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| 1 | Long-term antifibrotic action of interferon-γ treatment in patients with chronic hepatitis B virus infection显示文摘BACKGROUND:The first priority in treating fibrosis is to eliminate the causes that result in liver injury,e.g.,hepatitis B and C virus.However,in many liver diseases the cause is either unknown or untreatable.The present study was designed to investigate the long-term antifibrotic effect of interferon-gamma(IFN-γ)treatment in patients chronically infected with hepatitis B virus. METHODS:A total of 42 patients,30 treated with IFN-γand 12 controls,were enrolled from an original clinical trial(Clin Gastroenterol Hepatol 2005;3:819.).Three serial liver biopsies that were obtained at the initiation and end of IFN-γtreatment as well as 4 to 6 years after treatment discontinuation were assessed according to the modified Chevallier scoring system. RESULTS:Twenty-five out of 30 IFN-γ-treated patients were followed up until 4 to 6 years after the treatment was stopped. However,all controls were excluded from follow-up due to death,loss and elevated virus level within 2 years.Twenty-five IFN-γ-treated patients had stable serum liver function and liver fibrosis indices without any further antiviral or anti-fibrotic treatment.Improved inflammatory and fibrotic scores were found after nine months of IFN-γtreatment according to the modified Chevallier scoring system(inflammation:11.8±6.5 at the beginning of IFN-γtreatment vs.9.2±4.1 after 9 months, P<0.05;fibrosis:15.0±7.3 at baseline vs.12.6±6.8 after 9 months, P<0.05).Among them,14 patients accepted a third serial liver biopsy 4 to 6 years after treatment discontinuation,and the fibrotic score was increased(14.2±8.3 vs.11.9±7.6 after 9 months, P<0.05). CONCLUSIONS:Nine-month IFN-γtreatment significantly improves the fibrosis score in patients with chronic HBV infection.The majority of patients demonstrate stable serum biochemical indices and quality of life.However,they do not show a long-term benefit according to histological criteria. Given the limited sample size,long-term IFN-γtreatment regimens should be assessed in further clinical trials. | Peter R Mertens Steven Dooley | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 6 |
| 2 | Wilson’s disease显示文摘 | Aftab Ala Ann P Walker Keyoumars Ashkan James S Dooley Michael L Schilsky | 2007 | The Lancet . 2007 (9559)2007，，9559： | 3 |
| 3 | Mycoplasma pneumoniae infection in a pediatric population: Analysis of soluble immune markers as risk factors for asthma显示文摘 | Jaythoon Hassan Fiona Irwin Seamus Dooley Jeff Connell | 2008 | Human Immunology2008，，12： | 3 |
| 4 | A comparative study of the chemical kinetic characteristics of small methyl esters in diffusion flame extinction显示文摘 | Pascal Diévart Sang Hee Won Jing Gong Stephen Dooley Yiguang Ju | 2013 | Proceedings of the Combustion Institute2013，，1： | 2 |
| 5 | A kinetic model for methyl decanoate combustion显示文摘 | Pascal Diévart Sang Hee Won Stephen Dooley Frederick L. Dryer Yiguang Ju | 2012 | Combustion and Flame2012，，5： | 2 |
| 6 | Transmission of the U.S. subprime crisis to emerging markets: Evidence on the decoupling–recoupling hypothesis显示文摘 | Michael Dooley Michael Hutchison | 2009 | Journal of International Money and Finance2009，，8： | 2 |
| 7 | Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage显示文摘 | Steven Dooley Jafar Hamzavi Loredana Ciuclan Patricio Godoy Iryna Ilkavets Sabrina Ehnert Elke Ueberham Rolf Gebhardt Stephan Kanzler Andreas Geier Katja Breitkopf Honglei Weng Peter R. Mertens | 2008 | Gastroenterology2008，，2： | 2 |
| 8 | Multicenter analysis of soluble A xl reveals diagnostic value for very early stage hepatocellular carcinoma显示文摘 | Patrick Reichl Meng Fang Patrick Starlinger Katharina Staufer Rudolf Nenutil Petr Muller Kristina Greplova Dalibor Valik Steven Dooley Christine Brostjan Thomas Gruenberger Jiayun Shen Kwan Man Michael Trauner Jun Yu Chun Fang Gao Wolfgang Mikulits | 2015 | Int. J. Cancer2015，，2： | 2 |
| 9 | The cryogenic nitrogen automotive engine 显示文摘 | Dooley J Hammond R P | 1984 | Mechanical Engineering1984，，： | 1 |
| 10 | Changes in intraocular pressure and anterior segment morphometry after uneventful phacoemulsification cataract surgery 显示文摘 | Dooley I Charalampidou S Malik A | 2010 | Eye (Lond)2010，24，4： | 1 |
| 11 | A genetic fuzzy rule based image segmentation algorithm 显示文摘 | G C Karmakar L S Dooley | 2002 | Pattern Recognition Letters2002，23，10： | 1 |
| 12 | Knowledge Sharing in a Collaborative Networked Environment显示文摘 | Cormican Kathryn Dooley Lawrence | 2007 | Journal of Information & Knowledge Management2007，，6： | 1 |
| 13 | The Entrepreneurial University: Examining the UnderlayingAcademic Tensions显示文摘 | PHILPOTT K DOOLEY L O'REILLY C LUPTONG | 2011 | Technovation2011，31，1： | 1 |
| 14 | Prenatal care : touching the future 显示文摘 | Dooley EK Ringler RL Jr | 2012 | Prim Care2012，39，1： | 1 |
| 15 | Modulation of K+-induce synapto- somal calcium influx by gabapentin显示文摘 | Meder WP Dooley DJ | 2000 | Brain Research2000，875，12： | 1 |
| 16 | Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis显示文摘 | Dooley M A Jayne D Ginzler E M | 2011 | N Engl J Med2011，365，20： | 1 |
| 17 | Ca2+ channel alpha2delta ligands : novel modulators of neurotransmission 显示文摘 | Dooley D J Taylor C P Donevan S | 2007 | Trends Pharma- col Sci2007，28，2： | 1 |
| 18 | Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis 显示文摘 | Appel GB Contreras G Dooley MA | 2009 | J Am Soc Nephrol2009，20，5： | 1 |
| 19 | Networked creativity: a struc- tured management framework for stimulating innovation 显示文摘 | BRENNAN A DOOLEY L | 2005 | Technovation2005，25，12： | 1 |
| 20 | Attaining Decision Quality and Commitment from Dissent:The Moderating Effects of Loyalty and Competence in Strategic Decision Making Teams显示文摘 | Dooley R S Fryxell G E | 1999 | Academy of Management Journal1999，42，4： | 1 |
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