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| 1 | Initial management for acute lower gastrointestinal bleeding显示文摘Acute lower gastrointestinal bleeding(LGIB) is a common indication for hospital admission. Patients with LGIB often experience persistent or recurrent bleeding and require blood transfusions and interventions, such as colonoscopic,radiological, and surgical treatments. Appropriate decision-making is needed to initially manage acute LGIB, including emergency hospitalization, timing of colonoscopy, and medication use. In this literature review, we summarize the evidence for initial management of acute LGIB. Assessing various clinical factors,including comorbidities, medication use, presenting symptoms, vital signs, and laboratory data is useful for risk stratification of severe LGIB, and for discriminating upper gastrointestinal bleeding. Early timing of colonoscopy had the possibility of improving identification of the bleeding source, and the rate of endoscopic intervention, compared with elective colonoscopy. Contrast-enhanced computed tomography before colonoscopy may help identify stigmata of recent hemorrhage on colonoscopy, particularly in patients who can be examined immediately after the last hematochezia. How to deal with nonsteroidal antiinflammatory drugs(NSAIDs) and antithrombotic agents after hemostasis should be carefully considered because of the risk of rebleeding and thromboembolic events. In general, aspirin as primary prophylaxis for cardiovascular events and NSAIDs were suggested to be discontinued after LGIB. Managing acute LGIB based on this information would improve clinical outcomes. Further investigations are needed to distinguish patients with LGIB who require early colonoscopy and hemostatic intervention. | Tomonori Aoki Yoshihiro Hirata Atsuo Yamada Kazuhiko Koike | 2019 | World Journal of Gastroenterology2019，25，1： | 28 |
| 2 | Atmospheric lead pollution in fine particulate matter in Shanghai, China显示文摘The Pb-monitoring program was extended for 6 years from 2002 to 2007 at 17 representative urban sites (6 traffic, 5 industrial, and 6 residential sites), and 3 suburban sites to assess the lead pollution in fine particulate matter (PM2.5) after phasing out leaded gasoline in Shanghai. Compared with Pb levels reported in other places, the Pb pollution in Shanghai is still serious after phasing out leaded gasoline, which remains at high concentration range (213–176 ng/m3) in PM2.5 in winter. Significant spatial variation of Pb concentrations and strong seasonal variation of higher Pb concentration in winter than that in summer were detected. The size distribution of Pb in particulate matter has a unimodal mode that peaks at approximately 0.154–1.59 μm particle diameter, indicating that Pb is mainly concentrated in fine fraction. Lead in the fine fraction is enriched by a factor of 103–104 relative to Pb abundance in crust. Eight categories of Pb pollution sources were identified in the PM2.5 in the winter of 2007 in Shanghai. The important emission sources among them are vehicle exhaust derived from combustion of unleaded gasoline, metallurgic industry emission, and coal combustion emission. | LI Xiaolin ZHANG Yuanxun TAN Mingguang LIU Jiangfeng BAO Liangman ZHANG Guilin LI Yan IIDA Atsuo | 2009 | Journal of Environmental Sciences2009，21，8： | 20 |
| 3 | Sentinel lymph node navigation surgery for early stage gastric cancer显示文摘We attempted to evaluate the history of sentinel node navigation surgery(SNNS),technical aspects,tracers,and clinical applications of SNNS using Infrared Ray Electronic Endoscopes(IREE)combined with Indocyanine Green(ICG).The sentinel lymph node(SLN)is defined as a first lymph node(LN)which receives cancer cells from a primary tumor.Reports on clinical application of SNNS for gastric cancers started to appear since early 2000s.Two prospective multicenter trials of SNNS for gastric cancer have also been accomplished in Japan.Kitagawa et al reported that the endoscopic dual(dye and radioisotope)tracer method for SN biopsy was confirmed acceptable and effective when applied to the early-stage gastric cancer(EGC).We have previously reported the usefulness of SNNS in gastrointestinal cancer using ICG as a tracer,combined with IREE(Olympus Optical,Tokyo,Japan)to detect SLN.LN metastasis rate of EGC is low.Hence,clinical application of SNNS for EGC might lead us to avoid unnecessary LN dissection,which could preserve the patient’s quality of life after operation.The most ideal method of SNNS should allow secure and accurate detection of SLN,and real time observation of lymphatic flow during operation. | Norio Mitsumori Hiroshi Nimura Naoto Takahashi Masahiko Kawamura Hiroaki Aoki Atsuo Shida Nobuo Omura Katsuhiko Yanaga | 2014 | World Journal of Gastroenterology2014，20，19： | 15 |
| 4 | Prediction of lymph node metastasis and sentinel node navigation surgery for patients with early-stage gastric cancer显示文摘Accurate prediction of lymph node(LN) status is crucially important for appropriate treatment planning in patients with early gastric cancer(EGC). However,consensus on patient and tumor characteristics associated with LN metastasis are yet to be reached. Through systematic search,we identified several independent variables associated with LN metastasis in EGC,which should be included in future research to assess which of these variables remain as significant predictors of LN metastasis. On the other hand,even if we use these promising parameters,we should realize the limitation and the difficulty of predicting LN metastasis accurately. The sentinel LN(SLN) is defined as first possible site to receive cancer cells along the route of lymphatic drainage from the primary tumor. The absence of metastasis in SLN is believed to correlate with the absence of metastasis in downstream LNs. In this review,we have attempted to focus on several independent parameters which have close relationship between tumor and LN metastasis in EGC. In addition,we evaluated the history of sentinel node navigation surgery and the usefulness for EGC. | Atsuo Shida Norio Mitsumori Hiroshi Nimura Yuta Takano Taizou Iwasaki Muneharu Fujisaki Naoto Takahashi Katsuhiko Yanaga | 2016 | World Journal of Gastroenterology2016，22，33： | 13 |
| 5 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 6 | ANFIS-based Sensor Fusion System of Sit-to-stand for Elderly People Assistive Device Protocols显示文摘This paper describes the analysis and design of an assistive device for elderly people under development at the EgyptJapan University of Science and Technology(E-JUST) named E-JUST assistive device(EJAD).Several experiments were carried out using a motion capture system(VICON) and inertial sensors to identify the human posture during the sit-to-stand motion.The EJAD uses only two inertial measurement units(IMUs) fused through an adaptive neuro-fuzzy inference systems(ANFIS) algorithm to imitate the real motion of the caregiver.The EJAD consists of two main parts,a robot arm and an active walker.The robot arm is a 2-degree-of-freedom(2-DOF) planar manipulator.In addition,a back support with a passive joint is used to support the patient s back.The IMUs on the leg and trunk of the patient are used to compensate for and adapt to the EJAD system motion depending on the obtained patient posture.The ANFIS algorithm is used to train the fuzzy system that converts the IMUs signals to the right posture of the patient.A control scheme is proposed to control the system motion based on practical measurements taken from the experiments.A computer simulation showed a relatively good performance of the EJAD in assisting the patient. | Omar Salah Ahmed A.Ramadan Salvatore Sessa Ahmed Abo Ismail Makasatsu Fujie Atsuo Takanishi | 2013 | International Journal of Automation and computing2013，10，5： | 4 |
| 7 | Screening of SLC25A13 mutation in the Thai population显示文摘AIM:To determine the prevalence of SLC25A13 mutations in the Thai population.METHODS:A total of 1537 subjects representing the Thai population were screened for a novel pathologic allele p.Met1?(c.2T>C)and six previously known common SLC25A13 mutations:[Ⅰ](c.851_854delGTAT),[Ⅱ](g.IVS11+1G>A),[Ⅲ](c.1638_1660dup),[Ⅳ](p.S225X),[Ⅴ](IVS13+1G>A),and[XIX](g.IVS16ins3kb)using a newly developed TaqMan and established HybProbe assay,respectively.Sanger sequencing was employed for specimens showing an aberrant peak to confirm the targeted mutation as well as the unknown aberrant peaks detected.Frequencies of the mutations identified were compared in each region.Carrier frequency and disease prevalence of citrin deficiency caused by SCL25A13 mutations were estimated.RESULTS:p.Met1?was identified in the heterozygous state in 85 individuals,giving a carrier frequency of1/18,which suggests possible selective advantage of this variant.The question of p.Met1?homozygote lethality remains unanswered which may serve as an explanation as to why this homozygote has yet to be identified in patients/controls even with high allele frequency.The p.Met1?mutation has rarely been studied in populations other than Thai and Chinese;therefore,may have been overlooked.Development of the TaqMan assay in the present study would allow a simple,rapid,and cost-effective method for mass screening.Heterozygous mutations:[XIX]and[Ⅰ]were identified in 17 individuals,giving a carrier rate of 1/90 and a calculated homozygote rate of 1/33000.Two novel variants,g.IVS11+17C>G and c.1311C>T,of unknown clinical significance were identified at low frequency.CONCLUSION:This study highlighted the current underestimation of citrin deficiency and suggests the possible selective advantage of the p.Met1?allele. | Parith Wongkittichote Chonlaphat Sukasem Atsuo Kikuchi Wichai Aekplakorn Laran T Jensen Shigeo Kure Duangrurdee Wattanasirichaigoon | 2013 | World Journal of Gastroenterology2013，19，43： | 4 |
| 8 | Risk factors for small bowel angioectasia:The impact of visceral fat accumulation显示文摘AIM: To investigate visceral fat accumulation in association with the risk of small bowel angioectasia.METHODS: We retrospectively investigated 198 consecutive patients who underwent both capsule endoscopy and CT for investigation of obscure gastrointestinal bleeding(OGIB) from January 2009 to September 2013. The visceral fat area(VFA) and subcutaneous fat area were measured by CT, and information on comorbidities, body mass index, and medications was obtained from their medical records.Logistic regression analysis was used to evaluate associations.RESULTS: Capsule endoscopy revealed small bowel angioectasia in 18/198(9.1%) patients with OGIB.Compared to patients without small bowel angioectasia,those with small bowel angioectasia had a significantly higher VFA(96 ± 76.0 cm2 vs 63.4 ±51.5 cm2, P = 0.016) and a higher prevalence of liver cirrhosis(61% vs 22%, P < 0.001). The proportion of patients with chronic renal failure was higher in patients with small bowel angioectasia(22% vs 9%,P = 0.11). There were no significant differences in subcutaneous fat area or waist circumference. The prevalence of small bowel angioectasia progressively increased according to the VFA. Multivariate analysis showed that the VFA [odd ratio(OR) for each 10-cm2 increment = 1.1; [95% confidence interval(CI):1.02-1.19; P = 0.021] and liver cirrhosis(OR = 6.1,95%CI: 2.2-18.5; P < 0.001) were significant risk factors for small bowel angioectasia.CONCLUSION: VFA is positively associated with theprevalence of small bowel angioectasia, for which VFA and liver cirrhosis are independent risk factors in patients with OGIB. | Atsuo Yamada Ryota Niikura Yuka Kobayashi Hirobumi Suzuki Shuntaro Yoshida Hirotsugu Watabe Yutaka Yamaji Yoshihiro Hirata Kazuhiko Koike | 2015 | World Journal of Gastroenterology2015，21，23： | 4 |
| 9 | Experimental Study on a Single Layer Two-Way Grid Shell with Tension Members显示文摘Single layer two-way grid shell with in-plane and out-of-plane tension members is a new type of single-layer latticed shell roofs. Compared with traditional single-layer latticed shells,this new type has a unique mesh form and excellent rigidity. In order to further understand the buckling behaviors of single layer two-way grid cylindrical shell roof with tension members,the buckling experiments have been undertaken to investigate the effect of tension members,in either out-of-plane or in-plane placement. A single layer two-way grid cylindrical shell roof with out-of-plane tension members has been tested under symmetric and asymmetric loading. The tension member placement,the introducing initial axial force to tension members and the load patterns are considered to investigate the buckling behavior. Experimental results indicate that four long out-ofplane tension members work well under symmetrical loading,but only two long out-of-plane tension members work under asymmetrical loading. It can be concluded that the PC bar members used as tension members for this study are useful in the construction of a single layer two-way grid cylindrical shell roof with structural members intersecting at small angles. | Zhonghao Zhang Masumi Fujimoto Atsuo Takino Katsuhiko Imai | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，4： | 3 |
| 10 | Effects of Probability of Revelation of Defection and Penalty to Defection on Cooperative Behavior in 2-Person Prisoner's Dilemma Game显示文摘 | Atsuo Murata Takuma Kanagawa Naoki Hata | 2012 | Computer Technology and Application2012，3，11： | 3 |
| 11 | Impact of fecal occult blood on obscure gastrointestinal bleeding:Observational study显示文摘AIM: To elucidate the association between small bowel diseases(SBDs) and positive fecal occult blood test(FOBT) in patients with obscure gastrointestinal bleeding(OGIB).METHODS: Between February 2008 and August 2013, 202 patients with OGIB who performed both capsule endoscopy(CE) and FOBT were enrolled(mean age; 63.6 ± 14.0 years, 118 males, 96 previous overt bleeding, 106 with occult bleeding). All patients underwent immunochemical FOBTs twice prior to CE. Three experienced endoscopists independently reviewed CE videos. All reviews and consensus meeting were conducted without any information on FOBT results. The prevalence of SBDs was compared between patients with positive and negative FOBT.RESULTS: CE revealed SBDs in 72 patients(36%). FOBT was positive in 100 patients(50%) and negative in 102(50%). The prevalence of SBDs was significantly higher in patients with positive FOBT than those with negative FOBT(46% vs 25%, P = 0.002). In particular, among patients with occult OGIB, the prevalence of SBDs was higher in positive FOBT group than negative FOBT group(45% vs 18%, P = 0.002). On the other hand, among patients with previous overt OGIB, there was no significant difference in the prevalence of SBDs between positive and negative FOBT group(47% vs 33%, P = 0.18). In disease specific analysis among patients with occult OGIB, the prevalence of ulcer and tumor were higher in positive FOBT group than negative FOBT group. In multivariate analysis, only positive FOBT was a predictive factors of SBDs in patients with OGIB(OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend was evidentam on g patients with occult OGIB who underwent FOBT on the same day or a day before CE. The prevalence of SBDs in positive vs negative FOBT group were 54% vs 13% in patients with occult OGIB who underwent FOBT on the same day or the day before CE(P = 0.001), while there was no significant difference between positive and negative FOBT group in those who underwent FOBT two or more days before CE(43% vs 25%, P = 0.20).CONCLUSION: The present study suggests that positive FOBT may be useful for predicting SBDs in patients with occult OGIB. Positive FOBT indicates higher likelihood of ulcers or tumors in patients with occult OGIB. Undergoing CE within a day after FOBT achieved a higher diagnostic yield for patients with occult OGIB. | Yuka Kobayashi Hirotsugu Watabe Atsuo Yamada Hirobumi Suzuki Yoshihiro Hirata Yutaka Yamaji Haruhiko Yoshida Kazuhiko Koike | 2015 | World Journal of Gastroenterology2015，21，1： | 2 |
| 12 | Synthesis and structural aspects of LiMn2O4±a for rechargeable lithium batteries 显示文摘 | Atsuo Yamada Kaoru Miura Koichiro Hinokuma | 1995 | J Electrochem Soc1995，142，： | 2 |
| 13 | Study of moss as air pollution monitor by SRXRF technique显示文摘In order to explore the mechanism of moss as air pollution biomonitor, the moss samples were exposed in a pollution site of Shanghai Institute of Steel Research (SISR) and a control site of Shanghai Institute of Applied Physics (SIAP) simultaneously for one month. The concentrations of trace elements in the micro areas of leaf and stem, as well as in the whole moss tissue, were determined using synchrotron radiation X-ray fluorescence (SRXRF) method. The distributions of some metal elements such as Pb, Cu, Fe, Ni, Mn, Zn, Ca and K in the leaf surface and the stem slice were obtained. The results showed that the metallic ions were not evenly distributed after adsorption. In particular, some elements of K, Ni, Fe, Pb, etc., were concentrated in the leaf apex and the intermediate rib. Under pollution condition, the excessive Pb was adsorbed and deposited in the leaf. It caused serious damage to plant growth and ultrastructure, also suppressed moss’ normal absorption to the nutritive elements of K, Ca, etc. | ZHANG YuanXun CAO Tong ATSUO lida CAO QingChen LOU YuXia ZHANG GuiLin LI Yan | 2009 | Chinese Science Bulletin2009，54，17： | 2 |
| 14 | Assessment of the Risk Factors for Colonic Diverticular Hemorrhage显示文摘 | Atsuo Yamada Takafumi Sugimoto Shintaro Kondo Miki Ohta Hirotsugu Watabe Shin Maeda Goichi Togo Yutaka Yamaji Keiji Ogura Makoto Okamoto Haruhiko Yoshida Takao Kawabe Tateo Kawase Masao Omata | 2008 | Diseases of the Colon & Rectum2008，，1： | 2 |
| 15 | Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE) 7 m -β-CD as both a solubilizer and osmotic agent显示文摘 | Kazuto Okimoto Atsuo Ohike Rinta Ibuki Osamu Aoki Norio Ohnishi Roger A. Rajewski Valentino J. Stella Tetsumi Irie Kaneto Uekama | 1999 | Journal of Controlled Release1999，，2： | 2 |
| 16 | The association between arteriosclerosis related diseases and diverticular bleeding显示文摘 | Tomoko Okamoto Hirotsugu Watabe Atsuo Yamada Yoshihiro Hirata Haruhiko Yoshida Kazuhiko Koike | 2012 | International Journal of Colorectal Disease2012，，9： | 2 |
| 17 | A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria*显示文摘 | Satoshi Gando Toshiaki Iba Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Atsuo Murata Toshiaki Ikeda Hiroyasu Ishikura Masashi Ueyama Hiroshi Ogura Shigeki Kushimoto Daizoh Saitoh Shigeatsu Endo Shuji Shimazaki | 2006 | Critical Care Medicine2006，，3： | 2 |
| 18 | How Group Heuristics Promotes Cooperative Behavior in Social Dilemma SituationmExploration of Group Heuristics Effects on the Basis of Computer Simulation显示文摘 | Atsuo Murata Saki Kubo Naoki Hata | 2012 | Computer Technology and Application2012，3，10： | 2 |
| 19 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 2 |
| 20 | MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells显示文摘 | Atsuo Ochi Andrew H. Nguyen Andrea S. Bedrosian Harry M. Mushlin Saman Zarbakhsh Rocky Barilla Constantinos P. Zambirinis Nina C. Fallon Adeel Rehman Yuliya Pylayeva-Gupta Sana Badar Cristina H. Hajdu Alan B. Frey Dafna Bar-Sagi George Miller | 2012 | Journal of Experimental Medicine2012，，9： | 2 |
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