|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 2 | Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis显示文摘AIM: To investigate the clinical efficacy of leukocytapheresis (LCAP) in patients with active ulcerative colitis (UC), and to elucidate the mechanisms by determining the changes in the cytokine levels in the peripheral blood and of the functions of the peripheral blood leukocytes in these patients.METHODS: The subjects were 19 patients with active UC, with a mean clinical activity index (CAI) of 9.2. The LCAP was conducted using Cellsorba E. In each session of LCAP, 2-3 L of blood at the flow rate of 30-50 mL/min was processed. The treatment was carried out in approximately 1-h sessions, once a week, for 5-10 wk. Blood samples for determination of the cytokine levels were collected from the inflow side of the column (site of dehematization; at the start of LCAP) and outflow side of the column (at the end of LCAP). Blood samples for the determination of reactive-oxygen-producing cells were collected from the peripheral blood before and after LCAP.RESULTS: LCAP resulted in clinical improvement in all the 19 patients of UC recruited for this study. Remission (CAI: ≤4) was noted in 15 (79%) of the 19 patients. The blood level of the pro-inflammatory cytoline IL-6 was found to be decreased following treatment by LCAP, and the level of the anti-inflammatory cytokine IL-10 at the outflow side of the LCAP column was found to be significantly elevated as compared to that at the inflow side of the column. The reactive-oxygen-producing granulocytes in the peripheral blood of UC patients was increased as compared to that in healthy persons and the increase was found to be decreased following treatment by LCAP.CONCLUSION: LCAP exerted a high therapeutic efficacy in patients with active UC. Our findings suggest that LCAP is associated with enhanced production of the inhibitory cytokine IL-10 to indirectly inhibit the functions of the inflammatory leukocytes, and that inflammation is also considerably attenuated by the direct removal of reactiveoxygen-producing neutrophils from the peripheral blood. | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Masataka Kikuyama Tatsuo Tanaka Kenji Kondo Kou Tanaka Kenji Takai | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 3 | Field observations of debris-flow initiation processes on sediment deposits in a previous deep-seated landslide site显示文摘Although information regarding the initiation processes of debris flows is important for the development of mitigation measures,field data regarding these processes are scarce.We conducted field observations of debris-flow initiation processes in the upper Ichinosawa catchment of the Ohya landslide,central Japan.On 19 June 2012,our videocamera monitoring systems recorded the moment of debris-flow initiation on channel deposits(nine surges) and talus slopes(eight surges).The initiation mechanisms of these surges were classified into three types by analyzing the video images: erosion by the surface flow,movement of deposits as a mass,and upward development of the fluid area.The first type was associated with the progress of surface flow from the upper stream on unsaturated channel deposits.The second type was likely caused by an increase in the pore water pressure associated with the rising in the groundwater level in channel deposits;a continuous water supply from the upper stream by the surface flow might have induced this saturation.The third type was associated with changes in the downstream topography caused by erosion.The flow velocity of most surges was less than 3 m s^(-1) and they usually stopped within 100 m from the initiation point.Surges with abundant pore fluid had a higher flow velocity(about 3- 5 m s^(-1)) and could travel for alonger duration.Our observations indicate that the surface flow plays an important role in the initiation of debris flows on channel deposits and talus slopes. | Fumitoshi IMAIZUMI Satoshi TSUCHIYA Okihiro OHSAKA | 2016 | Journal of Mountain Science2016，13，2： | 4 |
| 4 | Laparoscopic and endoscopic cooperative surgery for duodenal tumor resection显示文摘 | Fumitoshi Hirokawa Michihiro Hayashi Yoshiharu Miyamoto Mitsuhiro Asakuma Tetsunosuke Shimizu Koji Komeda Yoshihiro Inoue Eiji Umegaki Kazuhisa Uchiyama | 2014 | Endoscopy2014，，： | 3 |
| 5 | Peritoneovenous shunt for intractable ascites due to hepatic lymphorrhea after hepatectomy显示文摘A peritoneovenous shunt has become one of the most effi cient procedures for intractable ascites due to liver cirrhosis.A case of intractable ascites due to hepatic lymphorrhea after hepatectomy for hepatocellular carcinoma that was successfully treated by the placement of a peritoneovenous shunt is presented.A 72-year-old Japanese man underwent partial resection of the liver for hepatocellular carcinoma associated with hepatitis C viral infection.After hepatectomy,a considerable amount of ascites ranging from 800-4600 mL per day persisted despite conservative therapy,including numerous infusions of albumin and plasma protein fraction and administration of diuretics.Since the patient's general condition deteriorated,based on the diagnosis of intractable hepatic lymphorrhea,a subcutaneous peritoneovenous shunt was inserted.The patient's postoperative course was uneventful and the ascites decreased rapidly,with serum total protein and albumin levels and hepatic function improving accordingly.For intractable ascites due to hepatic lymphorrhea after hepatectomy,we recommend the placement of a peritoneovenous shunt as a procedure that can provide immediate effectiveness without increased surgical risk. | Yoshihiro Inoue Michihiro Hayashi Fumitoshi Hirokawa Atsushi Takeshita Nobuhiko Tanigawa | 2011 | World Journal of Gastrointestinal Surgery2011，3，1： | 3 |
| 6 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 2 |
| 7 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis显示文摘 | Mito Kanatsu-Shinohara Kimiko Inoue Jiyoung Lee Momoko Yoshimoto Narumi Ogonuki Hiromi Miki Shiro Baba Takeo Kato Yasuhiro Kazuki Shinya Toyokuni Megumi Toyoshima Ohtsura Niwa Mitsuo Oshimura Toshio Heike Tatsutoshi Nakahata Fumitoshi Ishino Atsuo Ogura T | 2004 | Cell2004，，7： | 2 |
| 8 | Model and control of a flexible solar array paddle as a clamped-free rectangular plate 显示文摘 | Fumitoshi M Michinori H Hideaki S | 1996 | Automatica1996，32，1： | 1 |
| 9 | Prolonged Plasma Levels of Ketoprofen after Oral Administration of Its α- Cy- clodextrin Conjugate/Ethylcellulose Dispersion in Rats显示文摘 | Fumitoshi Hirayama Makoto Kamada Hideki Yano | 2002 | Journal of Inclusion Phenomeno and Macrocyclic Chemistry2002，44，： | 1 |
| 10 | 2-[Fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography versus whole-body diffusion-weighted MRI for detection of malignant lesions: initial experience显示文摘 | Tsuyoshi Komori Isamu Narabayashi Kaname Matsumura Mitsuru Matsuki Hiroyuki Akagi Yasuharu Ogura Fumitoshi Aga Itaru Adachi | 2007 | Annals of Nuclear Medicine2007，，4： | 1 |
| 11 | Crystallization and polymorphic transitions of chlorpropamide in aqueous 2-hydroxybutyl-β-cyclodextrin solution显示文摘 | Takako Ishiguro Fumitoshi Hirayama Daisuke Iohara | | 0，，1： | 1 |
| 12 | Biomater显示文摘 | Taishi Higashi Fumitoshi Hirayama Shogo Misumi | 2008 | (29) :3866-38712008，，29： | 1 |
| 13 | A Moderate Interaction of Mahosyl-a-cyclodextrin with Caco-2 Cells in Comparison with the Parent Cyclodextrin显示文摘 | Naomi O Hidetoshi A Fumitoshi H | 2001 | Biolocal and Pharmaceutical Bull2001，24，4： | 1 |
| 14 | Expression of adrenomedullin2/intermedin in human brain, heart, and kidney显示文摘 | Ryo M Fumitoshi S Osamu M | 2007 | Peptides2007，，28： | 1 |
| 15 | Effects of liraglutide on metabolic syndrome in WBN/Kob diabetic fatty rats supplemented with a high-fat diet显示文摘Background:Liraglutide,a GLP-1 receptor agonist,has recently been used to treat metabolic syndrome(MS)because of its anti-diabetic and anti-obesity effects.We have previously shown that Wistar Bonn Kobori diabetic and fatty(WBN/Kob-Leprfa,WBKDF)rats fed a high-fat diet(HFD)developed MS including marked obesity,hyperglycemia,and dyslipidemia.To obtain further information on WBKDF-HFD rats as a severe MS model,we performed a pharmacological investigation into the anti-MS effects of liraglutide in this model.Methods:Seven-week-old male WBKDF-HFD rats were allocated to three groups(n=8 in each group):a vehicle group,a low-dose liraglutide group,and a high-dose liraglutide group.They received subcutaneous injections of either saline or liraglutide at doses of 75 or 300μg/kg body weight once daily for 4 weeks.Results:Results showed that liraglutide treatment reduced body weight gain and food intake in a dose-dependent manner.The marked hyperglycemia and the glucose tolerance were also significantly ameliorated in the liraglutide-treated groups.Moreover,liraglutide also reduced the plasma triglyceride concentration and liver fat accumulation.Conclusions:The present study demonstrated that liraglutide could significantly alleviate MS in WBKDF-HFD rats,and the reaction to liraglutide is similar to human patients with MS.WBKDF-HFD rats are therefore considered to be a useful model for research on severe human MS. | Noriyuki Kaji Yoshiichi Takagi Satomi Matsuda Anna Takahashi Sakurako Fujio Fumitoshi Asai | 2020 | Animal Models and Experimental Medicine2020，3，1： | 1 |
| 16 | Proposal of a new structural thermal vacuum sensor with diode-thermistors combined with a micro-air-bridge heater显示文摘 | Fumitoshi Sakurai Hirao Ohta | 2007 | Microelectronics Journal2007，38，： | 1 |
| 17 | Studies on Polymer Stabilizers: Part IV - Prevention of oxidative discoloration 显示文摘 | Shin' ichi Yachigo Fumitoshi Kojima Manji Sasaki | 1992 | Polymer Degradation and Stability1992，37，2： | 1 |
| 18 | 2-[Fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography versus whole-body diffusion-weighted MRI for detection of malignant lesions: initial experience显示文摘 | Tsuyoshi Komori Isamu Narabayashi Kaname Matsumura Mitsuru Matsuki Hiroyuki Akagi Yasuharu Ogura Fumitoshi Aga Itaru Adachi | 2007 | Annals of Nuclear Medicine2007，，4： | 1 |
| 19 | Enantioselective catalytic ring opening of epoxides with carboxylic acids显示文摘 | JACOBSEN E N KAKIUCHI FUMITOSHI | 1997 | Tetrahedron Lett1997，38，5： | 1 |
| 20 | In vovo and in vitro correlation for delayed-release behavior of a molsidomine/o-carboxymethyl-o-ethyl-β-cyclodextrin complex in gastric acidity-controlled dogs显示文摘 | TAKASHI H FUMITOSHI H KANETO U | 1995 | J Pharm Pharmacol1995，47，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员