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| 1 | Single center experience of capsule endoscopy in patients with obscure gastrointestinal bleeding显示文摘AIM:To identify optimum timing to maximize diagnostic yield by capsule endoscopy (CE) in patients with obscure gastrointestinal bleeding (OGIB).METHODS:We identified patients who underwent CE at our institution from August 2003 to December 2009.Patient medical records were reviewed to determine type of OGIB (occult,overt),CE results and complications,and timing of CE with respect to onset of bleeding.RESULTS:Out of 385 patients investigated for OGIB,284 (74%) had some lesion detected by CE.In 222 patients (58%),definite lesions were detected that could unequivocally explain OGIB.Small bowel ulcer/erosions secondary to Crohn's disease,tuberculosis or non-steroidal anti-inflammatory agent use were the commonest lesions detected.Patients with overt GI bleeding for < 48 h before CE had the highest diagnostic yield (87%).This was significantly greater (P < 0.05) compared to that in patients with overt bleeding prior to 48 h (68%),as well as those with occult OGIB (59%).CONCLUSION:We established the importance of early CE in management of OGIB.CE within 48 h of overt bleeding has the greatest potential for lesion detection. | Mahesh Kumar Goenka Shounak Majumder Sanjeev Kumar Pradeepta Kumar Sethy Usha Goenka | 2011 | World Journal of Gastroenterology2011，17，6： | 39 |
| 2 | Palliation:Hilar cholangiocarcinoma显示文摘Hilar cholangiocarcinomas are common tumors of the bile duct that are often unresectable at presentation. Palliation, therefore, remains the goal in the majority of these patients. Palliative treatment is particularly indicated in the presence of cholangitis and pruritus but is often also offered for high-grade jaundice and abdominal pain. Endoscopic drainage by placing stents at endoscopic retrograde cholangio-pancreatography(ERCP) is usually the preferred modality of palliation. However, for advanced disease, percutaneous stenting has been shown to be superior to endoscopic stenting. Endosonography-guided biliary drainage is emerging as an alternative technique, particularly when ERCP is not possible or fails. Metal stents are usually preferred over plastic stents, both for ERCP and for percutaneous bili-ary drainage. There is no consensus as to whether it is necessary to place multiple stents within advanced hi-lar blocks or whether unilateral stenting would suffice. However, recent data have suggested that, contrary to previous belief, it is useful to drain more than 50% of the liver volume for favorable long-term results. In the presence of cholangitis, it is beneficial to drain all of the obstructed biliary segments. Surgical bypass plays a limited role in palliation and is offered primarily as asegment Ⅲ bypass if, during a laparotomy for resec-tion, the tumor is found to be unresectable. Photody-namic therapy and, more recently, radiofrequency abla-tion have been used as adjuvant therapies to improve the results of biliary stenting. The exact technique to be used for palliation is guided by the extent of the bili-ary involvement(Bismuth class) and the availability of local expertise. | Mahesh Kr Goenka Usha Goenka | 2014 | World Journal of Hepatology2014，6，8： | 16 |
| 3 | Capsule endoscopy:Present status and future expectation显示文摘Video capsule endoscopy(CE)since its introduction 13years back,has revolutionized our approach to small intestinal diseases.Obscure gastrointestinal bleed(OGIB)continues to be the most important indication for CE with a high sensitivity,specificity as well as positive and negative predictive values.It is best performed during ongoing bleed or immediately thereafter.Overt OGIB has a higher diagnostic yield than occult OGIB.However,even in iron deficiency anemia,CE is emerging as important investigation after initial negative work up.In suspected Crohn’s disease(CD),CE has been shown superior to traditional imaging and endoscopic technique and should be considered after a negative ileocolonoscopy.Although CE has also been used for evaluating established CD,a high capsule retention rate precludes its use ahead of cross-sectional imaging.Celiac disease,particularly where gastro-duodenoscopy cannot be performed or is normal,can also be investigated by CE.Small bowel tumor,hereditary polyposis syndrome,and non-steroidal anti-inflammatory drugs induced intestinal damage are other indications for CE.Capsule retention is the only significant adverse outcome of CE and occurs mostly in presence of intestinal obstruction.This can be prevented by use of Patency capsule prior to CE examination.Presence of cardiac pacemaker and intracardiac devices continue to be relative contraindications for CE,though data do not suggest interference of CE with these devices.Major limitations of CE today include failure to control its movement from outside,inability of CE to acquire tissue for diagnosis,and lack of therapeutic help.With ongoing interesting and exciting developments taking place in these areas,these issues would be solved in all probability in near future.CE has the potential to become one of the most important tools in diagnostic and possibly in the therapeutic field of gastrointestinal disorder. | Mahesh K Goenka Shounak Majumder Usha Goenka | 2014 | World Journal of Gastroenterology2014，20，29： | 9 |
| 4 | Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions显示文摘 | Sang Hoon Ahn Henry L. Y. Chan Pei-Jer Chen Jun Cheng Mahesh K. Goenka Jinlin Hou Seng Gee Lim Masao Omata Teerha Piratvisuth Qing Xie Hyung Joon Yim Man-Fung Yuen | 2010 | Hepatology International2010，，1： | 3 |
| 5 | Endotherapy of leaks and fistula显示文摘Perforations, leaks and fistula involving gastrointestinal(GI) tract are increasing encountered in clinical practice. There is a changing paradigm for their management with surgical approach being replaced by conservative approach including endoscopic therapy. Clips(through the scope and over the scope) and covered stent are front runners for endotherapy for GI leaks and fistula.Over the scope clips introduced recently, can treat larger defects compared to through the scope clips. Covered stents are suited for larger defects and those associated with luminal narrowing. However cervical esophagus, gastro-esophageal junction, stomach and right colonic lesions may be better for clip therapy rather than stenting. Recent developments in this field include use of endovac therapy which consists of a sponge with suction device, biodegradable stent, use of fibrin glue and some endo-suturing device. Conservative therapy with no surgical or endoscopic intervention, may be suitable for a small subset of patients. An algorithm based on location, size of defect, associated stricture, infection and available expertise needs to be developed to reduce the mortality and morbidity of this difficult clinical problem. | Mahesh Kumar Goenka Usha Goenka | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 3 |
| 6 | Radiation-induced proctosigmoiditis显示文摘 | R. Kochhar F. Patel S. C. Sharma S. Ayyagari R. Aggarwal M. K. Goenka B. D. Gupta S. K. Mehta | 1991 | Digestive Diseases and Sciences1991，，： | 2 |
| 7 | Analysis of crankshaft bear- ing using a mass conserving algorithm 显示文摘 | Paranjpe R S Goenka P K | 1990 | Tribology Transactions1990，33，3： | 1 |
| 8 | Adrenal imaging: a prim- er for oncosurgeons显示文摘 | Goenka AH Shah SN Remer EM | 2012 | J Surg Oncol2012，106，5： | 1 |
| 9 | Analysis of Crankshaft Bearing Using a Mass Conserving Algorithm 显示文摘 | Rohit S Paranjpe Pawan K Goenka | 1990 | Tribology Transaction1990，33，： | 1 |
| 10 | Elastohydrodynamic solution ofjournal bearings under dynamic loading显示文摘 | Oh K P Goenka P K | 1985 | Journal ofTribology1985，107，3： | 1 |
| 11 | Long‐term regional control in the observed neck following definitive chemoradiation for node‐positive oropharyngeal squamous cell cancer显示文摘 | Anuj Goenka Luc G.T. Morris Shyam S. Rao Suzanne L. Wolden Richard J. Wong Dennis H. Kraus Nisha Ohri Jeremy Setton Benjamin H. Lok Nadeem Riaz Borys R. Mychalczak Heiko Schoder Ian Ganly Jatin P. Shah David G. Pfister Michael J. Zelefsky Nancy Y. Lee | 2013 | Int. J. Cancer2013，，： | 1 |
| 12 | Dependence of vascular damage on higher frequency components in the rat-tail model显示文摘 | Goenka S Peelukhana SV Kim J | 2013 | Ind Health2013，51，4： | 1 |
| 13 | Leukocytosis and increased risk of atrial fibrillation after general thoracic surgery显示文摘 | Amar D Goenka A Zhang H | 2006 | Ann Thorac Surg2006，82，3： | 1 |
| 14 | Endoscopic retro-grade cholangiopancreatography in postcholecystectomysyndrome显示文摘 | Goenka MK Kochhar R Nagi B | 1996 | J Assoc Physicians India1996，44，2： | 1 |
| 15 | Colonoscopic fine needle aspiration cytology in the diagnosis of ileoceal tuberculosis显示文摘 | Kochbar R Rajwansbi A Goenka MK | 1991 | Am J Gastroenterol1991，86，： | 1 |
| 16 | Analysis of C: ankshaft Bearings Using a mass Conserving Algo- rithm显示文摘 | Rohit S Paanjpe Pawan K Goenka | 1990 | Tribology Transaction1990，33，： | 1 |
| 17 | A multidisciplinary approach to the management of a subgingivally fractured tooth : a clinical re- port显示文摘 | Goenka P Marwah N Dutta S | 2011 | J Prosthodont2011，20，3： | 1 |
| 18 | Natural history of isolated ventricular septal defect in the first five years of life显示文摘 | Mehta AV Goenka S Chidambaram B | 2000 | Tenn Med2000，93，4： | 1 |
| 19 | Transcriptional regulation by STAT6显示文摘 | Goenka S Kaplan MH | 2011 | Immunol Res2011，50，1： | 1 |
| 20 | IL-4 signaling, gene transcription regulation, and the control of effector T cells显示文摘 | Mark Boothby Ana L. Mora Mark A. Aronica Jeehee Youn James R. Sheller Shreevrat Goenka Linda Stephenson | 2001 | Immunologic Research (-)2001，，2： | 1 |
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