|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Probiotic yeasts: Anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice显示文摘AIM: To evaluate the in vitro immunomodulation capacity of various non-pathogenic yeast strains and to investigate the ability of some of these food grade yeasts to prevent experimental colitis in mice.METHODS: In vitro immunomodulation was assessed by measuring cytokines [interleukin (IL)-12p70,IL-10,tumor necrosis factor and interferon γ] released by human peripheral blood mononuclear cells after 24 h stimulation with 6 live yeast strains (Saccharomyces ssp.) and with bacterial reference strains.A murine model of acute 2-4-6-trinitrobenzene sulfonic acid (TNBS)-colitis was next used to evaluate the distinct prophylactic protective capacities of three yeast strains compared with the performance of prednisolone treatment.RESULTS: The six yeast strains all showed similar non-discriminating anti-inflammatory potential when tested on immunocompetent cells in vitro .However,although they exhibited similar colonization patterns in vivo ,some yeast strains showed significant anti-inflammatory activities in the TNBS-induced colitis model,whereas others had weaker or no preventive effect at all,as evidenced by colitis markers (body-weight loss,macroscopic and histological scores,myeloperoxidase activities and blood inflammatory markers).CONCLUSION: A careful selection of strains is required among the biodiversity of yeasts for specific clinical studies,including applications in inflammatory bowel disease and other therapeutic uses. | Benot Foligné Jo■lle Dewulf Pascal Vandekerckove Georges Pignède Bruno Pot | 2010 | World Journal of Gastroenterology2010，16，17： | 2 |
| 3 | The occurrence of N -nitrosamines, residual nitrite and biogenic amines in commercial dry fermented sausages and evaluation of their occasional relation显示文摘 | Eveline De Mey Katrijn De Klerck Hannelore De Maere Lore Dewulf Guy Derdelinckx Marie-Christine Peeters Ilse Fraeye Yvan Vander Heyden Hubert Paelinck | 2014 | Meat Science2014，，2： | 2 |
| 4 | Combining non-thermal plasma with heterogeneous catalysis in waste gas treatment: A review显示文摘 | Jim Van Durme Jo Dewulf Christophe Leys Herman Van Langenhove | 2007 | Applied Catalysis B Environmental2007，，3： | 2 |
| 5 | Combining non-thermal plasmawith heterogeneous catalysis in waste gas treatment:a review显示文摘 | JIM V D DEWULF J LEYS C | 2008 | Applied Catalysis B:Environment2008，78，34： | 1 |
| 6 | Social learning and water resources management 显示文摘 | PAHL-WOSTL C CRAPS M DEWULF A | 2007 | Ecology and Society2007，12，2： | 1 |
| 7 | Influence of pH on the sonolysis of ciprofloxacin: biodegradability, ecotoxieity and antibiotic activity of its degradation products 显示文摘 | BEL de E DEWULF J WITIE de B | 2009 | Chemosphere2009，77，2： | 1 |
| 8 | Efficient toluene abatement in indoor air by a plasma catalytic hybrid system 显示文摘 | J Van Durme J Dewulf W Sysmans | 2007 | Applied Catalysis B : Environmental2007，，74： | 1 |
| 9 | Properties of uhrathin high permittivity (Nb1-x Tax )2O5 films prepared by aqueous chemical solution deposition 显示文摘 | Hardy A Van Elshocht S Dewulf D | 2010 | Journal of Electrochemical Soci- ety2010，157，1： | 1 |
| 10 | Age and sex differences in mitotic activity within the zebra finch telencephalon 显示文摘 | Dewulf V Bottjer S W | 2002 | The Journal of Neuroscience2002，22，10： | 1 |
| 11 | Pitfalls and Solutions for the Trace Determination of Phthalates in Water Samples显示文摘 | Bart Tienpont Frank David Eric Dewulf Pat Sandra | 2005 | Chromatographia (-)2005，，7： | 1 |
| 12 | Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV显示文摘 | Catherine Daniel Florent Sebbane Sabine Poiret Denise Goudercourt Joelle Dewulf Chantal Mullet Michel Simonet Bruno Pot | 2008 | Vaccine2008，，8： | 1 |
| 13 | Performance of a composite membrane bioreactor treating toluene vapors: Inocula selection, reactor performance and behavior under transient conditions 显示文摘 | Kumar A Dewulf J Vercruyssen A | 2009 | Bioresource Technology2009，100，8： | 1 |
| 14 | Aqueous salting-out effect of inorganic cations and anions on non-electrolytes 显示文摘 | Gorgenyi M Dewulf J Van Langenhove H | 2006 | Chemosphere2006，65，5： | 1 |
| 15 | Gadolinium-niobates and-tantalates:Amorphous high-k materials by aqueous CSD 显示文摘 | Dewulf D Hardy A Van Elshocht S | 2012 | Journal of Electrochemical Society2012，159，6： | 1 |
| 16 | Neurogenesis within the juvenile zebra finch telencephalic ventricular zone: a map of proliferation activity 显示文摘 | Dewulf V Bottjer S W | 2005 | The Journal of Comparative Neurology2005，481，1： | 1 |
| 17 | Combining non-thermal plasma with heterogeneous catalysis in waste gas treatment: a review显示文摘 | DURME J V DEWULF J LEYS C | 2008 | Applied Catalysis B: Environmental2008，78，34： | 1 |
| 18 | Non-infectious factors as- sociated with stillbirth in pigs: a review显示文摘 | Vanderhaeghe C Dewulf J KruifA D | 2013 | Animal Reproduction Sci- ence2013，139，14： | 1 |
| 19 | Across-sectional study to collect risk factors associated with stillbirths in pig herds显示文摘 | Vanderhaeghe C Dewulf J Ribbens S | 2010 | Animal Reproduction Science2010，118，： | 1 |
| 20 | Evaluation of the epidemiological importance of classical swine fever infected, E2sub-unit marker vaccinated animals with RT-nPCR positive blood samples显示文摘 | Dewulf J Koenen F Ribbens S | 2005 | J Vet Med B Infect Dis Vet Public Health2005，52，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员