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| 1 | S-acylation-dependent association of the calcium sensor CBL2 with the vacuolar membrane is essential for proper abscisic acid responses显示文摘Calcineurin 象 B 一样(CBL ) 蛋白质贡献由与交往 CBL 蛋白质 kinases (CIPK ) 交往译码钙信号。当前,几乎仍然功能和在 vacuolar 膜是局部性的 CBL 蛋白质的特定的指向机制没有信息。在这研究,我们集中于 CBL2,丰富的 vacuolar 从 Arabidopsis thaliana 的未知功能的膜局部性的钙传感器。我们证明 CBL2 指向的 vacuolar 被三半胱氨酸残余的 S-acylation 明确地在它的 N 终点和那 CBL2 S-acylation 引起并且指向由一条 Brefeldin A 感觉迟钝的小径发生。CBL2 功能的损失在种子萌芽期间并且仅仅充分使植物变为过分敏感到植物激素 abscisic 酸(骆驼毛的织物) S-acylated 和适当地指向 vacuolar 的 CBL2 蛋白质能补充这变异的显型。这些调查结果定义为蛋白质指向小径的 S-acylation-dependent vacuolar 膜并且揭开在骆驼毛的织物回答的 vacuolar 钙传感器的一个关键角色。 | Oliver Batistic Marion Rehers Amir Akerman Kathrin Schlucking Leonie Steinhorst Shaul Yalovsky Jorg Kudla | 2012 | Cell Research2012，22，7： | 12 |
| 2 | Comparison of the diagnostic yield and outcomes between standard 8 h capsule endoscopy and the new 12 h capsule endoscopy for investigating small bowel pathology显示文摘AIM: To evaluate the completion rate and diagnostic yield of the Pill Cam SB2-ex in comparison to the Pill Cam SB2.METHODS:Two hundred cases using the 8-h Pill Cam SB2 were retrospectively compared to 200 cases using the 12 h Pill Cam SB2-ex at a tertiary academic center.Endoscopically placed capsules were excluded from the study.Demographic information,indications for capsule endoscopy,capsule type,study length,completion of exam,clinically significant findings,timestamp of most distant finding,and significant findings beyond 8 h were recorded.RESULTS:The 8 and 12 h capsule groups were well matched respectively for both age(70.90±14.19vs 71.93±13.80,P=0.46)and gender(45.5%vs48%male,P=0.69).The most common indications for the procedure in both groups were anemia and obscure gastrointestinal bleeding.Pill Cam SB2-ex had a significantly higher completion rate than Pill Cam SB2(88%vs 79.5%,P=0.03).Overall,the diagnostic yield was greater for the 8 h capsule(48.5%for SB2vs 35%for SB2-ex,P=0.01).In 4/70(5.7%)of abnormal SB2-ex exams the clinically significant findingwas noted in the small bowel beyond the 8 h mark.CONCLUSION:In our study,we found the Pill Cam SB2-ex to have a significantly increased completion rate,though without any improvement in diagnostic yield compared to the Pill Cam SB2. | Merajur Rahman Stuart Akerman Bethany De Vito Larry Miller Meredith Akerman Keith Sultan | 2015 | World Journal of Gastroenterology2015，21，18： | 12 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study显示文摘 | Anke M. Leufkens Daniel C. DeMarco Amit Rastogi Paul A. Akerman Kassem Azzouzi Richard I. Rothstein Frank P. Vleggaar Alessandro Repici Giacomo Rando Patrick I. Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H. Deprez Brian P. Sau | 2011 | Gastrointestinal Endoscopy2011，，3： | 5 |
| 5 | Animal models of migraine:looking at the component parts of a complex disorder显示文摘 | Bergerot A Holland PR Akerman S | 2006 | Eur J Neurosci2006，24，： | 1 |
| 6 | Paclitaxel, cisplatin, and concurrent radiation for esophageal cancer 显示文摘 | Safran H Gaissert H Akerman P | 2001 | Cancer Invest2001，19，1： | 1 |
| 7 | Cetuximab,paclitaxel,carboplatin and radiation for esophageal and gastric cancer显示文摘 | Suntharalingam M Dipertrillo T Akerman P | 2006 | J Clin Oncol2006，24，18： | 1 |
| 8 | Flow cytometreic S-phase fraction in soft tissue Sarcoma:prognostic importance analysed in 160 patients显示文摘 | Ferno M Akerman M | 1997 | Br J Cancer1997，75，1： | 1 |
| 9 | Control ofaxon branch dynamics by correlated activityin viro 显示文摘 | Ruthanezr ES Akerman C J Cline HT | 2003 | Science2003，301，5629： | 1 |
| 10 | Nanocrystal targeting in vivo显示文摘 | Akerman M E Chan W C W Laakkonen P | 2002 | Proceedings of the Na- tional Academy of Sciences of the United States of Amer- ica2002，99，12： | 1 |
| 11 | Pyramidal techniques for multi-sensor fusion 显示文摘 | Akerman A | 1992 | Senor Fu- sion1992，，： | 1 |
| 12 | Voltage-dependent calcium channels are involved in neurogenic dural vasodilatation via a presynaptic transmitter releasemechanism显示文摘 | Akerman S Williamson DJ Goadsby PJ | 2003 | Br J Pharmacol2003，140，3： | 1 |
| 13 | 17-beta-estradiol induces an inhibitor of active caspases显示文摘 | Zhang y Tounekti O Akerman B | 2001 | J Neurosci2001，21，20： | 1 |
| 14 | Primary evaluation of the local anesthetic Properties of the amino amide agent ropivacaine (LEA103)显示文摘 | Akerman B Hellberg IB Trossvik C | 1988 | Acta Anesthesia Stand1988，32，7： | 1 |
| 15 | Efficacy and mechanism of anti- convulsant drugs in migraine显示文摘 | Hoffmann J Akerman S Goadsby PJ | 2014 | Ex- pert Rev Clin Pharmacol2014，7，2： | 1 |
| 16 | Combined Morphologic and Karyotypic Study of 28 Myxoid Liposarcomas: Implications for a Revised Morphologic Typing (A Report from the CHAMP Group)显示文摘 | Giovanni Tallini Mans Akerman Paola Dal Cin Ivo DeWever Christopher D. M. Fletcher Nils Mandahl Fredrik Mertens Felix Mitelman Juan Rosai Anders Rydholm Raf Sciot Herman Van Den Berghe Wim Van Den Ven Roberta Vanni Helena Willen | 1996 | The American Journal of Surgical Pathology1996，，9： | 1 |
| 17 | Single-file electrophoretic transport and counting of individual DNA molecules in surfactant nanotubes显示文摘 | Tokarz M Akerman B Olofsson J | 2005 | Proc Natl Acad Sci USA2005，102，26： | 1 |
| 18 | Paclitaxel and concurrent radiation therapy for locally advanced adenocarcinomas of the pancreas, stomach, and gastroes ophageal junction 显示文摘 | Safran H Akerman P Cioffi W | 1999 | Semin Radiat Oncol1999，9，1： | 1 |
| 19 | Spiral Enteroscopy and Push Enteroscopy显示文摘 | Paul A. Akerman Daniel Cantero | 2009 | Gastrointestinal Endoscopy Clinics of North Americ2009，，3： | 1 |
| 20 | Core-needle biopsy performed by the cytopathologist:a technique to complement fine-needle aspiration of soft tissue and bone lesions显示文摘 | Domanske HA Akerman M Carlén B | | 0，，04： | 1 |
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