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| 1 | Adhesive small bowel adhesions obstruction: Evolutions in diagnosis, management and prevention显示文摘Intra-abdominal adhesions following abdominal surgery represent a major unsolved problem. They are the first cause of small bowel obstruction. Diagnosis is based on clinical evaluation, water-soluble contrast followthrough and computed tomography scan. For patients presenting no signs of strangulation, peritonitis or severe intestinal impairment there is good evidence to support non-operative management. Open surgery is the preferred method for the surgical treatment of adhesive small bowel obstruction, in case of suspected strangulation or after failed conservative management, but laparoscopy is gaining widespread acceptance especially in selected group of patients. 'Good' surgical technique and anti-adhesive barriers are the main current concepts of adhesion prevention. We discuss current knowledge in modern diagnosis and evolving strategies for management and prevention that are leading to stratified care for patients. | Fausto Catena Salomone Di Saverio Federico Coccolini Luca Ansaloni Belinda De Simone Massimo Sartelli Harry Van Goor | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 28 |
| 2 | Advanced gastric cancer:what we know and what we stillhave to learn显示文摘Gastric cancer is a common neoplastic disease and, more precisely, is the third leading cause of cancer death in the world, with differences amongst geographic areas. The definition of advanced gastric cancer is still debated. Different stadiating systems lead to slightly different stadiation of the disease, thus leading to variations between the single countries in the treatment and outcomes. In the present review all the possibilities of treatment for advanced gastric cancer have been analyzed. Surgery, the cornerstone of treatment for advanced gastric cancer, is analyzed first, followed by an investigation of the different forms and drugs of chemotherapy and radiotherapy. New frontiers in treatment suggest the growing consideration for intraperitoneal administration of chemotherapeutics and combination of traditional drugs with new ones. Moreover, the necessity to prevent the relapse of the disease leads to the consideration of administering intraperitoneal chemotherapy earlier in the therapeutical algorithm. | Federico Coccolini Giulia Montori Marco Ceresoli Simona Cima Maria Carla Valli Gabriela E Nita Arianna Heyer Fausto Catena Luca Ansaloni | 2016 | World Journal of Gastroenterology2016，22，3： | 25 |
| 3 | Acute appendicitis: Epidemiology, treatment and outcomesanalysis of 16544 consecutive cases显示文摘AIM To investigate the epidemiology,treatment and outcomes of acute appendicitis(AA) in a large population study.METHODS This is a retrospective cohort study derived from the administrative dataset of the Bergamo district healthcare system(more than 1 million inhabitants) from 1997 to 2013.Data about treatment,surgery,length of stay were collected.Moreover for each patients were registered data about relapse of appendicitis and hospital admission due to intestinal obstruction.RESULTS From 1997 to 2013 in the Bergamo district we collected 16544 cases of AA,with a crude incidence rate of 89/100000 inhabitants per year; mean age was 24.51 ± 16.17,54.7% were male and the mean Charlson's comorbidity index was 0.32 ± 0.92.Mortality was < 0.0001%.Appendectomy was performed in 94.7% of the patients and the mean length of stay was 5.08 ± 2.88 d; the cumulative hospital stay was 5.19 ± 3.36 d and 1.2% of patients had at least one further hospitalization due intestinal occlusion.Laparoscopic appendectomy was performed in 48% of cases.Percent of 5.34 the patients were treated conservatively with a mean length of stay of 3.98 ± 3.96 d; the relapse rate was 23.1% and the cumulative hospital stay during the study period was 5.46 ± 6.05 d.CONCLUSION The treatment of acute appendicitis in Northern Italy is slowly changing,with the large diffusion of laparoscopic approach; conservative treatment of non-complicated appendicitis is still a neglected option,but rich of promising results. | Marco Ceresoli Alberto Zucchi Niccolò Allievi Asaf Harbi Michele Pisano Giulia Montori Arianna Heyer Gabriela E Nita Luca Ansaloni Federico Coccolini | 2016 | World Journal of Gastrointestinal Surgery2016，8，10： | 14 |
| 4 | Peritoneal carcinomatosis显示文摘Several gastrointestinal and gynecological malignancies have the potential to disseminate and grow in the peritoneal cavity.The occurrence of peritoneal carcinomatosis(PC)has been shown to significantly decrease overall survival in patients with liver and/or extraperitoneal metastases from gastrointestinal cancer.During the last three decades,the understanding of the biology and pathways of dissemination of tumors with intraperitoneal spread,and the understanding of the protective function of the peritoneal barrier against tumoral seeding,has prompted the concept that PC is a loco-regional disease:in absence of other systemic metastases,multimodal approaches combining aggressive cytoreductive surgery,intraperitoneal hyperthermic chemotherapy and systemic chemotherapy have been proposed and are actually considered promising methods to improve loco-regional control of the disease,and ultimately to increase survival.The aim of this review article is to present the evidence on treatment of PC in different tumors,in order to provide patients with a proper surgical and multidisciplinary treatment focused on optimal control of their locoregional disease. | Federico Coccolini Federico Gheza Marco Lotti Salvatore Virzì Domenico Iusco Claudio Ghermandi Rita Melotti Gianluca Baiocchi Stefano Maria Giulini Luca Ansaloni Fausto Catena | 2013 | World Journal of Gastroenterology2013，19，41： | 9 |
| 5 | Esophagogastric junction gastrointestinal stromal tumor:Resection vs enucleation显示文摘Esophageal gastrointestinal stromal tumors(GISTs) are extremely uncommon,representing approximately 5% of GISTs with the majority of esophageal GISTs occurring at the esophagogastric junction(EGJ).The treatment options available for these GISTs are fairly controversial.Many different options are nowadays at our disposal.From surgery to the target therapies we have the possibility to treat the majority of GISTs,including those which are defined as unresectable.The EGJ GISTs represent a stimulating challenge for the surgeon.The anatomical location increases the possibility of postoperative complications.As the role of negative margins in GIST surgery is still controversial and the eff icacy of target therapy has been demonstrated,why not treat EGJ GISTs with enucleation and,where indicated,adjuvant target therapy? | Federico Coccolini Fausto Catena Luca Ansaloni Daniel Lazzareschi Antonio Daniele Pinna | 2010 | World Journal of Gastroenterology2010，16，35： | 7 |
| 6 | Antimicrobial management of intra-abdominal infections:Literature's guidelines显示文摘Antimicrobial management of severe intra-abdominal infections (IAIs) involves a delicate balance of optimizing empirical therapy,which has been shown to improve clinical outcomes,while simultaneously reducing unnecessary antimicrobial use.Two sets of guidelines for the management of intra-abdominal infections were recently published.In 2010,the Surgical Infection Society and the Infectious Diseases Society of America (SIS-IDSA) created guidelines for the diagnosis and management of complicated IAIs.The new SIS-IDSA guidelines replace those previously published in 2002 and 2003.The World Society of Emergency Surgery (WSES) guidelines represent additional contributions,made by specialists worldwide,to the debate regarding proper antimicrobial drug methodology.These guidelines represent the conclusions of the consensus conference held in Bologna,Italy,in July 2010 during the first congress of the WSES. | Massimo Sartelli Fausto Catena Federico Coccolini Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，9： | 7 |
| 7 | Peritoneal seeding from appendiceal carcinoma:A case report and review of the literature显示文摘Non-carcinoid appendiceal malignancies are rare entities,representing less than 0.5% of all gastrointestinal malignancies.Because of their rarity and particular biological behavior,a substantial number of patients affected by these neoplasms do not receive appropriate surgical resection.In this report,we describe a rare case of primary signetring cell carcinoma of the appendix with peritoneal seeding which occurred in a 40-year old man admitted at the Emergency Surgery Department with the clinical suspicion of acute appendicitis.After a surgical debulking and right hemicolectomy,the patient had systemic chemotherapy according to FOLFOX protocol.After completion of the latter,the patient underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy.This report offers a brief review of the literature and suggests an algorithm for the management of non-carci-noid appendiceal tumors with peritoneal dissemination. | Valentina R Bertuzzo Federico Coccolini Antonio D Pinna | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 6 |
| 8 | Laparoscopic management of intra-abdominal infections:Systematic review of the literature显示文摘AIM: To investigate the role of laparoscopy in diagnosis and treatment of intra abdominal infections.METHODS: A systematic review of the literature was performed including studies where intra abdominal infections were treated laparoscopically.RESULTS: Early laparoscopic approaches have become the standard surgical technique for treating acute cholecystitis. The laparoscopic appendectomy has been demonstrated to be superior to open surgery in acute appendicitis. In the event of diverticulitis, laparoscopic resections have proven to be safe and effective procedures for experienced laparoscopic surgeons and may be performed without adversely affecting morbidity and mortality rates. However laparoscopic resection has not been accepted by the medical community as the primary treatment of choice. In high-risk patients, laparoscopic approach may be used for exploration or peritoneal lavage and drainage. The successful laparoscopic repair of perforated peptic ulcers for experienced surgeons, is demonstrated to be safe and effective. Regarding small bowel perforations, comparative studies contrasting open and laparoscopic surgeries have not yet been conducted. Successful laparoscopic resections addressing iatrogenic colonic perforation have been reported despite a lack of literature-based evidence supporting such procedures. In post-operative infections, laparoscopic approaches may be useful in preventing diagnostic delay and controllingthe source.CONCLUSION: Laparoscopy has a good diagnostic accuracy and enables to better identify the causative pathology; laparoscopy may be recommended for the treatment of many intra-abdominal infections. | Federico Coccolini Cristian Tranà Massimo Sartelli Fausto Catena Salomone Di Saverio Roberto Manfredi Giulia Montori Marco Ceresoli Chiara Falcone Luca Ansaloni | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 5 |
| 9 | Gastrointestinal stromal tumor and mitosis,pay attention显示文摘The difference between stages Ⅰ and Ⅲ of gastric gastrointestinal stromal tumor depends principally on the number of mitosis.According with TNM classification,the presence in the tumor of high mitotic rate determines the upgrading.Many studies exposed different count techniques in evaluating the number of mitosis.An international standardized method to assess mitotic rate is needed. | Federico Coccolini Fausto Catena Luca Ansaloni Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，6： | 2 |
| 10 | The Treatment of Peritoneal Carcinomatosis in Advanced Gastric Cancer: State of the Art显示文摘 | Giulia Montori Federico Coccolini Marco Ceresoli Fausto Catena Nicola Colaianni Eugenio Poletti Luca Ansaloni George H. Sakorafas | 2014 | International Journal of Surgical Oncology2014，，： | 2 |
| 11 | Colorectal stenting as a bridge to surgery reduces morbidity and mortality in left-sided malignant obstruction: a predictive risk score-based comparative study显示文摘 | Vincenzo Cennamo Carmelo Luigiano Gianpiero Manes Rocco Maurizio Zagari Luca Ansaloni Carlo Fabbri Liza Ceroni Fausto Catena Antonio Daniele Pinna Lorenzo Fuccio Alessandro Mussetto Tino Casetti Federico Coccolini Nicola D’Imperio Franco Bazzoli | 2012 | Digestive and Liver Disease2012，，6： | 2 |
| 12 | WSES/SIS-E/WSIS/AAST/GAIS制定的免疫功能低下患者急腹症管理指南解读显示文摘世界急诊外科学会(WSES)联合欧洲外科感染学会(SIS-E)、世界外科感染学会(WSIS)、美国创伤外科协会(AAST)和全球外科感染联盟(GAIS)制定了有关免疫功能低下患者急腹症管理的指南,并于2021年8月9日在《世界急诊外科杂志》(WJES)上发表。该指南从免疫功能低下患者的定义、分类、诊断、治疗进行了详尽的阐述。此外,基于循证医学证据就免疫功能低下患者特异性急性腹腔感染、移植患者常见急性腹腔感染、人类免疫缺陷病毒(HIV)感染者或获得性免疫缺陷综合征(AIDS)患者的诊断和治疗以及围手术期类固醇的管理给出了指导意见。本文对该指南进行解读,以更好地理解免疫功能低下患者急腹症的诊治现状以及推荐意见,并就其局限性提出建议。 | 郑飞波 杨春勇 崔云峰 张雅敏 Federico Coccolini | 2022 | 中华危重病急救医学2022，34，3： | 2 |
| 13 | Water-soluble contrast agent in adhesive small bowel obstruction:a systematic review and meta-analysis of diagnostic and therapeutic value显示文摘 | Ceresoli M Coccolini F Catena F | 2015 | Am J Surg2015，19，12： | 1 |
| 14 | Surgery versus conservative antibiotic treatment in acute appendicitis:a systematic review and meta-analysis of randomized controlled trials显示文摘 | ANSALONI L CATENA F COCCOLINI F | 2011 | Dig Surg2011，28，3： | 1 |
| 15 | Inguinal hernia repair with porcine small intestine submueosa: 3-year follow-up results of a randomized controlled trial of Lichtenstein's repair with polypmpyleue mesh versus surgisis inguinal hernia matrix显示文摘 | Ansaloni L Catena F Coccolini F | 2009 | Am Surg2009，198，3： | 1 |
| 16 | Assessment of 126,913 inguinal hernia repairs in the Emilia-Romagna region of Italy:analysis of 10 years显示文摘 | Ansaloni L Coccolini F Fortuna D | 2014 | Hernia2014，18，2： | 1 |
| 17 | The Italian Regis- ter of Biological Prostheses显示文摘 | Coccolini F Poiasina E Bertoli P | 2013 | Eur Surg Res2013，50，34： | 1 |
| 18 | Peritoneal adhesions to prosthetic materials : an experimental comparative study of treated and untreated polypropylene meshes placed in the abdominal cavity 显示文摘 | Ansaloni L Catena F Coccolini F | 2009 | J Lapamendosc Adv Surg Tech A2009，19，3： | 1 |
| 19 | Meta-analysis of randomized trials comparing endoscopic stenting and surgical decompression for colorectal cancer obstruction显示文摘 | Vincenzo Cennamo Carmelo Luigiano Federico Coccolini Carlo Fabbri Marco Bassi Giuseppe Caro Liza Ceroni Antonella Maimone Paolo Ravelli Luca Ansaloni | 2013 | International Journal of Colorectal Disease2013，，6： | 1 |
| 20 | Gastrointestinal Perforations Following Kidney Transplantation显示文摘 | F. Catena L. Ansaloni F. Gazzotti R. Bertelli S. Severi F. Coccolini G. Fuga B. Nardo L. D’Alessandro A. Faenza A.D. Pinna | 2008 | Transplantation Proceedings2008，，6： | 1 |
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