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| 1 | The Basic Helix-Loop-Helix Transcription Factor MYC1 Is Involved in the Regulation of the Flavonoid Biosynthesis Pathway in Grapevine显示文摘以前的结果显示在葡萄藤(Vitis vinifera ) ,由 MYB 抄写因素的 flavonoid 小径基因的规定与基本 helix-loop-helix 蛋白质(bHLHs ) 取决于他们的相互作用。现在的学习描述从葡萄藤的因素说出 VvMYC1 的 bHLH 的第一功能的描述。这个抄写因素种系发生地与 Arabidopsis bHLH 蛋白质,它参予 flavonoid 生合成和表皮的房间命运的控制有关。二混血儿的试金表明了的短暂倡导者和酵母 VvMYC1 身体上与劝诱 flavonoid 小径基因的倡导者的 MYB5a, MYB5b, MYBA1/A2,和 MYBPA1 交往,这在 anthocyanin 或 proanthocyanidin (PA ) 包含了合成。另外,短暂倡导者试金表明 VvMYC1 涉及它的自己的表示的反馈规定。抄本在果浆的皮肤和种子与 anthocyanins 和舞步的合成在果浆发展相互关联期间 VvMYC1 铺平,建议 VvMYC1 涉及在这些机关的 anthocyanins 和 PA 合成的规定。同样, VvMYC1 和 VvMYBA1 的短暂表示在葡萄藤暂停房间导致 anthocyanin 合成。这些结果建议 VvMYC1 是在葡萄藤控制 anthocyanin 和 PA 生合成的 transcriptional 串联的部分。 | Imene Hichri Simon C. Heppel Jeremy Pillet Celine Leon Stefan Czemmel Serge Delrot Virginie Lauvergeat Jochen Bogs | 2010 | Molecular Plant2010，3，3： | 46 |
| 2 | Obesity leads to higher risk of sperm DNA damage in infertile patients显示文摘在在富饶上的男营养的影响的过去几年有成长兴趣。不孕被连接了到男过重或肥胖,并且常规精液参数值似乎在高身体团索引(BMI ) 的情况下被改变。在精子 DNA 正直上估计 BMI 的影响的一些研究被出版了,但是他们没导致强壮的一致。我们的目的是进一步探索在精子 DNA 正直和 BMI 之间的关系,通过 3 年的 multicentre 研究。在 subfertile 夫妇的 330 个男搭挡被包括。用标记的终端 uridine 刻痕结束(TUNEL ) 试金,我们在肥胖的人观察了精子 DNA 损坏的增加的率(机会比率(95 %信心间隔) :2.5 (1.2-5.1 )) 。 | Charlotte Dupont Celine Fauret Nathalie Sermondade Marouane Boubaya Florence Eustache Patrice Clement Pascal Briot Isabelle Berthaut Vincent Levy Isabelle Cedrin-Durnerin Brigitte Benzacken Pascale Chavatte-Palmer Rachel Levy | 2013 | Asian Journal of Andrology2013，15，5： | 27 |
| 3 | Current Trends in Pickering Emulsions: Particle Morphology and Applications显示文摘In recent years,Pickering emulsions and their applications have attracted a great deal of attention due to their special features,which include easy preparation and enhanced stability.In contrast to classical emulsions,in Pickering emulsions,solid microparticles or nanoparticles that localize at the interface between liquids are used as stabilizers,instead of surfactants,to enhance the droplet lifetime.Furthermore,Pickering emulsions show higher stability,lower toxicity,and stimuli-responsiveness,compared with emulsions that are stabilized by surfactants.Therefore,they can be considered attractive components for various uses,such as photocatalysis and the preparation of new materials.Moreover,the nanoparticle morphology strongly influences Pickering emulsion stability as well as the potential utilization of such emulsions.Here,we review recent findings concerning Pickering emulsions,with a particular focus on how the nanoparticles morphology(i.e.,cube,ellipsoid,nanosheet,sphere,cylinder,rod,peanut)influences the type and stability of such emulsions,and their current applications in different fields such as antibacterial activity,protein recognition,catalysis,photocatalysis,and water purification. | Danae Gonzalez Ortiz Celine Pochat-Bohatier Julien Cambedouzou Mikhael Bechelany Philippe Miele | 2020 | Engineering2020，6，4： | 22 |
| 4 | Synthesis and purification of long copper nanowires. Application to high performance flexible transparent electrodes with and without PEDOT:PSS显示文摘 | Celine Mayousse Caroline Celle Alexandre Carella Jean-Pierre Simonato | 2014 | Nano Research2014，7，3： | 16 |
| 5 | Helical tomotherapy and volumetric modulated arc therapy:New therapeutic arms in the breast cancer radiotherapy显示文摘AIM To analyse clinical and dosimetric results of helical tomotherapy(HT) and volumetric modulated arc therapy(VMAT) in complex adjuvant breast and nodes irradiation.METHODS Seventy-three patients were included(31 HT and 42 VMAT). Dose were 63.8 Gy(HT) and 63.2 Gy(VMAT) in the tumour bed, 52.2 Gy in the breast, 50.4 Gy in supraclavicular nodes(SCN) and internal mammary chain(IMC) with HT and 52.2 Gy and 49.3 Gy in IMC and SCN with VMAT in 29 fractions. Margins to particle tracking velocimetry were greater in the VMAT cohort(7 mm vs 5 mm).RESULTS For the HT cohort, the coverage of clinical target volumes was as follows: Tumour bed: 99.4% ± 2.4%; breast: 98.4% ± 4.3%; SCN: 99.5% ± 1.2%; IMC:96.5% ± 13.9%. For the VMAT cohort, the coverage was as follows: Tumour bed: 99.7% ± 0.5%, breast: 99.3% ± 0.7%; SCN: 99.6% ± 1.4%; IMC: 99.3% ± 3%. For ipsilateral lung, Dmean and V20 were 13.6 ± 1.2 Gy, 21.1% ± 5%(HT) and 13.6 ± 1.4 Gy, 20.1% ± 3.2%(VMAT). Dmean and V30 of the heart were 7.4 ± 1.4 Gy, 1% ± 1%(HT) and 10.3 ± 4.2 Gy, 2.5% ± 3.9%(VMAT). For controlateral breast Dmean was 3.6 ± 0.2 Gy(HT) and 4.6 ± 0.9 Gy(VMAT). Acute skin toxicity grade 3 was 5% in the two cohorts.CONCLUSION HT and VMAT in complex adjuvant breast irradiation allow a good coverage of target volumes with an acceptable acute tolerance. A longer follow-up is needed to assess the impact of low doses to healthy tissues. | Olivier Lauche Youlia M Kirova Pascal Fenoglietto Emilie Costa Claire Lemanski Celine Bourgier Olivier Riou David Tiberi Francois Campana Alain Fourquet David Azria | 2016 | World Journal of Radiology2016，8，8： | 7 |
| 6 | Quantitative and qualitative in vitro analysis of the stem cell potential of hematopoietic cells purified from murine skeletal muscle显示文摘鼠科的骨胳的肌肉包含造血的干细胞,而是这个潜力到目前为止没被学习份量上或品质上试管内。确定造血的干细胞潜力,我们在 long-termculture 开始使用了高度净化的 SP/CD45 (+) 房间房间(LTC-IC ) 试金。从鼠科的肌肉净化的 SP/CD45 (+) 房间人口被发现从肌肉与 1/640 .Single-cell-sorted SP/CD45 (+) 房间的 LTC-IC 频率举办重要干细胞活动在白天 16 点的展出柔韧的 proliferative 活动试管内(380 褶层扩大) ,特别在有 OP-9 层的文化以后,那也支持胚胎的干细胞。放大房间人口与 myeloid 的证据从单个房间 exhibitedmultilineage 区别能力发源,淋巴并且 NK 房间标记。因此,我们的结果证明能被 LTC-IC 试金确定的造血的干细胞第一次也在鼠科的骨胳的肌肉和表演存在,在单个房间的水平,这些房间展出多行的年龄区别能力和主要 proliferative 潜力。 | Celine Haond Frangoise Farace Martine Guillier Yann Lecluse Frederic Mazurier William Vainchenker Ali G Turhan | 2007 | Cell Research2007，17，9： | 4 |
| 7 | αV integrin:A new gastrin target in human pancreatic cancer cells显示文摘AIM:To analyse αV integrin expression induced by gas-trin in pancreatic cancer models. METHODS:αV integrin mRNA expression in human pan-creatic cancer cells was analysed using a 'cancer genes' array and confirmed by real-time reverse transcription-polymerase chain reaction (PCR). Western blotting and semi-quantitative immunohistochemistry were used to examine protein levels in human pancreatic cancer cell lines and pancreatic tissues, respectively. The role of αV integrin on gastrin-induced cell adhesion was examined using blocking anti-αV integrin monoclonal antibodies. Adherent cells were quantified by staining with crystal violet.RESULTS: Using a 'cancer genes' array we identified αV integrin as a new gastrin target gene in human pancreatic cancer cells. A quantitative real-time PCR approach was used to confirm αV integrin gene expression. We also demonstrate that Src family kinases and the PI 3-kinase, two signalling pathways specifically activated by the CCK-2 receptor (CCK2R), are involved in gastrin-mediated αV integrin expression. In contrast, inhibition of the ERK pathway was without any effect on αV integrin expression induced by gastrin. Our results also show that gastrin modulates cell adhesion via α V integrins. Indeed, in vitro adhesion assays performed on fibronectin show that gastrin significantly increases adhesion of pancreatic cancer cells. The use of blocking anti-αV integrin monoclonal antibodies completely reversed the increase in cell-substrate adhesion induced by gastrin. In addition, we showed in vivo that the targeted CCK2R expression in the pancreas of Elas-CCK2 mice, leads to the overexpression of αV integrin. This process may contribute to pancreatic tumour development observed in these transgenic animals. CONCLUSION:αV integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion. | Celine Cayrol Claudine Bertrand Aline Kowalski-Chauvel Laurence Daulhac Elizabeth Cohen-Jonathan-Moyal Audrey Ferrand Catherine Seva | 2011 | World Journal of Gastroenterology2011，17，40： | 4 |
| 8 | Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males显示文摘生活方式因素,可以影响男富饶例如重量和营养的地位,包括精子授精能力。这回顾的研究的目的是评估在身体团索引(BMI ) 和根据带绑定(ZB ) 估计的精子带 pellucida 绑定能力之间的协会测试,它被描述了是为预言的一个相关诊断工具在 vitro 授精(IVF ) 能力。从与主要自发或温和的男因素不孕诊断的夫妇的 306 个男病人被包括。在根据 ZB,测试索引的 BMI 和精液参数之间的关联被估计,和越过 BMI 范畴的阳性、否定的测试的频率。在这张选择人口, BMI 不与根据精子的能力估计绑在带 pellucida 的常规精液参数或精子质量有关。在男肥胖的情况下的 IVF 过程的以前描述的差的结果能由于另外的精子缺点,例如精子 capacitation 或 acrosome 反应的改变。在男 BMI 和生物结果之间的连接例如授精率,应该进一步在 IVF 过程期间被评估。 | Nathalie Sermondade Charlotte Dupont Celine Faure Marouane Boubaya Isabelle Cedrin-Durnerin Pascale Chavatte-Palmer Christophe Sifer Rachel Levy | 2013 | Asian Journal of Andrology2013，15，5： | 4 |
| 9 | 麦角硫因或可降低心血管疾病发生及死亡风险显示文摘目的近期研究发现一种健康饮食模式(HCFP)与降低心脏代谢疾病风险相关,但导致这种相关性的分子机制尚不明确。该研究旨在发现与这种饮食模式相关的血浆代谢物,并研究其与心脏代谢疾病发生和死亡风险的相关性。方法从全人群马尔默饮食和癌症研究中,筛选出3236名无心血管疾病和糖尿病史的参与者。运用液相色谱-质谱法对他们的112种血浆代谢物进行检测。通过多元线性回归和Bonfcrroni校正分析,发现其中与该饮食模式相关的代谢物。使用多变量Cox比例风险模型进行长期随访分析后,发现这些健康饮食的生物标志物与心脏代谢疾病的发生和死亡风险相关。结果平均随访21.4年期间,603人患心血管疾病,362人患糖尿病,843人死亡。基线资料中,5种健康饮食标志物与该饮食模式相关(P<0.0004),其中4种与至少一项研究终点相关(P<0.05)。麦角硫因是与该饮食模式相关性最强的代谢物,并且与降低冠心病风险(危害比0.85,P=0.01)、心血管死亡风险(危害比0.79,P=0.002)、全因死亡风险(麦角硫因每增加一个标准差的危害比,危害比0.86,P=4e-5)相关。结论我们发现高麦角硫因含量是降低心脏代谢疾病发生和死亡风险的独立标志物。而这种高含量很可能是由某种特殊的饮食方式造成的。 | Einar Smith Filip Ottosson Sophie Hellstrand Ulrika Ericson Marju Orho-Melander Celine Fernandez Olle Melander 冯博(译) | 2020 | 英国医学杂志中文版2020，23，4： | 4 |
| 10 | Non-Protein-Coding RNAs and their Interacting RNA-Binding Proteins in the Plant Cell Nucleus显示文摘到外部因素的真核细胞的房间的复杂回答被几 transcriptional 和 post-transcriptional 过程管理。他们中的几个发生在原子核并且被连接了到 non-protein-coding RNA 的行动(或 npcRNAs ) ,长、小的 npcRNAs,那最近作为基因表示的主要管理者出现了。规章的 npcRNAs 在原子核行动包括沉默相关的 RNA, intergenic npcRNAs,自然 antisense RNA,和源于在全球抄写和 RNA 处理活动之间的相互影响的另外的异常 RNA (例如 Dicers 和 RNA 依赖的聚合酶) 。通常,产生 npcRNAs 通过和 RNA 有约束力的蛋白质的相互作用施加他们的规章的效果(或 RBP ) 在 ribonucleoprotein 粒子以内(或 RNP ) 。RBP 的一个大组通过小介入 RNA (siRNAs ) 在 silencing 机械被含有,他们的本地化建议几在原子核行动在整个染色体的规模触发 epigenetic 和染色质变化。另外的原子 RBP 与 npcRNAs 交往并且改变他们的本地化。在分裂酵母, RNA 有约束力的 Mei2p 蛋白质,在成熟分裂的玩的枢轴的角色,交往, meiotic npcRNA 在它的原子重新本地化包含了。相关过程在植物被识别了, ENOD40 npcRNA 被显示出到重新本地化从原子核的原子点缀的 RBP 到在 Medicago truncatula 的细胞质。植物 RBP 也通过和特定的 antisense 抄本的相互作用在 FLC 地点在调停 RNA 的染色质 silencing 被含有。在这评论,我们在植物开发和压力回答在原子相关的进程和他们的含意的上下文讨论在 RBP 和 npcRNAs 之间的相互作用。我们建议这些相互作用可以增加调制在原子染色体和环境之间并且,因而的相互作用的规章的层控制植物发展粘性。 | Celine Charon Ana Beatriz Moreno Florian Bardou Martin Crespi | 2010 | Molecular Plant2010，3，4： | 3 |
| 11 | An update on biomarkers of potential benefit with bevacizumab for breast cancer treatment: Do we make progress?显示文摘As the first monoclonal antibody against vascular endothelial growth factor(VEGF), bevacizumab(BEV) is a definitely controversial antiangiogenic therapy in breast cancer. The initial excitement over improvements in progression-free survival(PFS) with BEV was tempered by an absence of overall survival(OS) benefit and serious adverse effects. Missing targeted population urged us to identify the predictive biomarkers for BEV efficacy. In this review we focus on the research in breast cancer and provide recent investigations on clinical, radiological,molecular and gene profiling markers of BEV efficacy, including the new results from randomized phase III clinical trials evaluating the efficacy of BEV in combination with comprehensive biomarker analyses. Current evidences indicate some predictive values for genetic variants, molecular imaging, VEGF pathway factors or associated factors in peripheral blood and gene profiling. The current challenge is to validate those potential biomarkers and implement them into clinical practice. | Xu Liang Huiping Li Florence Coussy Celine Callens Florence Lerebours | 2019 | Chinese Journal of Cancer Research2019，31，4： | 2 |
| 12 | Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system.The time frame for development from premalignant to malignant disease typically spans 10-15 years,and this latent period provides an ideal opportunity for early detection and intervention to improve patient outcomes.Currently,early diagnosis of CRC is hampered by a lack of suitable non-invasive biomarkers that are clinically or economically acceptable for populationbased screening.New blood-based protein biomarkers for early detection of CRC are therefore urgently required.The success of clinical biomarker discovery and validation studies is critically dependent on understanding and adjusting for potential experimental,analytical,and biological factors that can interfere with the robust interpretation of results.In this review we outline some important considerations for research groups undertaking biomarker research with exemplars from our studies.Implementation of experimental strategies to minimise the potential effects of these problems will facilitate the identification of panels of biomarkers with the sensitivity and specificity required for the development of successful tests for the early detection and surveillance of CRC. | Kim YC Fung Edouard Nice Ilka Priebe Damien Belobrajdic Aloke Phatak Leanne Purins Bruce Tabor Celine Pompeia Trevor Lockett Timothy E Adams Antony Burgess Leah Cosgrove | 2014 | World Journal of Gastroenterology2014，20，4： | 2 |
| 13 | A LIM Domain Protein from Tobacco Involved in Actin-Bundling and Histone Gene Transcription显示文摘从植物(秘鲁利玛机场之代号) 的二秘鲁利玛机场之代号包含域的蛋白质典型地展出双 cytoplasmicnuclear 分布,建议除了他们在肌动朊细胞骨架组织的以前描述的角色,他们参予原子过程。用针对识别绑种 histone 基因倡导者的因素的一幅西南的基于污点的屏幕,我们孤立包含烟草秘鲁利玛机场之代号蛋白质 WLIM2 (NtWLIM2 ) 的积极克隆 cDNA。用两块草地荧光灯蛋白质(GFP ) 基于熔化、基于免疫学的策略,我们提供 NtWLIM2 本地化到肌动朊细胞骨架,原子核,和核的清楚的证据。有趣地,由 latrunculin B 的肌动朊细胞骨架的混乱显著地增加 NtWLIM2 原子部分,指出可能的新奇 cytoskeletalnuclear 串音。生物化学并且电子显微镜学实验揭示 NtWLIM2 的能力直接把后者绑在肌动朊细丝并且到交叉连接进厚肌动朊捆。NtWLIM2 明确地绑在 Arabidopsis histone H4A748 基因倡导者的保存 octameric cis 元素(10 月) 并且这绑定大部分依靠两个秘鲁利玛机场之代号领域的 Electrophoretic 活动性移动试金表演。重要地,在 Arabidopsis 和烟草原物进行的基于记者的实验证实 NtWLIM2 的能力绑在并且在实时房间激活 H4A748 基因倡导者。表示研究在烟草 BY-2 房间增长和房间周期前进期间显示 NtWLIM2 mRNA 和 NtWLIM2 蛋白质的组成的存在,建议在基础 histone 基因表示的激活的 NtWLIM2 的一个角色。有趣地,两个都生活房间并且在 vitro 数据支持 NtWLIM2 di/oligomerization。我们建议 NtWLIM2 作为稳定肌动朊的蛋白质工作,它在改变的细胞骨架之上,梭到原子核以便修改基因表示。 | Danièle Moes Sabrina Gatti CEline Hoffmann Monika Dieterle Flora Moreau Katrin Neumann Marc Schumacher Marc Diederich Erwin Grill Wen-Hui Shen André Steinmetz Cldment Thomas | 2013 | Molecular Plant2013，6，2： | 2 |
| 14 | Activator for peroxide bleaching of mechanical pulp显示文摘 | Celine Leduc | | Appita Journal0，，4： | 2 |
| 15 | Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis显示文摘 | Min Jun Celine Foote Jicheng Lv Bruce Neal Anushka Patel Stephen J Nicholls Diederick E Grobbee Alan Cass John Chalmers Vlado Perkovic | 2010 | The Lancet . 2010 (9729)2010，，9729： | 2 |
| 16 | A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata显示文摘新 friedelane 类型 triterpene 说出 3-hydroxyfriedelane-7,12,22-trione,以及九已知的混合物从 Drypetes laciniata 兔笼的整个茎被孤立。(Euphorbiaceae ) 。他们的结构根据分光镜的方法被建立。新 triterpene 衍生物和已知的 saponin 为抗菌剂和抗真菌的活动被测试,他们显得中等积极。 | Simone Veronique Fannang Victor Kuete Celine Mbazoa Djama Marlise Diane J.Dongfack Jean Duplex Wansi Francois Tillequin Elisabeth Seguin Elizabeth Chosson Jean Wandji | 2011 | Chinese Chemical Letters2011，22，2： | 2 |
| 17 | Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa显示文摘Autophagy is invoIved in spermatogenesis by regulating germ cell maturation.This catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged organelles.Cryptorchidism is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in ejaculates.The aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid patients.Semen samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron microscopy.Autophagy protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm cells.LC3 was also detected in the midpiece of cryptorchid sperm tail.Autophagy substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid ones.Transmission electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid samples.Partly degraded mitochondria were frequently discerned in autophagic vacuoles.In conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to control.Our work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological conditions.Thus,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men. | Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 18 | An overview of forensic operations performed following the terrorist attacks on November 13,2015,in Paris显示文摘On the evening of November 13,2015,the city of Paris and its surroundings was hit by a series of attacks committed by terrorist groups,using firearms and explosives.The final toll was 140 people deceased(130 victims and 10 terrorists or their relatives)and more than 413 injured,making these attacks the worst mass killings ever recorded in Paris in peacetime.This article presents the forensic operations carried out at the Medicolegal Institute of Paris(MLIP)following these attacks.A total of 68 autopsies of bodies or body fragments and 83 external examinations were performed within 7 days,and the overall forensic operations(including formal identification of the latest victims)were completed 10 days after the attacks.Over this period,156 body presentations(some bodies were presented several times)were provided to families or relatives.Regarding the 130 civilian casualties,129 died from firearm wounds and one died from blast injuries after an explosion.Of the 10 terrorists or their relatives who were killed,eight died from suicide bombing,one was shot by police and one died from crush injuries due to partial collapse of a building following the police raid against a terrorist’s hideout after the attacks.All mass shootings were perpetrated with AK-47 or Zastava M70 assault rifles using 7.62mm39mm cartridges.In the case of ballistic injuries,death was most often obviously caused by craniocerebral injuries,extensive organ lacerations and/or massive haemorrhage.Among the terrorists killed by bombing,the lesion patterns were body transection,multiple amputations,extreme organ lacerations and the presence of foreign bodies owing to the shrapnel load(steel nuts,glass fragments)or the explosive charge fastening system of the devices.This discussion highlights the particular difficulties of interpretation encountered within the framework of ballistic injuries,a conclusion that should lead to a modest and realistic approach in these exceptional situations where forensic operations involve a very large number of victims in a constrained time. | Antoine Tracqui Celine Deguette Tania Delabarde Yann Delannoy Isabelle Plu Isabelle Sec Lilia Hamza Marc Taccoen Bertrand Ludes | 2020 | Forensic Sciences Research2020，5，3： | 2 |
| 19 | Capacity gaps in health facilities for case management of intestinal schistosomiasis and soil-transmitted helminthiasis in Burundi显示文摘Background:Schistosomiasis and soil-transmitted helminthiasis(STH)are endemic diseases in Burundi.STH control is integrated into health facilities(HF)across the country,but schistosomiasis control is not.The present study aimed to assess the capacity of HF for integrating intestinal schistosomiasis case management into their routine activities.In addition,the current capacity for HF-based STH case management was evaluated.Methods:A random cluster survey was carried out in July 2014,in 65 HF located in Schistosoma mansoni and STH endemic areas.Data were collected by semi-quantitative questionnaires.Staff with different functions at the HF were interviewed(managers,care providers,heads of laboratory and pharmacy and data clerks).Data pertaining to knowledge of intestinal schistosomiasis and STH symptoms,human and material resources and availability and costs of diagnostic tests and treatment were collected.Findings:Less than half of the 65 care providers mentioned one or more major symptoms of intestinal schistosomiasis(abdominal pain 43.1%,bloody diarrhoea 13.9%and bloody stool 7.7%).Few staff members(15.7%)received higher education,and less than 10%were trained in-job on intestinal schistosomiasis case management.Clinical guidelines and laboratory protocols for intestinal schistosomiasis diagnosis and treatment were available in one third of the HF.Diagnosis was performed by direct smear only.Praziquantel was not available in any of the HF.The results for STH were similar,except that major symptoms were more known and cited(abdominal pain 69.2%and diarrhoea 60%).Clinical guidelines were available in 61.5%of HF,and albendazole or mebendazole was available in all HF.Conclusions:The current capacity of HF for intestinal schistosomiasis and STH detection and management is inadequate.Treatment was not available for schistosomiasis.These issues need to be addressed to create an enabling environment for successful integration of intestinal schistosomiasis and STH case management into HF routine activities in Burundi for better control of these diseases. | Paul Bizimana Katja Polman Jean-Pierre Van Geertruyden Frederic Nsabiyumva Celine Ngenzebuhoro Elvis Muhimpundu Giuseppina Ortu | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 20 | Patrick navard swelling and dissolution of cellulose part 1 : free floating cotton and wood fibres in N-methylmorpholine-N-oxide-water mixture显示文摘 | Celine Cuissinat | 2006 | Macromol Symp2006，，244： | 1 |
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