Jacopo D’Agostino Henry Mercoli Jacques Marescaux | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，6： | 1 |
| 17 | Nanoscale mapping and functional analysis of individual adhesins on living bacteria显示文摘 | VINCENT D FRANCO D M CAMILLE L | 2005 | Nat Methods2005，2，7： | 1 |
| 18 | The epidemiology of cervical cancer 显示文摘 | Franco EL Schlecht NF Saslow D | 2003 | Cancer J2003，9，5： | 1 |
| 19 | Natural antioxidants from residual sources显示文摘 | MOURE A CRUZ J M FRANCO D | 2001 | Food Chemistry2001，72，： | 1 |
| 20 | Follicular loss in endoscopic surgery for ovarian endometriosis:quantitative and qualitative observations显示文摘 | Romualdi D Franco Zannoni G Lanzone A | | 0，，02： | 1 |
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