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| 1 | A randomized controlled trial of omega-3 fatty acids in dry eye syndrome显示文摘AIM:To evaluate the role of dietary supplementation of omega-3 fatty acids in dry eye syndrome.METHODS:A prospective,interventional,placebo controlled,double blind randomized trial was done at two referral eye centers.Two hundred and sixty-four eyes of patients with dry eye were randomized to receive one capsule(500mg)two times a day containing 325mg EPA and 175mg DHA for 3 months(omega-3 group).The omega-3 group was compared to a group of patients(n=254)who received a placebo(placebo group).There were 4 patient visits(at baseline,1 month,2 months and3 months).On each visit,recording of corrected distance visual acuity(CDVA),slit lamp examination and questionnaire based symptom evaluation and scoring was done.A symptomatic score of 0-6 was mild,6.1-12moderate and 12.1-18 severe dry eye.Response to intervention was monitored by routine tear function tests like Schirmer I test,tear film break-up time(TBUT),Rose Bengal staining and most notably,conjunctival impression cytology.RESULTS:Sixty-five percent of patients in the omega-3group and 33%of patients in placebo group had significant improvement in symptoms at 3 months(P=0.005).There was a significant change in both Schirmer's test value and TBUT values in the omega-3group(P<0.001),both comparisons.However,there was a larger drift in TBUT values in omega-3 than the placebo group,in comparison to Schirmer's test values.The mean TBUT score was 2.54±2.34 in the omega-3group and 0.13±0.16 in placebo group,respectively.The mean reduction in symptom score in omega-3 group was 2.02±0.96 as compared to 0.48±0.22 in placebogroup(P<0.001).Despite a slight increase mean score,the Schirmer scores did not correlate well with symptomatic improvement.CONCLUSION:Omega-3 fatty acids have a definite role for dry eye syndrome.The benefit seems to be more marked in conditions such as blepharitis and meibomian gland disease.The role of omega fatty acids in tear production and secretion needs further evaluation. | Rahul Bhargava Prachi Kumar Manjushrii Kumar Namrata Mehra Anurag Mishra | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 14 |
| 2 | Phacoemulsification versus small incision cataract surgery in patients with uveitis显示文摘AIM: To compare the safety and efficacy of phacoemulsification and small incision cataract surgery(SICS) in patients with uveitic cataract.·METHODS: In a prospective, randomized multi-centric study, consecutive patients with uveitic cataract were randomized to receive phacoemulsification or manual SICS by either of two surgeons well versed with both the techniques. A minimum inflammation free period of 3mo(defined as less than 5 cells per high power field in anterior chamber) was a pre-requisite for eligibility for surgery. Superior scleral tunnel incisions were used for both techniques. Improvement in visual acuity post-operatively was the primary outcome measure and the rate of post-operative complications and surgical time were secondary outcome measures, respectively. Means of groups were compared using t-tests. One way analysis of variance(ANOVA) was used when there were more than two groups. Chi-square tests were used for proportions. Kaplan Meyer survival analysis was done and means for survival time was estimated at 95%confidence interval(CI). A P value of <0.05 was considered statistically significant.·RESULTS: One hundred and twenty-six of 139 patients(90.6%) completed the 6-month follow-up. Seven patients were lost in follow up and another six excluded due to either follow-up less than six months(n=1) or inability implant an intraocular lens(IOL) because of insufficient capsular support following posterior capsule rupture(n=5). There was significant improvement in vision after both the procedures(paired t-test; P <0.001). On first postoperative day, uncorrected distance visual acuity(UDVA) was 20/63 or better in 31(47%)patients in Phaco group and 26(43.3%) patients in SICS group(P=0.384). The mean surgically inducedastigmatism(SIA) was 0.86 ±0.34 dioptres(D) in the phacoemulsification group and 1.16 ±0.28 D in SICS group. The difference between the groups was significant(t-test, P =0.002). At 6mo, corrected distance visual acuity(CDVA) was 20/60 or better in 60(90.9%) patients in Phaco group and 53(88.3%) in the manual SICS group(P =0.478). The mean surgical time was significantly shorter in the manual SICS group(10.8±2.9 versus 13.2±2.6min)(P <0.001). Oral prednisolone, 1 mg/kg body weight was given 7d prior to surgery, continued post-operatively and tapered according to the inflammatory response over 4-6wk in patients with previously documented macular edema, recurrent uveitis, chronic anterior uveitis and intermediate uveitis. Rate of complications like macular edema(Chi-square, P =0.459),persistent uveitis(Chi-square, P =0.289) and posterior capsule opacification(Chi-square, P =0.474) were comparable between both the groups.·CONCLUSION: Manual SICS and phacoemulsification do not differ significantly in complication rates and final CDVA outcomes. However, manual SICS is significantly faster. It may be the preferred technique in settings where surgical volume is high and access to phacoemulsification is limited, such as in eye camps. It may also be the appropriate technique for uveitic cataract under such circumstances. | Rahul Bhargava Prachi Kumar Shiv Kumar Sharma Manoj Kumar Avinash Kaur | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 8 |
| 3 | Foetal volumetry using Magnetic Resonance Imaging in intrauterine growth restriction显示文摘 | Mellisa S. Damodaram Lisa Story Elisanda Eixarch Prachi Patkee Abhilasha Patel Sailesh Kumar Mary Rutherford | 2012 | Early Human Development2012，，： | 1 |
| 4 | Peeling and aspiration of elschnig pearls! An effective alternative to Nd:YAG laser capsulotomy!显示文摘 | Rahul Bhargava Prachi Kumar Shiv Sharma Sumat Sharma Namrata Mehra Anuraag Mishra | 2013 | Indian Journal of Ophthalmology2013，，9： | 1 |
| 5 | A randomized controlled trial of peeling and aspiration of Elschnig pearls and neodymium: yttrium-aluminiumgarnet laser capsulotomy显示文摘AIM: To compare surgical peeling and aspiration and neodymium yttrium garnet laser capsulotomy for pearl form of posterior capsule opacification(PCO).METHODS: A prospective, randomized, double blind,study was done at Rotary Eye Hospital, Maranda,Palampur, India, Santosh Medical College Hospital,Ghaziabad, India and Laser Eye Clinic, Noida India.Consecutive patients with pearl form of PCO following surgery, phacoemulsification, manual small incision cataract surgery and conventional extracapsular cataract extraction(ECCE) for age related cataract, were randomized to have peeling and aspiration or neodymium yttrium garnet laser capsulotomy. Corrected distance visual acuity(CDVA), intra-operative and postoperative complications were compared.RESULTS: A total of 634 patients participated in the study, and 314(49.5%) patients were randomized to surgical peeling and aspiration group and 320(50.5%) to the Nd:YAG laser group. The mean pre-procedural log MAR CDVA in peeling and neodymium: yttrium-aluminium-garnet(Nd:YAG) laser group was 0.80 ±0.25 and 0.86 ±0.22, respectively. The mean final CDVA in peeling group(0.22 ±0.23) was comparable to Nd:YAG group(0.24 ±0.28; t-test, P =0.240). There was a significant improvement in vision after both the procedures(P <0.001). A slightly higher percentage of patients in Nd:YAG laser group(283/88.3%) than in peeling group(262/83.4%) had a CDVA of 0.5(20/63) or better at 9mo(P <0.001). On the contrary, patients havingCDVA worse than 1.00(20/200) was also significantly higher in Nd:YAG laser group as compared to peeling group(25/7.7% vs 15/4.7%, respectively). On application of ANCOVA, there was less than 0.001% risk that PCO thickness and total laser energy had no effect on rate of complications in Nd:YAG laser group and less than 0.001% risk that PCO thickness had no effect on complications in peeling group respectively. Sum of square analysis suggests that in the Nd:YAG laser group,thick PCO had a stronger impact on complications(Fischer test probability, P r <0.0001) than thin PCO and total laser energy(Fischer test probability, P r <0.002),respectively; similarly, in peeling group, thick PCO and preoperative vision had a stronger effect on complications than thin PCO, respectively(Fischer test probability, P r <0.001). The rate of complications like uveitis(P =0.527) and cystoid macular edema(P =0.068),did not differ significantly between both the groups.However, intraocular pressure spikes(P =0.046) and retinal detachment(P<0.001) were significantly higher in Nd:YAG laser group as compared to peeling group.Retinal detachment was more common in patients having degenerative myopia(7/87.5%, P <0.001). Recurrence of pearls was the most common cause of reduction of vision in the peeling group(24/7.6%, P <0.001).CONCLUSION: There is no alternative to Nd:YAG laser capsulotomy for fibrous subtype of PCO. For pearl form of PCO, both techniques are comparable with regard to visual outcomes. Nd:YAG laser capsulotomy has a higher incidence of IOP spikes and retinal detachment whereas recurrence of pearls may occur after successful peeling and aspiration. When posterior capsulotomy is needed in patients with retinal degenerations,retinopathies and pre-existing retinal breaks, the clinician should be cautious about increased risks of possible complications of Nd:YAG laser capsulotomy. | Rahul Bhargava Prachi Kumar Shiv Kumar Sharma Avinash Kaur | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 1 |
| 6 | Calreticulin transacetylase catalyzed modification of the TNF-α mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates显示文摘 | Usha Singh Ajit Kumar Rajesh Sinha Sushma Manral Shvetambri Arora Sant Ram Rakesh K. Mishra Prachi Gupta Surendra K. Bansal Ashok K. Prasad Shyam Biswal Virinder S. Parmar Hanumantharao G. Raj | 2010 | Chemico-Biological Interactions2010，，3： | 1 |
| 7 | Boundary Element Modeling of Multiconnected Ocean Basin in Visakhapatnam Port Under the Resonance Conditions显示文摘A mathematical model has been developed to analyze the influence of extreme water waves over multiconnected regions in Visakhapatnam Port,India by considering an average water depth in each multiconnected regions.In addition,partial reflection of incident waves on coastal boundary is also considered.The domain of interest is divided mainly into two regions,i.e.,open sea region and harbor region namely as Region-I and Region-II,respectively.Further,Region-II is divided into multiple connected regions.The 2-D boundary element method(BEM)including the Chebyshev point discretization is utilized to solve the Helmholtz equation in each region separately to determine the wave amplification.The numerical convergence is performed to obtain the optimum numerical accuracy and the validation of the current numerical approach is also conducted by comparing the simulation results with existing studies.The four key spots based on the moored ship locations in Visakhapatnam Port are identified to perform the numerical simulation.The wave amplification at these locations is estimated for monochromatic incident waves,considering approximate water depth and different reflection coefficients on the wall of port under the resonance conditions.In addition,wave field analysis inside the Visakhapatnam Port is also conducted to understand resonance conditions.The current numerical model provides an efficient tool to analyze the amplification on any realistic ports or harbors. | Prashant KUMAR Prachi PRIYA RAJNI | 2021 | China Ocean Engineering2021，35，5： | 0 |
| 8 | Mathematical Modeling of Moored Ship Motion in Arbitrary Harbor utilizing the Porous Breakwater显示文摘The motion of the moored ship in the harbor is a classical hydrodynamics problem that still faces many challenges in naval operations,such as cargo transfer and ship pairings between a big transport ship and some small ships.A mathematical model is presented based on the Laplace equation utilizing the porous breakwater to investigate the moored ship motion in a partially absorbing/reflecting harbor.The motion of the moored ship is described with the hydrodynamic forces along the rotational motion(roll,pitch,and yaw)and translational motion(surge,sway,and heave).The efficiency of the numerical method is verified by comparing it with the analytical study of Yu and Chwang(1994)for the porous breakwater,and the moored ship motion is compared with the theoretical and experimental data obtained by Yoo(1998)and Takagi et al.(1993).Further,the current numerical scheme is implemented on the realistic Visakhapatnam Fishing port,India,in order to analyze the hydrodynamic forces on moored ship motion under resonance conditions.The model incorporates some essential strategies such as adding a porous breakwater and utilizing the wave absorber to reduce the port’s resonance.It has been observed that these tactics have a significant impact on the resonance inside the port for safe maritime navigation.Therefore,the current numerical model provides an efficient tool to reduce the resonance within the arbitrarily shaped ports for secure anchoring. | Prachi Priya Prashant Kumar Gulshan Rajni | 2023 | China Ocean Engineering2023，37，5： | 0 |
| 9 | Regression analysis and features of negative activation energy for MHD nanofluid flow model:A comparative study显示文摘This article elucidates the impact of activation energy on magnetohydrodynamic(MHD)stagnation point nanofluid flow over a slippery surface in a porous regime with thermophoretic and Brownian diffusions.Negative activation energy is scarce in practice,but the impact of negative activation energy could not be neglected as it is noticed in chemical processes.The rate of some Arrhenius-compliant reactions is retarded by increasing the temperature and is therefore associated with negative activation energies,such as exothermic binding of urea or water.In some processes,the temperature dependence of the pressure-induced unfolding and the urea-induced unfolding of proteins at ambient pressure give negative activation energies.The present mathematical model is solved with successive linearization method(a spectral technique).A comparison of results is made for negative and positive values of activation energy.Apart from it,the quadratic multiple regression model is discussed briefly and explained with bar diagrams.It is observed that with rise in unsteadiness parameter from 0 to 1(taking positive activation energy),skin friction and Sherwood number are increased by 9.36%and 19%respectively,and Nusselt number is decreased by 26%.However,for negative activation energy,9.36%and 112%enhancement is observed in skin friction and Sherwood number,respectively. | B.Kumara Prachi Abhinav Singhal R.Nandkeolyar Pulkit Kumar Ali J.Chamkha | 2023 | Propulsion and Power Research2023，12，2： | 0 |
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