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| 1 | Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension显示文摘AIM:Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal hypertension.METHODS:Thirty healthy controls and 39 patients with clinically verified portal hypertension and increasedvascular resistance participated in the study.Liver di-ameters,portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler detection.Cross-section area,portal flow and index of vascular resistance were calculated.In collected blood samples,superoxide anion radical (O 2-),hydrogen per-oxide (H 2 O 2),index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO 2-) were determined.Time-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) administration.RESULTS:Oxidative stress parameters changed sig-nificantly during the study.H 2 O 2 decreased at the end of study,probably via O 2-mediated disassembling in Haber Weiss and Fenton reaction;O 2-increased signifi-cantly probably due to increased diameter and tension and decreased shear rate level.Consequently O 2-and H 2 O 2 degradation products,like hydroxyl radical,initi-ated lipid peroxidation.Increased blood flow was to some extent lower in patients than in controls due to double paradoxes,flow velocity decreased,shear rate decreased significantly indicating non Newtonian char-acteristics of portal blood flow.CONCLUSION:This pilot study could be a starting point for further investigation and possible implemen-tation of some antioxidants in the treatment of portal hypertension. | Andreja Vujanac Vladimir Jakovljevic Dusica Djordjevic Vladimir Zivkovic Mirjana Stojkovic Dragan Celikovic Nebojsa Andjelkovic Aleksandra Jurisic Skevin Dragan Djuric | 2012 | World Journal of Gastroenterology2012，18，4： | 7 |
| 2 | Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in ratsPentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats显示文摘BACKGROUND Recently,as a possible therapy resolving solution,pentadecapeptide BPC 157 therapy,has been used in alleviating various vascular occlusion disturbances.BPC 157 was previously reviewed as novel mediator of Robert cytoprotection and endothelium protection in the stomach,and gut-brain axis,beneficial therapy in gastrointestinal tract,with particular reference to vascular recruitment,ulcerative colitis and tumor cachexia,and other tissues healing.Here we raised new hypothesis about BPC 157 therapy in the Budd-Chiari syndrome in rats,rapid bypassing of the suprahepatic inferior caval vein occlusion,and rats recovery with the active and effective pharmacotherapy treatment.AIM To investigate Budd-Chiari syndrome model(inferior caval vein suprahepatic occlusion)resolution,since BPC 157 resolves various rat vascular occlusion.METHODS We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt,counteracted caval/portal hypertension,aortal hypotension,venous/arterial thrombosis,electrocardiogram disturbances,liver and gastrointestinal lesions(i.e.,stomach and duodenum hemorrhages,in particular,congestion).Rats with suprahepatic occlusion of the inferior vena cava by ligation were medicated at 1 min,15 min,24 h,or 48 h post-ligation.Medication consisted of 10μg/kg BPC 157,10 ng BPC 157 or 5 m L/kg saline,administered once as an abdominal bath or intragastric application.Gross and microscopic observations were made,in addition to assessments of electrical activity of the heart(electrocardiogram),portal and caval hypertension,aortal hypotension,thrombosis,hepatomegaly,splenomegaly and venography.Furthermore,levels of nitric oxide,malondialdehyde in the liver and serum enzymes were determined.RESULTS BPC 157 counteracted increased P wave amplitude,tachycardia and ST-elevation,i.e.,right heart failure from acute thrombotic coronary occlusion.The bypassing pathway of the inferior vena cava-azygos(hemiazygos)vein-superior vena cava and portocaval shunt occurred rapidly.Even with severe caval portal hypertension,BPC 157 antagonized portal and caval hypertension and aortal hypotension,and also reduced refractory ascites.Thrombosis of portal vein tributaries,inferior vena cava,and hepatic and coronary arteries was attenuated.In addition,there was reduced pathology of the lungs(severe capillary congestion)and liver(dilated central veins and terminal portal venules),decreased intestine hemorrhagic lesions(substantial capillary congestion,submucosal edema and architecture loss),and increased liver and spleen weight.During the period of ligation,nitric oxide-and malondialdehyde-levels in the liver remained within normal healthy values,and increases in serum enzymes were markedly reduced.CONCLUSION BPC 157 counteracts Budd Chiari syndrome in rats. | Slaven Gojkovic Ivan Krezic Borna Vrdoljak Dominik Malekinusic Ivan Barisic andreja Petrovic Katarina Horvat Pavlov Marijan Kolovrat Antonija Duzel Mario Knezevic Katarina Kasnik Kovac Domagoj Drmic Lovorka Batelja Vuletic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric | 2020 | World Journal of Gastrointestinal Pathophysiology2020，11，1： | 2 |
| 3 | Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children显示文摘 | Mojca Groselj-Grenc Alojz Ihan Maja Pavcnik-Arnol Andreja Natasa Kopitar Tanja Gmeiner-Stopar Metka Derganc | 2009 | Intensive Care Medicine2009，，11： | 2 |
| 4 | Inflammation markers in patients with coronary artery disease – comparison of intracoronary and systemic levels显示文摘 | Simona Kirbi? Ur?ka D. Breskvar Mi?o ?abovi? Igor Zupan Andreja Sinkovi? | 2010 | Wiener klinische Wochenschrift2010，，2： | 1 |
| 5 | Sodium ascorhyl phosphate in topical microemulsions 显示文摘 | POLONA SPICLIN MIHA HOMAR ANDREJA ZUPANCIC - VALANT | 2003 | International Journal of Pharmaceutics2003，，256： | 1 |
| 6 | Reduced combustion time model for methane in gas turbine flow fields显示文摘Computational fluid dynamics (CFD) modeling of the complex processes that occur within the burner of a gas turbine engine has become a critical step in the design process. However, due to computer limitations, it is very difficult to completely couple the fluid mechanics solver with the full combustion chemistry. Therefore, simplified chemistry models are required, and the topic of this research was to provide reduced chemistry models for CH4/O2 gas turbine flow fields to be integrated into CFD codes for the simulation of flow fields of natural gas-fueled burners. The reduction procedure for the CH4/O2 model utilized a response modeling technique wherein the full mechanism was solved over a range of temperatures, pressures, and mixture ratios to establish the response of a particular variable, namely the chemical reaction time. The conditions covered were between 1000 and 2500 K for temperature, 0.1 and 2 for equivalence ratio in air, and 0.1 and 50 atm for pressure. The kinetic time models in the form of ignition time correlations are given in Arrhenius-type formulas as functions of equivalence ratio, temperature, and pressure; or fuel-to-air ratio, temperature, and pressure. A single ignition time model was obtained for the entire range of conditions, and separate models for the low-temperature and high-temperature regions as well as for fuel-lean and rich cases were also derived. Predictions using the reduced model were verified using results from the full mechanism and empirical correlations from experiments. The models are intended for (but not limited to) use in CFD codes for flow field simulations of gas turbine combustors in which initial conditions and degree of mixedness of the fuel and air are key factors in achieving stable and robust combustion processes and acceptable emission levels. The chemical time model was utilized successfully in CFD simulations of a generic gas turbine combustor with four different cases with various levels of fuel-air premixing. | Mouna Lamnaouer Robert C. Ryder Andreja Brankovic Eric L. Petersen | 2009 | Journal of Natural Gas Chemistry2009，18，2： | 1 |
| 7 | German Association of Endocrine Surgeons practice guideline for the surgical management of malignant thyroid tumors显示文摘 | Henning Dralle Thomas J. Musholt Jochen Schabram Thomas Steinmüller Andreja Frilling Dietmar Simon Peter E. Goretzki Bruno Niederle Christian Scheuba Thomas Clerici Michael Hermann Jochen Ku?mann Kerstin Lorenz Christoph Nies Peter Schabram Arnold Trupka | 2013 | Langenbeck’s Archives of Surgery2013，，3： | 1 |
| 8 | Comparison of different physico-chemical methods for the removal of toxicants from landfill leachate显示文摘 | Magda Cotman Andreja ?gajnar Gotvajn | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 9 | Influence of starter cultures on the free fatty acids during ripening in Tea sausages显示文摘 | Andreja -Đurica Zuber Mirjana Horvat | 2007 | European Food Research and Technology2007，，4： | 1 |
| 10 | Sliding-mode motion controller with adaptive fuzzy disturbance estimation 显示文摘 | Rojko Andreja Jezemik Karel | 2004 | Transactions of Industrial Electronics2004，51，5： | 1 |
| 11 | Atherosclerotic burden in coronary and peripheral arteries in patients with first clinical manifestation of coronary artery disease显示文摘 | Igor Kranjec | 2002 | Heart and Vessels2002，16，6： | 1 |
| 12 | Comparison of antioxidative and synergistic effects of rosemary ex-tract withā-tocopherol,ascorbyl palmitate and citric acid In sunflower oil显示文摘 | Andreja Rizner Hras Majda Hadolin zeljko Knez et a1 | 2000 | Food chemist2000，71，： | 1 |
| 13 | Exploiting ICT potential in service firms in transition economies显示文摘 | Metka Jakli c Andreja Kotnik Patricia | 2006 | Service Industries Journal2006，26，3： | 1 |
| 14 | The stomach as a site for anthocyanins absorption from food 1 1 In memory of Livia Mattivi, who died on 15th March 2003.显示文摘 | Sabina Passamonti Urska Vrhovsek Andreja Vanzo Fulvio Mattivi | 2003 | FEBS Letters2003，，1： | 1 |
| 15 | Pentadecapeptide BPC 157 resolves Pringle maneuver in rats,both ischemia and reperfusion显示文摘BACKGROUND The Pringle maneuver[portal triad obstruction(PTO)]provides huge disturbances during ischemia and even more thereafter in reperfusion.Contrarily,a possible solution may be stable gastric pentadecapeptide BPC 157,with already documented beneficial effects in ischemia/reperfusion conditions.Recently,BPC 157,as a cytoprotective agent,successfully resolved vessel occlusions in rats(ischemic colitis;deep vein thrombosis,superior anterior pancreaticoduodenal vein;bile duct cirrhosis)through rapid collateral vessel recruitment to circumvent vessel occlusion.Thereby,medication BPC 157 regimens were administered as a single challenge before and during ischemia or,alternatively,at various time points during reperfusion.AIM To introduce BPC 157 therapy against pringle maneuver-damage.METHODS In deeply anesthetised rats,the portal triad was clamped up for 30 min.Rats then underwent reperfusion for either 15 min or 24 h.Medication[(10μg,10 ng/kg)regimens,administered as a single challenge]picked(a)ischemia,PTO period[at 5 min before(ip)or at 5 or 30 min of ligation time(as a bath to PTO)]or(b)reperfusion,post-PTO period[at 1 or 15 min(bath during surgery)or 24 h(ip)reperfusion-time].We provided gross,microscopy,malondialdehyde,serum enzymes,electrocardiogram,portal,caval,and aortal pressure,thrombosis and venography assessments.RESULTS BPC 157 counteracts electrocardiogram disturbances(increased P wave amplitude,S1Q3T3 QRS pattern and tachycardia).Rapidly presented vascular pathway(portal vein-superior mesenteric vein-inferior mesenteric vein-rectal veins-left ileal vein-inferior caval vein)as the adequate shunting immediately affected disturbed haemodynamics.Portal hypertension and severe aortal hypotension during PTO,as well as portal and caval hypertension and mild aortal hypotension in reperfusion and refractory ascites formation were markedly attenuated(during PTO)or completely abrogated(reperfusion);thrombosis in portal vein tributaries and inferior caval vein or hepatic artery was counteracted during portal triad obstruction PTO.Also,counteraction included the whole vicious injurious circle[i.e.,lung pathology(severe capillary congestion),liver(dilated central veins and terminal portal venules),intestine(substantial capillary congestion,submucosal oedema,loss of villous architecture),splenomegaly,right heart(picked P wave values)]regularly perpetuated in ischemia and progressed by reperfusion in Pringle rats.CONCLUSION BPC 157 resolves pringle maneuver-damage in rats,both for ischemia and reperfusion. | Marijan Kolovrat Slaven Gojkovic Ivan Krezic Dominik Malekinusic Borna Vrdoljak Katarina Kasnik Kovac Tamara Kralj Domagoj Drmic Ivan Barisic Katarina Horvat Pavlov Andreja Petrovic Antonija Duzel Mario Knezevic Ivan Mirkovic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric | 2020 | World Journal of Hepatology2020，12，5： | 1 |
| 16 | The Restructuring Role of Outward Foreign Direct In- vestment by Central European Firms: The Case of Slovenia显示文摘 | MARJAN SVETLICIC MATIJA ROJEC ANDREJA TRTNIK | 2000 | Advances in International Marketing2000，，10： | 1 |
| 17 | Inflammation markers in patients with coronary artery disease – comparison of intracoronary and systemic levels显示文摘 | Simona Kirbi? Ur?ka D. Breskvar Mi?o ?abovi? Igor Zupan Andreja Sinkovi? | 2010 | Wiener klinische Wochenschrift2010，，2： | 1 |
| 18 | Chlorine dioxide for minimally processed produce preservation:A review 显示文摘 | VICENTE M GOMEZ L ANDREJA R | 2008 | Trends in Food Science & Technology2008，，6： | 1 |
| 19 | Preventive and therapeutic antitumor effect of tumor vaccine composed of CPGODN class C and irradiated tumor cells is triggered through the APCS and activation of CTLs显示文摘 | Srdjan N Vida S Andreja K | 2007 | Vaccine2007，25，49： | 1 |
| 20 | C hlorin e dioxide for minimally processed produce preservation:a revie w显示文摘 | Vicente M Gómez-López Andreja Rajkovic Peter Ragaert | 2009 | Trends in Food Science and Technology2009，，1： | 1 |
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