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| 1 | A randomized controlled trial of omega-3 fatty acids in dry eye syndrome显示文摘AIM:To evaluate the role of dietary supplementation of omega-3 fatty acids in dry eye syndrome.METHODS:A prospective,interventional,placebo controlled,double blind randomized trial was done at two referral eye centers.Two hundred and sixty-four eyes of patients with dry eye were randomized to receive one capsule(500mg)two times a day containing 325mg EPA and 175mg DHA for 3 months(omega-3 group).The omega-3 group was compared to a group of patients(n=254)who received a placebo(placebo group).There were 4 patient visits(at baseline,1 month,2 months and3 months).On each visit,recording of corrected distance visual acuity(CDVA),slit lamp examination and questionnaire based symptom evaluation and scoring was done.A symptomatic score of 0-6 was mild,6.1-12moderate and 12.1-18 severe dry eye.Response to intervention was monitored by routine tear function tests like Schirmer I test,tear film break-up time(TBUT),Rose Bengal staining and most notably,conjunctival impression cytology.RESULTS:Sixty-five percent of patients in the omega-3group and 33%of patients in placebo group had significant improvement in symptoms at 3 months(P=0.005).There was a significant change in both Schirmer's test value and TBUT values in the omega-3group(P<0.001),both comparisons.However,there was a larger drift in TBUT values in omega-3 than the placebo group,in comparison to Schirmer's test values.The mean TBUT score was 2.54±2.34 in the omega-3group and 0.13±0.16 in placebo group,respectively.The mean reduction in symptom score in omega-3 group was 2.02±0.96 as compared to 0.48±0.22 in placebogroup(P<0.001).Despite a slight increase mean score,the Schirmer scores did not correlate well with symptomatic improvement.CONCLUSION:Omega-3 fatty acids have a definite role for dry eye syndrome.The benefit seems to be more marked in conditions such as blepharitis and meibomian gland disease.The role of omega fatty acids in tear production and secretion needs further evaluation. | Rahul Bhargava Prachi Kumar Manjushrii Kumar Namrata Mehra Anurag Mishra | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 14 |
| 2 | Stereotactic body radiation therapy for non-small cell lung cancer:A review显示文摘Stereotactic body radiation therapy(SBRT) is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC). A literature search primarily based on PubMed electronic databases was completed in July 2018. Inclusion and exclusion criteria were determined prior to the search, and only prospective clinical trials were included. Nineteen trials from 2005 to 2018 met the inclusion criteria, reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC. Patient eligibility,prescription dose and delivery, and follow up duration varied widely. Threeyears overall survival ranged from 43% to 95% with loco-regional control of up to 98% at 3 years. Up to 33% of patients failed distantly after SBRT at 3 years. SBRT was generally well tolerated with 10%-30% grade 3-4 toxicities and a few treatment-related deaths. No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT, central and peripheral lung tumors, or inoperable and operable patients. SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC. SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery. Decreasing fractionation schedules have been consistently shown to be both safe and effective. Distant failure is common, and chemotherapy may be considered for select patients. However, the survival benefit of additional interventions, such as chemotherapy, for early stage NSCLC treated with SBRT remains unclear. | Kavitha M Prezzano Sung Jun Ma Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 10 |
| 3 | Y chromosome microdeletions in azoospermic patients with Klinefelter's syndrome显示文摘瞄准:与 Klinefelter 的症候群(KFS ) 在 azoospermic 病人学习 Y 微删除的出现。方法:血和精液样品与 KFS 从 azoospermic 病人被收集(n = 14 ) 并且证明富饶的人的一个控制组(n = 13 ) 。精液分析根据世界卫生组织被做() 指南。血样品为 karyotyping,荧光灯的原位杂交(鱼) 和由放射性免疫测定刺激荷尔蒙(FSH ) 的血浆滤泡的测量被处理。决定 Y 微删除, 16 顺序的聚合酶链反应(PCR ) 标注了地点(圣) ,三基因(DFFRY, XKRY 和 RBM1Y ) 在孤立的 genomic DNA 上被执行。阴囊的好针渴望细胞学(FNAC ) 在选择情况中被做。结果:跨越一个 and AZFb 部位与 KFS 在 14 个 azoospermic 病人中的四个被发现的精子缺乏因素(AZF ) 的 Y 微删除。染色质组型和鱼分析表明显示出 Y 微删除的四个盒子,三个盒子有一 47, XXY/46, XY 染色体的模式和一个盒子有一 46, XY/47, XXY/48, XXXY/48, XXYY 染色体的模式。有 Y 微删除的一件样品的阴囊的 FNAC 揭示了形态学的 Sertoli 房间唯一的类型。然而,没有 Y 微删除在任何 13 个肥沃的人被观察。有 KFS 的所有病人提高了血浆 FSH 层次。结论:有 KFS 的病人可以怀有 Y 微删除并且为这些屏蔽应该是他们的诊断病情的检查的部分,特别地在那些考虑帮助了繁殖技术。 | Anurag Mitra Rima Dada Rajeev Kumar Narmada Prasad Gupta Kiran Kucheria Satish Kumar Gupta | 2006 | Asian Journal of Andrology2006，8，1： | 8 |
| 4 | Experimental assessment and prediction of temporal scour depth around a spur dike显示文摘Spur dikes are river training structures that have been extensively used worldwide for towards enhancing flood control and the stability of embankments and riverbanks.However,scour around spur dikes can be a major problem affecting their stability and hydraulic performance.The precise computation of temporal scour depth at spur dikes is very important for the design of economical and safe spur dikes.This study focuses on experimentally assessing the temporal variation of scour depth around a vertical wall spur dike and identifying the parameters,which mostly influence spur dike performance for a channel bed surface comprised of sand-gravel mixtures.In the current study,the authors did physical experiments in a flume based study to obtain new data,aimed at deriving a new predictive model for spur dike scour and comparing its performance to others found in the literature.It was found that the dimensionless temporal scour depth variation increases with an increase in(i)the threshold velocity ratio,(ii)the densimetric Froude number of the bed surface sediment mixture,(iii)the flow shallowness(defined as the ratio of the approach flow depth,y,to the spur dike’s transverse length,l),and(iv)the flow depth-particle size ratio.It is also concluded that the temporal scour depth variation in the sediment mixture is influenced by the non-uniformity of sediment and decreases with an increase in the non-uniformity of the sediment mixture.A new mathematical model is derived for the estimation of temporal scour depths in sand-gravel sediment mixtures.The proposed equation has been calibrated and validated with the experimental data,demonstrating a good predictive capacity for the estimation of temporal scour depth evolution. | Manish Pandey Manousos Valyrakis Meilan Qi Anurag Sharma Ajay Singh Lodhi | 2021 | International Journal of Sediment Research2021，36，1： | 8 |
| 5 | Current Status of Conventional and Molecular Interventions for Blast Resistance in Rice显示文摘Pyricularia oryzae anamorph of Magnaporthe oryzae is one of the most notorious fungal pathogens causing severe economic loss in rice production worldwide. Various methods, viz. cultural, biological and molecular approaches, are utilized to counteract this pathogen. Moreover, some tolerant or resistant rice varieties have been developed with the help of breeding programmes. Isolation and molecular characterization of different blast resistance genes now open the gate for new possibilities to elucidate the actual allelic variants of these genes via various molecular breeding and transgenic approaches. However, the behavioral pattern of this fungus breakups the resistance barriers in the resistant or tolerant rice varieties. This host-pathogen barrier will be possibly countered in future research by comparative genomics data from available genome sequence data of rice and M. oryzae for durable resistance. Present review emphasized fascinating recent updates, new molecular breeding approaches, transgenic and genomics approaches(i.e. mi RNA and genome editing) for the management of blast disease in rice. The updated information will be helpful for the durable, resistance breeding programme in rice against blast pathogen. | Deepti SRIVASTAVA Md SHAMIM Mahesh KUMAR Anurag MISHRA Pramila PANDEY Deepak KUMAR Prashant YADAV Mohammed Harrish SIDDIQUI Kapildeo Narayan SINGH | 2017 | Rice science2017，24，6： | 8 |
| 6 | Showering in Flint, MI: Is there a DBP problem?显示文摘Lead contamination in the City of Flint, MI has been well documented over the past two years, with lead levels above the EPA Action Level until summer 2016. This resulted from an ill-fated decision to switch from Detroit water(Lake Huron) with corrosion control, to Flint River water without corrosion control. Although lead levels are now closer to normal,reports of skin rashes have sparked questions surrounding tap water in some Flint homes.This study investigated the presence of contaminants, including disinfection by-products(DBPs), in the hot tap water used for showering in the homes of residents in Flint. Extensive quantitative analysis of 61 regulated and priority unregulated DBPs was conducted in Flint hot and cold tap water, along with the analysis of 50 volatile organic compounds and a nontarget comprehensive, broadscreen analysis, to identify a possible source for the reported skin rashes. For comparison, chlorinated hot and cold waters from three other cities were also sampled, including Detroit, which also uses Lake Huron as its source water.Results showed that hot water samples generally contained elevated levels of regulated and priority unregulated DBPs compared to cold water samples, but trihalomethanes were still within regulatory limits. Overall, hot shower water from Flint was similar to waters sampled from the three other cities and did not have unusually high levels of DBPs or other organic chemicals that could be responsible for the skin rashes observed by residents. It is possible that an inorganic chemical or microbial contaminant may be responsible. | Joshua M.Allen Amy A.Cuthbertson Hannah K.Liberatore Susana Y.Kimura Anurag Mantha Marc A.Edwards Susan D.Richardson | 2017 | Journal of Environmental Sciences2017，29，8： | 5 |
| 7 | Long-term outcomes of interventions for radiation-induced xerostomia:A review显示文摘Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen,submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia. A literature search was performed using the terms 'xerostomia' and 'radiation' or 'radiotherapy'; all prospective clinical trials were evaluated, and only studies that reported 1 year follow up were included. The search results yielded 2193 studies, 1977 of which were in English. Of those, 304 were clinical trials or clinical studies. After abstract review, 23 trials were included in the review evaluating the following treatment modalities: pilocarpine(three); cevimeline(one); amifostine(eleven);submandibular gland transfer(five); acupuncture like transcutaneous electrical nerve stimulation(ALTENS)(one); hyperbaric oxygen(one); and acupuncture(one). Pilocarpine, cevimeline, and amifostine have been shown in some studies to improve xerostomia outcomes, at the cost of toxicity. ALTENS has similar efficacy with fewer side effects. Submandibular gland transfer is effective but requires an elective surgery, and thus may not always be appropriate or practical.The use of intensity-modulated radiation therapy, in addition to dose deescalation in select patients, may result in fewer patients with late xerostomia,reducing the need for additional interventions. | Sung Jun Ma Charlotte I Rivers Lucas M Serra Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 4 |
| 8 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 9 | Graph-theoretic algorithms for cyber-physical vulnerability analysis of power grid with incomplete information显示文摘A key focus recently has been on assessing therisk of a coordinated cyber-physical attack and minimizing the impact of a successful attack. Most of the cyberattackers will have limited system information and conventional power grid N-1 security analysis cannot be extended to assess the risk. Centrality measures are widely used in the network science and an attacker with incomplete information can use it to identify power system vulnerabilities by defining the system as a complex network but without real-time system measurements. This paper presents a graph theory based centrality indices for vulnerability assessment of the power system due to various bus and branch contingencies using limited system information and provides a preliminary defense mechanism to prevent such an attack. Proposed work answers the fundamental question of possible attack scenarios by balancing risk(limited information with low risk to get caught orhigh risk attack to access more system information) and impact(identifying contingencies with maximal impact on system operation). Statistical comparisons are made between the graph theory measures compared to the corresponding DC power flow based N-X linear sensitivity measures. A unified N-X centrality based performance index is proposed and validated against the AC power flow based performance index by doing the real-time simulations of an N-3 attack scenario. Defensive mechanisms using topology-based performance indices are also presented. | Anurag K.SRIVASTAVA Timothy A.ERNSTER Ren LIU Vignesh G.KRISHNAN | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，5： | 4 |
| 10 | Graphene-based bipolar plates for polymer electrolyte membrane fuel cells显示文摘Bipolar plates(BPs)are a major component of polymer electrolyte membrane fuel cells(PEMFCs).BPs play a multifunctional character within a PEMFC stack.It is one of the most costly and critical part of the fuel cell,and hence the development of efficient and cost-effective BPs is of much interest for the fabrication of next-generation PEMFCs in future.Owing to high electrical conductivity and chemical inertness,graphene is an ideal candidate to be utilized in BPs.This paper reviews recent advances in the area of graphene-based BPs for PEMFC applications.Various aspects including the momentous functions of BPs in the PEMFC,favorable features of graphene.based BPs,performance evaluation of various reported BPs with their advantages and disadvantages,challenges at commercial level products and future prospects of frontier research in this direction are extensively documented. | Ram Sevak SINGH(El) Anurag GAUTAM Varun RAI | 2019 | Frontiers of Materials Science2019，13，3： | 3 |
| 11 | Effect of Downward Seepage on Turbulent Flow Characteristics and Bed Morphology around Bridge Piers显示文摘在这个工作,试验性的调查被追求了分析影响向下在在在冲积隧道的圆形的桥码头附近的旋涡结构的流动和相应变化的狂暴的特征上的渗出物。实验为没有渗出物, 10% 渗出物和 20% 渗出物盒子与不同尺寸的圆形的墩在沙床隧道被进行。象速度和雷纳兹压力那样的狂暴的流动统计的测量被发现在 scour 洞在以内否定墩在上游而申请向下,渗出物延迟在速度和雷纳兹引起减少的流动的颠倒强调。更高级的雷纳兹砍因为生产,应力在下游的方面占优势弄醒旋涡。到彻底的雷纳兹的所有爆炸事件的贡献砍压力生产被观察了增加与向下渗出物。不可分的规模的分析建议旋涡的那种尺寸与渗出物增加,它为粒子活动性的增加负责。开始搜索评价是消退逐渐地象与一样与膨胀预定的更多增加了向下渗出物。存在向下,渗出物向墩的下游的方面减少旋涡和移动的深度和长度。 | Rutuja Chavan Anurag Sharma Bimlesh Kumar | 2017 | Journal of Marine Science and Application2017，16，1： | 3 |
| 12 | Investigation on the Dynamic Responses of a Truss Spar Platform for Different Mooring Line Groups显示文摘任何漂浮的平台的动态回答依赖于团,僵硬和身体以及系在的系统的抑制特征。因此,学习对能最后帮助他们的费用到节俭的系统的单个贡献的效果是很必要的。这份报纸在一个 truss 圆材平台的回答上集中于系在的僵硬的效果,由线的不同组织获得了。学习是我们关于包括线虚荣,直径和方位角角度的效果的系在的系统的现在的研究的部分。站台与三 degrees-of-freedom 作为僵硬身体被建模,它的运动用含蓄的 Newmark 贝它技术在时间域被分析。系在的线恢复力量旅行关系用一条伪静电干扰途径被评估。有线的系在的系统以恢复力量以及平台的吝啬的位置在组展览的更少的数字安排了更好的性能,这被观察。然而,站台的动态运动为不同的线组仍然保持未受影响。 | Montasir Osman Ahmed Anurag Yenduri V. J. Kurian | 2015 | Journal of Marine Science and Application2015，14，2： | 2 |
| 13 | A prospective trial of volumetric intensity-modulated arc therapy vs conventional intensity modulated radiation therapy in advanced head and neck cancer显示文摘AIM: To prospectively compare volumetric intensitymodulated arc therapy(VMAT) and conventional intensity-modulated radiation therapy(IMRT) in coverage of planning target volumes and avoidance of multiple organs at risk(OARs) in patients undergoing definitive chemoradiotherapy for advanced(stage Ⅲ or Ⅳ)squamous cell cancer of the head and neck. METHODS: Computed tomography scans of 20 patients with advanced tumors of the larynx, naso-, oroand hypopharynx were prospectively planned using IMRT(7 field) and VMAT using two arcs. Calculated doses to planning target volume(PTV) and OAR were compared between IMRT and VMAT plans. Dose-volume histograms(DVH) were utilized to obtain calculated doses to PTV and OAR, including parotids, cochlea,spinal cord, brainstem, anterior tongue, pituitary and brachial plexus. DVH's for all structures were compared between IMRT and VMAT plans. In addition the planswere compared for dose conformity and homogeneity. The final treatment plan was chosen by the treating radiation oncologist. RESULTS: VMAT was chosen as the ultimate plan in 18 of 20 patients(90%) because the plans were thought to be otherwise clinically equivalent. The IMRT plan was chosen in 2 of 20 patients because the VMAT plan produced concentric irradiation of the cord which was not overcome even with an avoidance structure. For all patients, VMAT plans had a lower number of average monitor units on average(MU = 542.85) than IMRT plans(MU = 1612.58)(P < 0.001). Using the conformity index(CI), defined as the 95% isodose volume divided by the PTV, the IMRT plan was more conformal with a lower conformity index(CI = 1.61) than the VMAT plan(CI = 2.00)(P = 0.003). Dose homogeneity, as measured by average standard deviation of dose distribution over the PTV, was not different with VMAT(1.45 Gy) or IMRT(1.73 Gy)(P = 0.069). There were no differences in sparing organs at risk.CONCLUSION: In this prospective study, VMAT plans were chosen over IMRT 90% of the time. Compared to IMRT, VMAT plans used only one third of the MUs, had shorter treatment times, and similar sparing of OAR. Overall, VMAT provided similar dose homogeneity but less conformity in PTV irradiation compared to IMRT. This difference in conformity was not clinically significant. | Simon D Fung-Kee-Fung Rachel Hackett Lee Hales Graham Warren Anurag K Singh | 2012 | World Journal of Clinical Oncology2012，3，4： | 2 |
| 14 | Induction of Neutrophil Extracellular DNA Lattices by Placental Microparticles and IL-8 and Their Presence in Preeclampsia显示文摘 | Anurag Kumar Gupta Paul Hasler Wolfgang Holzgreve Stefan Gebhardt Sinuhe Hahn | 2006 | Human Immunology2006，，11： | 2 |
| 15 | Intrarectal Amifostine During External Beam Radiation Therapy for Prostate Cancer Produces Significant Improvements in Quality of Life Measured by EPIC Score显示文摘 | Nicole L. Simone Cynthia Ménard Benjamin P. Soule Paul S. Albert Peter Guion Sharon Smith Denise Godette Nancy S. Crouse Linda C. Sciuto Theresa Cooley-Zgela Kevin Camphausen C. Norman Coleman Anurag K. Singh | 2008 | International Journal of Radiation Oncology, Biology, Physics2008，，1： | 2 |
| 16 | Coupled Flutter and Buffeting Analysis of Long-Span Bridges显示文摘 | Anurag Jain Nicholas P. Jones Robert H. Scanlan | 1996 | Journal of Structural Engineering1996，，7： | 2 |
| 17 | Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models显示文摘 | Ryan B. Corcoran Katherine A. Cheng Aaron N. Hata Anthony C. Faber Hiromichi Ebi Erin M. Coffee Patricia Greninger Ronald D. Brown Jason T. Godfrey Travis J. Cohoon Youngchul Song Eugene Lifshits Kenneth E. Hung Toshi Shioda Dora Dias-Santagata Anurag Sin | 2013 | Cancer Cell2013，，： | 2 |
| 18 | Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative–nitrosative stress in rats显示文摘 | Vinod Tiwari Anurag Kuhad Mahendra Bishnoi Kanwaljit Chopra | 2009 | Pharmacology, Biochemistry and Behavior2009，，2： | 2 |
| 19 | Editorial: Post Operative Cognitive Dysfunction显示文摘 | Tej K Kaul Anurag Tawari | 2008 | J Anaesth Clin Pharmacol2008，24，2： | 1 |
| 20 | Relay selection for geographical forwarding in sleep - wake cycling wireless sensor networics显示文摘 | Naveen K P Anurag Kumar | 2013 | IEEE Transactions on Mobile Computing2013，11，3： | 1 |
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