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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 3 | 西藏甲玛铜多金属矿区成矿斑岩的岩浆混合作用:石英及长石斑晶新证据显示文摘西藏甲玛矿区斑岩内石英和长石斑晶的阴极发光(CL)特征及元素含量变化有效记录了岩浆演化、混合及补给事件。石英斑晶的显微生长结构表明,原始岩浆经历过2次铁镁质岩浆混合作用。根据石英斑晶中Ti含量的变化可知,在2次溶蚀前后,石英结晶温度分别增高了约110℃和80℃。此外,斜长石斑晶的反环带及其Ba、Sr、Fe等元素的浓度梯度、钾长石的镶边结构、黑云母的筛状结构等,都有效地证明了铁镁质岩浆与长英质岩浆混合作用的存在。根据这些研究结果,初步构建了该矿区岩浆混合作用模型,并推测了岩浆混合过程。在16Ma左右,岩石圈地幔拆沉,软流圈物质上涌导致正常下地壳部分熔融,产生了含Mo的钾质岩浆。原始岩浆房内形成了第Ⅰ世代自形的高温石英晶体核。软流圈上涌诱发了含大量地幔组分的新生镁铁质下地壳部分熔融,产生了含Cu、富水、高f(O2)的埃达克质岩浆熔体,并与含Mo的长英质岩浆发生了第1次岩浆混合作用。在此过程中,早期石英核部溶蚀,形成了高Ti的溶蚀表面。这些高f(O2)的混合岩浆在浅部地壳形成了大型岩浆房,并排泄出含Cu、Mo岩浆流体。在岩浆房中,石英晶体形成了均匀的生长环带和第Ⅱ世代的石英斑晶核。地幔减薄和岩石圈拆沉直接引起了地壳强烈伸展,形成了垂直于碰撞带的正断层系统和裂谷,使岩浆房内部的压力急剧减小,岩浆快速侵位。岩浆房的突然腾空,诱发了地幔物质上涌,造成了第2次基性岩浆的混入,促使第Ⅰ世代和第Ⅱ世代石英斑晶的边缘发生溶蚀。正是两次基性岩浆的加入,为成矿提供了大量的Cu、S。这是形成甲玛超大型铜多金属矿床不可或缺的因素。 | 彭惠娟 汪雄武 Müller Axel 秦志鹏 侯林 周云 | 2011 | 矿床地质2011，30，2： | 18 |
| 4 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 5 | Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images显示文摘Super-resolution structured illumination microscopy(SR-SIM) provides an up to twofold enhanced spatial resolution of fluorescently labeled samples. The reconstruction of high-quality SR-SIM images critically depends on patterned illumination with high modulation contrast. Noisy raw image data(e.g., as a result of low excitation power or low exposure time), result in reconstruction artifacts. Here, we demonstrate deep-learning based SR-SIM image denoising that results in high-quality reconstructed images. A residual encoding–decoding convolutional neural network(RED-Net) was used to successfully denoise computationally reconstructed noisy SR-SIM images.We also demonstrate the end-to-end deep-learning based denoising and reconstruction of raw SIM images into high-resolution SR-SIM images. Both image reconstruction methods prove to be very robust against image reconstruction artifacts and generalize very well across various noise levels. The combination of computational image reconstruction and subsequent denoising via RED-Net shows very robust performance during inference after training even if the microscope settings change. | ZAFRAN HUSSAIN SHAH MARCEL MÜLLER TUNG-CHENG WANG PHILIP MAURICE SCHEIDIG AXEL SCHNEIDER MARK SCHÜTTPELZ THOMAS HUSER WOLFRAM SCHENCK | 2021 | Photonics Research2021，9，5： | 11 |
| 6 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 7 | Non-invasive biomarkers for monitoring the fibrogenic process in liver:A short survey显示文摘The clinical course ofchronic liver diseases is significantly dependent on the progression rate and the extent offibrosis, i.e. the non-structured replacement of necrotic parenchyma by extracellular matrix. Fibrogenesis, i.e. the development offibrosis can be regarded as an unlimited wound healing process, which is based on matrix (connective tissue) synthesis in activated hepatic stellate cells, fibroblasts (fibrocytes), hepatocytes and biliary epithelial cells, which are converted to matrix-producing (myo-)fibroblasts by a process defined as epithelial-mesenchymal transition. Blood (noninvasive) biomarkers offibrogenesis and fibrosis can be divided into class and class analytes. Class biomarkers are those single tests, which are based on the pathophysiology offibrosis, whereas class biomarkers aremostly multiparametric algorithms, which have been statistically evaluated with regard to the detection and activity ofongoing fibrosis. Currently available markers fulfil the criteria ofideal clinical-chemical tests only partially, but increased understanding ofthe complex pathogenesis offibrosis offers additional ways for pathophysiologically well based serum (plasma) biomarkers. They include TGF-β-driven marker proteins, bone marrow-derived cells (fibrocytes), and cytokines, which govern proand anti-fibrotic activities. Proteomic and glycomic approaches ofserum are under investigation to set up specific protein or carbohydrate profiles in patients with liver fibrosis. These and other novel parameters will supplement or eventually replaceliver biopsy/histology, high resolution imaging analysis, and elastography for the detection and monitoring of patients at risk ofdeveloping liver fibrosis. | Axel M Gressner Chun-Fang Gao Olav A Gressner | 2009 | World Journal of Gastroenterology2009，15，20： | 5 |
| 8 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 9 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 10 | Heart rate deceleration runs for postinfarction risk prediction显示文摘 | Przemyslaw Guzik Jaroslaw Piskorski Petra Barthel Axel Bauer Alexander Müller Nadine Junk Kurt Ulm Marek Malik Georg Schmidt | 2012 | Journal of Electrocardiology2012，，1： | 3 |
| 11 | Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study显示文摘 | Axel Bauer Jan W Kantelhardt Petra Barthel Raphael Schneider Timo M?kikallio Kurt Ulm Katerina Hnatkova Albert Sch?mig Heikki Huikuri Armin Bunde Marek Malik Georg Schmidt | 2006 | The Lancet2006，，9523： | 3 |
| 12 | Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein显示文摘AIM:To investigate the mechanisms involved in a possible modulator role of interleukin(IL) -6 signalling on CYR61-CTGF-NOV(CCN) 2/connective tissue growth factor(CTGF) expression in hepatocytes(PC) and to look for a relation between serum concentrations of these two parameters in patients with acute inflammation. METHODS:Expression of CCN2/CTGF,p-STAT3,p-Smad 3/1 and p-Smad2 was examined in primary freshly isolated rat or cryo-preserved human PC exposed to various stimuli by Western blotting,electrophoretic mobility shift assay(EMSA) ,reporter-gene-assays and reversetranscriptase polymerase chain reaction. RESULTS:IL-6 strongly down-regulated CCN2/CTGF protein and mRNA expression in PC,enhanceable by extracellular presence of the soluble IL-6 receptor gp80,and supported by an inverse relation between IL-6 and CCN2/CTGF concentrations in patients'sera.The inhi-bition of TGFβ1 driven CCN2/CTGF expression by IL-6 did not involve a modulation of Smad2(and Smad1/3) signalling.However,the STAT3 SH2 domain binding peptide,a selective inhibitor of STAT3 DNA binding activity,counteracted the inhibitory effect of IL-6 on CCN2/CTGF expression much more pronounced than pyrrolidine-dithiocarbamate,an inhibitor primarily of STAT3 phosphorylation.An EMSA confirmed STAT3 binding to the proposed proximal STAT binding site in the CCN2/CTGF promoter. CONCLUSION:CCN2/CTGF is identified as a hepatocellular negative acute phase protein which is downregulated by IL-6 via the STAT3 pathway through interaction on the DNA binding level. | Olav A Gressner Ieva Peredniene Axel M Gressner | 2011 | World Journal of Gastroenterology2011，17，2： | 3 |
| 13 | A method for rapid derivation and propagation of neural progenitors from human embryonic stem cells显示文摘 | Mathilda Zetterstr?m Axell Suzana Zlateva Maurice Curtis | 2009 | Journal of Neuroscience Methods2009，，2： | 2 |
| 14 | Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury显示文摘 | Caudrillier Axelle Kessenbrock Kai Gilliss Brian M Nguyen John X Marques Marisa B Monestier Marc Toy Pearl Werb Zena Looney Mark R | 2012 | EN2012，，7： | 2 |
| 15 | Renal Cell Carcinoma With Tumor Thrombus Extension Into the Vena Cava: Prospective Long-Term Followup显示文摘 | Axel Haferkamp Patrick J. Bastian Hildegard Jakobi Maria Pritsch Jesco Pfitzenmaier Peter Albers Peter Hallscheidt Stefan C. Müller Markus Hohenfellner | 2007 | The Journal of Urology2007，，5： | 2 |
| 16 | Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells显示文摘瞄准:学习 C (CysC ) ,它由转变生长 factor-beta1 (TGF-beta1 ) 的规定和导出血小板的生长因素(PDGF ) 和有在这个特殊房间发信号的 TGF-beta1 的 CysC 的潜在的干扰打的 cystatin 的表示。方法:我们计算了 CysC 表达式在有教养, profibrogenic 肝的星形细胞和区分 trans 的 myofibroblasts 由北、西方弄污并且共焦的激光扫描显微镜学。结果:CysC 在 trans 区别期间显著地被增加。TGF-beta1 和 PDGF-BB 压制了 CysC 表示。而且, CysC 分泌物被处理与 TGF-beta1 导致。尽管 CysC 导致了 TGF 贝它的一种增加的有约束力的亲密关系,受体是由化学 cross-linking 估计了与打 III (beta-glycan )[125I ] 它没调制的 -TGF-beta1, 由评估 Smad2/3 磷酸化地位出现的 TGF-beta1 信号转导变异并且[CAGA ]-MLP-luciferase 记者基因试金。有趣地,流类型 III TGF 贝它受体 beta-glycan 在对待 CysC 的房间被减少。我们的数据显示那 CysC 表情起来在 trans 区别期间调整了。结论:在患肝疾病的病人的浆液的增加的 CysC 层次是至少部分由于在激活的肝的星形细胞的更高的表情。而且, TGF-beta1 影响 CysC 的分泌物,加亮在肝的纤维发生的前进的半胱氨酸朊酶的一个潜在地重要的角色。 | Axel M Gressner Birgit Lahme Steffen K Meurer Olav Gressner Raif Weiskirchen | 2006 | World Journal of Gastroenterology2006，12，5： | 2 |
| 17 | A prospective two-center study comparing wireless capsule endoscopy with intraoperative enteroscopy in patients with obscure GI bleeding显示文摘 | Dirk Hartmann Harald Schmidt Georg Bolz Dieter Schilling Frank Kinzel Axel Eickhoff Winfried Huschner Kathleen M?ller Ralf Jakobs Peter Reitzig Uwe Weickert Klaus Gellert Harald Schultz Klaus Guenther Hartmut Hollerbuhl Klaus Schoenleben Hans-Joachim Schu | 2005 | Gastrointestinal Endoscopy2005，，7： | 2 |
| 18 | Polybrominated diphenyl ethers (PBDEs) and alternative brominated flame retardants in air and seawater of the European Arctic显示文摘 | Axel M?ller Zhiyong Xie Renate Sturm Ralf Ebinghaus | 2011 | Environmental Pollution2011，，6： | 1 |
| 19 | Endocrine regulation of energy metabolism:Review of pathobiochemical and clinical chemical aspects of leptin,ghrelin,adiponectin,and resistin显示文摘 | Ursula M Axel MG | 2004 | Clini Chemi2004，50，： | 1 |
| 20 | Primary Gastric B-Cell Lymphoma: Results of a Prospective Multicenter Study显示文摘 | Wolfgang Fischbach* Brigitte Dragosics? Maria-Elisabeth Kolve-Goebeler§ Christian Ohmann∥ Axel Greiner? Qin Yang∥ Stephan B?hm? Patrick Verreet∥ Olaf Horstmann# Martin Busch** Eckhart Dühmke** Hans-Konrad Müller-Hermelink? Klaus Wilms§ | 2000 | Gastroenterology2000，，5： | 1 |
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