| 9 | eUREkA! T cells answer nature’s call显示文摘Nitrogen is critical for cell growth, proliferation, and function. Amino acid (AA) catabolism is a major source of intracellular nitrogen for biosynthesis but also generates the nitrogen-containing molecule ammonia (NH3+), which can accumulate to toxic levels in a cell if not exported to the circulation and detoxified by the urea cycle in the liver. In a recent paper in Nature Immunology, Tang et al. [1] discovered a functional urea cycle in memory T cells, which metabolizes ammonia, prevents its toxic accumulation. | Beth Kelly Erika L.Pearce | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
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