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| 1 | NTR/NRX Define a New Thioredoxin System in the Nucleus of Arabidopsis thaliana Cells显示文摘Thioredoxins (TRX ) 是细胞的氧化还原作用平衡的关键部件,调整通过 thiol/disulfide 交换反应的许多目标蛋白质。在更高的植物, TRX 组成其成员在几乎所有细胞的分隔空间被发现了的一个复杂 multigenic 家庭。尽管 chloroplastic 和 cytosolic TRX 系统大部分被学习了,一个原子 TRX 系统的存在很长时间是逃犯的。Nucleoredoxins (NRX ) 是在很真核细胞的有机体发现的潜在的原子 TRX。与哺乳动物,它怀有唯一的 NRX 相对照,被子植物通常拥有在三个亚科组织的多重 NRX。这里,我们证明分别地, Arabidopsis thaliana 有二 NRX 基因(AtNRX1 和 AtNRX2 ) 属于亚群我和 III。当 NRX1 怀有典型 TRX 时活跃地点(WCG/PPC ) , NRX2 有不正常的活跃地点(WCRPC 和 WCPPF ) 。不过, NRX1 和 NRX2 有二硫化物减小能力,尽管 NRX1 能被 thioredoxin reductase NTRA 独自减少。我们也证明 NRX1 和 NRX2 有双 nuclear/cytosolic 本地化。有趣地,我们发现了那 NTRA,以前作为 cytosolic 蛋白质识别了,在原子核部分也是局部性的,建议一个完全的 TRX 系统在原子核是功能的。我们证明 NRX1 是主要被发现一在 vivo 更暗淡。nrx1 和 nrx2 大美人异种植物不在标准生长条件下面展出 phenotypic 不安。然而, nrx1 异种显示出减少的花粉富饶显型,建议在 haploid 阶段的 NRX1 的一个特定的角色。 | Corinne Marchal Valerie Delorme-Hinoux Laetitia Bariat Wafi Siala Christophe Belin Julio Saez-Vasquez Christophe Riondet Jean-Philippe Reichheld | 2014 | Molecular Plant2014，7，1： | 5 |
| 2 | Primary and overall success rates for clinical outcomes after laparoscopic, endoscopic, and open pancreatic cystgastrostomy for pancreatic pseudocysts显示文摘 | Lora Melman Riad Azar Kathleen Beddow L. Michael Brunt Valerie J. Halpin J. Christopher Eagon Margaret M. Frisella Steven Edmundowicz Sreenivasa Jonnalagadda Brent D. Matthews | 2009 | Surgical Endoscopy2009，，2： | 3 |
| 3 | 国际卒中遗传学联盟的推荐意见(第2部分):生物样本的采集和储存显示文摘在2003年人类基因组测序以及全基因组基因分型技术发展的共同促进下,人类遗传学的进步已使我们识别出2000多个与性状相关的基因突变。由于这些突变大多数对疾病风险仅有微小的独立影响,因此成功的遗传学研究需要很大的样本量(包含数以千计、万计或者十万计的病例和对照)才能达到足够的研究效能。如此大的样本量积累需要依赖在人类遗传学研究乃至在临床研究中史无前例的大规模国际协作。现在已有许多常见疾病的专病联盟将大量独立机构和合作者联合起来。每个联盟均面临至少2个基本问题:如何整合具有足够数量、同质性和表型质量高的研究样本以及如何储存和分析来自入组受试者的生物样本,有时可能需要在数年间反复进行。 | Thomas W.K.Battey Valerie Valant Sylvia Baedorf Kassis Christina Kourkoulis Chaeyoung Lee Christopher D. Anderson Guido J. Falcone Jordi Jimenez-Conde Israel Fernandez-Cadenas Guillaume Pare Tatjana Rundek Michael L. James Robin Lemmens Tsong-Hai Lee Turgut Tatlisumak Steven J. Kittner Arne Lindgren Farrah J. Mateen Aaron L. Berkowitz Elizabeth G. Holliday Jennifer Majersik 李海峰 姜平 岳耀先 | 2015 | 国际脑血管病杂志2015，23，9： | 2 |
| 4 | Dihydrosphingosine-lnduced Programmed Cell Death in Tobacco BY-2 Cells Is Independent of H2O2 Production显示文摘 | Christophe Lachaud | 2011 | Molecular Plant2011，4，2： | 2 |
| 5 | Ethnobotanical study on medicinal use of wild and cultivated plants in middle, south and west Bosnia and Herzegovina显示文摘 | Broza ?ari?-Kundali? Christoph Dobe? Valerie Klatte-Asselmeyer Johannes Saukel | 2010 | Journal of Ethnopharmacology2010，，1： | 1 |
| 6 | Can soil microbial diversity influence plant metabolites and life history traits of a rhizophagous insect? A demonstration in oilseed rape显示文摘 | Tom Lachaise Morgane Ourry Lionel Lebreton Anne-Yvonne Guillerm-Erckelboudt Juliette Linglin Chrystelle Paty Valerie Chaminade Nathalie Marnet Julie Aubert Denis Poinsot Anne-Marie Cortesero Christophe Mougel | 2017 | Insect Science2017，24，6： | 1 |
| 7 | Toxicity to bivalve hemocytes of pathogenic Vibrio cytoplasmic extract 显示文摘 | Christophe L Jean-louis N Valerie B | 2001 | J Invertebr Pathol2001，77，4： | 1 |
| 8 | Prevalence and charac- terization of Shiga toxin - producing Escherichia coli isolated from cattle, food, and children during a one -year prospective study in France显示文摘 | Nathalie P Valerie L Christophe D | 2000 | J Clin Microbiol2000，38，3： | 1 |
| 9 | Laparoscopic gastric resection for gastrointestinal stromal tumors显示文摘 | Jennifer A. Sexton Richard A. Pierce Valerie J. Halpin J. Christopher Eagon William G. Hawkins David C. Linehan L. Michael Brunt Margaret M. Frisella Brent D. Matthews | 2008 | Surgical Endoscopy2008，，12： | 1 |
| 10 | Visual acuity after intravitreal triamcinolone for diabetic macular edema refractory to laser treatment: A meta-analysis显示文摘 | Christopher J. Rudnisky Valery Lavergne David Katz | 2009 | Canadian Journal of Ophthalmology/Journal canadien d’ophtalmologie2009，，5： | 1 |
| 11 | Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF显示文摘 | Paul T.C Wan Mathew J Garnett S.Mark Roe Sharlene Lee Dan Niculescu-Duvaz Valerie M Good Cancer Genome Project C.Michael Jones Christopher J Marshall Caroline J Springer David Barford Richard Marais | 2004 | Cell2004，，6： | 1 |
| 12 | Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients With Cirrhosis显示文摘 | Pierre–Emmanuel Rautou Julie Bresson Yannis Sainte–Marie Anne–Clemence Vion Valerie Paradis Jean–Marie Renard Cecile Devue Christophe Heymes Philippe Letteron Laure Elkrief Didier Lebrec Dominique Valla Alain Tedgui Richard Moreau Chantal M. Boulanger | 2012 | Gastroenterology2012，，1： | 1 |
| 13 | Incidence of residual choledocholithiasis detected by intraoperative cholangiography at the time of laparoscopic cholecystectomy in patients having undergone preoperative ERCP显示文摘 | Richard A. Pierce Sreenivasa Jonnalagadda Jennifer A. Spitler Deron J. Tessier Jane M. Liaw Shelly C. Lall Lora M. Melman Margaret M. Frisella Laura M. Todt L. Michael Brunt Valerie J. Halpin J. Christopher Eagon Steven A. Edmundowicz Brent D. Matthews | 2008 | Surgical Endoscopy2008，，11： | 1 |
| 14 | Preoperative Osseous Dysmorphology in unilateral complete cleft lip and palate :a quantitative analysis of computed tomography data 显示文摘 | Alex A Kane Valerie Burke DeLeon Christopher Valeri Devra BBecker | 2007 | Plastic and Reconstructive Surgery2007，119，4： | 1 |
| 15 | Laparoscopic gastric resection for gastrointestinal stromal tumors显示文摘 | Jennifer A. Sexton Richard A. Pierce Valerie J. Halpin J. Christopher Eagon William G. Hawkins David C. Linehan L. Michael Brunt Margaret M. Frisella Brent D. Matthews | 2008 | Surgical Endoscopy2008，，12： | 1 |
| 16 | Effectiveness of Telaprevir or Boceprevir in Treatment-Experienced Patients With HCV Genotype 1 Infection and Cirrhosis显示文摘 | Christophe Hezode Helene Fontaine Celine Dorival Fabien Zoulim Dominique Larrey Valerie Canva Victor De Ledinghen Thierry Poynard Didier Samuel Marc Bourliere Laurent Alric Jean–Jacques Raabe Jean–Pierre Zarski Patrick Marcellin Ghassan Riachi Pierre–Henr | 2014 | Gastroenterology2014，，： | 1 |
| 17 | Facet Joint Osteoarthritis and Low Back Pain in the Community-Based Population显示文摘 | Leonid Kalichman Ling Li David H. Kim Ali Guermazi Valery Berkin Christopher J. O?Donnell Udo Hoffmann Rob Cole David J. Hunter | 2008 | Spine2008，，23： | 1 |
| 18 | A fast algorithm for bidimensional EMD显示文摘 | Christophe Damerval Sylvain Meignen Valerie Perrier | 2005 | IEEE Signal Processing Letters2005，12，10： | 1 |
| 19 | Actin Cable Dynamics and Rho/Rock Orchestrate a Polarized Cytoskeletal Architecture in the Early Steps of Assembling a Stratified Epithelium显示文摘 | Alec Vaezi Christoph Bauer Valeri Vasioukhin Elaine Fuchs | 2002 | Developmental Cell2002，，3： | 1 |
| 20 | Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role on aldosterone-salt-induced fibrosis 显示文摘 | Christophe H Jean SS | 1999 | Hypertension1999，33，： | 1 |
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