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| 1 | Gut microbiota in autism and mood disorders显示文摘The hypothesis of an important role of gut microbiota in the maintenance of physiological state into the gastrointestinal(GI)system is supported by several studies that have shown a qualitative and quantitative alteration of the intestinal flora in a number of gastrointestinal and extra-gastrointestinal diseases.In the last few years,the importance of gut microbiota impairment in the etiopathogenesis of pathology such as autism,dementia and mood disorder,has been raised.The evidence of the inflammatory state alteration,highlighted in disorders such as schizophrenia,major depressive disorder and bipolar disorder,strongly recalls the microbiota alteration,highly suggesting an important role of the alteration of GI system also in neuropsychiatric disorders.Up to now,available evidences display that the impairment of gut microbiota plays a key role in the development of autism and mood disorders.The application of therapeutic modulators of gut microbiota to autism and mood disorders has been experienced only in experimental settings to date,with few but promising results.A deeper assessment of the role of gut microbiota in the development of autism spectrum disorder(ASD),as well as the advancement of the therapeutic armamentarium for the modulation of gut microbiota is warranted for a better management of ASD and mood disorders. | Francesca Mangiola Gianluca Ianiro Francesco Franceschi Stefano Fagiuoli Giovanni Gasbarrini Antonio Gasbarrini | 2016 | World Journal of Gastroenterology2016，22，1： | 23 |
| 2 | Role of Helicobacter pylori infection on nutrition and metabolism显示文摘Helicobacter pylori(H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome. | Francesco Franceschi Tortora Annalisa Di Rienzo Teresa D'Angelo Giovanna Gianluca Ianiro Scaldaferri Franco Gerardi Viviana Tesori Valentina Lopetuso Loris Riccardo Gasbarrini Antonio | 2014 | World Journal of Gastroenterology2014，20，36： | 11 |
| 3 | Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patients显示文摘AIM: To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients.METHODS: A total of 320 patients over 65 years with endoscopically diagnosed esophagitis were randomly assigned to one of the following treatments for 8 wk: (1) omeprazole 20 mg/d; (2) lansoprazole 30 mg/d; (3) pantoprazole 40 mg/d, or (4) rabeprazole 20 mg/d. Major symptoms, compliance, and adverse events were recorded. After 8 wk, endoscopy and clinical evaluation were repeated.RESULTS: Per protocol and intention to treat healing rates of esophagitis were: omeprazole = 81.0% and 75.0%, lansoprazole = 90.7% (P = 0.143 vs omeprazole) and 85.0%, pantoprazole = 93.5% (P = 0.04 vs omeprazole) and 90.0% (P = 0.02 vs omeprazole), rabeprazole = 94.6% (P = 0.02 vs omeprazole) and 88.8% (P = 0.04 vs omeprazole). Dividing patients according to the grades of esophagitis, omeprazole was significantly less effective than the three other PPIs in healing grade 1 esophagitis (healing rates: 81.8% vs 100%, 100% and 100%, respectively, P = 0.012). Pantoprazole and rabeprazole (100%) were more effective vs omeprazole (89.6%, P = 0.0001)and lansoprazole (82.4%, P = 0.0001) in decreasing heartburn. Pantoprazole and rabeprazole (92.2% and 90.1%, respectively) were also more effective vs lansoprazole (75.0%, P < 0.05) in decreasing acid regurgitation. Finally, pantoprazole and rabeprazole (95.2% and 100%) were also more effective vs lansoprazole (82.6%, P < 0.05) in decreasing epigastric pain.CONCLUSION: In elderly patients, pantoprazole and rabeprazole were significantly more effective than omeprazole in healing esophagitis and than omeprazole or lansoprazole in improving symptoms. H pylori infection did not influence the healing rates of esophagitis after a short-term treatment with PPI. | Alberto Pilotto Marilisa Franceschi Gioacchino Leandro Carlo Scarcelli Luigi Piero D'Ambrosio Francesco Paris Vito Annese Davide Seripa Angelo Andriulli Francesco Di Mario | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 4 | Extragastric Diseases and H elicobacter pylori显示文摘 | Claire Roubaud Baudron Francesco Franceschi Nathalie Salles Antonio Gasbarrini | 2013 | Helicobacter2013，，： | 5 |
| 5 | Extragastric M anifestations of H elicobacter pylori I nfection显示文摘 | Marko Bani? Francesco Franceschi Zarko Babi? Antonio Gasbarrini | 2012 | Helicobacter2012，，： | 3 |
| 6 | Antibodies Anti‐Caga Cross‐React with Trophoblast Cells: A Risk Factor for Pre‐Eclampsia?显示文摘 | Francesco Franceschi Nicoletta Di Simone Silvia D’Ippolito Roberta Castellani Fiorella Di Nicuolo Giovanni Gasbarrini Yoshio Yamaoka Tullia Todros Giovanni Scambia Antonio Gasbarrini | 2012 | Helicobacter2012，，6： | 2 |
| 7 | Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori显示文摘 | Antonio Gasbarrini Francesco Franceschi Raffaele Tartaglione Raffaele Landolfi Paolo Pola Giovanni Gasbarrini | 1998 | The Lancet1998，，9131： | 2 |
| 8 | High Prevalence of Celiac Disease in Italian General Population显示文摘 | Umberto Volta Stefano Bellentani Francesco Bianco Bianchi Giovanni Brandi Lucia De Franceschi Lucia Miglioli Alessandro Granito Fiorella Balli Claudio Tiribelli | 2001 | Digestive Diseases and Sciences2001，，7： | 1 |
| 9 | Rating systems for evaluation of the elbow显示文摘 | Umile Giuseppe Longo Francesco Franceschi Mattia Loppini | 2008 | Bri Med Bull2008，87，2： | 1 |
| 10 | Role of Helicobacter pylori Infection on Upper Gastrointestinal Bleeding in the Elderly (A Case-Control Study)显示文摘 | Alberto Pilotto Gioacchino Leandro Francesco Di Mario Marilisa Franceschi Loredana Bozzola Gianni Valerio | 1997 | Digestive Diseases and Sciences1997，，3： | 1 |
| 11 | Alcohol Dehydrogenase 3, Glutathione S-transferase M1 and T1 Polymorphisms, Alcohol Consumption and Hepatocellular Carcinoma (Italy)显示文摘 | Loredana Covolo Umberto Gelatti Renato Talamini Seymour Garte Paola Trevisi Silvia Franceschi Michela Franceschini Fabio Barbone Alessandro Tagger Maria Lisa Ribero Giovanni Parrinello Valter Donadon Giuseppe Nardi Francesco Donato | 2005 | Cancer Causes & Control2005，，7： | 1 |
| 12 | Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians’ offspring显示文摘 | Davide Gentilini Daniela Mari Davide Castaldi Daniel Remondini Giulia Ogliari Rita Ostan Laura Bucci Silvia M. Sirchia Silvia Tabano Francesco Cavagnini Daniela Monti Claudio Franceschi Anna Maria Blasio Giovanni Vitale | 2013 | AGE2013，，5： | 1 |
| 13 | High Prevalence of Celiac Disease in Italian General Population显示文摘 | Umberto Volta Stefano Bellentani Francesco Bianco Bianchi Giovanni Brandi Lucia De Franceschi Lucia Miglioli Alessandro Granito Fiorella Balli Claudio Tiribelli | 2001 | Digestive Diseases and Sciences2001，，7： | 1 |
| 14 | Alcohol Dehydrogenase 3, Glutathione S-transferase M1 and T1 Polymorphisms, Alcohol Consumption and Hepatocellular Carcinoma (Italy)显示文摘 | Loredana Covolo Umberto Gelatti Renato Talamini Seymour Garte Paola Trevisi Silvia Franceschi Michela Franceschini Fabio Barbone Alessandro Tagger Maria Lisa Ribero Giovanni Parrinello Valter Donadon Giuseppe Nardi Francesco Donato | 2005 | Cancer Causes & Control2005，，7： | 1 |
| 15 | Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia显示文摘 | PANZA Francesco FRANCESCHI Marilisa | 2007 | Dement Geriatr Cogn Disord2007，23，5： | 1 |
| 16 | Cross-Reactivity of Anti-CagA Antibodies With Vascular Wall Antigens: Possible Pathogenic Link Between Helicobacter pylori Infection and Atherosclerosis显示文摘 | Francesco Franceschi Antonia R. Sepulveda Antonio Gasbarrini Paolo Pola Nicolò Gentiloni Silveri Giovanni Gasbarrini David Y. Graham Robert M. Genta | 2002 | Circulation: Journal of the American Heart Association2002，，4： | 1 |
| 17 | Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases显示文摘AIM:To assess clinical and endoscopic response to propionyl-L-carnitine hydrochloride(PLC) in colonic inflammatory bowel disease.METHODS:Patients suffering from mild to moderate ulcerative colitis(UC) or Crohn's disease(CD) colitis,with disease activity index(DAI) between 3 and 10 and under stable therapy with oral aminosalicylates,mercaptopurine or azathioprine,for at least 8 wk prior to baseline assessments,were considered suitable for enrollment.Fourteen patients were enrolled to assume PLC 2 g/d(two active tablets twice daily) orally.Clinical-endoscopic and histological activity were assessed by DAI and histological index(HI),respectively,following a colonoscopy performed immediately before and after 4 wk treatment.Clinical response was defined as a lowering of at least 3 points in DAI and clinical remission as a DAI score ≤ 2.Histological response was defined as an improvement of HI of at least 1 point.We used median values for the analysis.Differences pre-and post-treatment were analyzed by Wilcoxon signed rank test.RESULTS:All patients enrolled completed the study.One patient,despite medical advice,took deflazacort 5 d before follow-up colonoscopy examination.No side effects were reported by patients during the trial.After treatment,71%(SE 12%) of patients achieved clinical response,while 64%(SE 13%) obtained remission.Separating UC from CD patients,we observed a clinical response in 60%(SE 16%) and 100%,respectively.Furthermore 60%(SE 16%) of UC patients and 75%(SE 25%) of CD patients were in clinical remission after therapy.The median DAI was 7 [interquartile range(IQR):4-8] before treatment and decreased to 2(IQR:1-3)(P < 0.01) after treatment.Only patients with UC showed a significant reduction of DAI,from a median 6.5(IQR:4-9) before treatment to 2(IQR:1-3) after treatment(P < 0.01).Conversely,in CD patients,although displaying a clear reduction of DAI from 7(IQR:5.5-7.5) before therapy to 1.5(IQR:0.5-2.5) after therapy,differences observed were not significant(P = 0.06).Seventy-nine percent(SE 11%) of patients showed improvement of HI of at least 1 point,while only one CD and two UC patients showed HI stability;none showed HI worsening.Median HI decreased from 1(IQR:1-2),to 0.5(IQR:0-1) at the endoscopic control in the whole population(P < 0.01),while it changed from 1(IQR:1-2) to 0.5(IQR:0-1) in UC patients(P < 0.01) and from 1.5(IQR:1-2) to 0.5(IQR:0-1) in CD patients(P = not significant).The two sample tests of proportions showed no significant differences in clinical and histological response or in clinical remission between UC and CD patients.No side effects were reported during treatment or at 4 wk follow-up visit.CONCLUSION:PLC improves endoscopic and histological activity of mild to moderate UC.Further studies are required to evaluate PLC efficacy in colonic CD patients. | Giuseppe Merra Giovanni Gasbarrini Lucrezia Laterza Marco Pizzoferrato Andrea Poscia Franco Scaldaferri Vincenzo Arena Francesca Fiore Achille Cittadini Alessandro Sgambato Francesco Franceschi Antonio Gasbarrini | 2012 | World Journal of Gastroenterology2012，18，36： | 1 |
| 18 | Insulin-dependent diabetes mellitus affects eradication rate of Helicobacter pylori infection显示文摘 | Antonio Gasbarrini Veronica Ojetti Dario Pitocco Francesco Franceschi Marcello Candelli Elena Sanz Torre Maurizio Gabrielli Giovanni Cammarota Alessandro Armuzzi Roberto Pola Paolo Pola Giovanni Ghirlanda Giovanni Gasbarrini | 1999 | European Journal of Gastroenterology & Hepatology1999，，7： | 1 |
| 19 | Dopaminergic agents and nutritional status in Parkinson’s disease显示文摘 | Alice Laudisio Davide L. Vetrano Eleonora Meloni Diego Ricciardi Francesco Franceschi Anna Rita Bentivoglio Roberto Bernabei Giuseppe Zuccalà | 2014 | Mov Disord2014，，12： | 1 |
| 20 | Beneficial Effects of Helicobacter pylori Eradication on Idiopathic Chronic Urticaria显示文摘 | Cristiana Di Campli Antonio Gasbarrini Eleonora Nucera Francesco Franceschi Veronica Ojetti Elena Sanz Torre Domenico Schiavino Paolo Pola Giampiero Patriarca Giovanni Gasbarrini | 1998 | Digestive Diseases and Sciences1998，，6： | 1 |
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