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| 1 | 分布式发电及其与电网的关系显示文摘分析了分布式发电的特点,讨论了分布式发电与电网的关系。 | Michelangelo Celozzi 何斯征 | 2003 | 能源工程2003，，5： | 18 |
| 2 | PTEN in liver diseases and cancer显示文摘The phosphoinositide 3-kinase (PI3K)/phosphatase and tensin homolog (PTEN)/Akt axis is a key signal transduction node that regulates crucial cellular functions, including insulin and other growth factors signaling, lipid and glucose metabolism, as well as cell survival and apoptosis. In this pathway, PTEN acts as a phosphoinositide phosphatase, which terminates PI3Kpropagated signaling by dephosphorylating PtdIns(3,4)P2 and PtdIns(3,4,5)P3. However, the role of PTEN does not appear to be restricted only to PI3K signaling antagonism, and new functions have been recently discovered for this protein. In addition to the well-established role of PTEN as a tumor suppressor, increasing evidence now suggests that a dysregulated PTEN expression and/or activity is also linked to the development of several hepatic pathologies. Dysregulated PTEN expression/activity is observed with obesity, insulin resistance, diabetes, hepatitis B virus/hepatitis C virus infections, and abusive alcohol consumption, whereas mutations/deletions have also been associated with the occurrence of hepatocellular carcinoma. Thus, it appears that alterations of PTEN expression and activity in hepatocytes are common and recurrent molecular events associated with liver disorders of various etiologies. These recent f indings suggest that PTEN might represent a potential common therapeutic target for a number of liver pathologies. | Marion Peyrou Lucie Bourgoin Michelangelo Foti | 2010 | World Journal of Gastroenterology2010，16，37： | 16 |
| 3 | role of microRNAs in the main molecular pathways of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs(miRNAs) are small noncoding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes. The aim of this review was to identify papers published in 2017 investigating the role of miRNAs in HCC tumorigenesis. miRNAs were classified according to their role in the main molecular pathways involved in HCC tumorigenesis:(1) m TOR;(2) Wnt;(3) JAK/STAT;(4) apoptosis; and(5) MAPK. The role of miRNAs in prognosis/response prediction was taken into consideration. Bearing in mind that the analysis of miRNAs in serum and other body fluids would be crucial for clinical management, the role of circulating miRNAs in HCC patients was also investigated. The most represented mi RNA-regulated pathway in HCC is m TOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by mi RNA expression levels. These miRNAs could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment. | Francesco Vasuri Michela Visani Giorgia Acquaviva Thomas Brand Michelangelo Fiorentino Annalisa Pession Giovanni Tallini Antonia D’Errico Dario de Biase | 2018 | World Journal of Gastroenterology2018，24，25： | 16 |
| 4 | Extent of lymphadenectomy and perioperative therapies:two open issues in gastric cancer显示文摘Gastric cancer is one of the leading causes of death for cancer worldwide,although geographical variations in incidence exist.Over the last decades,its incidence and mortality have gradually decreased in Western countries,while these have increased,or remained stable,in the other world regions.Gastric cancer is often diagnosed at an advanced stage,with the only notable exception of Japan,where nationwide screening programs are enforced,due to local high incidence.Curativeintent surgery(i.e.,gastrectomy,total or partial,and lymphadenectomy)remains the cornerstone of treatment of gastric cancer.Much has been debated about the extent of lymph node dissection and,although it is a valuable contribution to staging and cure,operative treatment only represents one aspect of overall effective management,as the risk of both locoregional and distant recurrences are high,and bear a poor prognosis.As a matter of fact,surgery,as a single modality treatment,has probably achieved its maximum efficacy for local control and survival,while other accompanying nonsurgical treatment modalities have to be taken into account,although their role is still the subject of considerable debate.The authors in this review present an update on the outcome of treatment of gastric cancer in relation to the extent of lymphadenectomy and of various nonsurgical preoperative,intraoperative,and postoperative strategies. | Andrea Giuliani Michelangelo Miccini Luigi Basso | 2014 | World Journal of Gastroenterology2014，20，14： | 14 |
| 5 | The meaning of tissue and serum HCV RNA quantitation in hepatitis C recurrence after liver transplantation: A retrospective study显示文摘 | Francesco Vasuri Maria Cristina Morelli Elisa Gruppioni Michelangelo Fiorentino Giorgio Ercolani Matteo Cescon Antonio Daniele Pinna Walter Franco Grigioni Antonia D’Errico-Grigioni | 2013 | Digestive and Liver Disease2013，，6： | 3 |
| 6 | phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease显示文摘AIM: To investigate the protein expression of phosphatase and tensin homolog(PTEN) in human liver biopsies of patients with alcoholic and non-alcoholic liver disease.METHODS: PTEN protein expression was assessed by immunohistochemistry in formalin-fixed, paraffinembedded liver sections of patients with non-alcoholic fatty liver disease(NAFLD)(n = 44) or alcoholic liver disease(ALD)(n = 25). Liver resections obtained from 3 healthy subjects candidate for partial liver donation served as controls. Histological evaluations were performed by two experienced pathologists, and diagnoses established based on international criteria. The intensity of the PTEN staining in nuclei was compared between steatotic and non-steatotic areas of each liver fragment analyzed. For each liver specimen, the antibody-stained sections were examined and scored blindly by three independent observers, who were unaware of the patients' clinical history.RESULTS: In healthy individuals, PTEN immunostaining was intense in both the cytoplasm and nuclei of all hepatocytes. However, PTEN was strongly downregulated in both the nucleus and the cytoplasm of hepatocytes from steatotic areas in patients with NAFLD, independently of the disease stage. In contrast, no changes in PTEN protein expression were observed in patients with ALD, regardless of the presence of steatosis or the stage of the disease. The degree of PTEN downregulation in hepatocytes of patients with NAFLD correlated with the percentage of steatosis(r = 0.3061, P = 0.0459) and the BMI(r = 0.4268, P = 0.0043). Hovewer, in patients with ALD, PTEN expression was not correlated with the percentage of steatosis with or without obesity as a confounding factor(P = 0.5574). Finally, PTEN expression level in steatotic areas of ALD patients was significantly different from that seen in steatotic areas of NAFLD patients(P < 0.0001).CONCLUSION: PTEN protein expression is downregulated early in NAFLD, but not in ALD. PTEN immunohistochemical detection could help in the differential diagnosis of NAFLD and ALD. | Andrea Sanchez-Pareja Sophie Clément Marion Peyrou Laurent Spahr Francesco Negro Laura Rubbia-Brandt Michelangelo Foti | 2016 | World Journal of Gastroenterology2016，22，14： | 2 |
| 7 | Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA‐21 up‐regulation in hepatocytes显示文摘 | Manlio Vinciguerra Antonino Sgroi Christelle Veyrat‐Durebex Laura Rubbia‐Brandt Leo H. Buhler Michelangelo Foti | 2009 | Hepatology2009，，4： | 2 |
| 8 | Determination of ochratoxin A in wine by means of immunoaffinity column clean-up and high-performance liquid chromatography 显示文摘 | Angelo Visconti Michelangelo Pascale Gianluca Centonze | 1999 | Journal of Chromatography A1999，864，： | 1 |
| 9 | Current analytical methods for trichothecene my- cotoxins in cereals 显示文摘 | Veronica M T Lattanzio Michelangelo Pascale Angelo Visconti | 2009 | Trends in Analytical Chemistry2009，28，6： | 1 |
| 10 | Analysis of T-2 and HT-2 toxins in cereal grains by immunoaffinity clean-up and liquid chromatography with fluorescence detection显示文摘 | Angelo Visconti Veronica Maria Teresa Lattanzio Michelangelo Pascale Miriam Haidukowski | 2005 | Journal of Chromatography A2005，，1： | 1 |
| 11 | Increased Vascular Endothelial Growth Factor Expression But Impaired Vascular Endothelial Growth Factor Receptor Signaling in the Myocardium of Type 2 Diabetic Patients With Chronic Coronary Heart Disease显示文摘 | Ferdinando Carlo Sasso Daniele Torella Ornella Carbonara Georgina M. Ellison Michele Torella Michelangelo Scardone Claudio Marra Rodolfo Nasti Raffaele Marfella Domenico Cozzolino Ciro Indolfi Maurizio Cotrufo Roberto Torella Teresa Salvatore | 2005 | Journal of the American College of Cardiology2005，，5： | 1 |
| 12 | The role of oxidative stress in paraquat-induced neurotoxicity in rats:protection by non peptidyl superoxide dismutase mimetic显示文摘 | Vincenzo Mollace Michelangelo Iannone Carolina Muscoli | 2003 | Neurosci Lett2003，335，3： | 1 |
| 13 | Fluorescence Polarization Immunoassay for Rapid, Accurate and Sensitive Determination of Ochratoxin A in Wheat显示文摘 | Vincenzo Lippolis Michelangelo Pascale Stefania Valenzano Anna Chiara Raffaella Porricelli Michele Suman Angelo Visconti | 2014 | Food Analytical Methods2014，，2： | 1 |
| 14 | External fixation in pelvic fractures显示文摘 | Michelangelo Scaglione Paolo Parchi Digrandi G | 2010 | Musculoskelet Surg2010，94，1： | 1 |
| 15 | Fast and easy muhiresidue method employing acetonitrile extraction/partitioning and ' dispersine - phase extraction' for the determi- nation of pesticide residues in product 显示文摘 | Michelangelo Anastassiaoles Steven J Lehotay Darinka Stajnbaher | | AOAC0，86，2： | 1 |
| 16 | Rapid method for determi- nation of phosphine residues in wheat 显示文摘 | Francesco L Michelangelo P Marco S | 2008 | Food Analysis Methods2008，，1： | 1 |
| 17 | Antiproliferative and antioxidant effects on breast cancer cells of oleuropein and its semisynthetic peracetylated derivatives显示文摘 | Stefania Bulotta Rosanna Corradino Marilena Celano Maria D’Agostino Jessica Maiuolo Manuela Oliverio Antonio Procopio Michelangelo Iannone Domenicantonio Rotiroti Diego Russo | 2011 | Food Chemistry2011，，4： | 1 |
| 18 | Oval and round window vibroplasty: a comparison of hearing results, risks and failures显示文摘 | Andrea Canale Federico Dagna Claudia Cassandro Pamela Giordano Federico Caranzano Michelangelo Lacilla Roberto Albera | 2014 | European Archives of Oto-Rhino-Laryngology2014，，10： | 1 |
| 19 | Mapping Wnt/13-catenin signaling during mouse development and in colorectal tumors显示文摘 | Silivia Maretto Michelangelo Cordenonsi SirioDupont | 2003 | Proc Natl Acad Sci USA2003，100，6： | 1 |
| 20 | Decrease of immuno- reactive catalase protein in specific areas of ageing rat brain 显示文摘 | Maria RC Maria RM Michelangelo I | 1997 | Neurosci Leg1997，228，1： | 1 |
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