|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Management of borderline and locally advanced pancreatic cancer:Where do we stand?显示文摘Many patients with pancreas cancer present with locally advanced pancreatic cancer(LAPC).The principle tools used for diagnosis and staging of LAPC include endoscopic ultrasound,axial imaging with computed tomography and magnetic resonance imaging,and diagnostic laparoscopy.The definition of resectability has historically been vague,as there is considerable debate and controversy as to the definition of LAPC.For the patient with LAPC,there is some level of involvement of the surrounding vascular structures,which include the superior mesenteric artery,celiac axis,hepatic artery,superior mesenteric vein,or portal vein.When feasible,most surgeons would recommend possible surgical resection for patients with borderline LAPC,with the goal of an R0 resection.For initially unresectable LAPC,neoadjuvant should be strongly considered.Specifically,these patients should be offered neoadjuvant therapy,and the tumor should be assessed for possible response and eventual resection.The efficacy of neoadjuvant therapy with this approach as a bridge to potential curative resection is broad,ranging from 3%-79%.The different modalities of neoadjuvant therapy include sin-gle or multi-agent chemotherapy combined with radiation,chemotherapy alone,and chemotherapy followed by chemotherapy with radiation.This review focuses on patients with LAPC and addresses recent advances and controversies in the field. | Jin He Andrew J Page Matthew Weiss Christopher L Wolfgang Joseph M Herman Timothy M Pawlik | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 2 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 3 | Recent progress in pancreatic cancer显示文摘 | Christopher L. Wolfgang Joseph M. Herman Daniel A. Laheru Alison P. Klein Michael A. Erdek Elliot K. Fishman Ralph H. Hruban | 2013 | CA A Cancer Journal for Clinicians2013，，5： | 7 |
| 4 | A multi‐institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer显示文摘 | Edward J. Kim Edgar Ben‐Josef Joseph M. Herman Tanios Bekaii‐Saab Laura A. Dawson Kent A. Griffith Isaac R. Francis Joel K. Greenson Diane M. Simeone Theodore S. Lawrence Daniel Laheru Christopher L. Wolfgang Terence Williams Mark Bloomston Malcolm J. Moo | 2013 | Cancer2013，，15： | 3 |
| 5 | Pancreatic Resection of Isolated Metastases from Nonpancreatic Primary Cancers显示文摘 | Sushanth Reddy MD Barish H. Edil MD John L. Cameron MD Timothy M. Pawlik MD MPH Joseph M. Herman MD Marta M. Gilson PhD Kurtis A. Campbell MD Richard D. Schulick MD Nita Ahuja MD Christopher L. Wolfgang MD PhD | 2008 | Annals of Surgical Oncology2008，，11： | 2 |
| 6 | Adjuvant Chemoradiation for Pancreatic Adenocarcinoma: The Johns Hopkins Hospital—Mayo Clinic Collaborative Study显示文摘 | Charles C. Hsu MD PhD Joseph M. Herman MD MSc Michele M. Corsini MD Jordan M. Winter MD Matthew D. Callister MD Michael G. Haddock MD John L. Cameron MD Timothy M. Pawlik MD MPH Richard D. Schulick MD Christopher L. Wolfgang MD PhD Daniel A. Laheru MD | 2010 | Annals of Surgical Oncology2010，，4： | 2 |
| 7 | Combining non-thermal plasma with heterogeneous catalysis in waste gas treatment: A review显示文摘 | Jim Van Durme Jo Dewulf Christophe Leys Herman Van Langenhove | 2007 | Applied Catalysis B Environmental2007，，3： | 2 |
| 8 | Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer’s Disease显示文摘 | Masaaki Takahashi Sylvain Doré Christopher D Ferris Taisuke Tomita Akira Sawa Herman Wolosker David R Borchelt Takeshi Iwatsubo Seong-Hun Kim Gopal Thinakaran Sangram S Sisodia Solomon H Snyder | 2000 | Neuron2000，，2： | 1 |
| 9 | Combined Morphologic and Karyotypic Study of 28 Myxoid Liposarcomas: Implications for a Revised Morphologic Typing (A Report from the CHAMP Group)显示文摘 | Giovanni Tallini Mans Akerman Paola Dal Cin Ivo DeWever Christopher D. M. Fletcher Nils Mandahl Fredrik Mertens Felix Mitelman Juan Rosai Anders Rydholm Raf Sciot Herman Van Den Berghe Wim Van Den Ven Roberta Vanni Helena Willen | 1996 | The American Journal of Surgical Pathology1996，，9： | 1 |
| 10 | Combining non-thermal plasma with heterogeneous catalysis in waste gas treatment: A review显示文摘 | Jim Van Durme Jo Dewulf Christophe Leys Herman Van Langenhove | 2007 | Applied Catalysis B Environmental2007，，3： | 1 |
| 11 | Oxygenated polycyclic aromatic hydrocarbons in atmospheric particulate matter: Molecular characterization and occurrence显示文摘 | Christophe Walgraeve Kristof Demeestere Jo Dewulf Ralf Zimmermann Herman Van Langenhove | 2009 | Atmospheric Environment2009，，15： | 1 |
| 12 | Clinicopathologic Analysis of Ampullary Neoplasms in 450 Patients: Implications for Surgical Strategy and Long-Term Prognosis显示文摘 | Jordan M. Winter John L. Cameron Kelly Olino Joseph M. Herman Mechteld C. Jong Ralph H. Hruban Christopher L. Wolfgang Frederic Eckhauser Barish H. Edil Michael A. Choti Richard D. Schulick Timothy M. Pawlik | 2010 | Journal of Gastrointestinal Surgery2010，，2： | 1 |
| 13 | Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients显示文摘 | K. Ranh Voong Jon Davison Timothy M. Pawlik Manuel O. Uy Charles C. Hsu Jordan Winter Ralph H. Hruban Daniel Laheru Sonali Rudra Michael J. Swartz Hari Nathan Barish H. Edil Richard Schulick John L. Cameron Christopher L. Wolfgang Joseph M. Herman | 2010 | Human Pathology2010，，1： | 1 |
| 14 | Effect of metabolic syndrome on perioperative outcomes after liver surgery: A National Surgical Quality Improvement Program (NSQIP) analysis显示文摘 | Neil H. Bhayani Omar Hyder Wayne Frederick Richard D. Schulick Christopher L. Wolgang Kenzo Hirose Barish Edil Joseph M. Herman Michael A. Choti Timothy M. Pawlik | 2012 | Surgery2012，，2： | 1 |
| 15 | Evaluating the Impact of a Single-Day Multidisciplinary Clinic on the Management of Pancreatic Cancer显示文摘 | Timothy M. Pawlik MD MPH Daniel Laheru MD Ralph H. Hruban MD JoAnn Coleman CRNP Christopher L. Wolfgang MD PhD Kurt Campbell MD Syed Ali MD Elliot K. Fishman MD Richard D. Schulick MD Joseph M. Herman MD MSc | 2008 | Annals of Surgical Oncology2008，，8： | 1 |
| 16 | Evalua- tion of coupling agents in poly(propylene)/fly ash compos- ites: effect on processing and mechanical properties显示文摘 | ITZIAR I A HERMAN P CHRISTOPHER M L | 2011 | Mac- romol Mater Eng2011，296，： | 1 |
| 17 | Pancreatic Resection of Isolated Metastases from Nonpancreatic Primary Cancers显示文摘 | Sushanth Reddy Barish H. Edil John L. Cameron Timothy M. Pawlik Joseph M. Herman Marta M. Gilson Kurtis A. Campbell Richard D. Schulick Nita Ahuja Christopher L. Wolfgang | 2008 | Annals of Surgical Oncology2008，，： | 1 |
| 18 | Power capabilities of elite bicycle motocross(BMX) racers during field testing In preparation for 2008 olympics显示文摘 | HERMAN CHRISTOPHER W MCGREGOR | 2009 | Med Sci Sports Exe2009，41，5： | 1 |
| 19 | Evaluation of Coupling Agents in Poly(propylene)/Fly Ash Composites:Effect on Processing and Mechanical Properties显示文摘 | Itziar Iraola-Arregui Herman Potgieter Christopher Mark Liauw | | 0，，09： | 1 |
| 20 | Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer显示文摘 | Gabriela Bindea Bernhard Mlecnik Marie Tosolini Amos Kirilovsky Maximilian Waldner Anna C. Obenauf Helen Angell Tessa Fredriksen Lucie Lafontaine Anne Berger Patrick Bruneval Wolf Herman Fridman Christoph Becker Franck Pagès Michael R. Speicher Zlatko Tra | 2013 | Immunity2013，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员