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| 1 | Intracellular tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Role of JAK/STAT signaling显示文摘 | Zeng, Y. Zhang, X. H. Huang, Z. Cheng, L. Yao, S. H. Qin, D. Chen, X. Y. Tang, Q. Lv, Z. G. Zhang, L. Lu, C. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 31 |
| 2 | The Y.D.and climate abrupt events in the early and middle Holocene:Stalagmite oxygen isotope record from Maolan,Guizhou,China显示文摘The isotope records which range from 3.9 kaBP to 15.7 kaBP with an average resolution of 90 a have been obtained from 45 cm to 193.6 cm of the upper part of D4 stalagmite from Dongguo Cave in Libo, Guizhou, by using system TIMS U-series dating and carbon and oxygen stable isotope analyses.The study indicates that the last cold event, the YD (Younger Dryas) event, of the last glacial period was apparently shown in D4 record, which started from 12.80 kaBP and ended in 11.58 kaBP, with a great range of drop in temperature. The end of the last glacial period was consistent with the termination I in oceanic isotope records and was with time limit of 11.3 kaBP. The three most distinct cold events in the early and middle Holocene occurred respectively in 10.91 kaBP, 8.27 kaBP and 4.75 kaBP, with a range of drop in tem- perature reaching 2—5℃. The climate abrupt events in thousand and hundred years scale re- corded in stalagmite δ O can be compared to those in GISP2 ice cores from Greenland in their 18 happening time and the range of their lasting time. The cold events in 8.27 kaBP and 4.75 kaBP can also be compared to CC3 stalagmite records in Ireland, which indicate that climate changes of short range in China monsoon areas, western Europe and polar regions, have the same driv- ing factor. This has a global significance. In addition, the trend of record curves in some time- stages is apparently different, which reflects probably the difference between environment in monsoon climate areas and in polar regions. | QIN Jiaming1, YUAN Daoxian1, CHENG Hai2, LIN Yushi1, ZHANG Meiliang1, WANG Fuxing1, R. L. Edwards2, WANG Hua1 & RAN Jingcheng3 1. The Karst Dynamic Laboratory, IKG, CAGS, Guilin 541004, China 2. Geology and Geophysics Department, Minnesota University, MN55455, USA 3. The Management of Maolan National Nature Reserve, Libo 558400, China | 2005 | Science China Earth Sciences2005，48，4： | 23 |
| 3 | 倒数第三次冰消期亚洲季风气候可能的类Younger Dryas事件显示文摘对湖北省神农架两个高海拔洞穴(天鹅洞:海拔1600m;永兴洞:海拔1400m)石笋实测了7个U-Th年龄、560个氧同位素以及年纹层厚度变化序列.天鹅洞石笋十年际分辨率δ18O曲线十分类似于江苏南京和贵州荔波石笋记录的波令暖期和新仙女木事件基本特征,表明本区石笋δ18O反映了区域性亚洲季风经向环流及其降水变化特征.相距天鹅洞约70km的永兴洞石笋高分辨率(平均30a左右)δ18O时间序列揭示了倒数第三次冰消期亚洲季风突变过程.基于3个U-Th年龄和连续5000a左右生长纹层计数结果,在245±5kaBP左右冰消期识别出一个千年级冷事件.这一事件持续时间为1371±59a,并在74±4a内快速向间冰期(MIS7e)突变,δ18O的变幅达2.30‰,相当于冰期/间冰期振幅的1/2强.这些事件特征类似于亚洲季风区石笋δ18O记录的新仙女木事件,说明新仙女木事件不是末次冰消期的一次偶然事件,很可能是第四纪冰盖、大尺度海洋/大气环流耦合作用的产物. | 陈仕涛 汪永进 孔兴功 刘殿兵 Cheng Hai L. R. Edwards | 2006 | 中国科学(D辑)2006，36，5： | 14 |
| 4 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 5 | Biological imaging without autofluorescence in the second near-infrared region显示文摘Fluorescence imaging is capable of acquiring anatomical and functional infor- mation with high spatial and temporal resolution. This imaging technique has been indispensable in biological research and disease detection/diagnosis. Imaging in the visible and to a lesser degree, in the near-infrared (NIR) regions below 900 nm, suffers from autofluorescence arising from endogenous fluorescent molecules in biological tissues. This autofluorescence interferes with fluorescent molecules of interest, causing a high background and low detection sensitivity. Here, we report that fluorescence imaging in the 1,500-1,700-nm region (termed "NIR-IIb") under 808-nm excitation results in nearly zero tissue autofluorescence, allowing for background-free imaging of fluorescent species in otherwise notoriously autofluorescent biological tissues, including liver. Imaging of the intrinsic fluorescence of individual fluorophores, such as a single carbon nanotube, can be readily achieved with high sensitivity and without autofluorescence background in mouse liver within the 1,500-1,700-nm wavelength region. | Shuo Diao Guosong Hong Alexander L. Antaris Jeffrey L. Blackbum Kai Cheng Zhen Cheng Hongjie Dai | 2015 | Nano Research2015，8，9： | 12 |
| 6 | Intelligent Visual Media Processing: When Graphics Meets Vision显示文摘计算机图形和计算机视觉社区在最近的年里一起仔细一直在工作,并且许多算法和应用程序被开发了在我们附近分析并且操作视觉媒介。在这现象后面有三个主要驱动力:1 ) 从因特网的大数据的可获得性为处理资源的不断增长的、广阔数量创造了一个要求;2 ) 强大的处理工具例如深神经的网络,为学习怎么处理异构的视觉数据提供有效方法;3 ) 新数据俘获设备例如 Kinect,在为 2D 图象理解和 3D 模型分析的算法之间的桥。这些驱动力仅仅最近出现了,并且我们相信计算机图形和计算机视觉社区仍然在他们的蜜月阶段的开始。在这个工作,我们调查计算机视觉技术怎么有益于计算机图形技术并且反过来也如此的最近的研究,并且在分析,操作,合成,和相互作用上盖住研究。我们也讨论存在问题并且建议可能的进一步的研究方向。 | Ming-Ming Cheng Qi-Bin Hou Song-Hai Zhang Paul L. Rosin | 2017 | Journal of Computer Science & Technology2017，32，1： | 11 |
| 7 | The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells显示文摘 | Sendurai A. Mani Wenjun Guo Mai-Jing Liao Elinor Ng. Eaton Ayyakkannu Ayyanan Alicia Y. Zhou Mary Brooks Ferenc Reinhard Cheng Cheng Zhang Michail Shipitsin Lauren L. Campbell Kornelia Polyak Cathrin Brisken Jing Yang Robert A. Weinberg | 2008 | Cell2008，，4： | 7 |
| 8 | Genetic variants in the death receptor 4 gene contribute to susceptibility to bladder cancer显示文摘 | Wang, M. L. Wang, M. M. Cheng, G. Zhang, Z. Z. Fu, G. B. Zhang, Z. D. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 6 |
| 9 | OPTIMIZATION OF AUTOBODY PANEL STAMPING PROCESS BASED ON DYNAMIC EXPLICIT FINITE ELEMENT METHOD显示文摘Taking CPU time cost and analysis accuracy into account, dynamic explicit finite ele- ment method is adopted to optimize the forming process of autobody panels that often have large sizes and complex geometry. In this paper, for the sake of illustrating in detail how dynamic explicit finite element method is applied to the numerical simulation of the autobody panel forming process,an example of optimization of stamping process pain meters of an inner door panel is presented. Using dynamic explicit finite element code Ls-DYNA3D, the inner door panel has been optimized by adapting pa- rameters such as the initial blank geometry and position, blank-holder forces and the location of drawbeads, and satisfied results are obtained. | X. G. Bao D. N. He D. Lu C. X. Li J. L. Cheng and J. Y. Jiang( 1) National Mold and Dies CAD Engineering Research Center, Shanghai 200030, China 2) Shanghai Volkswagen Automotive Company Ltd.(SVW), Shanghai 201805, China) | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，1： | 6 |
| 10 | Influence of alloying elements on microstructure and microhardness of Mg-Sn-Zn-based alloys显示文摘阶段进化在(88%-91%) Mg-8%Sn-1%Zn-X (X=Al, Mn 或 Ce ) 系统经由 CALPHAD 方法被分析,模拟在化学作文的精确选择被使用。象 Mg-8%Sn-1%Zn-based 合金的微观结构和 microhardness 上的艾尔, Mn 和 Ce 那样的不同 alloying 元素的增加的影响被调查。艾尔和 Mn 的联合增加显示出从艾尔或 Mn 的分开的增加不同的特征。到基础合金的 1%Al 和 1%Mn 的增加在 -Mg 矩阵谷物导致巨大的 Al-Mn 阶段的形成。Ce 元素的增加能精制第二最容易溶解猛抛并且与 Sn 形成金属间化合的混合物。好像杆的 Sn-Ce 阶段主要在谷物边界上介绍并且在禁止谷物生长起一个作用。Vickers microhardness 上的 alloying 元素的效果和基础合金的缩进尺寸效果被检验。 | W. L. CHENG S. PARK W. N. TANG B. S. YOU B. H. KOO | 2010 | Transactions of Nonferrous Metals Society of China2010，20，12： | 6 |
| 11 | RAS Is Regulated by the let-7 MicroRNA Family显示文摘 | Steven M. Johnson Helge Grosshans Jaclyn Shingara Mike Byrom Rich Jarvis Angie Cheng Emmanuel Labourier Kristy L. Reinert David Brown Frank J. Slack | 2005 | Cell2005，，5： | 5 |
| 12 | Comprehensive characterization of indoor airborne bacterial profile显示文摘This is the first detailed characterization of the airborne bacterial profiles in indoor environments. Two restaurants were selected for this study. Fifteen genera of bacteria were isolated from each restaurant and identified by three different bacterial identification systems including MIDI, Biolog and Riboprinter . The dominant bacteria of both restaurants were Gram-positive bacteria in which Micrococcus and Bacillus species were the most abundant. Most bacteria identified were representative species of skin and respiratory tract of human, and soil. Although the bacterial levels in these two restaurants were below the limit of the Hong Kong Indoor Air Quality Objective (HKIAQO) Level 1 standard (i.e., < 500 cfu/m3), the majority of these bacteria were opportunistic pathogens. These results suggested that the identity of airborne bacteria should also be included in the IAQ to ensure there is a safety guideline for the public. | P. L. Chan P. H. F. Yu Y. W. Cheng C. Y. Chan P. K. Wong | 2009 | Journal of Environmental Sciences2009，21，8： | 5 |
| 13 | 素食人群尿液^1H NMR代谢轮廓的多因素方差分析显示文摘结合方差分析(ANOVA)和偏最小二乘法判别分析(PLS-DA)两种分析技术,对素食和普食人群的尿液1H NMR谱进行分析.利用ANOVA方法将数据矩阵分解为几个独立因素矩阵,滤除干扰因素后,再利用PLS-DA对单因素数据进行建模分析.实验结果表明,ANOVA/PLS-DA方法可以有效地减少饮食因素和性别因素之间的相互影响,使分析结果更具有生物学意义. | 董继扬 邓伶莉 CHENG Kian-Kai GRIFFI NJulian L. 陈忠 | 2011 | 高等学校化学学报2011，32，12： | 4 |
| 14 | Emission inventory of anthropogenic air pollutants and VOC species in the Yangtze River Delta region, China显示文摘 | Huang C. Chen C. H. Li L. Cheng Z. Wang H. L. Huang H. Y. Streets D. G. Wang Y. J. Zhang G. F. Chen Y. R | 2011 | Atmospheric Chemistry and Physics2011，，230： | 4 |
| 15 | Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions显示文摘 | Sang Hoon Ahn Henry L. Y. Chan Pei-Jer Chen Jun Cheng Mahesh K. Goenka Jinlin Hou Seng Gee Lim Masao Omata Teerha Piratvisuth Qing Xie Hyung Joon Yim Man-Fung Yuen | 2010 | Hepatology International2010，，1： | 3 |
| 16 | The level of oncogene H-Ras correlates with tumorigenicity and malignancy显示文摘Normal bovine adrenocortical cells and some human fibroblasts can be transformed by SV40T and H-Ras in a Ras-dependent manner. We recently reported that high levels of Ras derived from 5' LTR of retrovirrus can induce highly malignant and fast growing tumors, while lower levels of Ras derived from internal ribosome entry site(IRES) promotes slower tumor growth and loss of malignancy. Ras derived from CMV promoters resulted in much lower Ras levels and loss of tumor malignancy and growth. Further studies showed that the tumors formed in the presence of lower levels of Ras and dominant negative P53(P53DD) had fewer apoptotic cells and grew faster than the tumors formed from cells with same level Ras and SV40T. Our studies suggest that low levels of Ras are insufficient to inhibit apoptosis induced by pRb inactivation. In contrast, high levels of Ras not only allow normal cells to exit senescence and form tumors, but also protect against pRb inhibition-induced cell apoptosis. | Sun, B. C. Gao, Y. Deng, L. Li, G. Q. Cheng, F. Wang, X. H. Nanjing Med Univ, Liver Transplantat Ctr, Affiliated Hosp 1, Jiangsu 210029, Peoples R China. Nanjing Med Univ, Liver Transplantat Ctr, Ctr Canc, Jiangsu 210029, Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 3 |
| 17 | A new genus of Asiatic short-tailed shrew (Soricidae, Eulipotyphla) based on molecular and morphological comparisons显示文摘Blarinellini is a tribe of soricine shrews comprised of nine fossil genera and one extant genus. Blarinelline shrews were once widely distributed throughout Eurasia and North America, though only members of the Asiatic short-tailed shrew genus Blarinella currently persist(mostly in southwestern China and adjacent areas). Only three forms of Blarinella have been recognized as either species or subspecies.However, recent molecular studies indicated a strikingly deep divergence within the genus, implying the existence of a distinct genus-level lineage. We sequenced the complete mitochondrial genomes and one nuclear gene of three Asiatic short-tailed and two North American shrews and analyzed them morphometrically and morphologically. Our molecular analyses revealed that specimens ascribed to B. griselda formed two deeply diverged lineages,one a close relative to B. quadraticauda, whereas the other—comprised of topotype specimens from southern Gansu—diverged from other Blarinella in the middle Miocene(ca. 18.2 million years ago(Ma),95% confidence interval=13.4–23.6 Ma). Although the skulls were similarly shaped in both lineages, we observed several diagnostic characteristics, including the shape of the upper P^4. In consideration of the molecular and morphological evidence, we recognize B. griselda as the sole species of a new genus, namely, Pantherina gen. nov. Interestingly,some characteristics of Pantherina griselda are more similar to fossil genera, suggesting it represents an evolutionarily more primitive form than Blarinella.Recognition of this new genus sheds light on the systematics and evolutionary history of the tribe Blarinellini throughout Eurasia and North America. | Kai He Xing Chen Peng Chen Shui-Wang He Feng Cheng Xue-Long Jiang Kevin L. Campbell | 2018 | Zoological Research2018，39，5： | 3 |
| 18 | Emission inventory of anthropogenic air pollutants and VOC species in the Yangtze River Delta region, China显示文摘 | Huang C. Chen C. H. Li L. Cheng Z. Wang H. L. Huang H. Y. Streets D. G. Wang Y. J. Zhang G. F. Chen Y. R | 2011 | Atmospheric Chemistry and Physics2011，，230： | 2 |
| 19 | Is High Serum Uric Acid a Risk Marker or a Target for Treatment? Examination of its Independent Effect in a Large Cohort With Low Cardiovascular Risk显示文摘 | Chi Pang Wen Ting-Yuan David Cheng Hui Ting Chan Min Kuang Tsai Wen-Shen Isabella Chung Shan Pou Tsai Mark L. Wahlqvist Yi Chen Yang Shiuan Be Wu Po Huang Chiang Sung Feng Wen | 2010 | American Journal of Kidney Diseases2010，，2： | 2 |
| 20 | Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma显示文摘 | Janel L. Kopp Guido von Figura Erin Mayes Fen-Fen Liu Claire L. Dubois John P. Morris Fong Cheng Pan Haruhiko Akiyama Christopher V.E. Wright Kristin Jensen Matthias Hebrok Maike Sander | 2012 | Cancer Cell2012，，6： | 2 |
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