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| 1 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 2 | Idarubicin vs doxorubicin in transarterial chemoembolization of intermediate stage hepatocellular carcinoma显示文摘BACKGROUND Liver cancer is the fifth most common cancer and the second cause of cancerrelated deaths worldwide.Transarterial chemoembolization(TACE)is the best treatment of intermediate hepatocellular carcinoma(HCC).Doxorubicin is the most commonly used drug despite a low level of evidence.AIM To compare the objective response rate of idarubicin-based TACE(Ida-TACE)against doxorubicin-based TACE(Dox-TACE)in intermediate stage HCC.METHODS Between January 2012 and December 2014,all patients treated with TACE at our academic hospital were screened.Inclusion criteria were patients with Child-Pugh score A or B,a performance status below or equal to 1,and no prior TACE.Either lipiodol TACE or drug-eluting beads TACE could be performed with 10 mg of idarubicin or 50 mg of doxorubicin.Each patient treated with idarubicin was matched with two doxorubicin-treated patients.The TACE response was assessed by independent radiologists according to the mRECIST criteria.RESULTS Sixty patients were treated with doxorubicin and thirty with idarubicin.There were 93%and 87%of cirrhotic patients and 87%and 70%of Child-Pugh A in the doxorubicin and idarubicin groups,respectively.The median number of HCC per patient was two in both groups with 31%and 26%of single nodules in doxorubicin and idarubicin groups,respectively.Objective response rate after first TACE was 76.7%and 73.3%(P=0.797)with 41.7%and 40.0%complete response in doxorubicin and idarubicin groups,respectively.Progression-free survival was 7.7 mo in both groups,and liver transplant-free survival was 24.9 mo and 21.9 mo in doxorubicin and idarubicin groups,respectively.Safety profiles were similar in both groups,with grade 3-4 adverse events in 35%of Dox-TACE and 43%of Ida-TACEs.CONCLUSION Ida-TACE and Dox-TACE showed comparable results in terms of efficacy and safety.Ida-TACE may represent an interesting alternative to Dox-TACE in the management of patients with intermediate stage HCC. | Gael Stephane Roth Yann Teyssier Melodie Abousalihac Arnaud Seigneurin Julien Ghelfi Christian Sengel Thomas Decaens | 2020 | World Journal of Gastroenterology2020，26，3： | 3 |
| 3 | A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver Resection显示文摘 | Jean–Charles Nault Aurélien De Reyniès Augusto Villanueva Julien Calderaro Sandra Rebouissou Gabrielle Couchy Thomas Decaens Dominique Franco Sandrine Imbeaud Francis Rousseau Daniel Azoulay Jean Saric Jean–Frédéric Blanc Charles Balabaud Paulette Bioulac | 2013 | Gastroenterology2013，，1： | 3 |
| 4 | Liver Resection for Transplantable Hepatocellular Carcinoma: Long-Term Survival and Role of Secondary Liver Transplantation显示文摘 | Daniel Cherqui Alexis Laurent Nicolas Mocellin Claude Tayar Alain Luciani Jeanne Tran Van Nhieu Thomas Decaens Monika Hurtova Riccardo Memeo Ariane Mallat Christophe Duvoux | 2009 | Annals of Surgery2009，，5： | 2 |
| 5 | Carbon and nitrogen dynamics in ageing earthworm casts in grasslands of the eastern plains of Colombia 显示文摘 | DECAENS T RANGEL A F ASAKAWA N THOMAS R J | 1999 | Biology and Fertility of Soils1999，30，1： | 1 |
| 6 | Suc- cessional changes, diversity of soil macro faunal com- munities on chalk grasslands in Upper-Normandy (France) 显示文摘 | Thierry Dutoit Thibaud Decaens Didier Alard | 1997 | Acta Oecologica1997，2，18： | 1 |
| 7 | Phosphorus fractions and dynamics in surface earthworm casts under native and improved grasslands in a Colombian savanna Oxisol显示文摘 | Jimenez J J Cepeda A Decaens T | 2003 | Soil Biology&Biochemistry2003，35，5： | 1 |
| 8 | Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas显示文摘 | Colnot S Decaens T Niwa-Kawakita M | 2004 | Proc Natl Acad Sci USA2004，101，17： | 1 |
| 9 | Soil invertebrates and ecosystem services显示文摘 | Lavelle P Decaens T Aubert M | 2006 | European Journal of Soil Biology2006，42，： | 1 |
| 10 | Induction of rat intestinal carcinogenesis with single doses, low and high repeated doses of 1,2-dimethylhydrazine 显示文摘 | Decaens C Gautier R Daher N | 1989 | Carcinogenesis1989，10，1： | 1 |
| 11 | Ape tumor suppressor gene is the 'zonation-keeper'of mouse liver显示文摘 | Benhamouche S Decaens T Godard C | | 0，，06： | 1 |
| 12 | Ape tumor suppressor gene is the 'zonation-keeper' of mouse liver 显示文摘 | Benhamouche S Decaens T Godard C | 2006 | Dev Cell2006，10，6： | 1 |
| 13 | Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas显示文摘 | Colnot S Decaens T Niwa-Kawakita M | 2004 | Proc Natl Acad Sci USA2004，101，17： | 1 |
| 14 | Liver Resection for Transplantable Hepatocellular Carcinoma: Long-Term Survival and Role of Secondary Liver Transplantation显示文摘 | Daniel Cherqui Alexis Laurent Nicolas Mocellin Claude Tayar Alain Luciani Jeanne Tran Van Nhieu Thomas Decaens Monika Hurtova Riccardo Memeo Ariane Mallat Christophe Duvoux | 2009 | Annals of Surgery2009，，5： | 1 |
| 15 | Imaging benign hepatocellular tumors: Atypical forms and diagnostic traps显示文摘 | L. Baranes M. Chiaradia F. Pigneur T. Decaens M. Djabbari B. Zega? C. Costentin A. Laurent J. Calderaro A. Rahmouni A. Luciani | | Diagnostic and Interventional Imaging (-)0，，： | 1 |
| 16 | Stabilization of be- ta-catenin affects mouse embryonic liver growth and hepato- blast fate显示文摘 | Decaens T Godard C de Reynis A | 2008 | Hepatology2008，47，1： | 1 |
| 17 | Liver Transplantation for Hepatocellular Carcinoma: A Model Including α-Fetoprotein Improves the Performance of Milan Criteria显示文摘 | Christophe Duvoux Fran?oise Roudot–Thoraval Thomas Decaens Fabienne Pessione Hanaa Badran Tullio Piardi Claire Francoz Philippe Compagnon Claire Vanlemmens Jérome Dumortier Sébastien Dharancy Jean Gugenheim Pierre–Henri Bernard René Adam Sylvie Radenne Fa | 2012 | Gastroenterology2012，，4： | 1 |
| 18 | Soil surface macrofaunal communities associated with earthworm casts in grasslands of the Eastern Plains of Colombia显示文摘 | DECAENS T MARINAI L LAVELLE P | 1999 | Applied Soil Ecology1999，13，： | 1 |
| 19 | Which in vitro models could be best used to study hepatocyte polarity?显示文摘 | Decaens C Durand M Grosse B | 2008 | Biol Cell2008，100，7： | 1 |
| 20 | Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma显示文摘 | Decaens T Roudot-Thoraval F Bresson-Hadni S | 2005 | Liver Transpl2005，11，7： | 1 |
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