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| 1 | New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease显示文摘AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI therapy.METHODS:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-ATPase.Quantitative real-time RT-PCR for each of the H+K+-ATPase subunits was performed.The p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII measurement.RESULTS:Twenty patients with LPR symptoms were included.In only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical staining.In another patient,real-time RT-PCR for each H+K+-ATPase subunit was positive.Fourteen out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/MII.Four patients had pathological results in both functional tests.Nine out of twenty patients responded to PPIs.CONCLUSION:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR symptoms.Alternative hypotheses for the pathomechanism are needed.The role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting. | Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj | 2015 | World Journal of Gastroenterology2015，21，3： | 14 |
| 2 | Value of liver computed tomography with iodixanol 270, 80 kVp and iterative reconstruction显示文摘AIM: To evaluate the image quality of hepatic multidetector computed tomography(MDCT) with dynamic contrast enhancement. METHODS: It uses iodixanol 270 mg/m L(Visipaque 270) and 80 kVp acquisitions reconstructed with sinogram affirmed iterative reconstruction(SAFIRE?) in comparison with a standard MDCT protocol. Fiftythree consecutive patients with known or suspected hepatocellular carcinoma underwent 55 CT examinations, with two different four-phase CT protocols. The first group of 30 patients underwent a standard 120 kVp acquisition after injection of Iohexol 350 mg/m L(Accupaque 350~?) and reconstructed with filtered back projection. The second group of 25 patients underwent a dual-energy CT at 80-140 kVp with iodixanol 270. The 80 kVp component of the second group was reconstructed iteratively(SAFIRE?-Siemens). All hyperdense and hypodense hepatic lesions ≥ 5 mm were identified with both protocols. Aorta and portal vessels/liver parenchyma contrast to noise ratio(CNR) in arterial phase, hypervascular lesion/liver parenchyma CNR in arterial phase, hypodense lesion/liver parenchyma CNR in portal and late phase were calculated in both groups.RESULTS: Aorta/liver and focal lesions altogether/liver CNR were higher for the second protocol(P = 0.0078 and 0.0346). Hypervascular lesions/liver CNR was not statistically different(P = 0.86). Hypodense lesion/liver CNR in the portal phase was significantly higher for the second group(P = 0.0107). Hypodense lesion/liver CNR in the late phase was the same for both groups(P = 0.9926).CONCLUSION: MDCT imaging with 80 kVp with iterative reconstruction and iodixanol 270 yields equal or even better image quality. | Diomidis Botsikas Isabelle Barnaure Sylvain Terraz Christoph D Becker Anastasia Kalovidouri Xavier Montet | 2016 | World Journal of Radiology2016，8，7： | 5 |
| 3 | Quantification of Obstructive and Nonobstructive Coronary Lesions by 64-Slice Computed Tomography显示文摘 | Alexander W. Leber Andreas Knez Franz von Ziegler Alexander Becker Konstantin Nikolaou Stephan Paul Bernd Wintersperger Maximilian Reiser Christoph R. Becker Gerhard Steinbeck Peter Boekstegers | 2005 | Journal of the American College of Cardiology2005，，1： | 4 |
| 4 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Sü? Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，6： | 3 |
| 5 | Dual Energy CT Characterization of Urinary Calculi: Initial In Vitro and Clinical Experience显示文摘 | Anno Graser Thorsten R. C. Johnson Markus Bader Michael Staehler Nicolas Haseke Konstantin Nikolaou Maximilian F. Reiser Christian G. Stief Christoph R. Becker | 2008 | Investigative Radiology2008，，2： | 3 |
| 6 | miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts显示文摘 | Anna M. Eiring Jason G. Harb Paolo Neviani Christopher Garton Joshua J. Oaks Riccardo Spizzo Shujun Liu Sebastian Schwind Ramasamy Santhanam Christopher J. Hickey Heiko Becker Jason C. Chandler Raul Andino Jorge Cortes Peter Hokland Claudia S. Huettner Ra | 2010 | Cell2010，，5： | 2 |
| 7 | 3H Dendrimer Nanoparticle Organ/Tumor Distribution显示文摘 | Shraddha S. Nigavekar Lok Yun Sung Mikel Llanes Areej El-Jawahri Theodore S. Lawrence Christopher W. Becker Lajos Balogh Mohamed K. Khan | 2004 | Pharmaceutical Research2004，，3： | 2 |
| 8 | RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F显示文摘 | Moritz Leppkes Christoph Becker Ivaylo I. Ivanov Sebastian Hirth Stefan Wirtz Clemens Neufert Sandrine Pouly Andrew J. Murphy David M. Valenzuela George D. Yancopoulos Burkhard Becher Dan R. Littman Markus F. Neurath | 2009 | Gastroenterology2009，，1： | 2 |
| 9 | Dual-source CT cardiac imaging: initial experience显示文摘 | Thorsten R. C. Johnson Konstantin Nikolaou Bernd J. Wintersperger Alexander W. Leber Franz Ziegler Carsten Rist Sonja Buhmann Andreas Knez Maximilian F. Reiser Christoph R. Becker | 2006 | European Radiology2006，，7： | 2 |
| 10 | Quantification of Obstructive and Nonobstructive Coronary Lesions by 64-Slice Computed Tomography显示文摘 | Alexander W. Leber Andreas Knez Franz von Ziegler Alexander Becker Konstantin Nikolaou Stephan Paul Bernd Wintersperger Maximilian Reiser Christoph R. Becker Gerhard Steinbeck Peter Boekstegers | 2005 | Journal of the American College of Cardiology2005，，1： | 2 |
| 11 | Ticagrelor Effects on Myocardial Infarction and the Impact of Event Adjudication in the Platelet Inhibition and Patient Outcomes (PLATO) Trial显示文摘 | Kenneth W. Mahaffey Claes Held Daniel M. Wojdyla Stefan K. James Hugo A. Katus Steen Husted Philippe Gabriel Steg Christopher P. Cannon Richard C. Becker Robert F. Storey Nardev S. Khurmi José C. Nicolau Cheuk-Man Yu Diego Ardissino Andrzej Budaj Joao Mor | 2014 | Journal of the American College of Cardiology2014，，： | 2 |
| 12 | Material differentiation by dual energy CT: initial experience显示文摘 | Thorsten R. C. Johnson Bernhard Krau? Martin Sedlmair Michael Grasruck Herbert Bruder Dominik Morhard Christian Fink Sabine Weckbach Miriam Lenhard Bernhard Schmidt Thomas Flohr Maximilian F. Reiser Christoph R. Becker | 2007 | European Radiology2007，，6： | 2 |
| 13 | Assessment of myocardial perfusion and viability from routine contrast-enhanced 16-detector-row computed tomography of the heart: preliminary results显示文摘 | Konstantin Nikolaou Javier Sanz Michael Poon Bernd J. Wintersperger Bernd Ohnesorge Teresa Rius Zahi A. Fayad Maximilian F. Reiser Christoph R. Becker | 2005 | European Radiology2005，，5： | 2 |
| 14 | Ex vivo coronary atherosclerotic plaque characterization with multi-detector-row CT显示文摘 | Christoph R. Becker Konstantin Nikolaou Michael Muders Gregor Babaryka Alexander Crispin U. Joseph Schoepf Udo Loehrs Maximilian F. Reiser | 2003 | European Radiology2003，，9： | 1 |
| 15 | Inhibitory Effects of Ticagrelor Compared With Clopidogrel on Platelet Function in Patients With Acute Coronary Syndromes显示文摘 | Robert F. Storey Dominick J. Angiolillo Shankar B. Patil Bhaloo Desai Rosemary Ecob Steen Husted Hakan Emanuelsson Christopher P. Cannon Richard C. Becker Lars Wallentin | 2010 | Journal of the American College of Cardiology2010，，： | 1 |
| 16 | Bacterial diversity of soils assessed by DGGE, T-RFLP and SSCP fingerprints of PCR-amplified 16S rRNA gene fragments: Do the different methods provide similar results?显示文摘 | Kornelia Smalla Miruna Oros-Sichler Annett Milling Holger Heuer Susanne Baumgarte Regina Becker Gabriele Neuber Siegfried Kropf Andreas Ulrich Christoph C. Tebbe | 2007 | Journal of Microbiological Methods2007，，3： | 1 |
| 17 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Süβ Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，2： | 1 |
| 18 | 质子转移反应质谱仪的技术改进及其在新领域中的应用显示文摘质子转移反应质谱仪(PTR-MS)拥有着独特的发展历程。1995年,世界上只有两个刊物报道这个相对陌生的技术。现在PTR-MS技术已经比较成熟,本文就其最新技术发展和新领域应用进行深入地讨论。 | Philipp SULZER Alfons JORDAN Lukas MARK Christopher A. MAYHEW Kurt BECKER Tilmann D. MARK | 2011 | 生命科学仪器2011，9，5： | 1 |
| 19 | ECG-gated reconstructed multi-detector row CT coronary angiography:effect of varying trigger delay on image quality显示文摘 | Cheng H Christoph R Becker AH | 2001 | Radiology2001，220，： | 1 |
| 20 | Inhibitory Effects of Ticagrelor Compared With Clopidogrel on Platelet Function in Patients With Acute Coronary Syndromes显示文摘 | Robert F. Storey Dominick J. Angiolillo Shankar B. Patil Bhaloo Desai Rosemary Ecob Steen Husted Hakan Emanuelsson Christopher P. Cannon Richard C. Becker Lars Wallentin | 2010 | Journal of the American College of Cardiology2010，，18： | 1 |
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