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| 1 | Hepatolithiasis and intrahepatic cholangiocarcinoma: A review显示文摘Although the incidence of hepatolithiasis is decreasing as the pattern of gallstone disease changes in Asia, the prevalence of hepatolithiasis is persistently high, especially in Far Eastern countries. Hepatolithiasis is an established risk factor for cholangiocarcinoma(CCA), and chronic proliferative inflammation may be involved in biliary carcinogenesis and in inducing the upregulation of cell-proliferating factors. With the use of advanced imaging modalities, there has been much improvement in the management of hepatolithiasis and the diagnosis of hepatolithiasis-associated CCA(HLCCA). However, there are many problems in managing the strictures in hepatolithiasis and differentiating them from infiltrating types of CCA. Surgical resection is recommended in cases of single lobe hepatolithiasis with atrophy, uncontrolled stricture, symptom duration of more than 10 years, and long history of biliaryenteric anastomosis. Even after resection, patients should be followed with caution for development of HL-CCA, because HL-CCA is an independent prognostic factor for survival. It is not yet clear whether hepatic resection can reduce the occurrence of subsequent HL-CCA. Furthermore, there are no consistent findings regarding prediction of subsequent HL-CCA in patients with hepatolithiasis. In the management of hepatolithiasis, important factors are the reduction of recurrence of cholangitis and suspicion of unrecognized HL-CCA. | Hyo Jung Kim Jae Seon Kim Moon Kyung Joo Beom Jae Lee Ji Hoon Kim Jong Eun Yeon Jong-Jae Park Kwan Soo Byun Young-Tae Bak | 2015 | World Journal of Gastroenterology2015，21，48： | 63 |
| 2 | Pancreatic fistula after pancreaticoduodenectomy:A comparison between the two pancreaticojejunostomy methods for approximating the pancreatic parenchyma to the jejunal seromuscular layer:Interrupted vs continuous stitches显示文摘瞄准:学习是由比较发现一种更好起作用的技术的这的目的为胰管空肠吻合术的外部层与连续的针打断了针,即在胰和空肠浆膜肌膜层的树桩实质之间的针,和其它为胰腺的漏的发生冒因素的风险。方法:在到 2004 年 10 月的时期 1997 年 1 月期间, 133 个病人与连续缝术为胰管空肠吻合术和 170 个病人的外部层与间断缝术在 pancreaticoduodenectomy 以后经历了 end-to-side 和 duct-to-mucosa 胰管空肠吻合术重建在我们由一位外科医生的机构。结果:在在诊断,胰的质地, octreotide 的使用和病理学的舞台的二个组之间没有有效差量。胰腺的管在间断缝术盒子之中并且在 10 发生在 14 个病人(11%)(6%) 在连续缝术盒子之中(P = 0.102 ) 。主要的胰腺的漏在三个间断缝术病人(2%) 和零个连续缝术病人发展了(P = 0.026 ) 。在里面多变量分析,软胰腺的一致性(机会比率, 5.5;95% 信心间隔 2.3-13.1 ) 并且胆总管癌症(机会比率, 3.7;95% CI 1.6-8.5 ) 胰腺的漏是预兆的。结论:胰腺的质地和病理是在决定 pancreaticojejunal 吻合和我们的连续缝术方法的命运与主要的胰腺的管的显著地减少的出现被执行的最重要的因素。在结论,连续缝术方法在执行 duct-to-mucosa 胰管空肠吻合术更可行、更安全。 | Seung Eun Lee Sung Hoon Yang Jin-Young Jang Sun-Whe Kim | 2007 | World Journal of Gastroenterology2007，13，40： | 31 |
| 3 | Small sphincterotomy combined with endoscopic papillary large balloon dilation versus sphincterotomy显示文摘AIM:To compare small sphincterotomy combined with endoscopic papillary large balloon dilation(SES+ ELBD)and endoscopic sphincterotomy(EST)for large bile duct stones. METHODS:We compared prospectively SES+ELBD (group A,n=27)with conventional EST(group B, n=28)for the treatment of large bile duct stones(≥ 15 mm).When the stone could not be removed with a normal basket,mechanical lithotripsy was performed. We compared the rates of complete stone removal with one session and application of mechanical lithotripsy. RESULTS:No significant differences were observed in the mean largest stone size(A:20.8 mm,B:21.3 mm), bile duct diameter(A:21.4 mm,B:20.5 mm),number of stones(A:2.2,B:2.3),or procedure time(A:18 min, B:19 min)between the two groups.The rates of complete stone removal with one session was 85%in group A and 86%in group B(P=0.473).Mechanical lithotripsy was required for stone removal in nine of 27 patients(33%)in group A and nine of 28 patients (32%,P=0.527)in group B.CONCLUSION:SES+ELBD did not show significant benefits compared to conventional EST,especially for the removal of large(≥15 mm)bile duct stones. | Hyun Gun Kim Young Koog Cheon Young Deok Cho Jong Ho Moon Do Hyun Park Tae Hoon Lee Hyun Jong Choi Sang-Heum Park Joon Seong Lee Moon Sung Lee | 2009 | World Journal of Gastroenterology2009，15，34： | 34 |
| 4 | Analysis of demographic characteristics in 3242 young age gastric cancer patients in Korea显示文摘AIM:To evaluate the epidemiologic features of young age gastric cancer(GC). METHODS:Retrospectively,a total of 3242 patients with GC between 18 and 45 years of age and 3000 sex-and age-matched controls were reviewed.All subjects were stratified into 3 groups based on age (A,18-30 years;B,31-40 years;C,41-45 years). Epidemiologic characteristics and risk factors were investigated with reference to their age and gender. RESULTS:Compared to controls,more frequent intake of high risk diet(P=0.00075),history of heavy smoking(P=0.00087),intake of heavy alcohol(P= 0.00091),lower social economic status(P=0.00083), body mass index>30(P=0.00097),urban residence(P=0.00065),and more frequent exposure to harmful occupational environments(P=0.00072)were observed in all age groups and both genders in young age GC.These relationships were weaker in females compared to males of the same age,and were stronger as the age of patients increased.However,in group C of young age GC patients,environmental factors played important roles in females and males with a similar body weight.In females,older age at first delivery(> 35 years),lack of lactation history,nulliparity,and poor nutritional status during pregnancy were significantly associated with an increased risk of GC(P=0.00034). In this study,252 patients(7.8%)had a family history of GC with high odds ratio(OR)(3.22-4.21).In particular, family history was more closely associated with GC in males(OR,4.21 in male vs 3.46 in female)and more advanced cases(P=0.00051). CONCLUSION:Hormonal associated factors were more commonly associated with females whereas environmental factors were more commonly associated with males in young age GC patients. | Hye Won Chung Sung Hoon Noh Jong-Baeck Lim | 2010 | World Journal of Gastroenterology2010，16，2： | 26 |
| 5 | Gastric cancer surgery in cirrhotic patients: Result of gastrectomy with D2 lymph node dissection显示文摘AIM: To explore the feasibility of performing gastrectomy with D2 lymphadenectomy in gastric cancer patients with liver cirrhosis.METHODS: A total of 7 178 patients were admitted with a diagnosis of liver cirrhosis from January 1993 to December 2003. We reviewed the records of 142 patients who were diagnosed with liver cirrhosis and gastric adenocarcinoma during the same period. Gastrectomy with D2 lymph node dissection for carcinoma of the stomach was performed in 94 patients with histologically proven hepatic cirrhosis.RESULTS: All but 12 patients were classified as Child's class A. Only 35 patients (37.2%) were diagnosed with cirrhosis before operation. Seventy-three patients underwent a subtotal gastrectomy (77.7%) and 21 patients (22.3%)underwent a total gastrectomy, each with D2 or more lymph node dissection. Two patients (3.8%) who had prophylactic intra-operative drain placement, died of postoperative complications from hepatorenal failure with intractable ascites. Thirty-seven patients (39.4%) experienced postoperative complications. The extent of gastric resection did not influence the morbidity whereas serum aspartate aminotransferase level (P = 0.011) and transfusion did (P= 0.008). The most common postoperative complication was ascites (13.9%) followed by wound infection (10.6%).CONCLUSION: We concluded that the presence of compensated cirrhosis, i.e. Child class A, is not a contraindication against gastrectomy with D2 or more lymph node dissection, when curative resection for gastric cancer is possible. Hepatic reserve and meticulous hemostasis are the likely determinants of operative prognosis. | Jun Ho Lee Junuk Kim Jae Ho Cheong Woo Jin Hyung Seung Ho Choi Sung Hoon Noh | 2005 | World Journal of Gastroenterology2005，11，30： | 25 |
| 6 | Nutritional risk index as a predictor of postoperative wound complications after gastrectomy显示文摘AIM:To investigate the correlation between the nutritional risk index (NRI) and postoperative wound complications.METHODS:From January 2008 through June 2008,669 patients who underwent curative gastrectomy for gastric cancer were included in a retrospective study.Medical records of consecutive patients were collected and analyzed to determine postoperative wound complication rates.The NRI was assessed on the fifth postoperative day and other possible risk factors for the incidence of wound complications were analyzed to identify the factors affecting postoperative wound complications.Patients with other postoperative complications were excluded from the study.RESULTS:On the 5th postoperative day,the NRI showed a malnutrition rate of 84.6% among postoperative patients.However,postoperative wound complications occurred in only 66/669 (9.86%) patients.Of the patients with wound complications,62/66 (94%) belonged to the malnourished group (NRI < 97.5),and 4/66 (6%) patients to the non-malnourished group (NRI ≥ 97.5).The only factor correlated with wound complications was the NRI on the 5th postoperative day (odds ratio of NRI ≥ 97.5 vs NRI < 97.5:0.653;95% confidence interval:0.326-0.974;P=0.014) according to univariate analysis as well as multivariate analysis.CONCLUSION:This study suggests that malnutrition immediately after surgery may play a significant role in the development of wound complications. | Cheong Ah Oh Dae Hoon Kim Seung Jong Oh Min Gew Choi Jae Hyung Noh Tae Sung Sohn Jae Moon Bae Sung Kim | 2012 | World Journal of Gastroenterology2012，18，7： | 25 |
| 7 | Endoscopic removal of gastric ectopic pancreas:An initial experience with endoscopic submucosal dissection显示文摘AIM:To evaluate the therapeutic usefulness and safety of endoscopic resection in patients with gastric ectopic pancreas.METHODS:A total of eight patients with ectopic pancreas were included.All of them underwent endoscopic ultrasonography before endoscopic resection.Endo-scopic resection was performed by two methods:endo-scopic mucosal resection(EMR)by the injection-and-cut technique or endoscopic mucosal dissection(ESD).RESULTS:We planned to perform EMR in all eight cases but EMR was successful in only four cases.In the other four cases,saline spread into surrounding normal tissues and the lesions becameattened,which made it impossible to remove them by EMR.Inthose four cases,we performed ESD and removed the lesions without any complications.CONCLUSION:If conventional EMR is difficult to remove gastric ectopic pancreas,ESD is a feasible alternative method for successful removal. | Dong Yup Ryu Gwang Ha Kim Do Youn Park Bong Eun Lee Jae Hoon Cheong Dong Uk Kim Hyun Young Woo Jeong Heo Geun Am Song | 2010 | World Journal of Gastroenterology2010，16，36： | 24 |
| 8 | 海上风电场雷击演化物理机制的研究综述显示文摘海上风力资源以其自身优势与丰富的储量,已成为未来风力发电重要的发展方向。随着陆上风力发电的饱和,风力发电逐渐呈现出向海上发展的趋势。但因海上风电具有不同于陆上的特点,许多关键问题有待进一步研究解决,尤其是海上风电机组极易遭受雷击,而雷电灾害是威胁风力发电安全的重要因素。对此本文从海上风电场的机组尺寸、地理位置和海洋环境等方面归纳总结了海上风电场雷击防护的特点,从雷电先导发展机理、叶片接闪器与导流通道雷击放电物理特性、雷击风机叶片机械爆裂损伤机理和海上风电机组雷电强场电磁暂态过程等方面分析了国内外现有海上风电雷击演化物理机制方面的研究现状,并据此提出海上风电防雷方面有待深入研究的四个课题方向。 | 郭子炘 李庆民 闫江燕 马宇飞 SiewWah Hoon | 2015 | 电气工程学报2015，10，5： | 24 |
| 9 | 大型风电场雷击防护研究面临的关键问题显示文摘从风电场雷击现场观测与长间隙放电实验模拟、叶片雷击接闪放电、风电机组雷击风险评估与防雷系统优化设计、叶片雷击损伤机制、雷击电磁暂态与防护、叶片防雷系统测试方法、海洋环境风机防雷新问题等方面,对风电场雷击防护技术领域的国内外研究现状进行了总结。梳理出5个亟待解决的问题:风机旋转对叶片附近空间电荷的影响;叶片接闪的极性效应与负极性上行先导物理模型;多先导起始竞争机制及风机群屏蔽效应;雷击桨叶损伤机制与冲击爆裂动力学建模;风电机组雷击风险评估方法。对这些问题的有效解决将从理论基础、设计原则、评估测试体系等多个层面,提升对风电场雷击现象的认知水平,指导风机桨叶和防雷系统的优化设计。 | 李庆民 郭子炘 张黎 Siew Wah Hoon | 2018 | 中国电机工程学报2018，38，18： | 24 |
| 10 | Synthesis of Porous NiO Nanocrystals with Controllable Surface Area and Their Application as Supercapacitor Electrodes显示文摘We report a facile way to grow various porous NiO nanostructures including nanoslices,nanoplates,and nanocolumns,which show a structure-dependence in their specific charge capacitances.The formation of controllable porosity is due to the dehydration and re-crystallization of β-Ni(OH)_(2) nanoplates synthesized by a hydrothermal process.Thermogravimetric analysis shows that the decomposition temperature of the β-Ni(OH)_(2) nanostructures is related to their morphology.In electrochemical tests,the porous NiO nanostructures show stable cycling performance with retention of specific capacitance over 1000 cycles.Interestingly,the formation of nanocolumns by the stacking of β-Ni(OH)_(2) nanoslices/plates favors the creation of small pores in the NiO nanocrystals obtained after annealing,and the surface area is over five times larger than that of NiO nanoslices and nanoplates.Consequently,the specific capacitance of the porous NiO nanocolumns(390 F/g)is significantly higher than that of the nanoslices(176 F/g)or nanoplates(285 F/g)at a discharge current of 5 A/g.This approach provides a clear illustration of the process-structure-property relationship in nanocrystal synthesis and potentially offers strategies to enhance the performance of supercapacitor electrodes. | Xiaojun Zhang Wenhui Shi Jixin Zhu Weiyun Zhao Jan Ma Subodh Mhaisalkar Tuti Lim Maria Yanhui Yang Hua Zhang Huey Hoon Hng Qingyu Yan | 2010 | Nano Research2010，3，9： | 24 |
| 11 | Characterization of focal liver masses using acoustic radiation force impulse elastography显示文摘AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their stiffness.METHODS:This prospective study included 62 patients with a focal liver mass that was well visualized on conventional ultrasonography performed in our institution from February 2011 to November 2011.Among them,12 patients were excluded for ARFI measurement failure due to a lesion that was smaller than the region of the interest and at an inaccessible location(deeper than 8 cm)(n = 7) or poor compliance to hold their breath as required(n = 5).Finally,50 patients with valid ARFI measurements were enrolled.If a patient had multiple liver masses,only one mass of interest was chosen.The masses were diagnosed by histological examination or clinical diagnostic criteria.During ultrasonographic evaluation,stiffness,expressed as velocity,was checked 10 times per focal liver mass and the surrounding liver parenchyma.RESULTS:After further excluding three masses that were non-diagnostic on biopsy,a total of 47 focal mass lesions were tested,including 39(83.0%) malignant masses [24 hepatocellular carcinomas(HCC),seven cholangiocellular carcinomas(CCC),and eight liver metastases] and eight(17.0%) benign masses(five hemangiomas and three focal nodular hyperplasias,FNH).Thirty-seven(74.0%) masses were confirmed by histological examination.The mean velocity was 2.48 m/s in HCCs,1.65 m/s in CCCs,2.35 m/s in metastases,1.83 m/s in hemangiomas,and 0.97 m/s in FNHs.Although considerable overlap was still noted between malignant and benign masses,significant differences in ARFI values were observed between malignant and benign masses(mean 2.31 m/s vs 1.51 m/s,P = 0.047),as well as between HCCs and benign masses(mean 2.48 m/s vs 1.51 m/s,P = 0.006).The areas under the receiver operating characteristics curves(AUROC) for discriminating the malignant masses from benign masses was 0.724(95%CI,0.566-0.883,P = 0.048),and the AUROC for discriminating HCCs from benign masses was 0.813(95%CI,0.649-0.976,P = 0.008).To maximize the sum of sensitivity and specificity,an ARFI value of 1.82 m/s was selected as the cutoff value to differentiate malignant from benign liver masses.Furthermore,the cutoff value for distinguishing HCCs from benign masses was also determined to be 1.82 m/s.The diagnostic performance of the sum of the ARFI values for focal liver masses and the surrounding liver parenchyma to differentiate liver masses improved(AUROC = 0.853;95%CI,0.745-0.960;P = 0.002 in malignant liver masses vs benign ones and AUROC = 0.948;95%CI,0.896-0.992,P < 0.001 in HCCs vs benign masses).CONCLUSION:ARFI elastography provides additional information for the differential diagnosis of liver masses.However,our results should be interpreted in clinical context,because considerable overlap in ARFI values existed among liver masses. | Hana Park Jun Yong Park Do Young Kim Sang Hoon Ahn Chae Yoon Chon Kwang-Hyub Han Seung Up Kim | 2013 | World Journal of Gastroenterology2013，19，2： | 22 |
| 12 | How good is cola for dissolution of gastric phytobezoars?显示文摘AIM:To evaluate the efficacy of cola treatment for gastric phytobezoars,including diospyrobezoars.METHODS:A total of 17 patients(range:48 to 78 years) with symptomatic gastric phytobezoars treated with cola and adjuvant endoscopic therapy were reviewed.Three liters of cola lavage(10 cases) or drink(7 cases) were initially used,and then endoscopic fragmentation was done for the remnant bezoars by using a lithotripsy basket or a polypectomy snare.The overall success of dissolving a gastric phytobezoars with using three liters of cola and the clinical and endoscopic findings were compared retrospectively between four cases of complete dissolution by using only cola and 13 cases of partial dissolution with cola.RESULTS:After 3 L of cola lavage or drinking,a complete dissolution of bezoars was achieved in four patients(23.5%),while 13 cases(76.5%) were only partially dissolved.Phytobezoars(4 of 6 cases) were observed more frequently than diospyrobezoars(0 of 11) in the group that underwent complete dissolution(P = 0.006).Gender,symptom duration,size of bezoar and method of cola administration were not significantly different between the two groups.Twelve of 13 patients with residual bezoars were completely treated with a combination of cola and endoscopic fragmentation.CONCLUSION:The rate of complete dissolution with three liters of cola was 23.5%,but no case of diospyrobezoar was completely dissolved using this method.However,pretreatment with cola may be helpful and facilitate endoscopic fragmentation of gastric phytobezoars. | Beom Jae Lee Jong-Jae Park Hoon Jai Chun Ji Hoon Kim Jong Eun Yeon Yoon Tae Jeen Jae Seon Kim Kwan Soo Byun Sang Woo Lee Jae Hyun Choi Chang Duck Kim Ho Sang Ryu Young-Tae Bak | 2009 | World Journal of Gastroenterology2009，15，18： | 22 |
| 13 | Primary endoscopic approximation suture under cap-assisted endoscopy of an ERCP-induced duodenal perforation显示文摘Duodenal perforation during endoscopic retrograde cholangiopancreatography(ERCP) is a rare complication,but it has a relatively high mortality risk.Early diagnosis and prompt management are key factors for the successful treatment of ERCP-related perforation.The management of perforation can initially be conservative in cases resulting from sphincterotomy or guide wire trauma.However,the current standard treatment for duodenal free wall perforation is surgical repair.Recently,several case reports of endoscopic closure techniques using endoclips,endoloops,or fully covered metal stents have been described.We describe four cases of iatrogenic duodenal bulb or lateral wall perforation caused by the scope tip that occurred during ERCP in tertiary referral centers.All the cases were simply managed by endoclips under transparent capassisted endoscopy.Based on the available evidence and our experience,endoscopic closure was a safe and feasible method even for duodenoscope-induced perforations.Our results suggest that endoscopists may be more willing to use this treatment. | Tae Hoon Lee Byoung Wook Bang Jee In Jeong Hyung Gil Kim Seok Jeong Seon Mee Park Don Haeng Lee Sang-Heum Park Sun-Joo Kim | 2010 | World Journal of Gastroenterology2010，16，18： | 19 |
| 14 | Oxidative stress and inflammatory signaling in cerulein pancreatitis显示文摘Oxidative stress is considered to be an important regulator of the pathogenesis of acute pancreatitis.Reactive oxygen species(ROS)regulate the activation of inflammatory cascades,the recruitment of inflammatory cells and tissue damage in acute pancreatitis.A hallmark of the inflammatory response in pancreatitis is the induction of cytokine expression,which is regulated by a number of signaling molecules including oxidant-sensitive transcription factors such as nuclear factor-κB(NF-κB)and activator protein-1(AP-1),signal transducer and activator of transcription 3(STAT3),and mitogen-activated protein kinases(MAPKs).Cross-talk between ROS and pro-inflammatory cytokines is mediated by NF-κB,AP-1,STAT3,and MAPKs;this crosstalk amplifies the inflammatory cascade in acute pancreatitis.Therapeutic studies have shown that antioxidants and natural compounds can have beneficial effects for patients with pancreatitis and can also influence the expression of proinflammatory cytokines in cerulein-induced pancreatitis.Since oxidative stress may activate inflammatory signaling pathways and contribute to thedevelopment of pancreatitis,antioxidant therapy may alleviate the symptoms or prevent the development of pancreatitis.Since chronic administration of high doses of antioxidants may have deleterious effects,dosage levels and duration of antioxidant treatment should be carefully determined. | Ji Hoon Yu Hyeyoung Kim | 2014 | World Journal of Gastroenterology2014，20，46： | 19 |
| 15 | Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis显示文摘瞄准:门静脉高血压是肝肝硬化的普通复杂并发症。肝内压力能以几个方法被提高。从内脏的内脏影响脉管系统, vasoconstrictors 的增加和增加的循环进门静脉系统的反常建筑学都可以作出贡献。因而内长的血管扩张药也许能减轻高血压。我们因此试图调查内长的血管扩张药的层次,氮的氧化物(没有) 并且通过氮的氧化物 synthase (NOS ) 的表示的一氧化碳(公司) 并且他我氧合酶(惊讶) 。方法:肝脏硬化症(n=20 ) 并且非肝脏硬化症(n=20 ) 肝从经历了外科的病人被获得。NOS 的各种各样的 isoforms 的 mRNA 和蛋白质表情并且惊讶用竞争 PCR,西方的污点和免疫组织化学被检验。结果:当内皮 NOS (eNOS ) 在硬变肝是起来调整的时,在可诱导的 NOS (i NOS ) 或神经元 NOS (nNOS ) 表情没有重要变化。附随地, caveolin-1, eNOS 的一个确定的下面管理者,是起来调整的。可诱导的 HO-1 和组成的 HO-2 被发现在不同本地化在硬变肝虽然显示出增加的表示。结论:NOS 表示力量的差别由于他们在在肝硬化的病理维持肝动态平衡或参与的不同角色。在高血压的肝以内的纯粹的应力可以导致 eNOS 的增加的表示。接着, caveolin-1 也被增加。这是否对进一步的肝硬化用作一个防御机理或是肝硬化的后果,是还未知的。HO-1 和 HO-2 的提高的表示建议公司可以微弱地作为血管扩张药虽然在它的角色补偿。它是可能的那个公司并且不在肝以内有平行或协调的功能并且可以在门静脉高血压的病理生理学反对地工作。 | Beatrice J Goh Bee Tee Tan Wei Min Hon Kang Hoe Lee Hoon Eng Khoo | 2006 | World Journal of Gastroenterology2006，12，4： | 19 |
| 16 | Management of the complications of endoscopic submucosal dissection显示文摘Endoscopic submucosal dissection(ESD) is currently widely accepted as a standard treatment option for early gastrointestinal neoplasms in Korea.However,ESD has technical difficulties and a longer procedure time than conventional endoscopic resection.So it may have a higher risk of complications than conventional endoscopic resection techniques.We,the ESD study group of Korean Society of Gastrointestinal Endoscopy,have experienced many complications,mostly treated by endoscopic or conservative management.Here,we introduce and share our experiences for managementof post ESD complications and review published papers on the topic. | Seong Hwan Kim Jeong Seop Moon Young Hoon Youn Ki Myung Lee Sung Joon Lee | 2011 | World Journal of Gastroenterology2011，17，31： | 19 |
| 17 | Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B显示文摘AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis B.METHODS:We included 154 consecutive patients in two treatment groups:the 'add-on' group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the 'switch/combination' group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as needed.The 'switch/combination' group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the 'add-on' group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the 'add-on' group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the 'add-on' group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment. | Tae Jung Yun Jin Yong Jung Chang Ha Kim Soon Ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | World Journal of Gastroenterology2012，18，47： | 19 |
| 18 | 进展期胃癌的外科治疗显示文摘全球每年约有800000例胃癌新发病例,居于最常见的恶性肿瘤第4位,肿瘤相关死亡原因第2位。虽然胃癌发病率在西方国家持续下降,但是在亚洲、拉丁美洲和东欧依旧保持较高水平。据报道,全球大约42%的胃癌患者在中国。随着手术技术的改进、综合治疗方法的进步以及早期诊断能力的提高,最近几十年胃癌的总体生存率得到逐步提升。 | Kyung Min Kim 胡彦锋 Ji Yeong An Hyoung LI Kim Jae Ho Cheong Woo Jin Hyung Sung Hoon Noh | 2011 | 中华消化外科杂志2011，10，6： | 18 |
| 19 | Design and Demonstration of a Locust-Like Jumping Mechanism for Small-Scale Robots显示文摘 | Quoc-Viet Nguyen Hoon Cheol Park | 2012 | Journal of Bionic Engineering2012，9，3： | 18 |
| 20 | Effect of an Artificial Caudal Fin on the Performance of a Biomimetic Fish Robot Propelled by Piezoelectric Actuators显示文摘This paper addresses the design of a biomimetic fish robot actuated by piezoceramic actuators and the effect of artificial caudal fins on the fish robot's performance. The limited bending displacement produced by a lightweight piezocomposite actuator was amplified and transformed into a large tail beat motion by means of a linkage system. Caudal fins that mimic the shape of a mackerel fin were fabricated for the purpose of examining the effect of caudal fin characteristics on thrust pro-duction at an operating frequency range. The thickness distribution of a real mackerel's fin was measured and used to design artificial caudal fins. The thrust performance of the biomimetic fish robot propelled by fins of various thicknesses was examined in terms of the Strouhal number,the Froude number,the Reynolds number,and the power consumption. For the same fin area and aspect ratio,an artificial caudal fin with a distributed thickness shows the best forward speed and the least power con-sumption. | Seok Heo Tedy Wiguna Hoon Cheol Park Nam Seo Goo | 2007 | Journal of Bionic Engineering2007，4，3： | 16 |
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