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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Role of diet and nutrition in inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs)are closely linked to nutrition.The latest research indicates that diet and nutrition are significantly involved in the etiopathogenesis of the disease,although their specific role throughout its clinical course still remains unclear.This study reviewed how diet and nutrition are associated with IBD development and management.Even though specific diets have been shown to bring about positive outcomes,there is currently no scientific consensus regarding an appropriate diet that would benefit all IBD patients.We suggest that individualized dietary recommendations are of the greatest importance and that diets should be planned to provide individual IBD patients with specific nutrient requirements while keeping all the clinical aspects of the patients in mind.Further research is clearly necessary to investigate nutritional factors involved in IBD development and,especially,to evaluate the applications of the diets during the course of the disease. | Marina Moreira de Castro Lívia Bitencourt Pascoal Karine Mariane Steigleder Beatriz Piatezzi Siqueira Ligiana Pires Corona Maria de Lourdes Setsuko Ayrizono Marciane Milanski Raquel Franco Leal | 2021 | World Journal of Experimental Medicine2021，11，1： | 2 |
| 3 | Dendritic cells in the pathogenesis and treatment of human diseases: a Janus Bifrons?显示文摘 | Nathalie Cools Annacarmen Petrizzo Evelien Smits Franco M Buonaguro Maria L Tornesello Zwi Berneman Luigi Buonaguro | 2011 | Immunotherapy2011，，10： | 2 |
| 4 | Cervical cancer: epidemiology,prevention and the role of human papillomavirus infection 显示文摘 | FRANCO E L DUARTEFRANCO E FERENCZY A | 2001 | CMAJ2001，164，7： | 1 |
| 5 | Time-dependent strength and creep in masonry 显示文摘 | Parsekian G A Franco L S | 2006 | TMS Journal2006，24，1： | 1 |
| 6 | Emerging role of capecitabine in gastric cancer 显示文摘 | Comella P Franco L Pharm D | 2009 | Pharmacotherapy2009，29，3： | 1 |
| 7 | Cervical cancer:epidemiology,prevention and the role of HPV infection显示文摘 | FRANCO E L DUARTE-FRANCO E FERENCZY A | 2001 | CMAJ2001，164，7： | 1 |
| 8 | Distributed architectures and logical-task decomposition in multimedia surveillance systems显示文摘 | Lucio M Franco O Foresti G L | 2001 | Proceedings of the IEEE2001，89，10： | 1 |
| 9 | Organic orchardfloor management systems for apple effect on rootstock perform- ance in the mid western United States 显示文摘 | Darios Roberto J Z Ronald L P Franco W | 2009 | HortScience2009，44，2： | 1 |
| 10 | Keratoconus staging: a computer-assisted ultrabiomicroscopic method compared with videokeratographic analysis显示文摘 | Avitabile T Franco L Ortisi E | 2004 | Cornea2004，23，7： | 1 |
| 11 | Nanoscale mapping and functional analysis of individual adhesins on living bacteria显示文摘 | VINCENT D FRANCO D M CAMILLE L | 2005 | Nat Methods2005，2，7： | 1 |
| 12 | Recent expansion of dengue virus serotype 3 in West Africa 显示文摘 | Franco L Di Caro A Carletti F | 2010 | Euro Surveill2010，15，19： | 1 |
| 13 | Effectsof glycosylation on heparin binding and antithromhin activation by hep-arin显示文摘 | Pol-Fachin L Franco Becker C Almeida Guimaraes J | 2011 | Proteins2011，79，9： | 1 |
| 14 | Overtopping formulas for caisson breakwaters with nonbreaking 3 D waves 显示文摘 | Franco C Franco L | 1999 | Journal of Waterway Port Coastal and Ocean Engineering1999，125，2： | 1 |
| 15 | Factors that affect the enzymatic degradation of natural starch granules effect of the size of the granules显示文摘 | Franco C M L Ciacco C F | 1992 | Starch1992，44，11： | 1 |
| 16 | Actinobacterial chitinase-like enzymes: profiles of rhizosphere versus non-rhizosphere isolates 显示文摘 | GONZALEZ- FRANCO A C DEOBALD L A SPIVAK A | 2003 | Microbiology2003，49，11： | 1 |
| 17 | Expression d COX- 1,(213X- 2, and inducible nitricoxide synthase protein in human gastric antrum with Helicobacter pylon infection显示文摘 | Franco L Talaminl G Carra G | 1999 | Prostaglandins Other Lipid Mediat1999，58，1： | 1 |
| 18 | Azacitidine adverse effects in patients with myelodysplastic syndromes 显示文摘 | San Miguel Amigo L Franco Osorio R Mercadal Vilchez S | 2011 | AdvTher2011，28，14： | 1 |
| 19 | Fatigue fracture of a nose landing gear in a military transport aircraft 显示文摘 | FRANCO L A L LOURENCO N J GRACA M L A | 2006 | Engineering Failure Analysis2006，13，3： | 1 |
| 20 | Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study显示文摘 | Maylene Wong Lidia Staszewsky Roberto Latini Simona Barlera Alberto Volpi Yann-Tong Chiang Raymond L Benza Sidney O Gottlieb Thomas D Kleemann Franco Rosconi Pieter M Vandervoort Jay N Cohn | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
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