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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | Interstitial cells of Cajal in the gut-A gastroenterologist’s point of view显示文摘Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specifi c treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, infantile hypertrophic pyloric stenosis, chronic intestinal pseudoobstruction and slow transit constipation. Moreover we discuss the role of the Cajal cells in the development of stromal tumors of the gastrointestinal tract. | Lucian M Negreanu Philippe Assor Bogdan Mateescu Catalin Cirstoiu | 2008 | World Journal of Gastroenterology2008，14，41： | 27 |
| 3 | Noninvasive investigations for non alcoholic fatty liver disease and liver fi brosis显示文摘Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of diseases that have insulin resistance in common and are associated with metabolic conditions such as obesity, type 2 diabetes mellitus, and dyslipidemia. NAFLD ranges from simple liver steatosis, which follows a benign course, to nonalcoholic steatohepatitis (NASH), a more severe entity, with necroinflmmation and f ibrosis, which can progress to cryptogenic cirrhosis and end-stage liver disease. Liver biopsy remains the gold standard for evaluating the degree of hepatic necroinflammation and f ibrosis; however, several noninvasive investigations, such as serum biomarkers, have been developed to establish the diagnosis and also to evaluate treatment response. These markers are currently neither available in all centers nor validated in extensive studies. Examples include high-sensitivity C reactive protein and plasma pentraxin 3, which are associated with extensive liver f ibrosis in NASH. Interleukin-6 correlates with inflammation, and cytokeratin-18 represents a marker of hepatocyte apoptosis (prominent in NASH and absent in simple steatosis). Tissue polypep-tide specif ic antigen seems to have a clinical utility in the follow-up of obese patients with NASH. | Carmen Fierbinteanu-Braticevici Ion Dina Ana Petrisor Laura Tribus Lucian Negreanu Catalin Carstoiu | 2010 | World Journal of Gastroenterology2010，16，38： | 21 |
| 4 | Metabolic syndrome and risk of subsequent colorectal cancer显示文摘The metabolic syndrome and visceral obesity have anincreasing prevalence and incidence in the generalpopulation. The actual prevalence of the metabolicsyndrome is 24% in US population and between24.6% and 30.9% in Europe. As demonstrated by many clinical trials (NAHANES , INTERHART) the metabolic syndrome is associated with an increased risk of both diabetes and cardiovascular disease. In addition to cardiovascular disease, individual components of the metabolic syndrome have been linked to the development of cancer, particularly to colorectal cancer. Colorectal cancer is an important public health problem; in the year 2000 there was an estimated total of 944 717 incident cases of colorectal cancer diagnosed world-wide. This association is sustained by many epidemiological studies. Recent reports suggest that individuals with metabolic syndrome have a higher risk of colon or rectal cancer. Moreover, the clusters of metabolic syndrome components increase the risk of associated cancer. The physiopathological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. Population and experimental studies demonstrated that hyperinsulinemia, elevated C-peptide, elevated body mass index, high levels of insulin growth factor-1, low levels of insulin growth factor binding protein-3, high leptin levels and low adiponectin levels are all involved in carcinogenesis. Understanding the pathological mechanism that links metabolic syndrome and its components to carcinogenesis has a major clinical signifi cance and may have profound health benefi ts on a number of diseases including cancer, which represents a major cause of mortality and morbidity in our societies. | Raluca Pais Horatiu Silaghi Alina Cristina Silaghi Mihai Lucian Rusu Dan Lucian Dumitrascu | 2009 | World Journal of Gastroenterology2009，15，41： | 16 |
| 5 | Atrial fibrillation in patients with gastroesophageal reflux disease: A comprehensive review显示文摘AIM:To analyze the potential relationship between gastroesophageal reflux disease(GERD)and the development of atrial fibrillation(AF).METHODS:Using the key words'atrial fibrillation and gastroesophageal reflux','atrial fibrillation and esophagitis,peptic','atrial fibrillation and hernia,hiatal'the PubMed,EMBASE,Cochrane Library,OVIDSP,WILEY databases were screened for relevant publications on GERD and AF in adults between January 1972-December 2013.Studies written in languages other than English or French,studies not performed in humans,reviews,case reports,abstracts,conference presentations,letters to the editor,editorials,comments and opinions were not taken into consideration.Articles treating the subject of radiofrequency ablation of AF and the consecutive development of GERD were also excluded.RESULTS:Two thousand one hundred sixty-one titles were found of which 8 articles met the inclusion criteria.The presence of AF in patients with GERD was reported to be between 0.62%-14%,higher compared to those without GERD.Epidemiological data provided by these observational studies showed that patients with GERD,especially those with more severe GERD-related symptoms,had an increased risk of developing AF compared with those without GERD,but a causal relationship between GERD and AF could not be established based on these studies.The mechanisms of AF as a consequence of GERD remain largely unknown,with inflammation and vagal stimulation playing a possible role in the development of these disorders.Treatment with proton pomp inhibitors may improve symptoms related to AF and facilitate conversion to sinus rhythm.CONCLUSION:Although links between AF and GERD exist,large randomized clinical studies are required for a better understanding of the relationship between these two entities. | Crina Roman Stanislas Bruley des Varannes Lucian Muresan Alina Picos Dan L Dumitrascu | 2014 | World Journal of Gastroenterology2014，20，28： | 16 |
| 6 | Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients.显示文摘A substantial proportion of patients with irritable bowel syndrome(IBS) associate their symptoms with the ingestion of specific foods. Therefore, in recent years, scientific research has increasingly focused on the role of diet in IBS and dietary management is now considered an important tool in IBS treatment. This article reviews the main dietary approaches in IBS emphasizing evidence from experimental and observational studies and summarizing the main diet and lifestyle recommendations provided by dietary guidelines and scientific literature. Despite the limited evidence for a beneficial role, general advice on healthy eating and lifestyle is recommended as the first-line approach in the dietary management of IBS. Standard recommendations include adhering to a regular meal pattern, reducing intake of insoluble fibers, alcohol, caffeine, spicy foods, and fat, as well as performing regular physical activity and ensuring a good hydration. Second-line dietary approach should be considered where IBS symptoms persist and recommendations include following a low FODMAP diet, to be delivered only by a healthcare professional with expertise in dietary management. The efficacy of this diet is supported by a growing body of evidence. In contrast, the role of lactose or gluten dietary restriction in the treatment of IBS remains subject to ongoing research with a lack of high-quality evidence. Likewise, further clinical trials are needed to conclude the efficacy of probiotics on IBS symptoms. | Anamaria Cozma-Petrut Felicia Loghin Doina Miere Dan Lucian Dumitrascu | 2017 | World Journal of Gastroenterology2017，23，21： | 16 |
| 7 | Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on proton pump inhibitors(PPIs) therapy and the risk of Clostridium difficile infection(CDI). METHODS We conducted a systematic search of MEDLINE/Pub Med and seven other databases through January 1990 to March 2017 for published studies that evaluated the association between PPIs and CDI. Adult case-control and cohort studies providing information on the association between PPI therapy and the development of CDI were included. Pooled odds ratios(ORs) estimates with 95% confidence intervals(CIs) were calculated using the random effect. Heterogeneity was assessed by I^2 test and Cochran's Q statistic.Potential publication bias was evaluated via funnel plot, and quality of studies by the Newcastle-Otawa Quality Assessment Scale(NOS). RESULTS Fifty-six studies(40 case-control and 16 cohort) involving 356683 patients met the inclusion criteria and were analyzed. Both the overall pooled estimates and subgroup analyses showed increased risk for CDI despite substantial statistical heterogeneity among studies. Meta-analysis of all studies combined showed a significant association between PPI users and the risk of CDI(pooled OR = 1.99, CI: 1.73-2.30, P < 0.001) as compared with non-users. The association remained significant in subgroup analyses: by design-case-control(OR = 2.00, CI: 1.68-2.38, P < 0.0001), and cohort(OR = 1.98, CI: 1.51-2.59, P < 0.0001); adjusted(OR = 1.95, CI: 1.67-2.27, P < 0.0001) and unadjusted(OR = 2.02, CI: 1.41-2.91, P < 0.0001); unicenter(OR = 2.18, CI: 1.72-2.75, P < 0.0001) and multicenter(OR = 1.82, CI: 1.51-2.19, P < 0.0001); age ≥ 65 years(OR = 1.93, CI: 1.40-2.68, P < 0.0001) and < 65 years(OR = 2.06, CI: 1.11-3.81, P < 0.01). No significant differences were found in subgroup analyses(test for heterogeneity): P = 0.93 for case-control vs cohort, P = 0.85 for adjusted vs unadjusted, P = 0.24 for unicenter vs multicenter, P = 0.86 for age ≥ 65 years and < 65 years. There was significant heterogeneity across studies(I^2 = 85.4%, P < 0.001) as well as evidence of publication bias(funnel plot asymmetry test, P = 0.002). CONCLUSION This meta-analysis provides further evidence that PPI use is associated with an increased risk for development of CDI. Further high-quality, prospective studies are needed to assess whether this association is causal. | Anca Trifan Carol Stanciu Irina Girleanu Oana Cristina Stoica Ana Maria Singeap Roxana Maxim Stefan Andrei Chiriac Alin Ciobica Lucian Boiculese | 2017 | World Journal of Gastroenterology2017，23，35： | 15 |
| 8 | Sulforaphane Protects Astrocytes Against Oxidative Stress and Delayed Death Caused by Oxygen and Glucose Deprivation显示文摘氧化应激是缺血再灌注后星形胶质细胞损伤和死亡的重要分子机制之一,可能成为有效的干预靶点。下述治疗策略可减轻缺血再灌注条件下产生的多种反应性氮氧化合物损伤。这种方法可通过使用化学试剂或适当条件促进转录活化因子NRF2从细胞浆转入细胞核,并与抗氧化基因反应位点结合,来诱导缺血再灌注后损伤细胞的Ⅱ期基因反应。本研究将验证如下假说:NRF2基因表达通路激活剂sulforaphane能对体外无氧无糖环境处理的培养皮质星形胶质细胞起神经保护作用。将皮质星形胶质细胞暴露于无氧无糖环境(OGD)4 h,于干预前48 h或干预后给予5μMsulforaphane(NRF2基因表达通路激活剂)培养48 h,两种培育条件下细胞死亡均明显减少。免疫细胞化学结果表明干预前给予sulforaphane处理,细胞中DNA/RNA氧化标志物8-hydroxy-2-deox-yguanosine的表达在恢复给氧4 h后降低,两种培育条件下胞浆内及胞核内NRF2的免疫反应均增强且NQO1(NRF2转录活化基因产物)的表达和酶活性均增强。本研究提示sulforaphane可通过激活NRF2抗氧化基因表达通路,减少体外缺氧再灌注后星形胶质细胞的死亡。 | CAMELIA A.DANILOV KRISH CHANDRASEKARAN JENNIFER RACZ LUCIAN SOANE CAROL ZIELKE AND GARY FISKUM | 2009 | 神经损伤与功能重建2009，4，2： | 12 |
| 9 | Real-time sono-elastography in the diagnosis of diffuse liver diseases显示文摘AIM: To analyze whether computer-enhanced dynamic analysis of elastography movies is able to better characterize and differentiate between different degrees of liver fibrosis. METHODS: The study design was prospective. A total of 132 consecutive patients with chronic liver diseases and healthy volunteers were examined by transabdominal ultrasound elastography. All examinations were done by two doctors.RESULTS: Due to the limitations of the method, we obtained high-quality elastography information in only 73.48% of the patients. The κ-means clustering method was applied to assess the inter-observer diagnosis varia- bility, which showed good variability values in accordance with the experience of ultrasound examination of every observer. Cohen’sκ test indicated a moderate agreement between the study observers (κ = 0.4728). Furthermore, we compared the way the two observers clustered the patients, using the test for comparing two proportions (t value, two-sided test). There was no statistically significant difference between the two physicians, regardless of the patients’ real status. CONCLUSION: Transabdominal real-time elastography is certainly a very useful method in depicting liver hard- ness, although it is incompletely tested in large multicenter studies. | Dan Ionut Gheonea Adrian S ǎftoiu Tudorel Ciurea Florin Gorunescu Sevastita Iordache Gabriel Lucian Popescu Smaranda Belciug Marina Gorunescu Larisa Sǎndulescu | 2010 | World Journal of Gastroenterology2010，16，14： | 9 |
| 10 | PillCam Colon 2 capsule in patients unable or unwilling to undergo colonoscopy显示文摘AIM: To assess the feasibility, accuracy and acceptability of PillCam Colon 2 in detection of significant lesions in colorectal cancer risk patients, unable or unwilling to perform colonoscopy. METHODS: This is a prospective, single center study using the second generation of PillCam Colon capsule. In all patients the readers were instructed to review the entire colon capsule endoscopy(CCE) examination using Rapid 7 software and additionally to note significant extra-colonic findings. Colonic significant findings were described according to European Society of Gastrointestinal Endoscopy guidelines. CCE procedure completion rate, level of bowel preparation and rate of adverse events were assessed. RESULTS: A total of 70 patients at risk of colorectal cancer were enrolled in the study. In three patients the procedure failed because the capsule was not functioning when entered the colon. PillCam Colon 2 showed positive findings in 23(34%, 95%CI: 21.6%-44.1%) of the remaining 67 patients. Six patients were diagnosedwith tumors: 4 with colon cancers, 1 with gastric cancer and 1 with a small bowel cancer. The capsule findings were confirmed after surgery in all these patients. The capsule excretion rate in twelve hours was 77% with 54 patients having a complete examination. The rectum was not explored during CCE procedure, in 16 patients(23%, 95%CI: 13.7%-34.1%). Every patient accepted CCE as an alternative exploration tool and 65/70(93%) agreed to have another future control by CCE. No complications were reported during or after CCE examination. CONCLUSION: PillCam Colon 2 capsule was effective in detecting significant lesions and might be considered an adequate alternative diagnostic tool in patients unable or unwilling to undergo colonoscopy. | Lucian Negreanu Ruxandra Babiuc Andreea Bengus Roxana Sadagurschi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 7 |
| 11 | 液压胀形金属板材的塑性行为表征(英文)显示文摘采用圆形和椭圆形的模具进行液压胀形试验。利用最近提出的椭圆形模具胀形方法来确定等效应力—应变曲线。该方法将ARAMIS系统测得的实验数据与分析相结合。在使用椭圆形模具的液压胀形实验中,随着模具椭圆度的减小,等效应力—应变曲线逐渐远离圆形模具胀形的曲线。通过胀形测试来确定DC04钢板在正次应变范围内的成形极限图。 | Lucian LZRESCU Dan-Sorin COMSA Ioan NICODIM Ioan CIOBANU Dorel BANABIC | 2012 | 中国有色金属学会会刊:英文版2012，22，S2： | 6 |
| 12 | Proportional fuzzy feed-forward architecture control validation by wind tunnel tests of a morphing wing显示文摘In aircraft wing design,engineers aim to provide the best possible aerodynamic performance under cruise flight conditions in terms of lift-to-drag ratio.Conventional control surfaces such as flaps,ailerons,variable wing sweep and spoilers are used to trim the aircraft for other flight conditions.The appearance of the morphing wing concept launched a new challenge in the area of overall wing and aircraft performance improvement during different flight segments by locally altering the flow over the aircraft's wings.This paper describes the development and application of a control system for an actuation mechanism integrated in a new morphing wing structure.The controlled actuation system includes four similar miniature electromechanical actuators disposed in two parallel actuation lines.The experimental model of the morphing wing is based on a full-scale portion of an aircraft wing,which is equipped with an aileron.The upper surface of the wing is a flexible one,being closed to the wing tip;the flexible skin is made of light composite materials.The four actuators are controlled in unison to change the flexible upper surface to improve the flow quality on the upper surface by delaying or advancing the transition point from laminar to turbulent regime.The actuators transform the torque into vertical forces.Their bases are fixed on the wing ribs and their top link arms are attached to supporting plates fixed onto the flexible skin with screws.The actuators push or pull the flexible skin using the necessary torque until the desired vertical displacement of each actuator is achieved.The four vertical displacements of the actuators,correlated with the new shape of the wing,are provided by a database obtained through a preliminary aerodynamic optimization for specific flight conditions.The control system is designed to control the positions of the actuators in real time in order to obtain and to maintain the desired shape of the wing for a specified flight condition.The feasibility and effectiveness of the developed control system by use of a proportional fuzzy feed-forward methodology are demonstrated experimentally through bench and wind tunnel tests of the morphing wing model. | Michel Joёl Tchatchueng Kammegne Ruxandra Mihaela Botez Lucian Teodor Grigorie Mahmoud Mamou Youssef Mebarki | 2017 | Chinese Journal of Aeronautics2017，30，2： | 6 |
| 13 | Classification of Soil Types Using Geographic Object-Based Image Analysis and Random Forests显示文摘There is increasing interest in developing automatic procedures to segment landscapes into soil spatial entities that replace conventional, expensive manual procedures for delineating and classifying soils. Geographic object-based image analysis(GEOBIA)partitions remote sensing imagery or digital elevation models into homogeneous image objects based on image segmentation. We used an object-based methodology for the detailed delineation and classification of soil types using digital maps of topography and vegetation as soil covariates, based on the Random Forests(RF) classifier. We compared the object-based method's results with those of a pixel-based classification using the same classifier. We used 18 digital elevation model derivatives and 5 remote sensing indices that were related to vegetation cover and soil. Using 171 soil profiles with their associated environmental variable values,the RF method was used to identify the most important soil type predictors for use in the segmentation process. A stack of rastergeodatasets corresponding to the selected predictors was segmented using a multi-resolution segmentation algorithm, which resulted in homogeneous objects related to soil types. These objects were further classified as soil types using the same method, RF. We also conducted a pixel-based classification using the same classifier and soil profiles, and the resulting maps were assessed in terms of their accuracy using 30% of the soil profiles for validation. We found that GEOBIA was an effective method for soil type mapping, and was superior to the pixel-based approach. The optimized object-based soil map had an overall accuracy of 58%, which was 10% higher than that of the optimized pixel-based map. | Andrei DORNIK Lucian DRAGUT Petru URDEA | 2018 | Pedosphere2018，28，6： | 4 |
| 14 | Influence of Chemical Pretreatment on the Dissolved Organics in Poplar Alkaline Peroxide Mechanical Pulping Effluent显示文摘The components of the effluent from the chemical pretreatment of poplar alkaline peroxide mechanical pulp(APMP) were analyzed in this study. The main dissolved organics were low-molecular weight(LMW) lignin, oligosaccharides, and monosaccharides. The lignin and sugar concentrations in the effluent obtained using different chemical pretreatment conditions and chemical dosages were analyzed using ultraviolet(UV) spectroscopy. This analysis provided a theoretical basis for the subsequent treatment and utilization of APMP effluent. The experimental results showed that the dosages of Na OH, H_2O_2, and Na_2 SiO_3 in the chemical pretreatment process affected the lignin and sugar concentrations in the effluent and that different chemicals had differing degrees of influence. The degree of influence exhibited the following order: Na OH>H_2O_2>Na_2SiO_3. More specifically, the dosages of Na OH and H_2O_2 had stronger influences on the lignin and sugar concentrations than that of Na_2 SiO_3. Indeed, the Na_2 SiO_3 dosage hardly affected the lignin and sugar concentrations in the effluent, but Na_2 SiO_3 could stabilize the chemical pretreatment system and improve the reactive efficiency of Na OH and H_2O_2. The pretreatment temperature and time also affected the organic components, and the influence of the temperature was stronger than that of time. | XinYu Wang JiaChuan Chen HongLei Chen Lucian A.Lucia GuiHua Yang QinWu | 2017 | Paper And Biomaterials2017，2，1： | 4 |
| 15 | 公司所有权和公司治理中的路径依赖理论显示文摘世界发达经济体之间,公司结构千差万别。我们提出的公司结构的路径依赖理论有助于理解这些差异。在任意时点,某经济体的公司结构部分依赖于该经济体早期所采用的结构。本文提出并分析了路径依赖的两种渊源——结构驱动及规则驱动。首先,一个经济体的公司结构依赖于该经济体在初始阶段具有的结构。初始所有权结构之所以会产生这种效果,是因为它影响到特定公司对有效率结构的判断,也因为它能够给某些当事人提供动力和权力以阻止对初始所有权结构进行改变。其次,影响着所有权结构的公司规则本身也依赖于经济体在初始阶段所采用的公司结构。初始所有权结构既可影响对何种规则有效率的判断,又可影响利益集团政治,而利益集团政治能够决定实际上选择何种规则。我们的路径依赖理论阐明了为何发达经济体能够顶住趋同的压力而保持着所有权结构上的差异。同时,该理论也为理解为何一些重要的差别可能持续存在提供了基础。 | Lucian Arye Bebchuk Mark J.Roe 宁桂君 | 2011 | 研究生法学2011，26，5： | 3 |
| 16 | Characterization and remediation of soils contaminated with uranium显示文摘 | Maria Gavrilescu Lucian Vasile Pavel Igor Cretescu | 2008 | Journal of Hazardous Materials2008，，2： | 3 |
| 17 | Spontaneous and antiviral-induced cutaneous lesions in chronic hepatitis B virus infection显示文摘AIM:To describe spontaneous,or interferon(IFN)-or immunization-induced skin lesions in hepatitis B virus(HBV)infection.METHODS:A comprehensive literature search of all the papers presenting case reports of dermatological lesions in patients with chronic HBV infection was carried out.We included only patients with histologically proven skin lesions that appeared in the normal course of hepatitis B infection,or after immunization for hepatitis B or antiviral treatment.RESULTS:We found 44 papers on this topic,reporting 151 cases.About 2%of patients with hepatitis B infection,mainly men,presented with skin lesions.Among patients with chronic hepatitis B,vasculitis and essential mixed cryoglobulinemia seemed to be the most frequent skin lesion(53.3%),followed by papular changes,rashes and Gianotti-Crosti syndrome,skin carcinoma and Henoch-Sch?nlein purpura were rare.IFN treatment seemed to be effective against HBV-associated and immunoglobulin-complex-mediated disease(vasculitis).Two cutaneous lesions(lichen planus andgranuloma annulare)were described after hepatitis B vaccination.Systemic lupus and lupus-like lesions were the most frequently encountered lesions after antiviral treatment.Immunosuppressive and steroid therapy ameliorates lichen planus lesions in 50%of cases.CONCLUSION:Vasculitis was the most frequent spontaneous skin lesion found in chronic hepatitis B.Lichen planus was most frequent after immunization and lupus/lupus-like lesions after IFN. | Ioana Grigorescu Dan Lucian Dumitrascu | 2014 | World Journal of Gastroenterology2014，20，42： | 3 |
| 18 | Neural Network Analysis of Dynamic Sequences of EUS Elastography Used for the Differential Diagnosis of Chronic Pancreatitis and Pancreatic Cancer显示文摘 | Adrian Saftoiu Peter Vilmann Florin Gorunescu Dan Ionut Gheonea Marina Gorunescu Tudorel Ciurea Gabriel Lucian Popescu Alexandru Iordache Sevastita Iordache | 2008 | Gastrointestinal Endoscopy2008，，5： | 2 |
| 19 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
| 20 | Sox2 Protein Expression is an Independent Poor Prognostic Indicator in Stage I Lung Adenocarcinoma显示文摘 | Lynette M. Sholl Justine A. Barletta Beow Y. Yeap Lucian R. Chirieac Jason L. Hornick | 2010 | The American Journal of Surgical Pathology2010，，8： | 2 |
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