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| 1 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 2 | 重组卡介苗表达的MalE蛋白T细胞表位的鉴定显示文摘目的 鉴定重组卡介苗表达的MalE蛋白T细胞表位。方法 用抗原提呈试验、T细胞增殖试验、ELISPOT试验和表位作图测试重组MalE蛋白的T细胞表位。结果 重组BCG MalE功能性表达了MalE蛋白的 4种H 2 d 限制性T细胞表位。结论 在 4种表位中 ,p6 8~ 82是重组MalE蛋白的主要T细胞表位 ,而其余 | 焦新安 Richard Lo-man Edith Driaud Sophie Burgaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2002 | 中华微生物学和免疫学杂志2002，22，1： | 3 |
| 3 | 重组卡介苗感染树突细胞的研究显示文摘在体内外试验中 ,树突细胞 (DC)均能摄取表达大肠杆菌麦芽糖结合蛋白 (MalE)的重组卡介苗 (rBCG·MalE)。应用流式细胞术测得荧光标记的rBCG·MalE在体内感染DC的水平在 1 % 2 % ,与感染巨噬细胞 (MΦ)的水平相当。体外抗原提呈试验结果显示 ,DC和MΦ能吞噬、加工rBCG·MalE并向T细胞杂交瘤FBU·B1 1提呈MalE蛋白抗原表位 ,而在体内试验中 ,从rBCG·MalE免疫小鼠脾脏中纯化的DC ,可检测到MalE表位MHCⅡ复合物 ,而纯化的MΦs却测不到。这表明DC在起始抗分枝杆菌的免疫保护中发挥关键作用。 | 焦新安 Richard Lo-Man Pierre Guermonprez Edith Dériaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 | 2002 | 扬州大学学报(农业与生命科学版)2002，23，1： | 2 |
| 4 | Primary Gastric B-Cell Lymphoma: Results of a Prospective Multicenter Study显示文摘 | Wolfgang Fischbach* Brigitte Dragosics? Maria-Elisabeth Kolve-Goebeler§ Christian Ohmann∥ Axel Greiner? Qin Yang∥ Stephan B?hm? Patrick Verreet∥ Olaf Horstmann# Martin Busch** Eckhart Dühmke** Hans-Konrad Müller-Hermelink? Klaus Wilms§ | 2000 | Gastroenterology2000，，5： | 1 |
| 5 | 查看详情显示文摘 | Olayide S L Lechner M D Brigitte H T | | 0，，05： | 1 |
| 6 | Liver Stiffness Measurement in Children Using FibroScan: Feasibility Study and Comparison With Fibrotest, Aspartate Transaminase to Platelets Ratio Index, and Liver Biopsy显示文摘 | Victor de Lédinghen Brigitte Le Bail Laurent Rebouissoux Céline Fournier Juliette Foucher Véronique Miette Laurent Castéra Laurent Sandrin Wassil Merrouche Frédéric Lavrand Thierry Lamireau | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，4： | 1 |
| 7 | Role of the host cell cycle in theAgrobacterium-mediated genetic transformation ofPetunia: Evidence of an S-phase control mechanism for T-DNA transfer显示文摘 | Estelle Villemont Frédéric Dubois Rajbir S. Sangwan Gérard Vasseur Yvan Bourgeois Brigitte S. Sangwan-Norreel | 1997 | Planta1997，，2： | 1 |
| 8 | Temperature and photoperiod effects on ovarian maturation and eggs laying of the crayfish, Orconectes limosus显示文摘 | Brigitte P | 1992 | Aquac1992，102，12： | 1 |
| 9 | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase显示文摘 | RALF T TANJA S BRIGITTE D | 2004 | Nature2004，432，7013： | 1 |
| 10 | Factors influencing transformation frequency of tomato (Lycopersicon esculentum)显示文摘 | Jeroen S C Brigitte D Leo S M | 1993 | Plant cell rep1993，12，： | 1 |
| 11 | Comparison of the LCx human immunodeficiency virus (HIV) RNA quantitative, RealTime HIV, and COBAS AmpliPrep-COBAS Taq- Man assays for quantitation of HIV type 1 RNA in plasma显示文摘 | Vincent F Brigitte M Marie-Noelle D | 2006 | J Clin Microhiol2006，44，8： | 1 |
| 12 | Surgical excision vs Mohs’ micrographic surgery for basal-cell carcinoma of the face: randomised controlled trial显示文摘 | Nicole WJ Smeets Gertruud AM Krekels Judith U Ostertag Brigitte AB Essers Carmen D Dirksen Fred HM Nieman HA Martino Neumann | 2004 | The Lancet2004，，9447： | 1 |
| 13 | Molecular genetic analysis of chalcone synthase in Lycopersicon esculentum and an anthocyanin-deficient mutant显示文摘 | Sharman D O Yusen T Brigitte S | 1990 | Mol Gen Genet1990，224，： | 1 |
| 14 | NOD2/CARD15 gene polymorphisms in Crohn’s disease: a genotype–phenotype analysis显示文摘 | Denis Heresbach Véronique Gicquel-Douabin Brigitte Birebent Pierre-Nicolas D’halluin Nathalie Heresbach-Le Berre Stéphane Dreano Laurent Siproudhis Alain Dabadie Michel Gosselin Jean Mosser Gilbert Semana Jean-Fran?ois Bretagne Jacqueline Yaouanq | 2004 | European Journal of Gastroenterology & Hepatology2004，，1： | 1 |
| 15 | Potential antitumor agents:Flavones and their derivatives from Linaria reflexa Desf 显示文摘 | ROSA T BRIGITTE D MONICA R L | 2005 | Bioorg & Med Chem Lett2005，15，21： | 1 |
| 16 | Direct evidence for ribonucleolytic activity of a PR-10-like protein from white lupin roots显示文摘 | Brigitte Bantignies Jacynthe Séguin Ingrid Muzac Fabienne Dédaldéchamp Patrick Gulick Ragai Ibrahim | | 0，2000，： | 1 |
| 17 | Innovation and network structural dynamics study of the alliance network of a ma jor sector of the biotechnology显示文摘 | BRIGITTE G BERNARD D | 2005 | Research Policy2005，34，10： | 1 |
| 18 | Determination of levamisole and thiabendazole in meat by HPLC and photodiode array detection显示文摘 | Brigitte W B Jean - Marie D Hedwig B | 1991 | Z Lebensm Unters Forsch1991，193，： | 1 |
| 19 | Prognostic Factors and Longterm Survival after Hepatic Resection for Hepatocellular Carcinoma Originating from Noncirrhotic Liver显示文摘 | Christophe Laurent Jean Frédéric Blanc Steeve Nobili Antonio Sa Cunha Brigitte le Bail Paulette Bioulac-Sage Charles Balabaud Maylis Capdepont Jean Saric | 2005 | Journal of the American College of Surgeons2005，，5： | 1 |
| 20 | Comparison of Five Commercial Enzyme-Linked Immunosorbent Assays for Detection of Antibodies to Bordetella pertussis显示文摘 | Marion R Brigitte D | 2000 | Clin Diagn Lab Immunol2000，7，3： | 1 |
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