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| 1 | 3D bioactive composite scaffolds for bone tissue engineering显示文摘Bone is the second most commonly transplanted tissue worldwide,with over four million operations using bone grafts or bone substitute materials annually to treat bone defects.However,significant limitations affect current treatment options and clinical demand for bone grafts continues to rise due to conditions such as trauma,cancer,infection and arthritis.Developing bioactive three-dimensional(3D)scaffolds to support bone regeneration has therefore become a key area of focus within bone tissue engineering(BTE).A variety of materials and manufacturing methods including 3D printing have been used to create novel alternatives to traditional bone grafts.However,individual groups of materials including polymers,ceramics and hydrogels have been unable to fully replicate the properties of bone when used alone.Favourable material properties can be combined and bioactivity improved when groups of materials are used together in composite 3D scaffolds.This review will therefore consider the ideal properties of bioactive composite 3D scaffolds and examine recent use of polymers,hydrogels,metals,ceramics and bio-glasses in BTE.Scaffold fabrication methodology,mechanical performance,biocompatibility,bioactivity,and potential clinical translations will be discussed. | Gareth Turnbull Jon Clarke Frederic Picard Philip Riches Luanluan Jia Fengxuan Han Bin Li Wenmiao Shu | 2018 | Bioactive Materials2018，3，3： | 40 |
| 2 | 应用Le Bissonnais法研究黄土丘陵区土壤团聚体稳定性显示文摘以黄土丘陵区森林草原过渡带燕沟流域植被自然恢复过程中6种植被类型为研究对象,应用Le Bissonnais(LB)法测定了不同植被类型下土壤水稳性团聚体,对比分析了LB法3种处理的测定结果与传统湿筛法(Yoder)的差异性。结果表明:在LB法3种湿润处理下,快速湿润处理(FW)对土壤团聚体结构的破坏程度最大,处理后土壤水稳性团聚体以0.05~0.5 mm为主;慢速湿润处理(SW)对团聚体的破坏程度最小,处理后土壤水稳性团聚体主要以>2 mm团聚体为主;而预湿后扰动处理(WS)对团聚体的破坏程度介于FW和SW之间,处理后土壤团聚体粒径分布比较均匀。说明该区土壤团聚体破坏的主要机制是土壤孔隙中的气泡爆破产生的消散作用。退耕100a期间,植被群落由1年生草本(4 a)—多年生灌草(16 a)—半灌木(29 a)—灌木(55 a)—乔木(100 a)方向演替过程中,土壤水稳性团聚体由小粒径向大粒径方向转变,土壤结构趋于稳定。LB法3种处理中,FW处理与SW处理所测得>0.5 mm团聚体含量和平均重量直径与土壤有机质和物理性黏粒之间存在显著的相关性,而WS处理未达到显著水平(P>0.05)。说明土壤有机质和物理性黏粒主要影响消散和黏粒膨胀引起的崩解作用,而对机械干扰引起的团聚体破坏无明显影响。LB法3种处理中,慢速湿润方法所获得土壤团聚体稳定性特征更接近湿筛法,适宜于黄土丘陵区植被恢复过程中土壤水稳性团聚体的测定。 | 郭曼 郑粉莉 安韶山 刘雨 王彬 Frederic Darboux | 2010 | 中国水土保持科学2010，8，2： | 21 |
| 3 | J波综合征专家上海共识:概念与认知的更新显示文摘序言
J波综合征(J wave syndromes,JW Ss),包括Brugada综合征(BrS)和早复极综合征(ERS)。有关Br S,在2000年和2004年分别举行了BrS的国际专家共识会议;有关ERS,直到2013年才在原发性遗传性心律失常专家共识里做出了针对ERS的指导意见。在2015年4月,心脏节律协会(HRS)、欧洲心脏节律协会(EHRA)和亚洲太平洋心脏节律协会(APHRS)的主要专家成员组成的工作组聚集在中国上海,审查了有关JWSs的新证据, | Charles Antzelevitch 严干新 Michael J.Ackerman Martin Borggrefe Domenico Corrado 郭继鸿(审核) Ihor Gussak Can Hasdemir Minoru Horie Heikki Huikuri 马长生 Hiroshi Morita Gi-Byoung Nam Frederic Sacher Wataru Shimizu Sami Viskin Arthur A.M.Wilde 刘霄燕(译) 揭起强(译) 吴林(审核) | 2016 | 临床心电学杂志2016，25，3： | 21 |
| 4 | Radiotherapy of high-grade gliomas: current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approaches显示文摘The current standards in radiotherapy of high-grade gliomas(HGG) are based on anatomic imaging techniques, usually computed tomography(CT) scanning and magnetic resonance imaging(MRI). The guidelines vary depending on whether the HGG is a histological grade 3 anaplastic glioma(AG) or a grade 4 glioblastoma multiforme(GBM). For AG, T2-weighted MRI sequences plus the region of contrast enhancement in T1 are considered for the delineation of the gross tumor volume(GTV), and an isotropic expansion of 15 to 20 mm is recommended for the clinical target volume(CTV). For GBM, the Radiation Therapy Oncology Group favors a two-step technique, with an initial phase(CTV1) including any T2 hyperintensity area(edema) plus a 20 mm margin treated with up to 46 Gy in 23 fractions, followed by a reduction in CTV2 to the contrast enhancement region in T1 with an additional 25 mm margin. The European Organisation of Research and Treatment of Cancer recommends a single-phase technique with a unique GTV, which comprises the T1 contrast enhancement region plus a margin of 20 to 30 mm. A total dose of 60 Gy in 30 fractions is usually delivered for GBM, and a dose of 59.4 Gy in 33 fractions is typically given for AG. As more than 85% of HGGs recur in field, dose-escalation studies have shown that 70 to 75 Gy can be delivered in 6 weeks with relevant toxicities developing in < 10% of the patients. However, the only randomized dose-escalation trial, in which the boost dose was guided by conventional MRI, did not show any survival advantage of this treatment over the reference arm. HGGs are amongst the most infiltrative and heterogeneous tumors, and it was hypothesized that the most highly aggressive areas were missed; thus, better visualization of these high-risk regions for radiation boost could decrease the recurrence rate. Innovations in imaging and linear accelerators(LINAC) could help deliver the right doses of radiation to the right subvolumes according to the dose-painting concept. Advanced imaging techniques provide functional information on cellular density(diffusion MRI), angiogenesis(perfusion MRI), metabolic activity and cellular proliferation [positron emission tomography(PET) and magnetic resonance spectroscopy(MRS)]. All of these non-invasive techniques demonstrated good association between the images and histology, with up to 40% of HGGs functionally presenting a high activity within the non- contrast-enhanced areas in T1. New LINAC technologies, such as intensity-modulated and stereotactic radiotherapy, help to deliver a simultaneous integrated boost(SIB) > 60 Gy. Trials delivering a SIB into a biological GTV showed the feasibility of this treatment, but the final results, in terms of clinical benefits for HGG patients, are still pending. Many issues have been identified: the variety of MRI and PET machines(and amino-acid tracers), the heterogeneity of the protocols used for image acquisition and post-treatment, the geometric distortion and the unreliable algorithms for co-registration of brain anatomy with functional maps, and the semi-quiescent but highly invasive HGG cells. These issues could be solved by the homogenization of the protocols and software applications, the simultaneous acquisition of anatomic and functional images(PET-MRI machines), the combination of complementary imaging tools(perfusion and diffusion MRI), and the concomitant addition of some ad hoc targeted drugs against angiogenesis and invasiveness to chemoradiotherapy. The integration of these hybrid data will construct new synthetic metrics for fully individualized treatments. | Frederic Dhermain | 2014 | Chinese Journal of Cancer2014，33，1： | 19 |
| 5 | 农田生物多样性对昆虫的生态调控作用显示文摘随着农田作物的单一性种植,植食性昆虫暴发、物种流失等问题日益突出,化学农药大量应用于作物有害生物的防治更加剧了对农田生态系统的破坏和不稳定性。因此,从生物多样性-农田生态系统-植食性昆虫的相互关系入手,探讨生物多样性的保护及其在农业有害生物防控上的应用,回归农田生态系统动态平衡的生态调控举措,成为可持续发展农业领域中研究的焦点之一。本文综述了农田生物多样性对昆虫生态影响的重要性及其生态功能,进一步阐述了农田生物多样性在农业生产中的应用及前景。 | 周海波 陈巨莲 程登发 Frederic Francis 刘勇 孙京瑞 | 2012 | 植物保护2012，38，1： | 18 |
| 6 | 昆虫内共生菌-昆虫-植物互作关系研究进展显示文摘在长期的协同进化过程中,昆虫与其体内的共生菌建立了密切的互利共生关系。昆虫内共生菌不仅能调控宿主昆虫的营养代谢和生殖代谢,还能协助昆虫抵御生物、非生物胁迫,提高昆虫对化学农药的抗性及对寄主植物的适应性等。因此,内共生菌是宿主昆虫生长发育及适应性的重要调控因子。目前,随着组学技术的不断发展,内共生菌在宿主昆虫和寄主植物中的原位功能不断被挖掘,通过对内共生菌-昆虫-植物互作模型的研究,将进一步揭示昆虫内共生菌与昆虫、植物的互作机理,加深对昆虫适应性机制的理解并推进新型害虫防控和靶标技术的研发。本文就昆虫内共生菌的起源、特点、分布和传递,昆虫内共生菌在昆虫-植物-环境互作中的作用,以及昆虫内共生菌研究的方法和新技术等方面进行了综述,并对未来昆虫内共生菌介导的防御效应及昆虫适应性机理等热点问题进行了展望。 | 李迁 范佳 孙京瑞 王满囷 Frederic Francis 陈巨莲 | 2016 | 植物保护学报2016，43，6： | 18 |
| 7 | 麦田间作对麦长管蚜的生态调控作用显示文摘[目的]探讨麦田间作对麦长管蚜种群的生态调控作用。[方法]田间调查小麦单作田、小麦与绿豆、小麦与豌豆以8:2行距间作田麦长管蚜种群数量及其时间动态变化;室内利用'Y'型嗅觉仪测定麦长管蚜对小麦、小麦与绿豆、小麦与豌豆不同组合气味的选择性。[结果]麦田间作不能影响麦蚜种群随时间动态变化曲线,但能在一定程度上降低麦长管蚜无翅蚜和有翅蚜的数量。室内麦长管蚜无翅蚜和有翅蚜显著选择寄主植物的气味。当小麦与绿豆或小麦与豌豆组合时对麦长管蚜没有吸引作用。[结论]非寄主植物的气味对寄主植物气味起掩盖作用,干扰蚜虫的寄主定位,这可能是间作低于单作蚜量的原因之一。 | 解海翠 陈巨莲 程登发 周海波 孙京瑞 刘勇 Frederic Francis | 2012 | 植物保护2012，38，1： | 12 |
| 8 | Role of terpenes from aphid-infested potato on searching and oviposition behavior of Episyrphus balteatus显示文摘应付病原体和昆虫攻击,植物开发防卫的不同机制,在两个直接(物理、化学) 并且间接方法(到食虫的 beneficials 的吸引人的 volatiles ) 。植物当时能表示由吸引草食动物食肉动物便于害虫的“自顶向下”的控制的特点。这里,我们由分析不稳定的模式调查土豆植物的间接防卫机制健康并且 aphid-infestedplants。在由 Myzus persicae 的射出的萜烯模式的重要变化大批出没于寄植物被观察。用稳固的阶段 MicroExtraction (SPME ) 和 GCMS,(E)-beta-farnesene (EBF ) 看起来被大批出没于蚜虫的土豆并且不由健康植物射出。为了在蚜虫以后估计这些不稳定的版本的 theinfochemical 角色,在 aphidophagous predatorsEpisyrphus balteatus 上损坏, hover 苍蝇 foraging 行为用观察员 5.0 软件被估计(Noldus, Wageningen,荷兰) 。没有蚜虫的土豆植物也被用作控制在食肉动物的不稳定的来源行为的学习。当大批出没于蚜虫的植物导致了有效寻找并且公认字义行为导致时生蛋,健康土豆植物的 kairomonal 效果都没被观察,在网笼子导致更长的不动持续时间和更短的寻找时期。E 的 Highoviposition 率。当大批出没于蚜虫的土豆被使用时, balteatus 被观察(每放并且每 48.9eggs 意味着女性) 。在另一方面,没有鸡蛋被 hover 苍蝇在 healthyaphid 免费的植物上生产。E。balteatus foraging 和繁殖行为在综合蚜虫害虫管理在与 activeinfochemical 分子的潜在的使用的关系根据从大批出没于蚜虫的植物的不稳定的排放被讨论。 | NICOLAS HARMEL RAKI ALMOHAMAD MARIE-LAURE FAUCONNIER PATRICK DU JARDIN FRANCOIS VERHEGGEN MICHEL MARLIER ERIC HAUBRUGE FREDERIC FRANCIS | 2007 | Insect Science2007，14，1： | 11 |
| 9 | Biological mesh reconstruction of the pelvic floor following abdominoperineal excision for cancer:A review显示文摘Extralevator abdominoperineal excision and pelvic exenteration are mutilating operations that leave wide perineal wounds.Such large wounds are prone to infection and perineal herniation,and their closure is a major concern to most surgeons.Different approaches to the perineal repair exist,varying from primary or mesh closure to myocutaneous flaps.Each technique has its own associated advantages and potential complications and the ideal approach is still debated.In the present study,we reviewed the current literature and our own local data regarding the use of biological mesh for perineal wound closure.Current evidence suggests that the use of biological mesh carries an acceptable risk of wound complications compared to primary closure and is similar to flap reconstruction.In addition,the rate of perineal hernia is lower in early follow-up,while long-term hernia occurrence appears to be similar between the different techniques.Finally,it is an easy and quick reconstruction method.Although more expensive than primary closure,the cost associated with the use of a biological mesh is at least equal,if not less,than flap reconstruction. | Boris Schiltz Nicolas Christian Buchs Marta Penna Cosimo Riccardo Scarpa Emilie Liot Philippe Morel Frederic Ris | 2017 | World Journal of Clinical Oncology2017，8，3： | 10 |
| 10 | 植物防御信号物质JA/SA对桃蚜解毒酶谷胱甘肽-S-转移酶及唾液腺基因C002表达诱导反应显示文摘茉莉酸(JA)与水杨酸(SA)为植物体内重要的防御反应信号物质,在植株受到机械损伤或病虫害侵害时可作为信号物质,激活下游相关防御反应.为应对植株的防御反应,昆虫通常通过提高自身相关解毒酶活性或分泌唾液蛋白调节寄主防御反应以增强对寄主植株适应性.本研究以桃蚜(Myzus persicae(Sulzer))体内的重要解毒酶谷胱甘肽-S-转移酶(GST)的sigma型及唾液腺特异表达基因C002为研究对象,分别以含有5 mmol/L JA或10 mmol/L SA的人工饲料直接饲喂桃蚜,在不同的取食时间点收集蚜虫,通过荧光定量PCR检测JA或SA对目的基因sigma GST及C002表达诱导反应.结果发现,当桃蚜直接取食含有JA或SA的人工饲料后,sigma GST及C002表达量都显著升高.表明,桃蚜可直接利用寄主植株防御反应信号物质JA或SA,提高体内相关解毒酶或者唾液蛋白基因表达量,以提高对寄主防御的适应性.为进一步开展桃蚜对植物防御反应适应性研究提供新的思路. | 张勇 范佳 赵兴延 刘勇 孙京瑞 Frederic Francis 陈巨莲 | 2016 | 中国科学:生命科学2016，46，5： | 10 |
| 11 | Capsule endoscopy in non-steroidal anti-inflammatory drugs-enteropathy and miscellaneous,rare intestinal diseases显示文摘Despite significant advances over the last decade, mucosal lesions of the small bowel are poorly detected by imaging studies such as CT scan, MRI-enteroclysis and contrast-enhanced abdominal ultrasound. Capsule endoscopy (CE) has dramatically changed the diagnostic approach to intestinal diseases. Moreover, the use of CE can be extended to include other conditions. However, it is diffi cult to assess the positive influence of CE on patient outcomes in conditions involving a small number of patients, or in critically ill and diff icult to examine patients. CE has the advantage of diagnosing intestinal lesions and of directing the use of double balloon enteroscopy (DBE) in order to obtain biopsy specimens. Moreover, CE allows repeated assessment in chronic conditions, especially to detect relapse of an infectious disease. | Gerard Gay Michel Delvaux Muriel Frederic | 2008 | World Journal of Gastroenterology2008，14，34： | 9 |
| 12 | Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Gert van Assche Walter Reinisch Jean–Frederic Colombel Geert D’Haens Douglas C. Wolf Martina Kron Mary Beth Tighe Andreas Lazar Roopal B. Thakkar | 2012 | Gastroenterology2012，，2： | 9 |
| 13 | Allogenic banking of dental pulp stem cells for innovative therapeutics显示文摘Medical research in regenerative medicine and cellbased therapy has brought encouraging perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from progenitors to pluripotent stem cells, have been investigated. Among these, dental pulp stem cells(DPSCs) are mesenchymal multipotent cells coming from the dental pulp, which is the soft tissue within teeth. They represent an interesting adult stem cell source because they are recovered in large amount in dental pulps with non-invasive techniques compared to other adult stem cell sources. DPSCs can be obtained from discarded teeth, especially wisdom teeth extracted for orthodontic reasons. To shift from promising preclinical results to therapeutic applications to human, DPSCs must be prepared in clinical grade lots and transformed into advanced therapy medicinal products(ATMP). As the production of patient-specific stem cells is costly and time-consuming, allogenic biobanking of clinical grade human leukocyte antigen(HLA)-typed DPSC lines provides efficient innovative therapeutic products. DPSC biobanks represent industrial and therapeutic innovations by using discarded biological tissues(dental pulps) as a source of mesenchymal stem cells to produce and store, in good manufacturing practice(GMP) conditions, DPSC therapeutic batches. In this review, we discuss about the challenges to transfer biological samples from a donor to HLA-typed DPSC therapeutic lots, following regulations, GMP guidelines and ethical principles. We also present some clinical applications, for which there is no efficient therapeutics so far, but that DPSCs-based ATMP could potentially treat. | Pierre-Yves Collart-Dutilleul Franck Chaubron John De Vos Frederic J Cuisinier | 2015 | World Journal of Stem Cells2015，7，7： | 7 |
| 14 | Habitat-induced reciprocal transformation in the root phenotype of Oriental ginseng is associated with alteration in DNA methylation显示文摘Oriental ginseng is an important medicinal plant that grows in 2 major forms or ecotypes,wild and domesticated.Each form differs conspicuously in root phenotype,but can be converted from one type to another by habitat.Here we show that the habi tat-induced transformation of ginseng root phenotype was accompanied by alteration in cytosine methylation at a large number of 5′-CCGG-3′sites detected by the methylation-sensitive polymorphism(MSAP)marker.The collective CG and CHG methylation levels of all 4 landraces of the domesticated form were significantly lower than those of the wild form.Interestingly,artificially transplanted ginseng plants recreated in both directions the methylation levels(at least in CHG)of their natural counterparts.The methylation differences between the 2 ginseng ecotypes were validated at 2 isolated MSAP loci bearing homology to a 5S rRNA gene or a copia retrotransposon.Our results implicate a link between epigenetic variation and habitat-induced phenotypic flexibility in Oriental ginseng. | NGEZAHAYO Frederic WANG XiaoLi YU XiaoMing JIANG LiLi CHU YunJie SHEN BaiHua YAN ZhongKai LIU Bao | 2011 | Chinese Science Bulletin2011，56，16： | 7 |
| 15 | Performances of local poultry breed fed black soldier fly larvae reared on horse manure显示文摘In poultry,feed based on maggots,like larvae of black soldier fly(Hermetia illucens) is an attractive option to substitute current ingredients which are expensive and often in direct or indirect competition with human food.Little information is currently available on the utility of these larvae in poultry feed,so goals of this study were to determine whether larvae could be reared on horse manure under traditional farming conditions and to evaluate the growth performances of a local poultry fed these larvae and the fatty acids profiles of their meat.After freezing and thawing,larvae were introduced in the feed of Ardennaise chickens between 30 and 80 days of age.Birds in the control group received a commercial standard feed,while those in the treatment group received the same commercial feed in which 8% was substituted with whole fresh larvae corresponding to 2% on a dry matter basis.Means ± standard errors of larval length and weight were 20.67 ± 2.21 mm and 0.14 ± 0.02 g,respectively.Mean larval percentages of dry matter and of substances extractable in diethyl ether were 24.6% and 23.1%,respectively.Larval fatty acids profiles were predominantly composed of lauric acid(28.1%) and palmitic acid(22.0%).Least squares means of weekly weights of chicken,adjusted for the effects of sex,replication and initial weights,were significantly higher(P < 0.05) by 77.03 ± 53.37 g in larvae-fed than in control chickens.All other measurements were not statistically different between larvae-fed and control chicken,including fatty acid profiles,protein content and w6/w3 ratio. | Nassim Moula Marie-Louise Scippo Caroline Douny Guy Degand Edwin Dawans Jean-Francois Cabaraux Jean-Luc Hornick Rudy C.Medigo Pascal Leroy Frederic Francis Johann Detilleux | 2018 | Animal Nutrition2018，，1： | 7 |
| 16 | Risk Factors for Opportunistic Infections in Patients With Inflammatory Bowel Disease显示文摘 | Murat Toruner Edward V. Loftus W. Scott Harmsen Alan R. Zinsmeister Robert Orenstein William J. Sandborn Jean–Frederic Colombel Laurence J. Egan | 2008 | Gastroenterology2008，，4： | 6 |
| 17 | 枫长镰管蚜气味结合蛋白OBP3的cDNA克隆和序列分析及其成虫嗅觉行为反应测定显示文摘枫长镰管蚜Drepanosiphum platanoidis是少数几种不分泌E-β-法尼烯(E-β-farnesene,EBF)的蚜虫之一。ApisOBP3是首个被鉴定的特异结合EBF的昆虫气味结合蛋白,来自于豌豆蚜Acyrthosiphum pisum。本研究通过基因克隆技术,在枫长镰管蚜体内获得2个表达ApisOBP3类似蛋白的cDNA序列,长度均为426bp,其中,5'末端的69bp为信号肽编码序列。编码的成熟蛋白分别命名为DplaOBP3-1和DplaOBP3-2,两个蛋白均由119个氨基酸残基组成,序列一致性为95.8%。与ApisOBP3的序列一致性分别为95.8%和98.3%。DplaOBP3-1,DplaOBP3-2及ApisOBP33个蛋白具有数量和位置完全一致的6个保守的半胱氨酸残基。以测得3D结构的马德拉蜚蠊Leucophaea maderae的信息素结合蛋白LmadPBP为模板比较建模,结果显示两个蛋白在疏水中心均具有与ApisOBP3一致的关键疏水残基及芳香族氨基酸残基Tyr84。利用四臂嗅觉仪测定枫长镰管蚜的嗅觉行为反应,结果显示:枫长镰管蚜残体挥发物及外源EBF对该蚜均有显著的驱避作用(P=0.01)。本研究提示,枫长镰管蚜具有种内报警信息素,该蚜残体挥发物即为其种内报警信息素;枫长镰管蚜尽管并不分泌EBF,但具有表达2种OBP3蛋白的基因,并可识别环境中的EBF且对其作出行为反应。 | 范佳 Sophie VANDERMOTEN Frederic FRANCIS 刘勇 陈巨莲 程登发 | 2011 | 昆虫学报2011，54，9： | 6 |
| 18 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 19 | 叶缘-年均温中国模型在定量重建中国新生代植物群古年均温中的应用显示文摘叶缘分析法是一种利用现代植被木本双子叶植物全缘叶物种百分比与年均温的函数关系,定量重建化石植物群古年均温的方法。该方法在新生代植物群的古年均温定量重建研究中得到了广泛的应用。目前基于世界不同地区现代植被的研究表明,尽管全缘叶物种百分比与年均温存在很好的相关性,但其相关性具有地区差异性。本文旨在总结叶缘分析法的研究进展,并介绍基于中国植被建立的叶缘—年均温中国模型;同时,采用该模型重建了中国新生代不同时期植物群的古年均温,且与前人采用其它模型得到的年均温重建值相比较。结果表明,叶缘—年均温中国模型能够有效地重建中国新生代植物群的古年均温值。 | 苏涛 星耀武 JACQUES Frederic M.B 陈文允 黄永江 刘裕生 周浙昆 | 2010 | 地质论评2010，56，5： | 6 |
| 20 | Helpfulness of the combination of acetic acid and FICE in the detection of Barrett's epithelium and Barrett's associated neoplasias显示文摘AIM:To investigate the mucosal morphology in Barrett's oesophagus by chromo and magnifying endoscopy.METHODS:A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid pulverisation combined with virtual chromoendoscopy using Fujinon intelligent chromoendoscopy(FICE) for semiological characterization of the mucosal morphology in Barrett's oesophagus and its neoplastic complications.Upper endoscopy using high definition whitelight,2% acid acetic pulverisation and FICE with high definition videoendoscopy were performed in 20 patients including 18 patients who presented with aspects of Barrett's oesophagus at endoscopy examination.Two patients used as controls had normal endoscopy and histological results.Prospectively,videos were watched blind from histological results by three trained FICE technique endoscopists.RESULTS:The videos of patients with high-grade dysplasia showed an irregular mucosal pattern in 14% using high definition white light endoscopy and in 100% using acid acetic-FICE combined.Videos did not identify irregular vascular patterns using high definition white light endoscopy,while acid acetic-FICE combined visualised one in 86% of cases.CONCLUSION:Combined acetic acid and FICE is a promising method for screening high-grade dysplasia and early cancer in Barrett's oesophagus. | Marine Camus Romain Coriat Sarah Leblanc Catherine Brezault Benoit Terris Elise Pommaret Marianne Gaudric Ariane Chryssostalis Frederic Prat Stanislas Chaussade | 2012 | World Journal of Gastroenterology2012，18，16： | 5 |
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