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| 1 | Diagnosis of biliary strictures after liver transplantation:Which is the best tool?显示文摘AIM: To evaluate the diagnostic value of different indirect methods like biochemical parameters, ultrasound (US) analysis, CT-scan and MRI/MRCP in comparison with endoscopic retrograde cholangiography (ERC), for diagnosis of biliary complications after liver transplantation. METHODS: In 75 patients after liver transplantation, who received ERC due to suspected biliary complications, the result of the cholangiography was compared to the results of indirect imaging methods performed prior to ERC. The cholangiography showed no biliary stenosis (NoST) in 25 patients, AST in 27 and ITBL in 23 patients. RESULTS: Biliary congestion as a result of AST was detected with a sensitivity of 68.4% in US analysis (specificity 91%), of 71% in MRI (specificity 25%) and of 40% in CT (specificity 57.1%). In ITBL, biliary congestion was detected with a sensitivity of 58.8% in the US, 88.9%in MRI and of 83.3% in CT. However, as anastomotic or ischemic stenoses were the underlying cause of biliary congestion, the sensitivity of detection was very low. InMRI detected the dominant stenosis at a correct localization in 22% and CT in 10%, while US failed completely. The biochemical parameters, showed no significant difference in bilirubin (median 5.7; 4,1; 2.5 mg/dL), alkaline phosphatase (median 360; 339; 527 U/L) or gamma glutamyl transferase (median 277; 220; 239 U/L) levels between NoST, AST and ITBL.CONCLUSION: Our data confirm that indirect imaging methods to date cannot replace direct cholangiography for diagnosis of post transplant biliary stenoses. However MRI may have the potential to complement or precede imaging by cholangiography. Optimized MRCP-processing might further improve the diagnostic impact of this method. | Thomas Zoepf Evelyn J. Maldonado-Lopez Philip Hilgard Alexander Dech■ne Massimo Malago Christoph E. Broelsch Joerg Schlaak Guido Gerken | 2005 | World Journal of Gastroenterology2005，11，19： | 32 |
| 2 | 防腐剂的作用及有效性评价方法概述显示文摘 | 薛虹宇 印桂琪 Evelyn G.Su | 2004 | 日用化学品科学2004，27，7： | 23 |
| 3 | Estimating liver weight of adults by body weight and gender显示文摘瞄准:为了为估计接枝的足够估计标准肝重量,为癌症在主要肝切除术在实时施主肝移植和残余肝缩放。方法:在这研究,体重和身高的人体测量的数据在 159 个实时的肝施主为与肝重量的关联被测试包括中间的肝的静脉经历了施主权利肝切除术。肝重量从在背表格获得的正确脑叶接枝重量被计算,在计算断层摄影术上由正确脑叶的比例划分了。结果:这些题目,所有汉语,有 35.8+/-10.5 年,和女性的吝啬的年龄到 118:41 的男比率。正确脑叶的吝啬的体积是 710.14+/-131.46 mL 并且在计算断层摄影术上占据了整个肝的 64.55%+/-4.47% 。正确脑叶称了 598.90+/-117.39 g,估计的肝重量是 927.54+/-168.78 g。当体重和身高受到多重逐步的线性回归分析时,身高被发现不足道。一样的体重的女性有稍微更低的肝重量。一个公式基于体重和性被导出:估计的标准肝重量(g)= 218 + BW (kg ) x 12.3 + 性 x 51 (R2 = 0.48 )( 女 = 0,男 = 1 ) 。基于这 159 个题目,的人体测量的数据肝重量用在白种人,日语,朝鲜语,和汉语上从研究导出的以前出版的公式被计算。所有公式与这个公式相比过高估计肝重量。日本公式为成年人过高估计估计的标准肝重量(ESLW ) 不到 60 kg。结论:对中国男性和女性适用的一个公式是可得到的。为单个赛跑的一个公式显得必要。 | See Ching Chan Chi Leung Liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong Sheung Tat Fan | 2006 | World Journal of Gastroenterology2006，12，14： | 22 |
| 4 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 5 | Disruption of the Sugar Transporters AtSWEET11 and AtSWEET12 Affects Vascular Development and Freezing Tolerance in Arabidopsis显示文摘Dear Editor, In plants,the transport of sugars from the site of biosynthesis to the site of utilization or storage relies on sugar transporters located in different subcellular compartments and different vascular cell types.The SWEET sugar transporter family is one such class and is represented by 17 members in Arabidopsis.AtSWEET1 was the first plant SWEET transporter to be characterized;it acts as a glucose uniporter in multiple systems (Chen et al.,2010). | Rozenn Le Hir Lara Spinner Patrick A. W. Klemens Dipankar Chakraborti Federica de Marco Francoise Vilaine Nelly Wolff Remi Lemoine Benoit Porcheron Carine Gery Evelyne Teoule Salem Chabout Gregory Mouille H. Ekkehard Neuhaus Sylvie Dinant Catherine Bellini | 2015 | Molecular Plant2015，8，11： | 16 |
| 6 | 健康城市——发展历程、建设方法和评估机制显示文摘健康城市的研究、监督和评价,必须建立在科学的方法和方法论基础上。调查既往导致健康不公平的因素,收集社会人口数据及编辑相关资料,总结市政当局直接或间接处理公平性问题的政策及程序,选择上述政策可产生影响和不能影响的政策进行比较,评价影响参与健康城市项目的各个因素,评价主观与客观的效益,寻求促进健康公平性的措施,这就是健康城市的评价与建设要回答的问题。 | Evelyne de Leeuw 郑英杰 | 2006 | 医学与哲学(A)2006，27，1： | 13 |
| 7 | 基于双频正交光栅一维相移的相位测量偏折术研究显示文摘提出一种新的相移方法,该方法将原独立的水平和垂直一维正弦光栅集成为单幅正交正弦光栅图,再采用双频光栅相移方法,从而实现仅通过某一特定方向相移即可获取两正交相位分布,并进而计算出待测面的梯度分布并由梯度分布恢复待测表面面形。详细介绍了双频光栅相移方法,推导了相移方向与双频光栅相移的对应关系。在传统方法中,须独立投影或显示水平和垂直一维正弦光栅,且分别进行相移测量,因此共需2×N幅图像(N≥3);而在双频正交光栅相移方法中,最少需要5幅图像。当采用机械相移时,传统方法需要二维相移机构,而该方法仅需一维相移机构,因此该方法具有成本低、测量速度快、结构简单等优点。实测的眼镜片结果,验证了该方法的可行性。 | 刘元坤 Evelyn Olesch 杨征 Gerd Hausler 苏显渝 | 2015 | 中国激光2015，42，3： | 13 |
| 8 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 9 | Comparison of peripapillary retinal nerve fiber layer thickness between myopia severity groups and controls显示文摘AIM: To compare the peripapillary retinal nerve fiber layer(RNFL) thickness measured via optical coherence tomography(OCT) between different groups of myopia severity and controls. METHODS: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Myopic patients were classified as low myopia(LM) [spherical equivalent(SE) from greater than-0.5 D, up to-3.0 D], moderate myopia(MM; SE greater than-3.0 D, up to-6.0 D) and high myopia(HM; SE greater than-6.0 D). The control group consisted of emmetropic(EM) patients(SE from +0.5 D to-0.5 D). A Zeiss Cirrus HD-OCT machine was used to measure the peripapillary RNFL thickness of both eyes of each subject. The mean peripapillary RNFL thickness between groups was compared using both analysis of variance and analysis of covariance.RESULTS: A total of 403 eyes of 403 subjects were included in this study. The mean age was 31.48±10.23 y. There were 180(44.7%) eyes with EM, 124(30.8%) with LM, 73(18.1%) with MM and 26(6.5%) with HM. All groups of myopia severity had a thinner average RNFL than the EM group, but after controlling for gender, age, and axial eye length, only the HM group differed significantly from the EM group(P=0.017). Likewise, the superior, inferior and nasal RNFL was thinner in all myopia groups compared to controls, but after controlling for confounders, only the inferior quadrant RNFL was significantly thinner in the HM group, when compared to the EM group(P=0.017). CONCLUSION: The average and inferior quadrant RNFL is thinner in highly myopic eyes compared to emmetropic eyes. Refractive status must be taken into consideration when interpreting the OCT of myopic patients, as RNFL thickness varies with the degree of myopia. | Evelyn Li Min Tai Jiunn Loong Ling Eng Hui Gan Hussein Adil Wan-Hiram Wan-Hazabbah | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 7 |
| 10 | Sessile serrated adenomas:Demographic,endoscopic and pathological characteristics显示文摘AIM:To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma(SSA) in a single center.METHODS:Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007.A retrospective chart review was performed to extract data on demographics,polyp characteristics,presence of synchronous adenomatous polyps or cancer,polypectomy methods,and related complications.RESULTS:One hundred and seventy-one(2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs.The mean(SE) size of the SSAs was 8.1(0.4) mm;42% of SSAs were ≤ 5 mm,and 69% were ≤ 9 mm.Fifty-one per cent of SSAs were located in the cecum or ascending colon.Approximately half of the patients had synchronous polyps of other histological types,including hyperplastic and adenomatous polyps.Synchronous adenocarcinoma was present in seven(4%) cases.Ninety-seven percent of polyps were removed by colonoscopy.CONCLUSION:Among patients with colon polyps,2.9% were found to have SSAs.Most of the SSAs were located in the right side and were safely managed by colonoscopy. | Suryakanth R Gurudu Russell I Heigh Giovanni De Petris Evelyn G Heigh Jonathan A Leighton Shabana F Pasha Isaac B Malagon Ananya Das | 2010 | World Journal of Gastroenterology2010，16，27： | 7 |
| 11 | 肥胖与体重正常的前列腺癌患者中miR-21,miR-221与miR.222表达与前列腺癌复发的关系显示文摘最近有报道发现某些miRNAs在肥胖和前列腺癌复发中都发挥重要,但是这些miRNAs与肥胖前列腺癌患者的癌症复发的关系还没有相关报道。本研究通过28名复发和37名未复发前列腺癌患者,研究了肥胖与miR-21,miR-221与miR-222表达之间的关系对前列腺癌复发的影响。用定量PCR测定miRNA的表达。COX比例风险模型调整过的就诊年龄、临床阶段、Gleason分值用来估计复发自由生存率的风险比例(HR)和95%置信区间(95%CI)。复发患者(78.6%)的miR.21表达明显比不复发患者(48.6%)低,而且低表达的人数也多(P=0.014)。这种差异在肥胖患者中尤其明显。多因素分析显示miR-21在肥胖患者中(HR=6.15,95%CI=I.04—36.48,P=0.045),是一个独立的风险因素,但在体重正常患者中(HR=1.28,95%CI=0.30—5.49,P=0.74)不是。未观察到miR-221和miR-222表达与复发之间的明显关联。总之,我们的研究显示miR-21与前列腺根治术后的前列腺癌复发有关联,同时miR-21的表达在复发与不复发之间的差异表达在肥胖患者中更明显。我们将来需要更大型的研究来证实这些初步的研究成果,并且查明其相关机制。 | Ernest K Amankwah Evelyn Anegbe Hyun Park Julio Pow-Sang Ardeshir Hakam Jong Y Park | 2013 | Asian Journal of Andrology2013，15，2： | 6 |
| 12 | Hepatitis B virus mutations potentially conferring adefovir/ tenofovir resistance in treatment-naive patients显示文摘Anti-hepatitis B virus(HBV)therapy leads to the emer- gence of mutant viral strains during the treatment of chronic hepatitis B with nucleos(t)ides analogues. The existence of HBV variants with primary antiviral resistance may be important for treatment choice. We studied two patients with chronic HBV infection by sequencing the HBV polymerase gene.They had adefovir-and tenofovir-related mutations in the viral polymerase,although they had never been treated. These mutations were rtV214A/rtN238T in one patient and rtA194T in the other.Thus,mutations in untreated patients deserve cautious surveillance.These data indicate that mutations that can theoretically confer adefovir or tenofovir resistance may emerge in treatmentnaive patients. | Rebecca Pastor Franois Habersetzer Samira Fafi-Kremer Michel Doffoёl Thomas F Baumert Jean-Pierre Gut Franoise Stoll-Keller Evelyne Schvoerer | 2009 | World Journal of Gastroenterology2009，15，6： | 6 |
| 13 | Population pharmacokinetics of ciclosporin in Chinese children with aplastic anemia: effects of weight, renal function and stanozolol administration显示文摘 | Shao-qing NI Wei ZHAO Jue WANG Su ZENG Shu-qing CHEN Evelyne JACQZ-AIGRAIN Zheng-yan ZHAO | 2013 | Acta Pharmacologica Sinica2013，34，7： | 6 |
| 14 | 发展健康城市项目的20个步骤显示文摘 | 王书梅 Evelyne de Leeuw | 2002 | 中国健康教育2002，18，1： | 5 |
| 15 | 急性视神经炎后视神经功能与视觉诱发电位的研究(英文)显示文摘目的:比较视神经炎患者和正常人的视神经功能与视觉诱发电位。方法:本研究为2011年9月至2013年2月在马来西亚大学眼科医院进行的横断面研究。研究包含在检查前3mo至2y间发生特发性神经炎一次的视神经炎患者20例和10例正常人。眼科检查包括视力、色觉、视觉灵敏度、视野和视觉诱发电位。独立t检验用于比较视神经炎组与对照组视神经功能和VEP参数的差异。在参数非正态分布时,Mann-Whitney试验用于比较两组间的中位数。结果:视神经炎组的平均年龄为30.8岁。在视神经炎发作至评估期间的平均持续时间为6.6个月。视神经炎组视力较差,平均LogM AR值(0.52)明显高于对照组(P=0.001)。色觉下降,视神经炎组的平均值为63%(P=0.001)。视神经炎患者的对比敏感度在四个空间频率上均有所下降[3CPD(P=0.029),6CPD(P=0.026),12CPD(P=0.002)、18CPD(P=0.006)]。视神经炎组的视野下降有统计学意义(P<0.001)。与对照组相比,视神经炎组的VEP P100潜伏期有轻微延长。但使用棋盘格模式1或2时,VEP潜伏期的差异不显著。视神经炎患者的VEP振幅较高,但两组差异无统计学意义。结论:视神经炎急性发作,平均6mo后视神经功能(即视力、色觉、对比敏感度和视野)显著下降。视神经炎组和对照组的VEP振幅和潜伏期无显著差异。VEP可能不是理想的诊断视神经炎既往发作史的试验,尽管VEP参数在浮动后趋于正常。 | Evelyn Tai Li Min Ng Seok Hui Jakiyah Daud Raja Azmi Mohd Noor Wan-Hazabbah Wan Hitam | 2017 | 国际眼科杂志2017，17，5： | 5 |
| 16 | Human viral pathogens are pervasive in wastewater treatment center aerosols显示文摘Wastewater treatment center(WTC) workers may be vulnerable to diseases caused by viruses, such as the common cold, influenza and gastro-intestinal infections. Although there is a substantial body of literature characterizing the microbial community found in wastewater, only a few studies have characterized the viral component of WTC aerosols,despite the fact that most diseases affecting WTC workers are of viral origin and that some of these viruses are transmitted through the air. In this study, we evaluated in four WTCs the presence of 11 viral pathogens of particular concern in this milieu and used a metagenomic approach to characterize the total viral community in the air of one of those WTCs. The presence of viruses in aerosols in different locations of individual WTCs was evaluated and the results obtained with four commonly used air samplers were compared.We detected four of the eleven viruses tested, including human adenovirus(h Ad V),rotavirus, hepatitis A virus(HAV) and Herpes Simplex virus type 1(HSV1). The results of the metagenomic assay uncovered very few viral RNA sequences in WTC aerosols, however sequences from human DNA viruses were in much greater relative abundance. | Evelyne Brisebois Marc Veillette Vanessa Dion-Dupont Jacques Lavoie Jacques Corbeil AlexANDer Culley Caroline Duchaine | 2018 | Journal of Environmental Sciences2018，30，5： | 5 |
| 17 | Phase 2 trial of linifanib (ABT‐869) in patients with unresectable or metastatic hepatocellular carcinoma显示文摘 | Han Chong Toh Pei‐Jer Chen Brian I. Carr Jennifer J. Knox Sharlene Gill Peter Ansell Evelyn M. McKeegan Barry Dowell Michelle Pedersen Qin Qin Jiang Qian Frank A. Scappaticci Justin L. Ricker Dawn M. Carlson Wei Peng Yong | 2012 | Cancer2012，，2： | 4 |
| 18 | IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice显示文摘 | Petrasek Jan Bala Shashi Csak Timea Lippai Dora Kodys Karen Menashy Victoria Barrieau Matthew Min So-Yun Kurt-Jones Evelyn A Szabo Gyongyi | 2012 | EN2012，，10： | 4 |
| 19 | 影响增殖性糖尿病视网膜病变玻璃体切除术后视力改善的因素(英文)显示文摘目的:分析影响增殖性糖尿病视网膜病变(PDR)玻璃体切除术后视力改善的因素。方法:回顾性分析。收集2014-01/2014-12在马来西亚吉打州,亚罗士打Sultanah Bahiyah医院收治的PDR行玻璃体切除术病例资料,包括1y内患者统计,基线视力(VA)和LogMAR术后最佳矫正视力。使用IBM SPSS Statistics Version 22.0进行数据分析。结果:共103例患者。平均年龄51.2y。在多变量分析中,每个0 logMAR基线VA的1 logMAR术前正偏差与0.859logMAR的术后改善相关(P<0.001)。同样,术前附着的黄斑与玻璃体切除术后的logMAR视力改善相关(b=0.374,P=0.003)。无虹膜新血管和无术后并发症与玻璃体切除术后改善的logMAR视力相关,分别为1.126(P=0.001)和0.377(P=0.005)。无长效眼内填充与玻璃体切除术后logMAR视力改善相关,为0.302(P=0.010)。结论:玻璃体切除术后与视力改善的相关因素是:术前视力较差,黄斑附着,无虹膜新生血管,无术后并发症和未使用长效眼内填充物。了解视力改善的因素将有助于玻璃体视网膜手术的决策。 | Evelyn Tai Li Min Goh Yihu Wan-Hazabbah Wan Hitam Haslina Mohd Ali | 2017 | 国际眼科杂志2017，17，8： | 4 |
| 20 | 定量药理学在儿科临床个体化治疗中的应用显示文摘目前我国儿童用药安全已引起社会广泛关注.儿童用药存在种类匮乏、剂型较少、用法不明、研发滞后等问题.住院患儿超说明书用药的情况约占70%,在新生儿患者中的比例更是高达80%~97%[1].药品说明书中常见到"儿童剂量酌减"、"遵医嘱"等表述.儿童的生长和发育处于连续的和动态的发展变化过程中,由于生理的变化,成人和儿童之间存在着显著的药代动力学(pharmacokinetics)和药效学(pharmacodynamics)差异 [2]. | 郝国祥 郑义 Jacqz-Aigrain Evelyne 赵维 | 2015 | 中华儿科杂志2015，53，9： | 4 |
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