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| 1 | 5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells显示文摘以前,导出髓的干细胞(MSC ) 与不确定的脱氧核糖核酸甲基转移酶禁止者 5-azacytidine 对待的老鼠骨头被报导区分 intocardiomyocytes。现在的学习的目的是在从健康骨髓施主获得的人的单音的原子房间调查类似的区别策略的效率。After1-3 段落,文化为 24 h 暴露于到 6 星期进一步的文化跟随的 5-azacytidine (3 mciroM ) 。药处理没导致 myogenic 标记 MyoD 或心脏的 markersNkx2.5 和 GATA-4 的表示并且没在后续期间产出跳动的房间。在补丁夹钳实验,近似 10-15% 对待,未经治疗的房间展出了 L 类型 Ca (2+) 水流。几乎所有房间表面地出现了修正快速或慢的激活动力学的 K (+) 水流。在与匹配时间的控制相比在 6 星期处理以后加倍的 +60 mV 意味着当前的振幅。对待的房间的 Membranecapacitance 比在在处理以后的 controls2 星期内显著地大并且在 6 个星期以后仍然保持高。为 K (+) 隧道 Kv1.1, Kv1.5, Kv2.1, Kv4.3 和 KCNMA1 并且为 Ca (2+) 隧道 Ca (v) 的 mRNAs 的表示层次 1.2 没被 5-azacytidine 影响。在以前显示出禁止 hMSC 的快速或慢慢地激活的 K (+) 水流的集中的 Treatmentwith 钾隧道块 ers tetraethylammonium 和 clofilium 禁止了这些房间的增长。我们的结果建议尽管有进 cardiomyocytes 的 hMSC 的区别的缺席,有 5-azacytidine 的处理在当前的密度引起了深刻变化。 | Bartosz Balanal Cecilia Nicoletti Ihor Zahanich Eva M Graf Torsten Christ Sabine Boxberger Ursula Ravens | 2006 | Cell Research2006，16，12： | 20 |
| 2 | Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation显示文摘The intimate connection and the strict mutual cooperation between the gut and the liver realizes a functional entity called gut-liver axis.The integrity of intestinal barrier is crucial for the maintenance of liver homeostasis.In this mutual relationship,the liver acts as a second firewall towards potentially harmful substances translocated from the gut,and is,in turn,is implicated in the regulation of the barrier.Increasing evidence has highlighted the relevance of increased intestinal permeability and consequent bacterial translocation in the development of liver damage.In particular,in patients with non-alcoholic fatty liver disease recent hypotheses are considering intestinal permeability impairment,diet and gut dysbiosis as the primary pathogenic trigger.In advanced liver disease,intestinal permeability is enhanced by portal hypertension.The clinical consequence is an increased bacterial translocation that further worsens liver damage.Furthermore,this pathogenic mechanism is implicated in most of liver cirrhosis complications,such as spontaneous bacterial peritonitis,hepatorenal syndrome,portal vein thrombosis,hepatic encephalopathy,and hepatocellular carcinoma.After liver transplantation,the decrease in portal pressure should determine beneficial effects on the gut-liver axis,although are incompletely understood data on the modifications of the intestinal permeability and gut microbiota composition are still lacking.How the modulation of the intestinal permeability could prevent the initiation and progression of liver disease is still an uncovered area,which deserves further attention. | Alberto Nicoletti Francesca Romana Ponziani Marco Biolato Venanzio Valenza Giuseppe Marrone Gabriele Sganga Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，33： | 19 |
| 3 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 4 | Feasibility and safety of EUS-guided cryothermal ablation in patients with locally advanced pancreatic cancer显示文摘 | Paolo Giorgio Arcidiacono Silvia Carrara Michele Reni Maria Chiara Petrone Stefano Cappio Gianpaolo Balzano Cinzia Boemo Stefano Cereda Roberto Nicoletti Markus Dominik Enderle Alexander Neugebauer Daniel von Renteln Axel Eickhoff Pier Alberto Testoni | 2012 | Gastrointestinal Endoscopy2012，，6： | 3 |
| 5 | The Preoperative Manometric Pattern Predicts the Outcome of Surgical Treatment for Esophageal Achalasia显示文摘 | Renato Salvador Mario Costantini Giovanni Zaninotto Tiziana Morbin Christian Rizzetto Lisa Zanatta Martina Ceolin Elena Finotti Loredana Nicoletti Gianfranco Da Dalt Francesco Cavallin Ermanno Ancona | 2010 | Journal of Gastrointestinal Surgery2010，，11： | 2 |
| 6 | Medial temporal lobe abnormalities in pediatric unipolar depression显示文摘 | Sheila C. Caetano Manoela Fonseca John P. Hatch Rene L. Olvera Mark Nicoletti Kristina Hunter Beny Lafer Steven R. Pliszka Jair C. Soares | 2007 | Neuroscience Letters2007，，3： | 2 |
| 7 | Cymbopogon citratus -synthesized gold nanoparticles boost the predation efficiency of copepod Mesocyclops aspericornis against malaria and dengue mosquitoes显示文摘 | Kadarkarai Murugan Giovanni Benelli Chellasamy Panneerselvam Jayapal Subramaniam Tirupathi Jeyalalitha Devakumar Dinesh Marcello Nicoletti Jiang-Shiou Hwang Udaiyan Suresh Pari Madhiyazhagan | 2015 | Experimental Parasitology2015，，： | 2 |
| 8 | Angiotensin Ⅱ stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress 显示文摘 | Pueyo ME Gonzalez W Nicoletti A | 2000 | Arterioscler Thromb Vasc Biol2000，20，3： | 2 |
| 9 | Effects of Tumour Necrosis Factor-α on Human Sperm Motility and Apoptosis显示文摘 | Anna Perdichizzi Ferdinando Nicoletti Sandro La Vignera Nunziata Barone Rosario D’Agata Enzo Vicari Aldo E. E. Calogero | 2007 | Journal of Clinical Immunology2007，，2： | 2 |
| 10 | Interleukin-2 induces apoptosis in mouse thymocytes显示文摘 | Nicoletti I Pagliacci MC | 1993 | Cell Immunol1993，146，： | 1 |
| 11 | A rapid and simple method for measuring thymoeyte apoptosis propiduim iodide staining and flow cytometry显示文摘 | Miglioti G Paglicci MC | 1991 | J Immun Methods1991，139，2： | 1 |
| 12 | Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects显示文摘 | Brarabilla P Nicoletti MA Harenski K | 2002 | Neuropsychoparmacology2002，27，： | 1 |
| 13 | Effect of liposuction on insulin resistance and vascular inflammatory markers in obese women显示文摘 | Giugliano G Nicoletti G Grlla E | 2004 | Br J Plast Surg2004，57，3： | 1 |
| 14 | Wolfgang lindner quinine-versus carbamoylated quinine-based chiral anion exchangers: A comparison regarding enantioselectivity for N-protected amino acids and other chiral acids 显示文摘 | Mandl A Nicoletti L Lammerhofer M | 1999 | J of Chromatogr A1999，858，： | 1 |
| 15 | Angiotensin II stimulates endothelial vascular cell adhesion molecule 1 via nuclear factor kappa B activation induced by intracellular oxidative stress显示文摘 | Pueyo ME Gonzalez W Nicoletti A | 2000 | Arterioscler Thromb Vasc Biol2000，20，3： | 1 |
| 16 | Prediction of the response to citalopram and reboxetine in post - stroke de- pressed patients 显示文摘 | Rampello L Chiech io S Nicoletti G | 2004 | Psychopharmacology2004，173，12： | 1 |
| 17 | Vascularendothelial growth factor is up-regulated after status epilepticus andprotects against seizure-induced neuronal loss in hippocampus显示文摘 | Nicoletti JN Shah SK McCloskey DP | 2008 | Neuroscience2008，151，1： | 1 |
| 18 | Combination of cyclophosphamide and interferon-beta halts progression in patients with rapidly transitional multiple sclerosis显示文摘 | Patti F Cataldi ML Nicoletti F | 2001 | Neurol Neurosurg Psychiatry2001，71，： | 1 |
| 19 | A concurrent engineering decision model: management of the project activities information flow显示文摘 | NICILO F | 1998 | International Journal of Production Economics1998，54，： | 1 |
| 20 | Angiotensin Ⅱ stimulates endothelial vascularcell adhesion molecule-1 via nuclear factor-кB activation induced by intracellularoxidative stress显示文摘 | Pueyo ME Gonzalez W Nicoletti A | 2000 | Arterioscler Thromb Vasc Biol2000，20，： | 1 |
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