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| 1 | Distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in surface water and sediments from Baiyangdian Lake in North China显示文摘Persistent organochlorine compounds,including hexachlorocyclohexanes (HCHs),dichlorodiphenyltrichloroethanes (DDTs) and polychlorinated biphenyls (PCBs) were analyzed in surface water and sediments from Baiyangdian Lake,North China.Total concentrations of HCHs,DDTs and PCBs in surface water were in the range of 3.13-10.60,4.05-20.59 and 19.46-131.62 ng/L,respectively,and total concentrations of HCHs,DDTs and PCBs in sediments were 1.75-5.70,0.91-6.48 and 5.96-29.61 ng/g dry weight,respectively.Among the groups of HCHs (sum of α-HCH,β-HCH,γ-HCH and δ-HCH) and DDTs (sum of DDT,DDD and DDE),the predominance of β-HCH,DDE and DDD in water and sediment samples was clearly observed.This observation suggested that β-HCH was resistant to biodegradation and the DDTs had been transformed to its metabolites,DDE and DDD.For PCBs,penta-,hexa-and hepta-chlorinated congeners were the most abundant compounds in the both phases.Furthermore,the partitioning of chlorinated compounds between sediment and water was investigated to understand their transport and fates in aquatic ecosystems.The results indicated that average logs of organic carbon-normalized sediment-water partition coefficients (logK'oc) for OCPs varied between 3.20 and 5.53,and for PCBs,logK'oc values ranged from 3.19 to 5.57.The observed logK'oc was lower than their equilibrium logKoc predicted from linear model,which may be attributed to the solubility enhancement effect of colloidal matter in water phase and the disequilibrium between sediment and water. | Guohua Dai Xinhui Liu Gang Liang Xu Han Liu Shi Dengmiao Cheng Wenwen Gong | 2011 | Journal of Environmental Sciences2011，23，10： | 44 |
| 2 | Cold-chain transportation in the frozen food industry may have caused a recurrence of COVID-19 cases in destination:Successful isolation of SARS-CoV-2 virus from the imported frozen cod package surface显示文摘Coronavirus disease 2019(COVID-19)pandemic has spread in 220 countries/regions towreak havoc to human beings around theworld.At present,the second wave of COVID-19 has begun in many European countries.The complete control of COVID-19 is very urgent.Although China quickly brought the virus under control,there have been eight sporadic outbreaks in China since then.Both in Xinfadi of Beijing and Dalian outbreak of COVID-19,environmental swab samples related to imported cold chain food were tested nucleic acid positive for SARS-CoV-2.In this outbreak in Qingdao,we directly isolated SARS-CoV-2 from the cod outer package's surface swab samples.This is the first time worldwide,SARS-CoV-2 were isolated from the imported frozen cod outer package's surface,which showed that imported frozen food industry could import SARS-CoV-2 virus. | Peipei Liu Mengjie Yang Xiang Zhao Yuanyuan Guo Liang Wang Jing Zhang Wenwen Lei Weifang Han Fachun Jiang William J.Liu George F.Gao Guizhen Wu | 2020 | Biosafety and Health2020，2，4： | 41 |
| 3 | Initial identification of heavy metals contamination in Taihu Lake, a eutrophic lake in China显示文摘A detailed investigation of seven heavy metals (Cu, Cd, Cr, As, Pb, Zn, Ni) in the water column, interstitial water and surface sediment was conducted to quantify the extent of their contamination in Taihu Lake. Results showed the average total concentrations ranged from 0.93 μg/L for Cd to 47.03 μg/L for Zn. The dissolved concentrations in the overlying water ranged from 0.06 μg/L for Cd to 15.86 μg/L for Zn. The metals in the Taihu Lake surface water were primarily in the particulate phase, especially for Cd, whose particulate concentration represented 94.3% of the total. In the surface sediment, the mean concentrations for Cr, Ni, Cu, Zn, As, Cd and Pb were 41.50, 28.72, 27.82, 65.46, 5.94, 0.82 and 41.17 mg/kg, respectively. The metals in the water column and sediments of Taihu Lake displayed significant spatial variations, and the higher metal concentrations mainly occurred in the north and west of Taihu Lake, especially in Zhushan Bay and West Taihu Lake. A quality assessment indicated that most of the metals in the surface water of Taihu Lake had no or low adverse health effects on organisms, except for Pb and Cu, which may cause chronic toxicity. Compared with the 'Consensus-Based Sediment Quality Guidelines', the polluting metals were Cr, Ni and Cd, and the polluted regions were confined to Zhushan Bay, Meiliang Bay and the west of Taihu Lake, especially for north of Zhushan Bay. The polluted areas for Cr, Ni and Cd were 14.36, 34.70 and 13.24 km 2 , respectively. We suggest that Cr, Ni, and Cd in the polluted areas should be addressed and that tissue chemistry and sediment toxicity assessments be performed as soon as possible. | Xia Jiang Wenwen Wang Shuhang Wang Bo Zhang Jiachen Hu | 2012 | Journal of Environmental Sciences2012，24，9： | 26 |
| 4 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 5 | MicroRNA528 Affects Lodging Resistance of Maize by Regulating Lignin Biosynthesis under Nitrogen-Luxury Conditions显示文摘在氮(N) 奢侈条件下面的住宿实质地减少庄稼产量和种子质量。然而,植物住宿抵抗的分子的机制仍然保持大部分不清楚,特别在玉米。我们这里报导 ZmmiR528 的表示, monocot 特定的 microRNA,被 N 导致 ? 奢侈但是由 N 缺乏减少了。我们由 thioacidolysis 和 N 奢侈显著地减少的乙酰溴化物分析证明在玉米的木质素以及它的全部的内容的 H, G,和 S 单体的产生射击。我们进一步示威 ? 那 ZmLACCASE3 (ZmLAC3 ) 编码包含铜的 laccases,和 ZmLACCASE5 (ZmLAC5 ) 是 ZmmiR528 的目标。在杂交显示出的 situ, ZmmiR528 是,这主要在玉米表示了脉管的纸巾。显著地增加的 ZmLAC3 的 ZmmiR528 或 overexpression 击倒木质素内容和玉米的树皮透度计抵抗起源。相反,转基因的玉米植物 overexpressing ZmmiR528 减少了木质素内容和树皮透度计抵抗并且对在揭示的 N 奢侈定序 conditions.?RNA 分析下面的住宿敏感那 ZmPAL7 和 ZmPAL8 是在转基因的玉米线 downregulating ZmmiR528 的 upregulated。在 N 奢侈条件下面, ZmPALs 的表示层次比在野类型在 ZmmiR528 击倒的线是高得多的并且 ? 转基因的玉米线 overexpressing ZmmiR528。一起拿,这些结果显示由调整 ZmLAC3 和 ZmLAC5 的表示, ZmmiR528 在 N 奢侈条件下面影响玉米住宿抵抗。 | Qing Sun Xiaogang Liu Juan Yang Wenwen Liu Qingguo Du Hongqiu Wang Chunxiang Fu Wen-Xue Li | 2018 | Molecular Plant2018，11，6： | 21 |
| 6 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 7 | Soliton bursts and deterministic dissipative Kerr soliton generation in auxiliary-assisted microcavities显示文摘Dissipative Kerr solitons in resonant frequency combs offer a promising route for ultrafast mode-locking,precision spectroscopy and time-frequency standards.The dynamics for the dissipative soliton generation,however,are intrinsically intertwined with thermal nonlinearities,limiting the soliton generation parameter map and statistical success probabilities of the solitary state.Here,via use of an auxiliary laser heating approach to suppress thermal dragging dynamics in dissipative soliton comb formation,we demonstrate stable Kerr soliton singlet formation and soliton bursts.First,we access a new soliton existence range with an inverse-sloped Kerr soliton evolution—diminishing soliton energy with increasing pump detuning.Second,we achieve deterministic transitions from Turinglike comb patterns directly into the dissipative Kerr soliton singlet pulse bypassing the chaotic states.This is achieved by avoiding subcomb overlaps at lower pump power,with near-identical singlet soliton comb generation over twenty instances.Third,with the red-detuned pump entrance route enabled,we uncover unique spontaneous soliton bursts in the direct formation of low-noise optical frequency combs from continuum background noise.The burst dynamics are due to the rapid entry and mutual attraction of the pump laser into the cavity mode,aided by the auxiliary laser and matching well with our numerical simulations.Enabled by the auxiliary-assisted frequency comb dynamics,we demonstrate an application of automatic soliton comb recovery and long-term stabilization against strong external perturbations.Our findings hold potential to expand the parameter space for ultrafast nonlinear dynamics and precision optical frequency comb stabilization. | Heng Zhou Yong Geng Wenwen Cui Shu-Wei Huang Qiang Zhou Kun Qiu Chee Wei Wong | 2019 | Light(Science & Applications)2019，8，1： | 16 |
| 8 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 9 | Nondestructive determination of nutritional information in oilseed rape leaves using visible/near infrared spectroscopy and multivariate calibrations显示文摘Nitrogen, phosphorus and potassium content are the three most important nutritional parameters for growing oilseed rape. We investigated visible and near infrared (Vis/NIR) spectroscopy combined with chemometrics for the fast and nondestructive determination of nutritional information in oilseed rape leaves. A total of 154 leaf samples were collected, with 104 randomly selected as the calibration set, and the remaining 50 samples used as the validation set. The performance of eight different preprocessing methods was compared in partial least squares (PLS) models. Some effective wavelengths selected by a successive projections algorithm (SPA) were also used to develop linear SPA-PLS, nonlinear back propagation neural network (BPNN), and nonlinear least squares-support vector machine (LS-SVM) models to determine nutritional information. The best prediction models were DOSC-PLS for nitrogen with r=0.9743 and RMSEP=0.1459, DOSC-SPA-BPNN for phosphorus with r=0.7054 and RMSEP=0.0594, and DOSC-SPA-BPNN for potassium with r=0.9380 and RMSEP=0.1788. The prediction precision for nitrogen and potassium determinations was acceptable for further practical applications, whereas further studies are needed to improve the prediction precision for phosphorus. The results indicated that Vis/NIR spectroscopy is feasible for nondestructive determination of nutritional information in oilseed rape leaves. It also provided an alternative technique for detecting other growth information about oilseed rape leaves. | LIU Fei NIE PengCheng HUANG Min KONG WenWen HE Yong | 2011 | Science China(Information Sciences)2011，54，3： | 14 |
| 10 | Effects of pyrite on the spontaneous combustion of coal显示文摘 | Jun Deng Xiaofeng Ma Yutao Zhang Yaqing Li Wenwen Zhu | 2015 | International Journal of Coal Science & Technology2015，2，4： | 14 |
| 11 | Influence of the post-treatment of HZSM-5 zeolite on catalytic performance for alkylation of benzene with methanol显示文摘The porous material HZSM-5 zeolite with micro-mesopore hierarchical porosity was prepared by post-treatment(combined alkali treatment and acid leaching) of parent zeolite and its catalytic performance for benzene alkylation with methanol was investigated. The effect of post-treatment on the textural properties was characterized by various techniques(including ICP-AES, XRD, nitrogen sorption isotherms, SEM, NH3-TPD, Py-IR and TG). The results indicated that the post-treatment could modify the structural and acidic properties of HZSM-5 zeolite. In this procedure, not only additional mesopores were created by selective extraction of silicon but also the acidity was tuned. Consequently, the modified HZSM-5 zeolite showed larger external surface area with less acid sites as compared to the parent zeolite. It was found out that the modified zeolite exhibited a higher benzene conversion and xylene selectivity for alkylation of benzene with methanol as well as excellent life span of the catalyst than conventional ones. This can be explained by the facts that the presence of additional mesopores improved the diffusion property in the reactions. Furthermore, the modified zeolite showed an appropriate Br?nsted acidity for effective suppression of the side reaction of methanol to olefins, thus reduced the accumulation of coke on the HZSM-5 zeolite, which was favorable for the catalyst stability. In comparison with the parent HZSM-5 zeolite,the modified zeolite by alkali treatment and acid leaching showed better performance for the benzene alkylation with methanol. | Qingtao Wang Wenwen Han Hualei Hu Jinghui Lyu Xiaolong Xu Qunfeng Zhang Hongjing Wang Xiaonian Li | 2017 | Chinese Journal of Chemical Engineering2017，25，12： | 13 |
| 12 | Response to paleoatmospheric CO_2 concentration of Solenites vimineus(Phillips)Harris(Ginkgophyta)from the Middle Jurassic of the Yaojie Basin,Gansu Province,China显示文摘Solenites vimineus (Phillips) Harris (Ginkgophyta) specimens with well-preserved cuticles were collected from five different beds in the oil shale member of the Middle Jurassic Yaojie Formation in the Yaojie Basin, Gansu Province, northwestern China. Gross morphology and fine structures of the fossil leaves were studied, and stomatal parameters were analyzed, according to which, the paleoatmospheric CO2 concentration can be deduced as 1512-1896 ppm that would have caused an increase in mean temperature of about 6.5-7.4℃. Carbon isotopes from the fossils indicate that the carbon isotopic discrimination and water use efficiency (WUE) of S. vimineus were raised nearly obtaining the ideal physiologic state in increased CO2 concentrations and temperature conditions, suggesting that S. vimineus records the paleoenvironmental information of the Middle Jurassic Yaojie Basin and can be used for environmental reconstruction. | YAN DeFei SUN BaiNian XIE SanPing LI XiangChuan WEN WenWen | 2009 | Science China Earth Sciences2009，52，12： | 13 |
| 13 | Analysis of EET on Ca increasing the melting point of Mg_(17)Al_(12) phase显示文摘The present investigation showed that the additions of Ca to the alloy AZ91 were mainly dissolved into the Mg17Al12 phase and increased its melting point and thermal stability, which would have great effects on the high-temperature properties of AZ91 alloy. The empirical electron theory (EET) of solid and molecules was used to calculate the valence electron structures (VES) of Mg17Al12 intermetallic compound with and without Ca addition. The results showed that Ca dissolving in Mg17Al12 phase increased the strength of bonds that control the thermal stability of Mg17Al12 phase. Additions of Ca also made the distribution of the valence electrons on the dominant bond network more uniform in the whole unit cell of Mg17Al12. The theoretical conclusions well account for the experimental results. | MIN Xuegang, DU Wenwen, XUE Feng & SUN YangshanDepartment of Material Science and Engineering, Southeast University, Nanjing 210096, China | 2002 | Chinese Science Bulletin2002，47，13： | 13 |
| 14 | Evaluation of pelvic visceral functions after modified nerve-sparing radical hysterectomy显示文摘 | Wang Wenwen Li Bin Zuo Jing Zhang Gongyi Yang Yeduo Zeng Hongmei Li Xiaoguang | 2014 | Chinese Medical Journal2014，，4： | 13 |
| 15 | miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β显示文摘miR-142 和 miR-223 作为造血的特定的 microRNAs 被识别了。miR-223 在 myeloid 系开发有关键功能。然而, miR-142 的功能仍然保持不清楚。在这研究,我们发现那 miR-142, miR-223 稀释了造血的房间,和那 miR-223 的增长通过 LMO2-L/-S isoforms 和 CEBP- 尾的起来调整的 miR-142 表示。miR-223 否定地 post-transcriptionally 调整了 LMO2-L/-S isoforms 和 CEBP- 尾,当 CEBP- 尾断然调整了 LMO2-L/-S isoforms 并且否定地两个都 LMO2-L/-S isoforms 调整了 miR-142 时。这些结果揭示一条新奇 miR-223 鈥擟E BP-尾鈥擫M O2 鈥攎i R-142 规章的小径,它在造血作用有枢轴的功能。 | Wei Sun Wenwen Shen Shuang Yang Fen Hu Huihui Li Tian-Hui Zhu | 2010 | Cell Research2010，20，10： | 12 |
| 16 | Circadian Evening Complex Represses Jasmonate-lnduced Leaf Senescence in Arabidopsis显示文摘 | Yuanyuan Zhang Yan Wang Hua Wei Na Li Wenwen Tian Kang Chong Lei Wang | 2018 | Molecular Plant2018，11，2： | 12 |
| 17 | Mild hypothermia combined with a scaffold of Ng Rsilenced neural stem cells/Schwann cells to treat spinal cord injury显示文摘Because the inhibition of Nogo proteins can promote neurite growth and nerve cell differentiation, a cell-scaffold complex seeded with Nogo receptor(Ng R)-silenced neural stem cells and Schwann cells may be able to improve the microenvironment for spinal cord injury repair. Previous studies have found that mild hypothermia helps to attenuate secondary damage in the spinal cord and exerts a neuroprotective effect. Here, we constructed a cell-scaffold complex consisting of a poly(D,L-lactide-co-glycolic acid)(PLGA) scaffold seeded with Ng R-silenced neural stem cells and Schwann cells, and determined the effects of mild hypothermia combined with the cell-scaffold complexes on the spinal cord hemi-transection injury in the T9 segment in rats. Compared with the PLGA group and the Ng R-silencing cells + PLGA group, hindlimb motor function and nerve electrophysiological function were clearly improved, pathological changes in the injured spinal cord were attenuated, and the number of surviving cells and nerve fibers were increased in the group treated with the Ng R-silenced cell scaffold + mild hypothermia at 34°C for 6 hours. Furthermore, fewer pathological changes to the injured spinal cord and more surviving cells and nerve fibers were found after mild hypothermia therapy than in injuries not treated with mild hypothermia. These experimental results indicate that mild hypothermia combined with Ng R gene-silenced cells in a PLGA scaffold may be an effective therapy for treating spinal cord injury. | Dong Wang Jinhua Liang Jianjun Zhang Shuhong Liu Wenwen Sun | 2014 | Neural Regeneration Research2014，9，24： | 12 |
| 18 | Benzene alkylation with methanol over phosphate modified hierarchical porous ZSM-5 with tailored acidity显示文摘The acidity and acid distribution of hierarchical porous ZSM-5 were tailored via phosphate modification. The catalytic results showed that both benzene conversion and selectivity of toluene and xylene increased with the presence of appropriate amount of phosphorus. Meanwhile, side reactions such as methanol to olefins related with the formation of by-product ethylbenzene formation and isomerization of xylene to meta-xylene were suppressed efficiently. The acid strength and sites amount of Br?nsted acid of the catalyst were crucial for improving benzene conversion and yield of xylene, whereas passivation of external surface acid sites played an important role in breaking thermodynamic equilibrium distribution of xylene isomers. | Jinghui Lyu Hualei Hu Carolyn Tait Jiayao Rui Caiyi Lou Qingtao Wang Wenwen Han Qunfeng Zhang Zhiyan Pan Xiaonian Li | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 11 |
| 19 | Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways显示文摘Neocryptotanshinone(NCTS) is a natural product isolated from traditional Chinese herb Salvia miltiorrhiza Bunge. In this study, we investigated its anti-inflammatory effects in lipopolysaccharide(LPS)-stimulated mouse macrophage(RAW264.7) cells. MTT results showed that NCTS partly reversed LPS-induced cytotoxicity. Real-time PCR results showed that NCTS suppressed LPS-induced mRNA expression of inflammatory cytokines, including tumor necrosis factor α(TNFα), interleukin-6(IL-6) and interleukin-1β(IL-1β). Moreover, NCTS could decrease LPS-induced nitric oxide(NO)production. Western blotting results showed that NCTS could down-regulate LPS-induced expression of inducible nitric oxide synthase(iNOS), p-IκBα, p-IKKβ and p-NF-κB p65 without affecting cyclooxygenase-2(COX-2). In addition, NCTS inhibited LPS-induced p-NF-κB p65 nuclear translocation.In conclusion, these data demonstrated that NCTS showed anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways. | Chuanhong Wu Wenwen Zhao Xuenong Zhang Xiuping Chen | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 11 |
| 20 | Research progress in ZnO single-crystal:growth, scientific understanding, and device applications显示文摘Zinc oxide,a wide band-gap semiconductor,has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices,semiconductor photocatalysis,and diluted magnetic semiconductors.Due to the undisputed lattice integrity,ZnO single crystals are essential for the fabrication of high-quality ZnO-based photoelectronic devices,and also believed to be ideal research subjects for understanding the underlying mechanisms of semiconductor photocatalysis and diluted magnetic semiconductors.This review,which is organized in two main parts,introduces the recent progress in growth,basic characterization,and device development of ZnO single crystals,and some related works in our group.The first part begins from the growth of ZnO single crystal,and summarizes the fundamental and applied investigations based on ZnO single crystals.These works are composed of the fabrication of homoepitaxial ZnO-based photoelectronic devices,the research on the photocatalysis mechanism,and dilute magnetic mechanism.The second part describes the fabrication of highly thermostable n-type ZnO with high mobility and high electron concentration through intentional doping.More importantly,in this part,a conceptual approach for fabricating highly thermostable p-type ZnO materials with high mobility through an integrated three-step treatment is proposed on the basis of the preliminary research. | Feng Huang Zhang Lin Wenwen Lin Jiye Zhang Kai Ding Yonghao Wang Qinghong Zheng Zhibing Zhan Fengbo Yan Dagui Chen Peiwen Lv Xian Wang | 2014 | Chinese Science Bulletin2014，59，12： | 11 |
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