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29篇 您的检索式:作者名="Imbeaud"
    题名 作者 年代 出处 被引量
1Has-miR-31-3p表达与K-ras基因野生型转移性结直肠癌患者抗EGFR治疗的无进展生存期有关显示文摘目前抗EGFR治疗只应用于KRAS野生型转移性结直肠患者,然在这些患者的获益率只有不到40%。因而寻找更多更精确的生物标志物用于筛选出最适宜的治疗患者显得尤为迫切。为此,多中心协作开展了一项研究,该研究目的是筛选出能预测KRAS野生型转移性结直肠患者抗EGFR治疗疗效的miRNAs。该研究分析了87例mCRC患者miRNA表达谱,这些患者均对化疗耐受而选用抗EGFR治疗。其中包括回顾性的33例新鲜冷冻组织标本、35例福尔马林固定石蜡包埋标本,以及19例前瞻性研究获得新鲜冻藏标本。之后对前瞻性研究中转移性结直肠癌抗EGFR治疗患者中19例新鲜冻存和26例福尔马林固定石蜡标本(共45例)进行独立验证。Manceau G Imbeaud S Thiebaut R 2014中华结直肠疾病电子杂志2014,3,1:7
2Comparative Transcriptomic Analysis of Salt Adaptation in Roots of Contrasting Medicago truncatula Genotypes显示文摘进化差异能被和不同环境的植物的相互作用驾驶。涉及生态的改编到不能生活的限制的分子的底能用 genomic 工具被探索。荚是世界范围的主要庄稼,土壤咸度是在这些植物影响产量的一个主要压力。我们在 Medicago truncatula 荚分析了让对比回答腌应力的二遗传型的根 transcriptome:TN1.11,在咸突尼斯的土壤,和参考 Jemalong A17 遗传型取样了。TN1.11 植物在盐应力以及钠离子的微分累积下面看增加的根生长是否与 A17 相比。Transcriptomic 分析揭示了盐优先地在 TN1.11 的根顶调整的特定的基因簇,尤其是那些与植物生长素小径有关并且到在 histone 变体 isoforms 的变化。编码抄写因素(TF ) 的许多基因也是响应盐在二遗传型之间调整的差别。在为功能的研究选择的那些之中,在大多数差别在遗传型之间调整了的 bHLH 类型 TF 的 A17 遗传型的根的 overexpression 显著地在盐应力下面改进了根生长。尽管有微分 transcriptional 回答的全球复杂性,我们建议这 bHLH TF 表情的增加可以被连接到 M 的改编。truncatula 到盐的土壤环境。Ons Zahaf Sandrine Blanchet Axel de Zelicourt Benoit Alunni Julie Plet Carole Laffont Laura de Lorenzo Sandrine Imbeaud Jean-Laurent lchante Anouck Diet Mounawer Badri Ana Zabalza Esther M. Gonzalez Herve Delacroix Veronique Gruber Florian Frugier Martin Crespi 2012Molecular Plant2012,5,5:7
3A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver Resection显示文摘Jean–Charles Nault Aurélien De Reyniès Augusto Villanueva Julien Calderaro Sandra Rebouissou Gabrielle Couchy Thomas Decaens Dominique Franco Sandrine Imbeaud Francis Rousseau Daniel Azoulay Jean Saric Jean–Frédéric Blanc Charles Balabaud Paulette Bioulac 2013Gastroenterology2013,,1:3
4Identification of Novel Oncogenes and Tumor Suppressors in Hepatocellular Carcinoma显示文摘Sandrine Imbeaud Yannick Ladeiro Jessica Zucman-Rossi 2010Semin Liver Dis2010,,01:2
5Towards standardization of RNA quality assessment using user-independent classifiers of microcapillary electrophoresis traces显示文摘Imbeaud S Graudens E Boulanger V 0,,:1
6Clinical aspects and molecular genetics of the persistent mtillerian duct syndrome 显示文摘Josso N Pieard JY Imbeaud S 1997Clin Endocrinol1997,47,2:1
7Integrated a- nalysis of somatic mutations and focal copy-number chan- ges identifies key genes and pathways in hepatocellular carcinoma显示文摘Guichard C Amaddeo G Imbeaud S 2012Nat Genet2012,44,6:1
8Integrated analysis of somatic mutations and focal copy number changes identifies key genes and pathways in hepatocellular carcinoma显示文摘Guichard C Amaddeo G Imbeaud S Nat Genet0,44,6:1
9Towards standardiza tion of RNA quality assessment using userindependent classifiers of microcapillary electrophoresis traces显示文摘Imbeaud S Grandens E Bonlaneper V 2005Nucleic Acid Res2005,3356,:1
10Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and path- ways in hepatocellular earcinoma显示文摘Guiehard C Amaddeo G Imbeaud S 2012Nat Genet2012,44,6:1
11Integrated analysis of somatic mutations and focal copy-number changes iden tifies key genes and pathways in hepatocellular carcinoma显示文摘Guichard C Amaddeo G Imbeaud S 2012Nat Genet2012,44,69:1
12Surgical and genetic aspects of persistent mttllerian duct syndrome 显示文摘Loeff DS Imbeaud S Reyes HM 1994J Pediatr Surg1994,29,1:1
13Clinical aspects and molecular genetics of the persistent Mullerian duct syndrome 显示文摘Josso N Picard JY Imbeaud S 1997Clin Endocrinol( Oxf)1997,47,2:1
14From functional genomics to systems biology: concepts and practices显示文摘Auffray C Imbeaud S Roux-Rouquié M Hood L 2003C R Biol2003,326,1011:1
15Insensitivity to anti-mullerian hormone due to a mutation in the human anti-mullerian hormone receptor 显示文摘Imbeaud S Faure E Lamarre I 1995Nature Genetics1995,11,4:1
16Identification of novel onco-genes and tumor suppressors in hepatocellular carcinoma显示文摘Imbeaud S Ladeiro Y Zucman-Rossi J 0,,:1
17Insensitivity to anti-miillerian hormone due to a mutation in the human anti-mullerian hormone receptor显示文摘Imbeaud S Fa ure E Lamarre L 1995Nat Genet1995,11,4:1
18Towards standardization of RNA quality assessment using user-independent classifiers of microcapillary electrophoresis traces 显示文摘Imbeaud S Graudens E Boulanger V 2005Nucleic Acids Res2005,33,6:1
19From functional genomics to systems biology:concepts and practices显示文摘Auffray C Imbeaud S Roux-Rouquie M 2003Crit Rev Biol2003,326,1011:1
20Surgical and genetic aspects of persistent mullerian duct syndrome 显示文摘Loeff DS Imbeaud S Reyes HM 1994J Pediatr Surg1994,29,1:1
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