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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Requirement for IGF-I in Epidermal Growth Factor-Mediated Cell Cycle Progression of Mammary Epithelial Cells显示文摘 | MALINDA A S MONICA M R AIMEE V L | 2002 | Endocrinology2002，143，5： | 1 |
| 3 | The Insulin-Like Growth Factors (IGFs) and IGF binding proteins in postnatal development of murine mammary glands显示文摘 | TERESA L W MONICA M R MALINDA A S | 2000 | Journal of Mammary Gland Biology and Neoplasia2000，5，1： | 1 |
| 4 | The Insulin-Like Growth Factors (IGF) and IGF type Ⅰ receptor during postnatal growth of the murine mammary gland: sites of messenger ribonucleic acid expression and potential functions显示文摘 | MONICA M R TERESA L W | 1999 | Endocrinology1999，140，1： | 1 |
| 5 | Pyrene degradation by yeasts and filamentous fungi显示文摘 | Cristina R M Monica L S Cecilia C M | 2002 | Environmental Pollution2002，117，： | 1 |
| 6 | Effect of human chorionic gonadctrophin supplementation during different culture periods on in viro maturation of canine oocytes显示文摘 | Monica D R Johanna D L Pedro M | 2005 | Theriogenology2005，64，： | 1 |
| 7 | Visual performance result after Tetraftex accommodating intraocular lens implantation 显示文摘 | Donald R Monica L | 2007 | Ophthalmology2007，114，： | 1 |
| 8 | Potential antitumor agents:Flavones and their derivatives from Linaria reflexa Desf 显示文摘 | ROSA T BRIGITTE D MONICA R L | 2005 | Bioorg & Med Chem Lett2005，15，21： | 1 |
| 9 | Management of papillary breast lesions diagnosed on core-needle biopsy: Clinical pathologic and radiologic analysis of 276 cases with surgical follow-up 显示文摘 | Monica R Jared L Michael C | 2012 | J Am Coil Surg2012，1，： | 1 |
| 10 | An Atlas of Mouse Mammary Gland Development 显示文摘 | MONICA M R KATHRYN L S | 2000 | J Mammary Gland Biol Neoplasia2000，5，2： | 1 |
| 11 | Pyrene degradation by yeasts and filamentous fungi显示文摘 | Cristina R M Monica L S Cecilia C M | 2002 | Environ Pollut2002，117，： | 1 |
| 12 | Multiplex Lateral-Flow Test Strips Fabricated by Two-Dimensional Shaping 显示文摘 | Erin M F Monica R M Gabriel P L | 2009 | Applied Materials and Interfaces2009，1，1： | 1 |
| 13 | Host adaptation and host–parasite co-evolution in Cryptosporidium : implications for taxonomy and public health显示文摘 | Lihua Xiao Irshad M Sulaiman Una M Ryan Ling Zhou Edward R Atwill Monica L Tischler Xichen Zhang Ronald Fayer Altaf A Lal | 2002 | International Journal for Parasitology2002，，14： | 1 |
| 14 | Pyrene degradation by yeasts and filamentous fungi显示文摘 | CRISTINA R M MONICA L S CECILIA C M | 2002 | Environmental Pollution2002，117，： | 1 |
| 15 | Chemotherapy and operation for invasive thymoma显示文摘 | Federico R Francesco S Monica L | 1993 | J Thorac Cardiovasc Surg1993，106，3： | 1 |
| 16 | Structural and magnetic properties of NiZn ferrites prepared by microwave sintering 显示文摘 | Monica Sorescu Diamandeseu L Peelamedu R | 2004 | Journal of Magnetism and Magnetic Materials2004，279，23： | 1 |
| 17 | Quantifying Self-Report Measures’ Overestimation of Mobility Scores Postarthroplasty/Invited Commentary/Invited Commentary/Author Response显示文摘 | Stratford Paul W Kennedy Deborah M Maly Monica R MacIntyre Norma J Mizner Ryan L Pua Yong Hao Bennell Kim L | 2010 | Physical Therapy2010，，9： | 1 |
| 18 | Relationship between volatile components of citrus fruit essential oils and anticrobial action of Penicillium digitatum and penicillium italicum显示文摘 | Duccio R L Caccioni Monica Guizzardi | 1998 | International Journal of Food Microbiology1998，43，： | 1 |
| 19 | Production of lipids and docosahexasaenoic acid ( DHA ) by a native Thraus- tochytrium strain 显示文摘 | CAROLINA S ALLISON L MONICA R | 2013 | European Journal of Lipid Science and Technology2013，115，8： | 1 |
| 20 | Adoption of PERILIPIN as a unif-ying nomenclature for the mammalian PAT-family ofintracellular lipid storage droplet proteins显示文摘 | Alan R Kimmel Dawn L Brasaemle Monica McAn-drews-Hill | 2010 | TheJournal of Lipid Research2010，51，： | 1 |
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