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| 1 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015,21,43: | 21 |
| 2 | Management of hepatocellular adenoma: Solitary-uncomplicated, multiple and ruptured tumors显示文摘AIM: While hepatocellular adenomas (Has) have often been studied as a unique entity, we aimed to better define current management of the various forms of Has.METHODS: Twenty-five consecutive patients operated for solitary-uncomplicated (9), multiple (6), and ruptured (10)Has were reviewed according to management strategies and outcomes.RESULTS: All solitary-uncomplicated Has (ranged 2.2-14 cm in size) were removed. Out of 25 Has, 2 (8%) included foci of carcinoma. In the multiple HA group, previously undiagnosed tumors were identified during surgery in 5/6cases. In three cases with multiple spread HA, several lesions had to be left unresected. They remained unmodified after 4-, 6-, and 6-year radiological follow-up. Patients with ruptured HA (ranged 1.7-10 cm in size) were initially managed with hemodynamic support and angiography,allowing the embolization of actively bleeding tumors in two patients. All ruptured tumors were subsequently removed 5.5 d (range 4-70 d) after admission. CONCLUSION: Tumors suspected of HA, regardless of the size, should be resected, because of high chances of rupture causing bleeding, and/or containing malignant foci.Although it is desirable to remove all lesions of multiple HA, this may not be possible in some patients, for whom long-term radiological follow-up is advised. Ruptured HA can be managed by hemodynamic support and angiography,allowing scheduled surgery. | Christian Toso Pietro Majno Axel Andres Laura Rubbia-Brandt Thierry Berney Leo Buhler Philippe Morel Gilles Mentha | 2005 | World Journal of Gastroenterology2005,11,36: | 9 |
| 3 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management显示文摘 | Axel Dignass James O. Lindsay Andreas Sturm Alastair Windsor Jean-Frederic Colombel Mathieu Allez Gert D’Haens André D’Hoore Gerassimos Mantzaris Gottfried Novacek Tom ?resland Walter Reinisch Miquel Sans Eduard Stange Severine Vermeire Simon Travis Gert | 2012 | Journal of Crohn’s and Colitis2012,,10: | 4 |
| 4 | A Score Predicting Survival After Liver Retransplantation for Hepatitis C Virus Cirrhosis显示文摘 | Axel Andres Eric Gerstel Christophe Combescure Sonal Asthana Shaheed Merani Pietro Majno Thierry Berney Philippe Morel Norman Kneteman Gilles Mentha Christian Toso | 2012 | Transplantation2012,,7: | 3 |
| 5 | Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases显示文摘 | Daria Zorzi M.D. John T. Mullen M.D. Eddie K. Abdalla M.D. Timothy M. Pawlik M.D. M.P.H. Axel Andres M.D. Andrea Muratore M.D. Steven A. Curley M.D. Gilles Mentha M.D. Lorenzo Capussotti M.D. Jean-Nicolas Vauthey M.D | 2006 | Journal of Gastrointestinal Surgery2006,,1: | 2 |
| 6 | Effect of Surgical Margin Status on Survival and Site of Recurrence After Hepatic Resection for Colorectal Metastases显示文摘 | Timothy M. Pawlik Charles R. Scoggins Daria Zorzi Eddie K. Abdalla Axel Andres Cathy Eng Steven A. Curley Evelyne M. Loyer Andrea Muratore Gilles Mentha Lorenzo Capussotti Jean-Nicolas Vauthey | 2005 | Annals of Surgery2005,,5: | 2 |
| 7 | Upgrading of waste derived solid fuel by steam gasification显示文摘 | COLETTE BRAEKMAN-DANHEUX AXELLE DHAEYERE ANDRE FONTANA | 1998 | Fuel1998,77,12: | 1 |
| 8 | Indications for and Outcomes After Combined Lung and Liver Transplantation: A Single-Center Experience on 13 Consecutive Cases显示文摘 | Gerrit Grannas Michael Neipp Marius M. Hoeper Jens Gottlieb Rainer Lück Thomas Becker Andre Simon Christian P. Strassburg Michael P. Manns Tobias Welte Axel Haverich Jürgen Klempnauer Bj?rn Nashan Martin Strueber | 2008 | Transplantation2008,,4: | 1 |
| 9 | Upgrading of waste derived solid fuel by steam gasification 显示文摘 | COLLETTE BREAEKMAN -DANHEUX AXELLE D HAEYCIE ANDRE FONTANA | 1998 | Fuel1998,77,12: | 1 |
| 10 | Catechol-O-Methyltransferase and Blood Pressure in Humans显示文摘 | Jens Jordan Axel Lipp Jens Tank Christoph Schr?der Mandy Stoffels Gabriele Franke Andre Diedrich Guy Arnold David S. Goldstein Arya M. Sharma Friedrich C. Luft | 2002 | Circulation: Journal of the American Heart Association2002,,4: | 1 |
| 11 | Operativemanagement of colorectal liver metastases 显示文摘 | Gilles Mentha Sylvain Terraz Axel Andres | 2013 | Semin Liver Dis2013,33,: | 1 |
| 12 | Diagnostic accuracy of multidetector computed tomography coronary angiography in patients with angiographically proven coronary artery disease显示文摘 | Axel K Andres FK Stephen S | 2004 | J Am Cardiol2004,5,: | 1 |
| 13 | Upgrading of waste derived solid fuel by steam gasification显示文摘 | Colette B D Axelle D Andre F | 1998 | Fuel1998,77,172: | 1 |
| 14 | A Survival Analysis of the Liver-First Reversed Management of Advanced Simultaneous Colorectal Liver Metastases: A LiverMetSurvey-Based Study显示文摘 | Axel Andres Christian Toso Rene Adam Eduardo Barroso Catherine Hubert Lorenzo Capussotti Eric Gerstel Arnaud Roth Pietro E. Majno Gilles Mentha | 2012 | Annals of Surgery2012,,5: | 1 |
| 15 | Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases显示文摘 | Daria Zorzi M.D. John T. Mullen M.D. Eddie K. Abdalla M.D. Timothy M. Pawlik M.D. M.P.H. Axel Andres M.D. Andrea Muratore M.D. Steven A. Curley M.D. Gilles Mentha M.D. Lorenzo Capussotti M.D. Jean-Nicolas Vauthey M.D | 2006 | Journal of Gastrointestinal Surgery2006,,1: | 1 |
| 16 | Upgrading of waste derived solid fuel by steam gasification显示文摘 | Colette B D Axelle D André F | 1998 | Fuel1998,77,2: | 1 |
| 17 | Oxidation of H2, CO and methane in SOFCs with Ni/YSZ-cermet anodes显示文摘 | Andre W Bastian S Axel C | 2002 | Solid State lonics2002,,152153: | 1 |
| 18 | Result of emergency Hartmann' s operation for obstructive or perforated left-sided coloreetal cancer显示文摘 | Pierre Charbonnet Pascal Gervaz Axel Andres | 2008 | World J of Surg Oncol2008,6,1: | 1 |
| 19 | Systematic review and meta‐analysis of fibrin sealants for patients undergoing pancreatic resection显示文摘 | Lorenzo A. Orci Graziano Oldani Thierry Berney Axel Andres Gilles Mentha Philippe Morel Christian Toso | 2014 | HPB2014,,1: | 1 |
| 20 | Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury显示文摘 | David Gazzieri Marcello Trevisani Jochen Springer Selena Harrison Graeme S. Cottrell Eunice Andre Paola Nicoletti Daniela Massi Sandra Zecchi Daniele Nosi Marco Santucci Norma P. Gerard Monica Lucattelli Giuseppe Lungarella Axel Fischer Eileen F. Grady Ni | 2007 | Free Radical Biology and Medicine2007,,4: | 1 |