|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus显示文摘AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B.METHODS We enrolled 52 children(between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B(CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1(rs1131476), OAS2(rs1293747),OAS3(rs2072136), OASL(rs10849829) and IL28B(rs12979860, rs12980275 and rs8099917) genes were studied to examine their associations with responses to IFN treatment in paediatric patients. We adopted two criteria for the therapeutic response, achieving an hepatitis B virus(HBV) DNA level < 2000 IU/m L and normalization of ALT activity(< 40 IU/L). To perform the analyses, we compared the patients in terms of achieving a partial response(PR) and a complete response(CR) upon measurement at the 24-wk posttreatment follow-up. RESULTS The PR and CR rates were 80.8% and 42.3%, respectively. Factors such as age, gender and liver histology had no impact on the type of response(partial or complete). A statistically significant relationship between higher baseline HBV DNA and ALT activity levels and lower rates of PR and CR was shown(P < 0.05). The allele association analysis revealed that only the IL-28 B rs12979860(C vs T) and IL28 B rs12980275(A vs G) markers significantly affected the achievement of PR(P = 0.021, OR = 3.3, 95%CI: 1.2-9.2 and P = 0.014, OR = 3.7, 95%CI: 1.3-10.1, respectively). However, in the genotype analysis, only IL-28 B rs12980275 was significantly associated with PR(AA vs AG-GG, P = 0.014, OR = 10.9, 95%CI: 1.3-93.9). The association analysis for CR showed that the TT genotype of IL28 B rs12979860 was present only in the no-CR group(P = 0.033) and the AA genotype of OASL rs10849829 was significantly more frequent in the noCR group(P = 0.044, OR = 0.26, 95%CI: 0.07-0.88). The haplotype analysis revealed significant associations between PR and CR and OAS haplotype(P = 0.0002 and P = 0.001, respectively), but no association with IL28 B haplotype was observed.CONCLUSION IL28 B and OAS polymorphisms are associated with different clinical outcomes in CHB children treated with interferon. | Krzysztof Domagalski Malgorzata Pawlowska Agnieszka Zalesna Malgorzata Pilarczyk Pawel Rajewski Waldemar Halota Andrzej Tretyn | 2016 | World Journal of Gastroenterology2016，22，41： | 7 |
| 2 | Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein显示文摘 | Li-Fan Lu To-Ha Thai Dinis Pedro Calado Ashutosh Chaudhry Masato Kubo Kentaro Tanaka Gabriel B. Loeb Hana Lee Akihiko Yoshimura Klaus Rajewsky Alexander Y. Rudensky | 2009 | Immunity2009，，1： | 2 |
| 3 | Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE) 7 m -β-CD as both a solubilizer and osmotic agent显示文摘 | Kazuto Okimoto Atsuo Ohike Rinta Ibuki Osamu Aoki Norio Ohnishi Roger A. Rajewski Valentino J. Stella Tetsumi Irie Kaneto Uekama | 1999 | Journal of Controlled Release1999，，2： | 2 |
| 4 | Assessment of genetic diversity and relationship among a collection of US sweet sorghum germplasm by SSR markers显示文摘 | Ali M L Rajewski J F Baenziger P S | 2008 | Mol Breeding2008，21，： | 1 |
| 5 | Generation and analysis of interleukin - 4 deficient mice 显示文摘 | Kuhn R Rajewsky K Muller W | 1991 | Science1991，254，： | 1 |
| 6 | Independent control of immunogloimlin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting显示文摘 | GU H ZOU Y R RAJEWSKY K | 1993 | Cell1993，73，6： | 1 |
| 7 | Silencing of microRNAs in vivo with 'antagomirs' 显示文摘 | Kriitzfeldt J Rajewsky Nj3raich tL | 2005 | Nature2005，438，7068： | 1 |
| 8 | The evolution of gene regula- tion by transcription factors and microRNAs显示文摘 | Chen K Rajewsky N | 2007 | Nat Rev Genet2007，8，2： | 1 |
| 9 | Silencing ofmicroRNAs in vivo with 'antagomirs'显示文摘 | Krutzfeldt J Rajewsky N Braich R | 2005 | Nature2005，438，7068： | 1 |
| 10 | Silencing of microRNAs in vivo with 'antagomirs' 显示文摘 | Krutzfeldt J Rajewsky N Braich R | 2005 | Nature2005，438，7068： | 1 |
| 11 | Silencing of microRNAs in vivo with 'antagomirs' 显示文摘 | Krutzfeldt J Rajewsky N Braich R | 2005 | Nature2005，438，7068： | 1 |
| 12 | Silencing of microRNAs in vivo with'antagomirs'显示文摘 | Krützfeldt J Rajewsky N Braich R | 2005 | Nature2005，438，7068： | 1 |
| 13 | Generation and analysis of interleukin-4 deficient mouse显示文摘 | Kiihn R Rajewsky K Muller W | 1991 | Science1991，254，： | 1 |
| 14 | The evolution of gene regulation by transcription factors and microRNAs显示文摘 | CHEN K RAJEWSKY N | | 0，，02： | 1 |
| 15 | Liver carcinogenesis by diethylnitrosamine in the rat显示文摘 | Dauber W Frankenberg H | 1966 | Science1966，152，718： | 1 |
| 16 | MicroRNA control in the immune system: Basic principles 显示文摘 | Xiao C Rajewsky K | 2009 | Cell2009，136，1： | 1 |
| 17 | Silencing of microRNAsin vivo with antagomirs显示文摘 | Krutzfeldt J Rajewsky N Braich R | 2005 | Nature2005，438，5： | 1 |
| 18 | Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice显示文摘 | Rajewsky K Roes J | 1995 | Nature1995，376，： | 1 |
| 19 | Interleukin- 10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwarzman reaction but not endotoxin, tolerance 显示文摘 | Berg DJ Kuhn R Rajewsky K | 1995 | Clin Invest1995，96，： | 1 |
| 20 | Generation and analysis of interleukin - 4 deficient mice显示文摘 | Kuhn R Rajewsky K | 1991 | Science1991，254，5032： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员