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| 1 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 2 | 全科医学科研的范畴、研究需求和适用方法——《欧洲全科医学/家庭医学和基本医疗保健科研纲要》中文摘译显示文摘本文对《欧洲全科医学/家庭医学和基本医疗保健科研纲要》的中文译稿进行了重点摘登。该文件由欧洲全科医学科研网络制订,包括7部分内容:序言、导言、方法、结果、独立章节,讨论和启示。作为在欧洲发展全科医学科研的核心指南,该文件对欧洲的全科医学学科和科研发展产生了深远的影响。欧洲的全科医学体系和以此为基础而构建的学科理论共识与我国全科医学当前的实际情况可能更为接近。因篇幅所限,本文刊登了其中最重要,对中国研究者也最实用的5部分内容,包括:(1)导言——全科医学的核心能力/特征以及全科医学科研的意义;(2)结果——全科医学的6个核心领域(基本保健管理、'以人为本'的照护、解决具体问题的技能、综合的方法、以社区为导向、整体的方法)的科研范畴,研究需求和适用方法;(3)独立章节——如何发展基本的科研能力和避免常见的科研失误;(4)讨论——未来的全科医学科研重点;(5)启示——科学协会、研究机构、患者参与、科研工作、期刊、科研政策在发展学科方面应注重的问题。因欧洲的全科医学体制和我国较为相似,且存在一定的科研发展代差,该文件在当前阶段也可为我国全科医学研究者所用,基于全科医学学科的视角,从概念、分类学、范围和科研方法等方面,为我国全科医学科研的发展提供参照。 | Eva Hummers-Pradier Martin Beyer Patrick Chevallier Sophia Eilat-Tsanani Christos Lionis Lieve Peremans Davorina Petek Imre Rurik Jean Karl Soler Henri E.J.H.Stoffers Pinar Topsever Mehmet Ungan Paul van Royen Hanny Prick 无 | 2022 | 中国全科医学2022，25，9： | 4 |
| 3 | Oncogenic driver mutations in non-small cell lung cancer: Past, present and future显示文摘Lung cancer,of which non-small lung cancer is the most common subtype,represents the leading cause of cancer related-death worldwide.It is now recognized that a significant proportion of these patients present alterations in certain genes that drive oncogenesis.In recent years,more of these so-called oncogenic drivers have been identified,and a better understanding of their biology has allowed the development new targeted agents.This review aims to provide an update about the current landscape of driver mutation in non-smallcell lung cancer.Alterations in Kirsten rat sarcoma,epidermal growth factor receptor,MET,anaplastic lymphoma kinase,c-ROS oncogene 1,v-raf murine sarcoma viral oncogene homolog B,neurotrophic receptor tyrosine kinase,human epidermal growth factor 2,neuregulin-1 and rearranged during transfection are discussed,as well as agents targeting these alterations.Current standards of treatment as well as promising future strategies are presented.Currently,more than fifteen targeted agents are food and Drug administration-approved for seven oncogenic drivers in non-small-cell lung cancer,highlighting the importance of actively searching for these mutations.Continuous and future efforts made in defining the biology of each of these alterations will help to elucidate their respective resistance mechanisms,and to define the best treatment strategy and therapeutic sequence. | Mathieu Chevallier Maxime Borgeaud Alfredo Addeo Alex Friedlaender | 2021 | World Journal of Clinical Oncology2021，12，4： | 4 |
| 4 | 2060年中国实现碳中和所面临的挑战:现状与展望显示文摘China’s high ambitions to reach peak CO_(2) emissions by 2030 and carbon neutrality by 2060 make carbon mitigation an urgent issue with widespread societal consequences.To develop an achievable roadmap and an effective portfolio of climate policies,it is essential that a clear picture of the magnitude and uncertainty of China’s current carbon balance is available,at both national and regional levels. | 陈报章 陈发虎 Philippe Ciais 张慧芳 吕洪刚 汪涛 Frédéric Chevallier 刘竹 袁文平 Wouter Peters | 2022 | Science Bulletin2022，67，20： | 3 |
| 5 | Price drivers and structural breaks in European carbon prices 2005–2007显示文摘 | Emilie Alberola Julien Chevallier Beno??t Chèze | 2007 | Energy Policy2007，，2： | 3 |
| 6 | Gut microbiome in allogeneic hematopoietic stem cell transplantation and specific changes associated with acute graft vs host disease显示文摘Allogeneic hematopoietic stem cell transplantation(aHSCT)is a standard validated therapy for patients suffering from malignant and nonmalignant hematological diseases.However,aHSCT procedures are limited by potentially life-threatening complications,and one of the most serious complications is acute graft-versus-host disease(GVHD).During the last decades,DNA sequencing technologies were used to investigate relationship between composition or function of the gut microbiome and disease states.Even if it remains unclear whether these microbiome alterations are causative or secondary to the presence of the disease,they may be useful for diagnosis,prevention and therapy in aHSCT recipients.Here,we summarized the most recent findings of the association between human gut microbiome changes and acute GVHD in patients receiving aHSCT. | Quentin Le Bastard Patrice Chevallier Emmanuel Montassier | 2021 | World Journal of Gastroenterology2021，27，45： | 2 |
| 7 | Modeling snowmelt-runoff under climate scenarios in the Hunza River basin, Karakoram Range, Northern Pakistan显示文摘 | Adnan Ahmad Tahir Pierre Chevallier Yves Arnaud Luc Neppel Bashir Ahmad | 2011 | Journal of Hydrology2011，，1： | 2 |
| 8 | Carbon futures and macroeconomic risk factors: A view from the EU ETS显示文摘 | Julien Chevallier | 2009 | Energy Economics2009，，4： | 2 |
| 9 | From bariatric to metabolic surgery:15 years experience in a French university hospital显示文摘 | Jean Marc Chevallier | 2010 | Bulletin de l''Académie nationale de médecine2010，194，1： | 1 |
| 10 | Developing a draft schedule using templates and rules 显示文摘 | Nicola J Chevallier Alan D Russell | 2001 | Journal of Construction Engineer- ing and Management2001，127，5： | 1 |
| 11 | The ap- plication of NMR to study changes in polar metabolite concentrations in beef longissimus dorsi stored for differ- ent periods post mortem 显示文摘 | Graham S F Kennedy T Chevallier O | 2010 | Metabolomics2010，6，3： | 1 |
| 12 | The prediction of hillslope flow paths for distributed hydrological modeling using digital terrain models 显示文摘 | Quinn P F Beven K J Chevallier P | 1991 | Hydrological Processes1991，5，1： | 1 |
| 13 | Sonographic diagnosis of solitary solid liver nodules in cancer patients显示文摘 | J.-N. Bruneton C. Raffaelli C. Balu-Maestro B. Padovani P. Chevallier M.-Y. Mourou | 1996 | European Radiology1996，，4： | 1 |
| 14 | Laparoscopic gastric banding: a minimally invasive surgical treatment for morbid obesity: prospective study of 500 consecutive patients显示文摘 | Zinziudohoue F Chevallier JM Douard R | 2003 | Ann Surg2003，237，1： | 1 |
| 15 | Interventional radiology in the management of complications after liver transplantation显示文摘 | Denys A Chevallier P Doenz F | 2004 | Eur Radiol2004，14，： | 1 |
| 16 | Easy and fast detection and genotyping of high-risk human papillomavirus by dedicated DNA Microarrays显示文摘 | Albrecht V Chevallier A Magnone V | 2006 | Journal of Virological Methods2006，137，2： | 1 |
| 17 | Allogeneic hematopoietic stem-cell transplantation for myeloid sarcoma:a retrospective study from the SFGM-TC显示文摘 | CHEVALLIER P MOHTY M LIOURE B | 2008 | J Clin Oncol2008，26，： | 1 |
| 18 | Celiac trunk compression by arcuate ligament and living-related liver transplantation:a two-step strategy for flow-induced enlargement of donor hepatic artery显示文摘 | Douard R Ettorre GM Chevallier JM | 2002 | Surg Rediol Anat2002，24，5： | 1 |
| 19 | Basal cell carcinoma overlying histiocytofibroma显示文摘 | Rotteleur G Chevallier JM Piette F | 1983 | Acta Derm Venereol1983，63，6： | 1 |
| 20 | Automated schedule gen- eration 显示文摘 | Chevallier N Russell A D | 1998 | Canadian Journal of Civil Engineering1998，25，6： | 1 |
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