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| 1 | role of microRNAs in the main molecular pathways of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs(miRNAs) are small noncoding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes. The aim of this review was to identify papers published in 2017 investigating the role of miRNAs in HCC tumorigenesis. miRNAs were classified according to their role in the main molecular pathways involved in HCC tumorigenesis:(1) m TOR;(2) Wnt;(3) JAK/STAT;(4) apoptosis; and(5) MAPK. The role of miRNAs in prognosis/response prediction was taken into consideration. Bearing in mind that the analysis of miRNAs in serum and other body fluids would be crucial for clinical management, the role of circulating miRNAs in HCC patients was also investigated. The most represented mi RNA-regulated pathway in HCC is m TOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by mi RNA expression levels. These miRNAs could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment. | Francesco Vasuri Michela Visani Giorgia Acquaviva Thomas Brand Michelangelo Fiorentino Annalisa Pession Giovanni Tallini Antonia D’Errico Dario de Biase | 2018 | World Journal of Gastroenterology2018，24，25： | 16 |
| 2 | Follicular variant of papillary thyroid carcinoma: a clinicopathologic study of a problematicentity显示文摘 | Liu J Singh B Tallini G | 2006 | Cancer2006，107，6： | 1 |
| 3 | HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas,pulmonary chondroid hamartomas,endometrial polyps,and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes显示文摘 | Vanni R Ianfioletti G | 2000 | Lab Invest2000，80，1： | 1 |
| 4 | Combined Morphologic and Karyotypic Study of 28 Myxoid Liposarcomas: Implications for a Revised Morphologic Typing (A Report from the CHAMP Group)显示文摘 | Giovanni Tallini Mans Akerman Paola Dal Cin Ivo DeWever Christopher D. M. Fletcher Nils Mandahl Fredrik Mertens Felix Mitelman Juan Rosai Anders Rydholm Raf Sciot Herman Van Den Berghe Wim Van Den Ven Roberta Vanni Helena Willen | 1996 | The American Journal of Surgical Pathology1996，，9： | 1 |
| 5 | RET Oncogene activation in papillary thyroid carcinoma显示文摘 | Tallini G Asa S L | 2001 | Adv Anat Pathol2001，8，6： | 1 |
| 6 | RET oncogene activation in papillary thyroid carcinoma显示文摘 | Tallini G Asa SL | 2001 | Adv Ana Pathol2001，8，34： | 1 |
| 7 | Papillary thyroid microcarcinoma with fatal outcome: evidence of tumor progression in lymph node metastases: Report of 3 cases, with morphological and molecular analysis 显示文摘 | Piana S Ragazzi M Tallini G | 2013 | Hum Pathol2013，44，4： | 1 |
| 8 | Antitumor Activity of Lenvatinib (E7080): An Angiogenesis Inhibitor That Targets Multiple Receptor Tyrosine Kinases in Preclinical Human Thyroid Cancer Models显示文摘 | Osamu Tohyama Junji Matsui Kotaro Kodama Naoko Hata-Sugi Takayuki Kimura Kiyoshi Okamoto Yukinori Minoshima Masao Iwata Yasuhiro Funahashi Giovanni Tallini | 2014 | Journal of Thyroid Research2014，，： | 1 |
| 9 | Morphologic, immunophenotypic, and molecular evolution of bone marrow innolvement in non - Hodgkins lymphoma 显示文摘 | Crotty PL Smith BR Tallini G | | Pinagn Mol Pathol 19 980，7，2： | 1 |
| 10 | Fra-1 expression in hyperplastic and neoplastic thyroid diseases显示文摘 | Chiappetta G Tallini G De Biasio M C | | 0，，11： | 1 |
| 11 | Papillary thyroid mi with fatal outcome : evidence of tumor progression in lymph node metas- tases : Report of 3 cases, with morphological and molecular analysis显示文摘 | Piana S Ragazzi M Tallini G | 2013 | Hum Pathol2013，44，4： | 1 |
| 12 | Molecular pathobiology of thyroid neoplasms显示文摘 | Tallini G | | 0，，： | 1 |
| 13 | Morphologic,immunophenotypic,and molecular evaluation of bone marrow involvement in non-Hodgkin's lymphoma 显示文摘 | Crotty PL Smith BR Tallini G | 1998 | Diagn Mol Pathol1998，7，2： | 1 |
| 14 | Follicular variant of papillary thyroid carcinoma: a clinicopathologic study of a problematic entity显示文摘 | Liu J Singh B Tallini G | 2006 | Cancerj2006，107，6： | 1 |
| 15 | Follicular variant of papillary thyroid carcinoma:a clinicopathologic study of a problematic entity显示文摘 | Liu J Singh B Tallini G | 2006 | Cancer2006，107，6： | 1 |
| 16 | Downergulation of p27KIP1 and Ki67/Mibl labeling index support the classification of thyroid carcinoma into prngnostieally relevant categories 显示文摘 | Tallini G Gareia-t/nstan G Herrero A | 1999 | Am J Surg Pathol1999，23，6： | 1 |
| 17 | Follicular variant of papillary thyroid carcinoma:a clinicopathologic study of a problematic entity显示文摘 | Liu J Singh B Tallini G | | 0，，： | 1 |
| 18 | Follicular variant of papillary thyroid carcinoma : a clinicopathologic study of a problematic entity显示文摘 | Liu J Singh B Tallini G | 2006 | Cancer2006，107，6： | 1 |
| 19 | Frequent chromosomal DNA unbalance in thyroid oncocytic (Hurthle cell)neoplasms detected by comparative genomic hybridization 显示文摘 | Tallini G Hsueh A Liu S | 1999 | Lab Invest1999，79，5： | 1 |
| 20 | Follicular variant of papillary thyroid carcinoma:a clinicopathologic study of a problematic entity显示文摘 | Liu J Singh B Tallini G | 2006 | Cancer2006，107，6： | 1 |
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