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| 1 | 2018美国卒中协会/美国心脏协会急性缺血性卒中患者早期管理指南显示文摘2013年《急性缺血性卒中患者早期管理指南》发表后,高质量的新证据使急性缺血性卒中(acute ischemic stroke,AIS)患者的循证治疗发生重大变化。2013年以来,在美国心脏协会(American Heart Association,AHA)重点关注的与AIS患者管理相关专题的更新、指南及科学声明中,已经整合了这些证据。 | Powers WJ Rabinstein AA Ackerson T 车睿雯 高瑜 吉康祥 吉训明 蒋芳 李传辉 李芳芳 刘宇嘉 吕彦锋 马红蕊 任明 魏文静 王彬成 吴川杰 吴隆飞 喻琬童 张莉 | 2018 | 中国脑血管病杂志2018,15,3: | 953 |
| 2 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020,28,3: | 516 |
| 3 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病源性轻度认知障碍诊断标准推荐显示文摘美国国立老化研究所(NIA)和阿尔茨海默病协会(ADA)组织了一个工作组,负责阿尔茨海默病(AD)痴呆前症状阶段——即本文所称的AD源性轻度认知障碍(MCI)的诊断标准的制订及完善。该工作组制订了以下两套标准:(1)在缺乏相应条件进行先进影像技术及脑脊液检查时,医务人员适用的核心临床标准;(2)适用于包括临床试验在内的科学研究的研究标准。后者纳入了基于影像技术及脑脊液检查的生物标志物的应用。并根据所出现的生物标志物的性质,将最终MCI诊断的确定性程度分为4个级别。而要使生物标志物有效应用于诊断,并在社区医疗服务中规范使用,尚需做大量的工作。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly JJ Mayeux R Mohs RC Morris JC Rossor MN Schehens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽黄(译) 礼媛(译) | 2012 | 中华神经科杂志2012,45,5: | 51 |
| 4 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病痴呆诊断标准的推荐显示文摘由美国国立老化研究所(NIA)和阿尔茨海默病(AD)协会组织了一个工作组,负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性,既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用,也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准,保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上,工作组对临床诊断标准做了一些修改,保留了“可能的AD痴呆”的术语,但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础,但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断,还有许多工作摆在面前。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽(译) 韩阅(译) | 2012 | 中华神经科杂志2012,45,5: | 52 |
| 5 | 2018美国卒中协会/美国心脏协会急性缺血性卒中患者早期管理指南显示文摘(接第3期)3一般性支持治疗和急诊处理3.1气道、呼吸和氧饱和3.1.1急性卒中并发意识障碍及延髓性麻痹影响气道功能者,建议进行气道支持及辅助通气。推荐等级Ⅰ,证据水平C-EO,同2013版AIS指南。3.1.2建议补充氧气以保持氧饱和度>94%。推荐等级Ⅰ,证据水平C-LD,同2013版AIS指南。3.1.3 AIS患者无低氧表现不建议补充氧气。 | Powers WJ Rabinstein AA Ackerson T 车睿雯 高瑜 吉康祥 吉训明 蒋芳 李传辉 李芳芳 刘宇嘉 吕彦锋 马红蕊 任明 魏文静 王彬成 吴川杰 吴隆飞 喻琬童 张莉 | 2018 | 中国脑血管病杂志2018,15,4: | 55 |
| 6 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003,5,1: | 38 |
| 7 | 《过敏性鼻炎及其对哮喘的影响(ARIA)》指南2019版过敏性鼻炎管理路径(中国版)显示文摘2018年12月3日,慢性疾病管理大会在巴黎召开,经过与会的过敏科学及气道疾病领域的专家和患者组织讨论,针对未来鼻炎和哮喘的管理,推荐采用真实世界综合管理路径评估系统,旨在实现数字化、综合化、以人为本的管理。本文是该文件的摘要版,其中也介绍了中国过敏性鼻炎和哮喘的流行状况以及《过敏性鼻炎及其对哮喘的影响》(ARIA)在中国应用的具体情况。 | Bachert C Fokkens WJ Haahtela T Hellings PH Klimek L Papadopoulos N Pham-Thi N PfaarO Valiulis A Ventura MT Onorato G Czarlewski W Bedbrook A Bousquet J 王向东(编译) 王成硕(编译) 郑铭(编译) 杜崑(编译) 张罗(编译) | 2019 | 中国耳鼻咽喉头颈外科2019,26,12: | 23 |
| 8 | Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi显示文摘BACKGROUND:Many Chinese herbs,especially herbal injections,have been shown to have anti-tumor effects in recent years.However,since most reports focus on the clinical effectiveness of these herbs,their mechanisms of action are not well understood.In this study,we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis,SC),and monitored the expression of Bcl-2 and caspase-8.METHODS:Injectable SC was applied to HepG2 cells at different concentrations and the cells were collected 12,24 and 48 hours later.5-fluorouracil was used as a positive control group,and fluorescence-activated cell-sorting cytometry was used to measure the apoptosis rate of HepG2 cells and the expression of Bcl-2 and caspase-8 proteins.RESULTS:SC induced apoptosis in HepG2 cells in a concentration and time-dependent manner,and the expression of caspase-8 was elevated and prolonged.However,it did not significantly influence the expression of Bcl-2.CONCLUSION:Injectable SC may induce apoptosis in HCC cells by regulating the expression of caspase-8. | Department of General Surgery (Lu Y and Zhang BY),Department of Bio-Information (Jia ZX),Affiliated Medical College Hospital,Qingdao University,Qingdao 266003,China Shanghai Jiaotong University School of Medicine,Shanghai 200025,China (Wu WJ) Department of Medicine,Heze Medical College,Heze 274000,China (Lu ZQ) | 2011 | Hepatobiliary & Pancreatic Diseases International2011,10,3: | 17 |
| 9 | 中国与西方国家的生态工程比较显示文摘生态工程正在世界上很多国家发展,但在中国与西方产生和发展的历史背景、社会、经济及当前科技水平有所不同,故在研究和应用目的、理论基础与发展现状、研究与应用对象、设计原则、技术路线、能源、生物多样性、价值等方面各有特点。为了取长补短、相互学习,以期推动生态工程在全球发展,本文比较了这些特点。 | 颜京松 Mits.,WJ | 1994 | 农村生态环境1994,10,1: | 15 |
| 10 | 美国心脏协会/美国卒中协会急性缺血性卒中血管内治疗早期管理指南(2015年版)显示文摘自"急性缺血性卒中早期管理指南2013年版"发布以来,出现了大量关于急性缺血性卒中血管内治疗的高质量证据[1]。本版更新的指南主要基于2013年以来8项血管内治疗随机临床试验和其他相关数据的分析结果,同时兼顾了2013年指南的证据,并非对上版指南后的文献作全面回顾,而是依据最新的证据作出推荐。本指南与既往指南的重叠部分,以本指南的推荐为准。 | Powers WJ Derdeyn CP Biller J 吴川杰 薛芳 焦力群 朱凤水 | 2015 | 中国脑血管病杂志2015,12,10: | 11 |
| 11 | Isolation and Structure Elucidation of Autolytimycin, A New Compound Produced by Streptomyces Autolyticus JX-47显示文摘Autolytimycin 1 was isolated from the culture filtrate of Streptomyces autolyticus JX-47, together with two known compounds, lebstatin 2 and 17-O-demethyl-geldanamycin 3. These compounds showed the activities of anti-HSV-I. The structure of 1 was determined by spectral analysis. | Li, MG Wu, SH Zhao, LX Zhang, Q Li, WJ Cui, XL Xu, LH Wu, DG Jiang, CL | 2001 | Chinese Chemical Letters2001,12,10: | 10 |
| 12 | 乳腺叶状肿瘤中CD117的表达与不利的病理学参数和患者的低生存率相关(英)显示文摘CD117(C—kit)是由KIT基因编码的Ⅲ型酪氨酸激酶受体,其表达异常与基因突变和多种肿瘤相关。有关CD117在叶状肿瘤中的表达一直存在争议。作者旨在研究叶状肿瘤中CD117的表达与KIT基因的突变情况,及其与病理学参数和临床转归的相关性。本研究共272例,在组织芯片上利用免疫组化研究了CD117的表达,用甲苯胺蓝染色来标示肥大细胞。 | Tan WJ 魏建国 | 2015 | 诊断病理学杂志2015,22,6: | 9 |
| 13 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011,30,1: | 8 |
| 14 | 性传播疾病的流行病学及预防显示文摘在美国,每年约有1200万性传播疾病患者,其中淋病约140万,梅毒13万,衣原体感染400万,人类乳头瘤病毒感染50~100万,生殖器疱疹20~50万,艾滋病45000例。应慎重看待这组数字,因为很多性传播疾病未予报告,许多不易诊断,还有许多无症状或症状不明显者。控制性传播疾病只能通过医务人员坚持不懈地努力,去认识,治疗性传播疾病以及在预防性传播疾病的传播中常规咨询病人才能实现。 | Kassler WJ 骆丹 | 1994 | 国外医学(皮肤性病学分册)1994,20,2: | 8 |
| 15 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013,11,1: | 8 |
| 16 | 骨折相关性感染定义的共识显示文摘骨折相关性感染(fracture related infection,FRI)是创伤骨科一种常见的严重并发症.迄今为止,尚无明确定义,因此很难对该并发症带来的影响进行准确评估和对现有的研究展开比较.为解决这一难题,在AO基金会的支持下,我们成立了一个由科学家和医学专家组成的专家组,旨在对FRI定义达成的共识. | Metsemakers WJ Morgenstern M McNally MA Moriarty TF McFadyen I Scarborough M Athanasou NA Ochsner PE Kuehl R Raschke M Borens O 谢肇 Velkes S Hungerer S Kates SL Zalavras C Giannoudis PV Richard RG Verhofstad MH 喻胜鹏 孙东 汪小华 | 2018 | 中华骨科杂志2018,38,9: | 8 |
| 17 | 2018美国卒中协会/美国心脏协会急性缺血性卒中患者早期管理指南显示文摘3.7机械取栓,3.7.1符合阿替普酶静脉溶栓指征的患者应接受阿替普酶静脉溶栓治疗,即使正在考虑血管内治疗。推荐等级Ⅰ,证据水平A,改写自2015版血管内治疗指南。 | 车睿雯(译) 高瑜(译) 吉康祥(译) 蒋芳(译) 李芳芳(译) 刘宇嘉(译) 吕彦锋(译) 马红蕊(译) 任明(译) 魏文静(译) 王彬成(译) 吴川杰(译) 吴隆飞(译) 喻琬童(译) 张莉(译) 吉训明(译) 李传辉(译) Powers WJ Rabinstein AA Ackerson T | 2018 | 中国脑血管病杂志2018,15,5: | 5 |
| 18 | BOUNDARY ELEMENT APPROXIMATION OF STEKLOV EIGENVALUE PROBLEM FOR HELMHOLTZ EQUATION显示文摘Steklov eigenvalue problem of Helmholtz equation is considered in the present paper. Steklov eigenvalue problem is reduced to a new variational formula on the boundary of a given domain, in which the self-adjoint property of the original differential operator is kept and the calculating of hyper-singular integral is avoided. A numerical example showing the efficiency of this method and an optimal error estimate are given. | Tang, WJ Guan, Z Han, HD | 1998 | Journal of Computational Mathematics1998,16,2: | 5 |
| 19 | 自我血压监测对轻中度高血压患者治疗依从性的影响显示文摘 | 张玲玉 叶鹏 van Onzenoort HA Verberk WJ Kroon AA | 2010 | 中华高血压杂志2010,18,8: | 5 |
| 20 | Giant magneto-impedance effects in nanocrystalline soft magnetic alloy ribbons显示文摘SINCE the discovery of the giant magneto-impedance (GMI) effects in amorphous wire (or rib-bon) of CoFeSiB and nanocrystalline wire (or film) of FeCuNbSiB, it has attracted greatattention due to its promising potential applications in industry. Amorphous (and nanocrys-talline) soft magnetic alloys have very large magnetic permeability, when an ac driving currentand an external magnetic field (EMF) are applied, the EMF will damp the magnetic fluxchange caused by the ac driving current, thus the magnetic permeability will decrease; as a re- | Ku, WJ Ge, FD Yan, G Wang, XY Zhu, J | 1997 | Chinese Science Bulletin1997,42,12: | 5 |