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| 1 | Alcohol-induced steatosis in liver cells显示文摘Alcohol-induced fatty liver (steatosis) was believed to result from excessive generation of reducing equivalents from ethanol metabolism, thereby enhancing fat accumulation. Recent findings have revealed a more complex picture in which ethanol oxidation is still required, but specific transcription as well as humoral factors also have important roles. Transcription factors involved include the sterol regulatory element binding protein 1 (SREBP-1) which is activated to induce genes that regulate lipid biosynthesis. Conversely, ethanol consumption causes a general down-regulation of lipid (fatty acid) oxidation, a reflection of inactivation of the peroxisome proliferator- activated receptor-alpha (PPAR-α) that regulates genes involved in fatty acid oxidation. A third transcription factor is the early growth response-1 (Egr-1), which is strongly induced prior to the onset of steatosis. The activities of all these factors are governed by that of the principal regulatory enzyme, AMP kinase. Important humoral factors, including adiponectin, and tumor necrosis factor-α (TNF-α), also regulate alcohol-induced steatosis. Their levels are affected by alcohol consumption and by each other. This review will summarize the actions of these proteins in ethanol-elicited fatty liver. Because steatosis is now regarded as a significant risk factor for advanced liver pathology, an understanding of the molecular mechanisms in its etiology is essential for development of effective therapies. | Terrence M Donohue Jr | 2007 | World Journal of Gastroenterology2007，13，37： | 21 |
| 2 | Autophagy and ethanol-induced liver injury显示文摘The majority of ethanol metabolism occurs in the liver. Consequently, this organ sustains the greatest damage from ethanol abuse. Ethanol consumption disturbs the delicate balance of protein homeostasis in the liver, causing intracellular protein accumulation due to a disruption of hepatic protein catabolism. Evidence indicates that ethanol or its metabolism impairs trafficking events in the liver, including the process of macroautophagy, which is the engulfment and degradation of cytoplasmic constituents by the lysosomal system. Autophagy is an essential, ongoing cellular process that is highly regulated by nutrients, endocrine factors and signaling pathways. A great number of the genes and gene products that govern the autophagic response have been characterized and the major metabolic and signaling pathways that activate or suppress autophagy have been identified. This review describes the process of autophagy, its regulation and the possible mechanisms by which ethanol disrupts the process of autophagic degradation. The implications of autophagic suppression are discussed in relation to the pathogenesis of alcohol-induced liver injury. | Terrence M Donohue Jr | 2009 | World Journal of Gastroenterology2009，15，10： | 11 |
| 3 | Implication of altered proteasome function in alcoholic liverinjury显示文摘The proteasome is a major protein-degrading enzyme, which catalyzes degradation of oxidized and aged proteins, signal transduction factors and cleaves peptides for antigen presentation. Proteasome exists in the equilibrium of 26S and 20S particles. Proteasome function is altered by ethanol metabolism, depending on oxidative stress levels: low oxidative stress induces proteasome activity, while high oxidative stress reduces it. The proposed mechanisms for modulation of proteasome activity are related to oxidative modification of proteasomal proteins with primary and secondary products derived from ethanol oxidation. Decreased proteolysis by the proteasome results in the accumulation of insoluble protein aggregates, which cannot be degraded by proteasome and which further inhibit proteasome function. Mallory bodies, a common signature of alcoholic liver diseases, are formed by liver cells, when proteasome is unable to remove cytokeratins. Proteasome inhibition by ethanol also promotes the accumulation of pro-apoptotic factors in mitochondria of ethanol-metabolizing liver cells that are normally degraded by proteasome. In addition, decreased proteasome function also induces accumulation of the negative regulators of cytokine signaling (I-kB and SOCS), thereby blocking cytokine signal transduction. Finally, ethanol-elicited blockade of interferon type 1 and 2 signaling and decreased proteasome function impairs generation of peptides for MHC class Ⅰ-restricted antigen presentation. | Natalia A Osna Terrence M Donohue Jr | 2007 | World Journal of Gastroenterology2007，13，37： | 10 |
| 4 | Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis显示文摘This review describes the principal pathways of macroautophagy (i.e. autophagy), microautophagy and chaperone-mediated autophagy as they are currently known to occur in mammalian cells. Because of its crucial role as an accessory digestive organ, the liver has a particularly robust autophagic activity that is sensitive to changes in plasma and dietary components. Ethanol consumption causes major changes in hepatic protein and lipid metabolism and both are regulated by autophagy, which is significantly affected by hepatic ethanol metabolism. Ethanol exposure enhances autophagosome formation in liver cells, but suppresses lysosome function. Excessive ethanol consumption synergizes with hepatitis C virus (HCV) to exacerbate liver injury, as alcohol-consuming HCV patients frequently have a longer course of infection and more severe manifestations of chronic hepatitis than abstinent HCV patients. Alcohol-elicited exacerbation of HCV infection pathogenesis is related to modulation by ethanol metabolism of HCV replication. Additionally, as part of this mechanism, autophagic proteins have been shown to regulate viral (HCV) replication and their intracel-lular accumulation. Because ethanol induces autophagosome expression, enhanced levels of autophagic proteins may enhance HCV infectivity in liver cells of alcoholics and heavy drinkers. | Natalia A Osna Paul G Thomes Terrence M Donohue | 2011 | World Journal of Gastroenterology2011，17，20： | 5 |
| 5 | Use of mycophenolate mofetil in inflammatory bowel disease显示文摘AIM:To assess the efficacy and safety of mycophenolate mofetil(MMF)prospectively in inflammatory bowel disease(IBD)patients intolerant or refractory to conventional medical therapy.METHODS:Crohn's disease(CD)or ulcerative colitis/ IBD unclassified(UC/IBDU)patients intolerant or refractory to conventional medical therapy received MMF(500-2000 mg bid).Clinical response was assessed by the Harvey Bradshaw index(HBI)or colitis activity index(CAI)after 2,6 and 12 mo of therapy,as were steroid usage and adverse effects.RESULTS:Fourteen patients(9 CD/5 UC/IBDU;8M/6F;mean age 50.4 years,range 28-67 years)were treated and prospectively assessed for their response to oral MMF.Of the 11 patients who were not in remission on commencing MMF,7/11(63.6%)achieved remission by 8 wk.All 3 patients in remission on commencing MMF maintained their remission.Ten patients were still on MMF at 6 mo with 9/14(64.3%)in remission,while of 12 patients followed for 12 mo,8 were in remission without dose escalation(66.7%).Three patients were withdrawn from the MMF due to drug intolerance.There were no serious adverse events attributed due to the medication.CONCLUSION:MMF demonstrated efficacy in the management of difficult IBD.MMF appeared safe,well tolerated and efficacious for both short and long-term therapy,without the need for dose escalation.Further evaluation of MMF comparing it to conventional immunosuppressants is required. | Terrence Tan Ian Craig Lawrance | 2009 | World Journal of Gastroenterology2009，15，13： | 5 |
| 6 | 玻璃体内注射曲安奈德治疗继发于IRVAN的黄斑水肿(英文)显示文摘目的:报告玻璃体内注射曲安奈德对特发性视网膜炎、血管炎、动脉瘤及视神经视网膜炎(IRVAN)所致的黄斑水肿的治疗效果。方法:病例报告。结果:患者诊断为特发性视网膜炎、血管炎、动脉瘤及视神经视网膜炎导致的伴有视力丧失的继发性黄斑水肿。玻璃体内注射曲安奈德后黄斑水肿减轻,视力显著改善。结论:以前的报告建议采取全视网膜光凝,玻璃体切除术及全身和眼部类固醇治疗。对于继发于IRVAN的黄斑水肿和血管炎,玻璃体内注射曲安奈德是一种安全有效的治疗方法。 | Terrence Kwong-Weng Soong Visvaraja Subrayan Choo May May | 2010 | 国际眼科杂志2010，10，11： | 4 |
| 7 | 中国苏铁属濒危植物的初步研究显示文摘本文对我国苏铁属植物分布、资源现状、植物濒危原因进行了初步考察和研究,提出了苏铁植物保护的四点建议。 | 蒲红 杨四林 Terrence W.Walters | 1993 | 资源开发与保护1993，9，3： | 3 |
| 8 | Efficacy of texture analysis of pre-operative magnetic resonance imaging in predicting microvascular invasion in hepatocellular carcinoma显示文摘BACKGROUND Presence of microvascular invasion(MVI)indicates poorer prognosis postcurative resection of hepatocellular carcinoma(HCC),with an increased chance of tumour recurrence.By present standards,MVI can only be diagnosed postoperatively on histopathology.Texture analysis potentially allows identification of patients who are considered‘high risk’through analysis of pre-operative magnetic resonance imaging(MRI)studies.This will allow for better patient selection,improved individualised therapy(such as extended surgical margins or adjuvant therapy)and pre-operative prognostication.AIM This study aims to evaluate the accuracy of texture analysis on pre-operative MRI in predicting MVI in HCC.METHODS Retrospective review of patients with new cases of HCC who underwent hepatectomy between 2007 and 2015 was performed.Exclusion criteria:No preoperative MRI,significant movement artefacts,loss-to-follow-up,ruptured HCCs,previous hepatectomy and adjuvant therapy.Fifty patients were divided into MVI(n=15)and non-MVI(n=35)groups based on tumour histology.Selected images of the tumour on post-contrast-enhanced T1-weighted MRI were analysed.Both qualitative(performed by radiologists)and quantitative data(performed by software)were obtained.Radiomics texture parameters were extracted based on the largest cross-sectional area of each tumor and analysed using MaZda software.Five separate methods were performed.Methods 1,2 and 3 exclusively made use of features derived from arterial,portovenous and equilibrium phases respectively.Methods 4 and 5 made use of the comparatively significant features to attain optimal performance.RESULTS Method 5 achieved the highest accuracy of 87.8%with sensitivity of 73%and specificity of 94%.CONCLUSION Texture analysis of tumours on pre-operative MRI can predict presence of MVI in HCC with accuracies of up to 87.8%and can potentially impact clinical management. | Jordan Zheng Ting Sim Terrence Chi Hong Hui Tong Kuan Chuah Hsien Min Low Cher Heng Tan Vishal GShelat | 2022 | World Journal of Clinical Oncology2022，13，11： | 3 |
| 9 | Environmentally Sensitive Productivity Analysis of the Canadian Pulp and Paper Industry, 1959-1994: An Input Distance Function Approach显示文摘 | Atakelty Hailu Terrence S. Veeman | 2000 | Journal of Environmental Economics and Management2000，，3： | 2 |
| 10 | Lysosome and proteasome dysfunction in alcohol-induced liver injury显示文摘The review describes research findings on the influence of alcohol consumption on two crucial catabolic systems in hepatocytes:the lysosome and the ubiquitin-proteasome system(UPS).The lysosome is a membrane-bound organelle that degrades all aging and/or damaged organelles and hydrolyzes all forms of macromolecules.The UPS is mostly proteolytic.It carries out the majority of its functions in the soluble portion of the cytoplasm(cytosol)and degrades nearly all intracellular proteins,particularly those with short half-lives,so that their levels are tightly controlled.Our review will briefly discuss the epidemiology of alcohol abuse and the spectrum of alcohol-induced liver disease(AILD).We will explain why ethanol(EtOH)metabolism,but not EtOH alone,is hepatotoxic.Then,we will summarize how heavy drinking alters hepatic catabolic systems,resulting in liver enlargement that develops from hepatocyte swelling due,in part,to aberrant accumulation of undegraded lipid droplets(steatosis)and undegraded proteins(proteopathy).Our detailed description of each catabolic system will highlight its discoverer(s)and emphasize each system’s characteristics.Most important,we will review the evidence that chronic EtOH consumption disrupts hepatic lysosome biogenesis and inhibits the UPS by impeding hepatic proteasome activity.It will become evident that each of these EtOH-induced defects has far-reaching functional consequences.Finally,we will describe current and potential therapeutic interventions for alleviating EtOH-induced liver injury.The most effective intervention is the cessation of EtOH consumption.However,there are other potential approaches using natural or synthetic compounds that activate autophagy or the proteasome to enhance the degradation of accumulated lipid droplets or proteins,respectively,which could alleviate AILD.These approaches,now in their early stages of investigation,will also be discussed in this review. | Terrence M.Donohue.Jr Natalia A.Osna Kusum K.Kharbanda Paul G.Thomes | 2019 | Liver Research2019，3，3： | 2 |
| 11 | 新转化膜在汽车行业内的应用近况显示文摘过去60年间,化学公司一直为汽车制造商提供最先进的磷酸锌转化膜,若将该转化膜适当地用于金属表面,可增强漆膜的附着力和防腐蚀性。磷酸盐转化膜在过去几年中经历了多次变革,目前,该转化膜的一些主要成分及副产品在新的环境政策下受到更加严格的控制,金属及其处理行业现在面临着将传统的磷酸锌膜替换为新一代产品的挑战。本文将介绍新一代氧化锆转化膜的优势,并讨论其性能和工艺成本的节省情况。过去数年内,该技术获得了极大进展,2007年几条新转化膜商业生产线已经开始试运行。文中还将展示这些试行生产线的成果,并讨论该技术的未来发展。 | Terrence R.Giles Bruce H.Goodreau William E.Fristad Jens Kroemer Michael Frank | 2008 | 汽车工艺与材料2008，，11： | 2 |
| 12 | Functions of autophagy in normal and diseased liver显示文摘 | Mark J. Czaja Wen-Xing Ding Terrence M. Donohue Scott L. Friedman Jae-Sung Kim Masaaki Komatsu John J. Lemasters Antoinette Lemoine Jiandie D. Lin Jing-hsiung James Ou David H. Perlmutter Glenn Randall Ratna B. Ray Allan Tsung Xiao-Ming Yin | 2013 | Autophagy2013，，8： | 2 |
| 13 | Combining Task Scheduling in Power Adaptive Dynamic Reconfigurable System显示文摘Supplying the electronic equipment by exploiting ambient energy sources is a hot spot. In order to achieve the match between power supply and demands under the variance of environments at real time, a reconfigurable technique is taken. In this paper, a dynamic power consumption model by using a lookup table as a unit is proposed. Then, we establish a system-level task scheduling model according to the task type. Based on single instruction multiple data (SIMD) architecture which contains a processing system and a control system with a Nios Ⅱ processor, a practical dynamic reconfigurable system is built. The approach is evaluated on a hardware platform. The test results show that the system can automatically adjust the power consumption in case of external energy input changing. The utilization of the system dynamic power of their portion is from 80.05% to 91.75% during the first task assignment. During the entire processing cycle, the total energy efficiency is 97.67%. | Hui Dong Le-Tian Huang Jun-Shi Wang Terrence Mak | 2012 | Journal of Electronic Science and Technology2012，10，4： | 2 |
| 14 | A Review of Fluid Inclusions in Diagenetic Systems显示文摘The study of fluid inclusions can help constrain the conditions at which diagenetic minerals precipitated,leading to a better understanding of the geologic controls and relative timing of changes in porosity and/or mineralising events.Many of the diagenetic minerals are easily deformed and it is important to check for any post-entrapment changes to the inclusions.Possible post-entrapment changes include reaction with the host crystal,necking down,nucleation metastability and thermal reequilibration.The recommended method of detecting these problems is to examine individual fluid inclusion assemblages(FIAs) and report data for each individual FIA.These studies have been enhanced by the development of new micro-analytical techniques such as micro-fluorescence spectroscopy,micro-infrared spectroscopy,nuclear magnetic resonance,various mass spectrometry techniques and the analysis of individual fluid inclusions using laser ablation/decrepitation methods.Special techniques have been developed for hydrocarbon-bearing inclusions such as the Grains containing Oil Inclusions(GOI),Fluid Inclusion Stratigraphy(FIS),and the Molecular Composition of Inclusions(MCI) techniques.The fluid inclusions that form in some minerals during diagenesis provide the only direct means of examining the fluids present in these systems.They provide useful temperature,pressure,and fluid composition data that cannot be obtained by other means. | Terrence P.MERNAGH | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 2 |
| 15 | Customer satisfaction with services: putting perceived value into the equation显示文摘 | Gordon H.G. McDougall Terrence Levesque | 2000 | Journal of Services Marketing2000，，5： | 2 |
| 16 | Designing the service guarantee: Unconditional or specific显示文摘 | McDougall Gordon H G Terrence Levesque and Peter Vanderplaat | 1998 | Journal of Services Marketing1998，12，4： | 1 |
| 17 | Non-Parametric productivity analysis with undesirable outputs: An application to the canadian pulp and paper industry显示文摘 | Hailu Atakelty Terrence S Veeman | 2001 | American Journal of Agricultural Ecortomics2001，83，3： | 1 |
| 18 | Immunity to influenza A H9N2 viruses induced by infection and vaccination显示文摘 | Xiuhua Lu Mary Renshaw Terrence M | 2001 | J of Virology2001，75，10： | 1 |
| 19 | Corneal Ectasia After Excimer Laser Keratorefractive Surgery: Histopathology, Ultrastructure, and Pathophysiology显示文摘 | Daniel G. Dawson J. Bradley Randleman Hans E. Grossniklaus Terrence P. O’Brien Sander R. Dubovy Ingo Schmack R. Doyle Stulting Henry F. Edelhauser | 2008 | Ophthalmology2008，，12： | 1 |
| 20 | The use of short, wide implants in posterior areas with reduced bone height: a retrospective investigation显示文摘 | Terrence J Griffin Wai S Cheung | 2004 | The Journal of Prosthetic Dentistry2004，，2： | 1 |
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