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| 1 | Amalgamated gold-nanoalloys with enhanced catalytic activity for the detection of mercury ions(Hg^2+)in seawater samples显示文摘Mercury(Hg)is extremely toxic,and continues to cause major threats to aquatic life,human health and the environment.Hg^2+mainly derives from seawater as a product of atmospheric deposition,therefore there is great demand for sensing approaches that can detect Hg^2+in seawater samples.Herein,we demonstrate that the peroxidase-mimicking activity of gold nanoparticles(AuNPs)or so-called nanozymes,can be exploited for the detection of Hg^2+ions in various water samples.In a high electrolyte environment,the catalytic activity for the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)was significantly diminished due to poor stability of the bare-AuNPs.This activity was reduced by-73.7%when the NaCl concentration was higher than 1.168%,which is much lower than that of seawater(-3.5%),thus presenting its unsuitability for detecting Hg^2+in harsh water matrices.To overcome this limitation,AuNPs were first functionalized with oligo-ethylene glycol(OEG),of which their colloidal form presented high stability in NaCl concentrations up to 20%and across a wide range of pHs from 1-14.Interestingly,the catalytic activity of OEG-AuNPs for the oxidation of TMB was strongly suppressed by the coating,but enhanced upon formation of Au-Hg amalgamation.This novel finding underlies a straightforward,sensitive,and highly selective detection platform for Hg^2+in water samples.The approach could detect the exposure limit level for Hg^2+in drinking water(i.e.,2 ppb for tap and bottled water)as set by the United States Environmental Protection Agency(EPA)and the World Health Organization(WHO).When Hg^2+was spiked into a 3.5%saline solution and a coastal seawater certified reference material(CRM),the detection limits were found to be 10 ancM 3 ppb,respectively,which exceed the Hg^2+concentrations commonly found within seawater(-60-80 ppb).The whole procedure takes less than 45 min to conduct,providing a highly innovative,rapid and low-cost approach for detecting Hg^2+in complex water matrices. | Natasha Logan Claire McVey Christopher Elliott Cuong Cao | 2020 | Nano Research2020，13，4： | 6 |
| 2 | Unusual switchable peroxidase-mimicking nanozyme for the determination of proteolytic biomarker显示文摘Detection of enzyme biomarkers originating from either bio-fluids or contaminating microorganisms is of utmost importance in clinical diagnostics and food safety. Herein, we present a simple, low-cost and easy-to-use sensing approach based on the switchable peroxidase-mimicking activity of plasmonic gold nanoparticles (AuNPs) that can catalyse for the oxidation of 3,3’,5’5-tetramethylbenzidine (TMB) for the determination of protease enzyme. The AuNP surface is modified with casein, showing dual functionalities. The first function of the coating molecule is to suppress the intrinsic peroxidase-mimicking activity of AuNPs by up to 77.1%, due to surface shielding effects. Secondly, casein also functions as recognition sites for the enzyme biomarker. In the presence of protease, the enzyme binds to and catalyses the degradation of the coating layer on the AuNP surface, resulting in the recovery of peroxidase-mimicking activity. This is shown visually in the development of a blue colored product (oxidised TMB) or spectroscopically as an increase in absorbance at 370 and 650 nm. This mechanism allows for the detection of protease at 44 ng·mL^-1 in 90 min. The nanosensor circumvents issues associated with current methods of detection in terms of ease of use, compatibility with point-of-care testing, low-cost production and short analysis time. The sensing approach has also been applied for the detection of protease spiked in ultra-heat treated (UHT) milk and synthetic human urine samples at a limit of detection of 490 and 176 ng·mL^-1, respectively, showing great potential in clinical diagnostics, food safety and quality control. | Claire McVey Natasha Logan Nguyen T. K. Thanh Christopher Elliott Cuong Cao | 2019 | Nano Research2019，12，3： | 5 |
| 3 | Food Safety Strategies:The One Health Approach to Global Challenges and China’s Actions显示文摘WORLD FOOD SAFETY DAY World Food Safety Day(WFSD)(1)celebrated on 7 June 2021 aims to draw attention and inspire action to help prevent,detect and manage foodborne risks,contributing to food security,human health,economic prosperity,agriculture,market access,tourism and sustainable development.The theme of 2021,“Safe food today for a healthy tomorrow”,stresses that production and consumption of safe food has immediate and long-term benefits for people,the planet and the economy.Recognizing the systemic connections between the health of people,animals,plants,the environment and the economy will help us meet the needs of the future. | Di Wu Christopher Elliott Yongning Wu | 2021 | China CDC weekly2021，3，24： | 4 |
| 4 | Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)显示文摘 | Raymond L. Benza Dave P. Miller Mardi Gomberg-Maitland Robert P. Frantz Aimee J. Foreman Christopher S. Coffey Adaani Frost Robyn J. Barst David B. Badesch C. Gregory Elliott Theodore G. Liou Michael D. McGoon | 2010 | Circulation2010，，2： | 2 |
| 5 | Methods for the Detection of Polyether Ionophore Residues in Poultry显示文摘 | Christopher T Elliott D Glenn Kennedy W John McCaughey | 1998 | Analyst1998，123，： | 1 |
| 6 | Updated Clinical Classification of Pulmonary Hypertension显示文摘 | Gérald Simonneau Ivan M. Robbins Maurice Beghetti Richard N. Channick Marion Delcroix Christopher P. Denton C. Gregory Elliott Sean P. Gaine Mark T. Gladwin Zhi-Cheng Jing Michael J. Krowka David Langleben Norifumi Nakanishi Rogério Souza | 2009 | Journal of the American College of Cardiology2009，，1： | 1 |
| 7 | Gold Nanozymes:From Concept to Biomedical Applications显示文摘In recent years,gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase,oxidase,catalase,superoxide dismutase or reductase.This,merged with their ease of synthesis,tunability,biocompatibility and low cost,makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical analyses.Herein,over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential applications.The review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties,as well as external parameters such as pH or temperature.Yet,real applications often require specific biorecognition elements to be immobilized onto the nanozymes,leading to unexpected positive or negative effects on their activity.Thus,rational design of efficient nanozymes remains a challenge of paramount importance.Different implementation paths have already been explored,including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase activities.The review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities,as more than one of them could coexist.Likewise,further toxicity studies are required to ensure the applicability of gold nanozymes in vivo.Current challenges and future prospects of gold nanozymes are discussed in this review,whose significance can be anticipated in a diverse range of fields beyond biomedicine,such as food safety,environmental analyses or the chemical industry. | Javier Lou‑Franco Bhaskar Das Christopher Elliott Cuong Cao | 2021 | Nano-Micro Letters2021，13，1： | 1 |
| 8 | Hapten synthesis and antibody production for the development of a melamine immunoassay显示文摘 | Hongtao Lei Yudong Shen Lijun Song Jinyi Yang Olivier P. Chevallier Simon A. Haughey Hong Wang Yuanming Sun Christopher T. Elliott | 2010 | Analytica Chimica Acta2010，，1： | 1 |
| 9 | Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)显示文摘 | Raymond L. Benza Dave P. Miller Mardi Gomberg-Maitland Robert P. Frantz Aimee J. Foreman Christopher S. Coffey Adaani Frost Robyn J. Barst David B. Badesch C. Gregory Elliott Theodore G. Liou Michael D. McGoon | 2010 | Circulation2010，，2： | 1 |
| 10 | Development of a novel immunobiosensor method for the rapid detection of okadaic acid contamination in shellfish extracts显示文摘 | Nuria M. Llamas Linda Stewart Terry Fodey H. Cowan Higgins María Luisa R. Velasco Luis M. Botana Christopher T. Elliott | 2007 | Analytical and Bioanalytical Chemistry2007，，2： | 1 |
| 11 | Results of a clinical phase I dose-escalation study of cytarabinein combination with fixed-dose vinorelbine, paclitaxel, etoposideand cisplatin for the treatment of relapsed/refractory lymphoma显示文摘 | Sagar Lonial Martha Arellano Donald Hutcherson Amelia Langston Christopher Flowers L. T. Heffner Elliott Winton Mary Jo Lechowicz Edmund K. Waller | 2006 | Leukemia & Lymphoma2006，，10： | 1 |
| 12 | Development of an ELISA screening test for nitroimidazoles in egg and chicken muscle显示文摘 | Anne-Catherine Huet Leen Mortier Els Daeseleire Terrence Fodey Christopher Elliott Philippe Delahaut | 2004 | Analytica Chimica Acta2004，，1： | 1 |
| 13 | Using the theory of planned behavior to predict observed driving behavior 显示文摘 | Elliott Mark A Christopher A | 2007 | British Journal of Social Psy- chology2007，46，1： | 1 |
| 14 | Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice显示文摘 | Justin H. Nguyen Satoshi Yamamoto Jeffery Steers Daniel Sevlever Wenlang Lin Naoki Shimojima Monica Castanedes-Casey Petrina Genco Todd Golde Elliott Richelson Dennis Dickson Michael McKinney Christopher B. Eckman | 2005 | Journal of Hepatology2005，，6： | 1 |
| 15 | Myoglobin, creatine-kinase-MB and cardiac troponin-I 60-minute ratios predict infarct-related artery patency after thrombolysis for acute myocardial infarction显示文摘 | Milenko J Tanasijevic Christopher P Cannon Elliott M Antman Donald R Wybenga George A Fischer Christine Grudzien C.Michael Gibson James W Winkelman Eugene Braunwald | 1999 | Journal of the American College of Cardiology1999，，： | 1 |
| 16 | Production and characterisation of polyclonal antibodies to a derivative of 3-amino-2-oxazolidinone, a metabolite of the nitrofuran furazolidone显示文摘 | Kevin M. Cooper Anthony Caddell Christopher T. Elliott D.Glenn Kennedy | 2004 | Analytica Chimica Acta2004，，： | 1 |
| 17 | Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice显示文摘 | Justin H. Nguyen Satoshi Yamamoto Jeffery Steers Daniel Sevlever Wenlang Lin Naoki Shimojima Monica Castanedes-Casey Petrina Genco Todd Golde Elliott Richelson Dennis Dickson Michael McKinney Christopher B. Eckman | 2005 | Journal of Hepatology2005，，6： | 1 |
| 18 | Production and characterization of polyclonal antibodies to a derivative of 3- amino-2-oxazolidinone,a metabo- lite of the nitrofuran furazolidone显示文摘 | Kevin MCooper Anthony Caddell Christopher T Elliott | 2004 | Analytica Chimica Acta2004，520，： | 1 |
| 19 | Myoglobin, creatine kinase MB, and cardiac troponin-I to assess reperfusion after thrombolysis for acute myocardial infarction: Results from TIMI 10A显示文摘 | Milenko J. Tanasijevic Christopher P. Cannon Donald R. Wybenga George A. Fischer Christine Grudzien C.Michael Gibson James W. Winkelman Elliott M. Antman Eugene Braunwald | 1997 | American Heart Journal1997，，： | 1 |
| 20 | Updated Clinical Classification of Pulmonary Hypertension显示文摘 | Gérald Simonneau Ivan M. Robbins Maurice Beghetti Richard N. Channick Marion Delcroix Christopher P. Denton C. Gregory Elliott Sean P. Gaine Mark T. Gladwin Zhi-Cheng Jing Michael J. Krowka David Langleben Norifumi Nakanishi Rogério Souza | 2009 | Journal of the American College of Cardiology2009，，1： | 1 |
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