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| 1 | Extract of Yokukansan improves anxiety-like behavior and increases serum brain-derived neurotrophic factor in rats with cerebral ischemia combined with amyloid-β42 peptide显示文摘OBJECTIVE: To examine the effects of Yokukansan(YKS) extract on two endogenous modulators of anxiety, brain-derived neurotrophic factor(BDNF)and serotonin (5-HT)_(2A) receptors pharmacologically, in the ischemic rat model of dementia.METHODS: The cerebral ischemia(CI) was induced by bilateral occlusion of the vertebral and common carotid arteries(4-vessel occlusion ischemia). The CI was combined with the amyloid-β42 peptide(A42) injected intracerebroventricularly, and referreβdto as CI+Aβ. Anxiety-like behaviors were assessed by elevated plus maze(enclosed arm), light/dark transition test(dark chamber), and open-field test.Wet-dog shakes were induced by the 5-HT_(2A) receptor agonist 2, 5-dimethoxy-4-iodoamphetamine(DOI). The concentration of BDNF in serum was determined by enzyme-linked immuno sorbent assay.RESULTS: CI + Aβ increased anxiety, as demonstrated by the increase of time spent in the enclosed arms and dark chambers, and locomotion in the outer zone of the open field(thigmotaxis). CI + Adecreased the serum concentration of BDNF. YKS reβ-duced the anxiety-like behaviors, suppressed the DOI-induced wet-dog shakes and increased serum BDNF concentrations.CONCLUSION: Our findings suggest that YKS extract improves CI + Aβ-induced anxiety by antagonizing 5-HT_(2A) receptors and increasing BDNF. | Ai Nogami-Hara Kaori Kubota Kotaro Takasaki Takuya Watanabe Nobuaki Egahira Hikari Iba Risako Fujikawa Shutaro Katsurabayashi Funda Bolukbasi Hatip Izzettin Hatip-Al-Khatib Katsunori Iwasaki | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 3 |
| 2 | Dyspepsia and Irritable Bowel Syndrome After a Salmonella Gastroenteritis Outbreak: One-Year Follow-up Cohort Study显示文摘 | Fermín Mearin Marc Pérez-Oliveras Antonia Perelló Jaume Vinyet Anabel Iba?ez Jordi Coderch Mónica Perona | 2005 | Gastroenterology2005，，1： | 2 |
| 3 | Massive energy storage system for effective usage of renewable energy显示文摘The current energy trend indicates a strong thrust toward transforming renewable energy as a major power source.To achieve this mission,battery energy storage systems(BESSs)are indispensable.Although BESSs are expensive,cost reduction can be achieved by using BESSs for multiple purposes,such as load leveling,business continuity planning,frequency control,capacity market,arbitrage,and emergency power.In this paper,various applications of BESSs are classified.The possibility of achieving conflict-free combination of different applications is demonstrated.The total required energy storage capacity in Japan is estimated to be 150–200 GWh by 2030.The present status of NaS batteries for multipurpose use and new trends in battery-based businesses are introduced. | Kenji IBA | 2022 | Global Energy Interconnection2022，5，3： | 2 |
| 4 | A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria*显示文摘 | Satoshi Gando Toshiaki Iba Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Atsuo Murata Toshiaki Ikeda Hiroyasu Ishikura Masashi Ueyama Hiroshi Ogura Shigeki Kushimoto Daizoh Saitoh Shigeatsu Endo Shuji Shimazaki | 2006 | Critical Care Medicine2006，，3： | 2 |
| 5 | Acclimative response to temperature stress in higher plants: approaches of gene engineering for tem- perature to tolerance 显示文摘 | IBA K | 2001 | Annual Review of Plant Biol- ogy2001，53，： | 1 |
| 6 | Hydrogen absorption by Laves phase related BCC solid solution显示文摘 | Akiba E Iba H | 1998 | Intermetallics1998，6，： | 1 |
| 7 | Reactive Power Optimization by Genetic Algorithm显示文摘 | Kenji Iba | 1994 | IEEE Trans on Power Systems1994，9，2： | 1 |
| 8 | Laparoscopy-assisted low an- terior resection with a prolapsing technique for low rectal cancer 显示文摘 | Fukunaga M Kidokoro A Iba T | 2005 | Surg Today2005，35，7： | 1 |
| 9 | Development of ultra-high sensitivity bioluminescent enzyme immunoassay for prostate-specific antigen (PSA) using firefly luciferase 显示文摘 | Seto Y Iba T Abe K | 2001 | Luminescence2001，16，4： | 1 |
| 10 | Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs显示文摘 | Iba O Matsubara H Nozawa Y | 2002 | Circulation2002，106，15： | 1 |
| 11 | Power electronics and its applications to renewableenergy in Japan显示文摘 | Junichi Arai Kenji Iba Toshihisa Funabashi | 2008 | IEEE Circuit and SystemsMagazine2008，8，3： | 1 |
| 12 | Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs显示文摘 | Iba O Matsubara H Nozawa Y | | 0，，： | 1 |
| 13 | Intraoperative measurement of pres- sure adjacent to the ulnar nerve in patients with cubital tunnel syn- drome显示文摘 | Iba K Wada T Aoki M | 2006 | J Hand Surg Am2006，31，4： | 1 |
| 14 | 显示文摘 | Akiba E Iba H | 1998 | Intermetallics1998，6，： | 1 |
| 15 | Frequent co-localization of Cox-2and laminin-5 r2 chain at the invasive front of early-stage lungadenocarcinomas显示文摘 | Niki T Kohno T Iba S | 2002 | Am J Pathol2002，160，3： | 1 |
| 16 | Acclimative response to temperature stress in higher plant:approaches of gene engineering for temperature tolerance 显示文摘 | Iba K | 2002 | Ann Rev Plant Biol2002，53，： | 1 |
| 17 | Reactive power optimization by genetic algorithm显示文摘 | IBA K | 1994 | IEEE Transactions on Power Systems1994，9，2： | 1 |
| 18 | Rivaroxaban attenuates leukocyte adhesion in the microvaseulature and thrombus formation in an experimental mouse model of type 2 diabetes mellitus 显示文摘 | Iba T Aihara K Yamada A et a 1 | 2014 | Thromb Res2014，133，2： | 1 |
| 19 | Angiogenesis by implantation of mononuclear cells and platelets into ischemic limb显示文摘 | Iba O Matasubara H Nozawa Y | 2002 | Circulation2002，106，： | 1 |
| 20 | Expression of vascular endothelial growth factor A, B ,C and D and their relationships to lymph node status in lung adenocarcinoma显示文摘 | Niki T Iba S Tokunou M | 2000 | Clin Cancer Res2000，6，6： | 1 |
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