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| 1 | The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation显示文摘 | Vidisha Tripathi Jonathan D. Ellis Zhen Shen David Y. Song Qun Pan Andrew T. Watt Susan M. Freier C. Frank Bennett Alok Sharma Paula A. Bubulya Benjamin J. Blencowe Supriya G. Prasanth Kannanganattu V. Prasanth | 2010 | Molecular Cell2010，，6： | 4 |
| 2 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 3 | Further extension of the opine concept: Plasmids in Agrobacterium rhizogenes cooperate for opine degradation显示文摘 | Annik Petit Chantal David Gary A. Dahl Jeffrey G. Ellis Pierre Guyon Francine Casse-Delbart Jacques Tempé | 1983 | MGG Molecular & General Genetics1983，，2： | 3 |
| 4 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance显示文摘 | James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Ellis W.T. Wong Fumin Chang Brian Lehmann David M. Terrian Michele Milella Agostino Tafuri Franca Stivala Massimo Libra Jorg Basecke Camilla Evangelisti Alberto M. Martelli Richard | 2006 | BBA - Molecular Cell Research2006，，8： | 3 |
| 5 | Modelling the information seeking patterns of engineers and research scientists in an industrial environment显示文摘 | David Ellis Merete Haugan | 1997 | Journal of Documentation1997，，4： | 2 |
| 6 | The utility of immunohistochemical detection of DNA mismatch repair gene proteins显示文摘 | Jinru Shia Nathan A. Ellis David S. Klimstra | 2004 | Virchows Archiv2004，，5： | 2 |
| 7 | Plants, selenium and human health显示文摘 | Danielle R Ellis David E Salt | 2003 | Current Opinion in Plant Biology2003，，3： | 2 |
| 8 | Two-Year Outcomes After Sirolimus-Eluting Stent Implantation显示文摘 | Giora Weisz Martin B. Leon David R. Holmes Dean J. Kereiakes Mel R. Clark Barry M. Cohen Stephen G. Ellis Patrick Coleman Carolyn Hill Chunxue Shi Donald E. Cutlip Richard E. Kuntz Jeffrey W. Moses | 2006 | Journal of the American College of Cardiology2006，，7： | 2 |
| 9 | One-Year Clinical Results With the Slow-Release, Polymer-Based, Paclitaxel-Eluting TAXUS Stent: The TAXUS-IV Trial显示文摘 | Gregg W. Stone Stephen G. Ellis David A. Cox James Hermiller Charles O’Shaughnessy James Tift Mann Mark Turco Ronald Caputo Patrick Bergin Joel Greenberg Jeffrey J. Popma Mary E. Russell | 2004 | Circulation: Journal of the American Heart Association2004，，16： | 2 |
| 10 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 11 | High-Dose Split-Course Radiation Therapy for Anal Cancer: Outcome Analysis Regarding the Boost Strategy (CORS-03 Study)显示文摘 | Jean-Michel Hannoun-Levi Cécile Ortholan Michel Resbeut Eric Teissier Philippe Ronchin Didier Cowen Audrey Zaccariotto Karen Bénézery Eric Fran?ois Naji Salem Steve Ellis David Azria Jean-Pierre Gerard | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 12 | Involvement of Matrix metalloproteinases and down-regulation by tumor necrosis factor α blockade in spondylarthropathy显示文摘 | Bernard V Elli K David TY | 2004 | Arthritis Rheum2004，50，： | 1 |
| 13 | Coronary Heart Disease/Thrombosis/Myocardial-Infarction: Marked Inflammatory Sequelae to Implantation of Biodegradable and Nonbiodegradable Polymers in Porcine Coronary Arteries显示文摘 | Willem J. van der Giessen A. Michael Lincoff Robert S. Schwartz Heleen M.M. van Beusekom Patrick W. Serruys David R. Jr Holmes Stephen G. Ellis Eric J. Topol | 1996 | Circulation1996，，7： | 1 |
| 14 | Comparison of GRCop-84 to Other Cu Alloys with High Thermal Conductivities显示文摘 | Henry C. Groh David L. Ellis William S. Loewenthal | 2008 | Journal of Materials Engineering and Performance2008，，4： | 1 |
| 15 | Plants, selenium and hu- man health显示文摘 | Danielle R Ellis David E Salt | 2003 | Current Opinion in Plant Biology2003，6，3： | 1 |
| 16 | Natriuretic peptides 显示文摘 | Ellis R David G Samson WK | 1998 | N Engl J Med1998，339，5： | 1 |
| 17 | Comparison of the patterns of codon usage and bias betweenBrugia, Echinococcus, Onchocerca andSchistosoma species显示文摘 | John Ellis David A. Morrison Bernd Kalinna | 1995 | Parasitology Research1995，，5： | 1 |
| 18 | Cryosurgery as primary treatment for localized prostate cancer 显示文摘 | David S Ellis | 2002 | Urol2002，60，12： | 1 |
| 19 | CRC Surgery Trends in Kenya, 1993–2005显示文摘 | Hassan Saidi Elly O. Nyaim Joseph W. Githaiga David Karuri | 2008 | World Journal of Surgery2008，，2： | 1 |
| 20 | Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression显示文摘 | Michael C. Schmid Christie J. Avraamides Holly C. Dippold Irene Franco Philippe Foubert Lesley G. Ellies Lissette M. Acevedo Joan R.E. Manglicmot Xiaodan Song Wolfgang Wrasidlo Sara L. Blair Mark H. Ginsberg David A. Cheresh Emilio Hirsch Seth J. Field Ju | 2011 | Cancer Cell2011，，6： | 1 |
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