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| 1 | Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl]rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro显示文摘瞄准:调查 cyclosporine 的效果 A (CsA )(MMF ) , FK-506,和 mycophenolate mofetil 和 40-0-[2-hydroxyethyl ] 人的肝内的增长上的 rapamycin (RAD ) 胆汁的上皮细胞(BEC ) 在试管内。方法:BEC 与免疫从六个人的肝织物标本被孤立磁性的分离方法并且与 CsA, FK-506, RAD,和 MMF 在试管内的不同集中对待。房间的增长被 MTT 试金分别地在 24 和 48 h 术后疗法测量。变化的单程的分析被用来分析结果。在 BEC 的 CK 19 的表示被流动血细胞计数和西方的污点监视。结果:BEC 的六根线被建立。他们为 4-18 wk 在试管内幸存。流动血细胞计数分析证明这些房间总是表示了 CK19。CsA, FK-506, RAD,和 MMF 以一种剂量依赖者方式禁止了 BEC 的增长。禁止 BEC (P<0.05 ) 的增长的 CsA, FK-506, RAD,和 MMF 的最低集中分别地是 500, 100, 0.25,和 100 mug/L。然而,由 BEC 的 CK19 的表示没被改变。结论:CsA, FK-506, RAD,和 MMF 在人的肝内 BEC 在试管内上有 antiproliferative 效果,当 RAD 有最强壮的生长禁止的效果时。他们在 transplant 病人的肝新生和胆汁管损害上的可能的效果应该进一步被调查。 | Chao Liu Thomas Schreiter Andrea Frilling Uta Dahmen Christoph E Broelsch Guido Gerken Ulrich Treichel | 2005 | World Journal of Gastroenterology2005，11，48： | 7 |
| 2 | Successful photodynamic therapy for biliary papillomatosis:A case report显示文摘Papillomatosis of the bile duct is a rare disease with a high risk of malignant transformation. Therapeutical options include partial hepatectomy and liver transplantation. A previously healthy 65-years old male developed jaundice and right upper abdominal quadrant pain in 1996. A villous adenoma of the distal bile duct was diagnosed. A Whipple procedure was performed. In 2002 the patient turned symptomatic again. Another adenoma was found in the right hepatic duct resulting in a right hepatectomy. Two years later the patient again developed cholestasis. After drainage of the left hepatic duct with a percutaneous transhepatic cholangial drainage (PTCD) catheter, a recurrent biliary adenomatosis was diagnosed by cholangioscopy. As there was no surgical option left, the patient received photodynamic therapy (PDT) for the recurrent biliary papillomatosis. Three mo after he received further photodynamic therapies, the bile duct epithelium appeared normal and the patient had no signs of adenomatosis, both macroscopically and histologically. The follow-up cholangioscopy in late 2005 revealed only a small papilloma without the need for intervention. In early 2006, the patient died of multi organ failure without signs of extrahepatic cholestasis or cholangitis at the age of 75, 10 years after the diagnosis of biliary papillomatosis was established. The patient exceeded the average life expectancy of patients with biliary papillomatosis by far. Thus, PDT might be a sufficient therapeutic option for recurrent papillomatosis patients with no significant side effects. | Lars P Bechmann Philip Hilgard Andrea Frilling Brigitte Schumacher Hideo A Baba Guido Gerken Thomas Zoepf | 2008 | World Journal of Gastroenterology2008，14，26： | 7 |
| 3 | Liver transplantation and multivisceral transplantation in the management of patients with advanced neuroendocrine tumours显示文摘Orthotopic liver transplantation(OLT) represents a generally accepted albeit somewhat controversially discussed therapeutic strategy in highly selected patients with non-resectable hepatic metastases from neuroendocrine tumours(NET). Whilst there are some exclusion criteria, these are not universally followed, and the optimal set of inclusion parameters for deeming patients eligible has not yet been elucidated. This is due to heterogeneity in the study populations, as well differing approaches employed and also divergences in selection criteria between centres. Recent data have suggested that OLT may represent the most efficacious approach in terms of overall and disease-free survival to the management of NET metastatic to the liver when conducted in accordance with the modified Milan criteria. Therefore, a consensus set of selection criteria requires definition to facilitate stringent and fair allocation of deceased-donor organs, as well as consideration for living-donor organs. In the context of classically non-resectable metastatic tumour bulk, multivisceral transplantation with or without the liver may also be indicated, yet experience is very limited. In this review, we discuss the diagnostic work-up of patients in whom the aforementioned transplantation approaches are being considered, critically analyse the published experience and also anticipate future developments in this field, including a discussion of immediate and longer-term research priorities. | Ashley Kieran Clift Andrea Frilling | 2018 | World Journal of Gastroenterology2018，24，20： | 5 |
| 4 | Computer-Assisted Surgery Planning for Complex Liver Resections: When Is It Helpful? A Single-Center Experience Over an 8-Year Period显示文摘 | Arnold Radtke Georgios C. Sotiropoulos Ernesto P. Molmenti Tobias Schroeder Heinz O. Peitgen Andrea Frilling Dieter C. Broering Christoph E. Broelsch Massimo Malagó | 2010 | Annals of Surgery2010，，5： | 4 |
| 5 | Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time PCR analysis显示文摘AIM: To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling. METHODS: Oligonucleotide arrays (Affymetrix U133A) were used to establish a specific gene expression profile of intrahepatic CCC in comparison to corresponding non- malignant liver tissue. To validate the expression values of the most overexpressed genes, RT-PCR experiments were performed. RESULTS: Five hundred and fifty-two statistically differentially expressed genes/ESTs (221 probes significantly up-regulated, 331 probes down-regulated; P < 0.05; fold change > 2; ≥ 70%) were identified. Using these data and two-dimensional cluster analysis,a specific gene expression profile was obtained allowing fast and reproducible differentiation of CCC, which was confirmed by supervised neuronal network modelling. The most consistently overexpressed gene (median fold change 33.5, significantly overexpressed in 100%) encoded osteopontin. Furthermore, an association of various genes with the histopathological grading could be demonstrated. CONCLUSION: A highly specific gene expression profile for intrahepatic CCC was identified, allowing for its fast and reproducible discrimination against non- malignant liver tissue and other liver masses. The most overexpressed gene in intrahepatic CCC was the gene encoding osteopontin. These data may lead to a better understanding of human cholangiocarcinogenesis. | Holger G Hass Oliver Nehls Juergen Jobst Andrea Frilling Ulrich Vogel Stephan Kaiser | 2008 | World Journal of Gastroenterology2008，14，16： | 4 |
| 6 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial显示文摘 | Gunnar Folprecht Thomas Gruenberger Wolf O Bechstein Hans-Rudolf Raab Florian Lordick J?rg T Hartmann Hauke Lang Andrea Frilling Jan Stoehlmacher Jürgen Weitz Ralf Konopke Christian Stroszczynski Torsten Liersch Detlev Ockert Thomas Herrmann Eray Goekkurt | 2010 | Lancet Oncology2010，，1： | 3 |
| 7 | Right Living Donor Liver Transplantation: An Option for Adult Patients: Single Institution Experience With 74 Patients显示文摘 | Massimo Malagó Giuliano Testa Andrea Frilling Silvio Nadalin Camino Valentin-Gamazo Andreas Paul Hauke Lang Ulrich Treichel Vito Cicinnati Guido Gerken Christoph Erich Broelsch | 2003 | Annals of Surgery2003，，6： | 2 |
| 8 | Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study)显示文摘 | Riccardo Lencioni Laura Crocetti Roberto Cioni Robert Suh Derek Glenn Daniele Regge Thomas Helmberger Alice R Gillams Andrea Frilling Marcello Ambrogi Carlo Bartolozzi Alfredo Mussi | 2008 | Lancet Oncology2008，，7： | 2 |
| 9 | Major bile duct injuries after laparoscopic cholecystectomy: A tertiary center experience显示文摘 | Andrea Frilling M.D. Ph.D. Jun Li M.D. Frank Weber M.D. Nils Roman Frühauf M.D. Jennifer Engel Susanne Beckebaum M.D. Andreas Paul M.D. Thomas Z?pf M.D. Massimo Malago M.D. Ph.D. Christoph Erich Broelsch M.D. Ph.D | 2004 | Journal of Gastrointestinal Surgery2004，，6： | 1 |
| 10 | Survival and Recurrence Rates after Resection for Hepatocellular Carcinoma in Noncirrhotic Livers显示文摘 | Hauke Lang Georgios C. Sotiropoulos Eirini I. Brokalaki Klaus Jürgen Schmitz Christian Bertona Gabriele Meyer Andrea Frilling Andreas Paul Massimo Malagó Christoph E. Broelsch | 2007 | Journal of the American College of Surgeons2007，，1： | 1 |
| 11 | Surgical Management of Segmental and Sectoral Bile Duct Injury After Laparoscopic Cholecystectomy: a Challenging Situation显示文摘 | Jun Li Andrea Frilling Silvio Nadalin Sonia Radunz Juergen Treckmann Hauke Lang Massimo Malago Christoph Erich Broelsch | 2010 | Journal of Gastrointestinal Surgery2010，，2： | 1 |
| 12 | Dual-modality FDG-PET/CT in follow-up of patients with recurrent iodine-negative differentiated thyroid cancer显示文摘 | Lutz S. Freudenberg Andrea Frilling Hilmar Kühl Stefan P. Müller Walter Jentzen Andreas Bockisch Gerald Antoch | 2007 | European Radiology2007，，12： | 1 |
| 13 | 27-bp Deletion in the ret proto-oncogene as asomatic mutation associated with medullary thyroid carcinoma显示文摘 | Frilling Andrea | 1998 | Springer-Verlag J Mol Med1998，76，5： | 1 |
| 14 | Major bile duct injuries after laparoscopic cholecystectomy: A tertiary center experience显示文摘 | Andrea Frilling M.D. Ph.D. Jun Li M.D. Frank Weber M.D. Nils Roman Frühauf M.D. Jennifer Engel Susanne Beckebaum M.D. Andreas Paul M.D. Thomas Z?pf M.D. Massimo Malago M.D. Ph.D. Christoph Erich Broelsch M.D. Ph.D | 2004 | Journal of Gastrointestinal Surgery2004，，6： | 1 |
| 15 | Incidence of Finding Residual Disease for Incidental Gallbladder Carcinoma: Implications for Re-resection显示文摘 | Timothy M. Pawlik Ana Luiza Gleisner Luca Vigano David A. Kooby Todd W. Bauer Andrea Frilling Reid B. Adams Charles A. Staley Eduardo N. Trindade Richard D. Schulick Michael A. Choti Lorenzo Capussotti | 2007 | Journal of Gastrointestinal Surgery2007，，11： | 1 |
| 16 | Dual-modality FDG-PET/CT in follow-up of patients with recurrent iodine-negative differentiated thyroid cancer显示文摘 | Lutz S. Freudenberg Andrea Frilling Hilmar Kühl Stefan P. Müller Walter Jentzen Andreas Bockisch Gerald Antoch | 2007 | European Radiology2007，，12： | 1 |
| 17 | The Role of Surgery in Caroli’s Disease显示文摘 | Maximilian Bockhorn Massimo Malagó Hauke Lang Silvio Nadalin Andreas Paul Fuat Saner Andreja Frilling Christoph E. Broelsch | 2006 | Journal of the American College of Surgeons2006，，6： | 1 |
| 18 | Major bile duct injuries after laparoscopic cholecystectomy: a tertiary center experience显示文摘 | Andrea Frilling Jun Li Frank Weber Nils Roman Frühauf Jennifer Engel Susanne Beckebaum Andreas Paul Thomas Z?pf Massimo Malago Christoph Erich Broelsch | 2004 | Journal of Gastrointestinal Surgery2004，，6： | 1 |
| 19 | Liver Transplantation for Hepatocellular Carcinoma in Cirrhosis within the Eurotransplant Area: An Additional Option with “Livers that Nobody Wants”显示文摘 | Georgios C. Sotiropoulos Andreas Paul Ernesto Molmenti Hauke Lang Andrea Frilling Bogdan P. Napieralski Silvio Nadalin Jürgen Treckmann Eirini I. Brokalaki Till Gerling Christoph E. Broelsch Massimo Malagó | 2005 | Transplantation2005，，7： | 1 |
| 20 | Surgical Management of Segmental and Sectoral Bile Duct Injury After Laparoscopic Cholecystectomy: a Challenging Situation显示文摘 | Jun Li Andrea Frilling Silvio Nadalin Sonia Radunz Juergen Treckmann Hauke Lang Massimo Malago Christoph Erich Broelsch | 2010 | Journal of Gastrointestinal Surgery2010，，2： | 1 |
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