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| 1 | The effect of phase angle and wing spacing on tandem flapping wings显示文摘In a tandem wing configuration, the hindwing often operates in the wake of the forewing and, hence, its performance is affected by the vortices shed by the forewing. Changes in the phase angle between the flapping motions of the fore and the hind wings, as well as the spacing between them, can affect the resulting vortex/wing and vortex/vortex interactions. This study uses 2D numerical simulations to investigate how these changes affect the leading dege vortexes (LEV) generated by the hindwing and the resulting effect on the lift and thrust coefficients as well as the efficiencies. The tandem wing configuration was simulated using an incompressible Navier-Stokes solver at a chord-based Reynolds number of 5 000. A harmonic single frequency sinusoidal oscillation consisting of a combined pitch and plunge motion was used for the flapping wing kinematics at a Strouhal number of 0.3. Four different spacings ranging from 0.1 chords to 1 chord were tested at three different phase angles, 0 , 90 and 180 . It was found that changes in the spacing and phase angle affected the timing of the interaction between the vortex shed from the forewing and the hindwing. Such an interaction affects the LEV formation on the hindwing and results in changes in aerodynamic force production and efficiencies of the hindwing. It is also observed that changing the phase angle has a similar effect as changing the spacing. The results further show that at different spacings the peak force generation occurs at different phase angles, as do the peak efficiencies. | Timothy M. Broering Yong-Sheng Lian | 2012 | Acta Mechanica Sinica2012，28，6： | 12 |
| 2 | Computer-Assisted Surgery Planning for Complex Liver Resections: When Is It Helpful? A Single-Center Experience Over an 8-Year Period显示文摘 | Arnold Radtke Georgios C. Sotiropoulos Ernesto P. Molmenti Tobias Schroeder Heinz O. Peitgen Andrea Frilling Dieter C. Broering Christoph E. Broelsch Massimo Malagó | 2010 | Annals of Surgery2010，，5： | 4 |
| 3 | Inducible Rubicon facilitates viral replication by antagonizing interferon production显示文摘The RUN domain Beclin-1-interacting cysteine-rich-containing(Rubicon)protein is involved in the maturation step of autophagy and the endocytic pathway as a Beclin-1-binding partner,but little is known regarding the role of Rubicon during viral infection.Here,we performed functional studies of the identified target in interferon(IFN)signaling pathways associated with Rubicon to elucidate the mechanisms of viral resistance to IFN.The Rubicon protein levels were elevated in peripheral blood mononuclear cells,sera and liver tissues from patients with hepatitis B virus(HBV)infection relative to those in healthy individuals.Assays of the overexpression and knockdown of Rubicon showed that Rubicon significantly promoted HBV replication.In addition,Rubicon knockdown resulted in the inhibition of enterovirus 71,influenza A virus and vesicular stomatitis virus.The expression o0f Rubicon led to the suppression of virus-induced type-I interferon(IFN-αand IFN-β)and type-III interferon(IFN-λ1).Translocation of activated IRF3 and IRF7 from the cytoplasm to the nucleus was involved in this process,and the NF-κB essential modulator(NEMO),a key factor in the IFN pathway,was the target with which Rubicon interacted.Our results reveal a previously unrecognized function of Rubicon as a virus-induced protein that binds to NEMO,leading to the inhibition of type-I interferon production.Rubicon thus functions as an important negative regulator of the innate immune response,enhances viral replication and may play a role in viral immune evasion. | Yushun Wan Wei Cao Tao Han Sheng Ren Jian Feng TieLong Chen Jun Wang Ruth Broering Mengji Lu Ying Zhu | 2017 | Cellular & Molecular Immunology2017，14，7： | 4 |
| 4 | Liver transplantation for hepatitis B virus: Decreasing indication and changing trends显示文摘AIM: To evaluate the indication and outcome of hepatitis B virus(HBV)-related liver transplantation(LT) in the era of newer antiviral agents.METHODS: We collected data on all patients who underwent transplantation at King Faisal Specialist Hospital and Research Center.These data included demographic,perioperative and long-term postoperative follow-up data including viral serological markers,HBV DNA,and repeated liver imaging.Between January 1990 and January 2012,133 patients(106 males and 27 females) underwent LT for HBV-related cirrhosis at our center.All patients were followed up frequently during the first year following transplantation,according to our standard protocol; follow-up visits occurred every 3-6 mo thereafter.Breakthrough infection was definedas re-emergence of HBV-DNA or hepatitis B surface antigen(HBs Ag) while on treatment.Five patients transplanted prior to 1992 did not receive immediate posttransplant anti-HBV prophylaxis; all other patients were treated with HBIG and at least one nucleos(t)ide analog.RESULTS: One hundred and thirty-three patients underwent LT for HBV and were followed for a median of 82 mo(range: 1-274).The rates of post-LT survival and HBV recurrence during the follow-up period were 89% and 11%,respectively.The following factors were associated with disease recurrence: younger age(44.3 ± 16.2 years vs 51.4 ± 9.9 years,P = 0.02),positive pretransplant hepatitis B e antigen(HBe Ag)(60% vs 14%,P < 0.0001),detectable pretransplant HBV DNA(60% vs 27%,P = 0.03),positive posttransplant HBs Ag(80% vs 4%,P < 0.0001) and positive posttransplant HBe Ag(27% vs 1%,P < 0.0001).Forty-four(33%) patients had hepatocellular carcinoma(HCC).In the first(pre-2007) group,HBV was the second leading indication for LT after hepatitis C virus infection.A total of 64 transplants were performed,including 46(72%) for decompensated HBV cirrhosis,12(19%) for decompensated cirrhosis complicated by HCC and 6(10%) for compensated cirrhosis complicated by HCC.In the second group,nonalcoholic steatohepatitis surpassed HBV as the second leading indication for LT.A total of 69 HBV related transplants were performed,including 43(62%) for decompensated HBV cirrhosis,7(10%) for decompensated cirrhosis complicated by HCC and 19(27.5%) for compensated cirrhosis complicated by HCC.There was a significant(P = 0.007) increase in the number of transplants for compensated cirrhosis complicated by HCC.CONCLUSION: The use of potent anti-HBV agents has led to a changing trend in the indications for LT.HBV is currently the third leading indication for LT in this hyperendemic area. | Waleed Al-hamoudi Hussien Elsiesy Abdulrahman Bendahmash Nasser Al-masri Safiyya Ali Naglaa Allam Mohammed Al Sofayan Hamad Al Bahili Mohammed Al Sebayel Dieter Broering Sammy Saab Faisal Abaalkhail | 2015 | World Journal of Gastroenterology2015，21，26： | 4 |
| 5 | Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections显示文摘 | Xiaoyong Zhang Anke Kraft Ruth Broering Joerg F Schlaak Ulf Dittmer Mengji Lu | 2012 | Expert Opinion on Drug Discovery2012，，7： | 3 |
| 6 | Role of Toll-like receptor 2 in the immune response against hepadnaviral infection显示文摘 | Xiaoyong Zhang Zhiyong Ma Hongyan Liu Jia Liu Zhongji Meng Ruth Broering Dongliang Yang Joerg F. Schlaak Michael Roggendorf Mengji Lu | 2012 | Journal of Hepatology2012，，3： | 2 |
| 7 | Robotic surgery and liver transplantation:A single-center experience of 501 robotic donor hepatectomies显示文摘Background:Over the past two decades robotic surgery has been introduced to many areas including liver surgery.Laparoscopic liver surgery is an alternative minimally invasive approach.However,moving on to the complexity of living donor hepatectomies,the advantages of robotic versus laparoscopic approach have convinced us to establish the robotic platform as a standard for living donor hepatectomy.Methods:From November 2018 to January 2022,501 fully robotic donor hepatectomies,including 177 left lateral donor lobes,112 full left lobes and 212 full right lobes were performed.Grafts were donated to 296 adult recipients and 205 pediatric recipients.Donor age,sex,body weight,body mass index(BMI),graft weight,graft to body weight ratio(GBWR),operative time,blood loss,first warm ischemic time,pain score,length of intensive care unit(ICU)stay and hospital stay,and complications were retrospectively analyzed based on a prospectively kept database.Recipients were evaluated for graft and patient survival,age,sex,BMI,body weight,model of end-stage liver disease score,blood loss,transfusions,operative time,cold ischemic time,length of hospital stay and complications.Results:There was no donor mortality.Two cases needed to be converted to open surgery.The median blood loss was 60 mL(range 20-800),median donor operative time was 6.77 h(range 2.93-11.53),median length of hospital stay was 4 days(range 2-22).Complication rate in donors classified following ClavienDindo was 6.4%(n=32)with one grade Ⅲ complication.Three-year actual recipient overall survival was 91.4%;87.5% for adult recipients and 97.1% for pediatric recipients.Three-year actual graft overall survival was 90.6%;87.5% for adult recipients and 95.1% for pediatric recipients.In-hospital mortality was 6%,9.1%(27/296)for adult recipients and 1.4%(3/205)for pediatric recipients.The recipients’morbidity was 19.8%(n=99).Twenty-eight recipients(5.6%)had biliary and 22(4.4%)vascular complications.Six(12.0%)recipients needed to be re-transplanted.Conclusions:With growing experience it is nowadays possible to perform any donor hepatectomy by robotic approach regardless of anatomical variations and graft size.Donor morbidity and quality for life results are encouraging and should motivate other transplant centers with interest in minimally invasive donor surgery to adopt this robotic technique. | Maren Schulze Yasser Elsheikh Markus Ulrich Boehnert Yasir Alnemary Saleh Alabbad Dieter Clemens Broering | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，4： | 2 |
| 8 | Human Monoclonal Antibody MBL‐HCV1 Delays HCV Viral Rebound Following Liver Transplantation: A Randomized Controlled Study显示文摘 | R. T. Chung F. D. Gordon M. P. Curry T. D. Schiano S. Emre K. Corey J. F. Markmann M. Hertl J. J. Pomposelli E. A. Pomfret S. Florman M. Schilsky T. J. Broering R. W. Finberg G. Szabo P. D. Zamore U. Khettry G. J. Babcock D. M. Ambrosino B. Leav M. Leney | 2013 | American Journal of Transplantation2013，，4： | 2 |
| 9 | The role of an- timullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count显示文摘 | Broer SL Mol BW Hendriks D | 2009 | Fertil Ster- il2009，91，3： | 1 |
| 10 | Expression of surfactant associ-ated protein-A and Clara cell 10 kilodahon mRNA in neoplastic and non-neoplastichuman lung tissue as detected by in situ hybridization 显示文摘 | Broers J L Jensen S M Travis W D | 1992 | Lab Invest1992，66，3： | 1 |
| 11 | Stability of biocatalysts 显示文摘 | Polizzi KM Bommarius AS Broering JM Chaparro - Riggers JF | 2007 | Current Opinion in Chemical Biolo- gy2007，11，2： | 1 |
| 12 | The Role of the Neutral Amino acid Transporter B0AT1 (SLC6A19) in Hartnup Disorder and Protein Nutrition显示文摘 | Stefan Broer | | 0，，06： | 1 |
| 13 | Pathophysiology and clinical significance of the abdominal compartment syndrome显示文摘 | Grubben AC van Baardwijk AA Broering DC | 2001 | Zentralblatt für Chirurgie2001，，08： | 1 |
| 14 | Electron beam lithography-resolution limits显示文摘 | Broers A N Hoole A C F Ryan J M | 1996 | Microelectronic Engineering1996，32，： | 1 |
| 15 | Toll‐like receptor‐mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen显示文摘 | M. Jiang R. Broering M. Trippler L. Poggenpohl M. Fiedler G. Gerken M. Lu J. F. Schlaak | 2014 | J Viral Hepat2014，，12： | 1 |
| 16 | Extended drainage versus resection in surgery for chronic pancreatitis:a prospective randomized trial comparing the longitudinal pancreaticojejunostomy combined with local pancreatic head excision with the pylorus-preserving pancreatoduodenectomy显示文摘 | Izbicki JR Bloechle C Broering DC | 1998 | Ann Surg1998，228，6： | 1 |
| 17 | AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis 显示文摘 | Broer SL Dolleman M Opmeer BC | 2011 | Hum Reprod Update2011，17，： | 1 |
| 18 | Added vaiue of ovarian reserve testing on patient characteris- tics in the prediction o显示文摘 | BROER S L VAN DISSELDORP J BROEZE K A | 2012 | Human Reproduc- tion Update2012，19，1： | 1 |
| 19 | Effect of an increased intake of {alpha}-linolenic acid and group nutritional edu cation on cardiovascular risk factors: the Mediterranean Alphalinolenic Enriched Groningen Dietary Intervention (MARGAPIN) study 显示文摘 | Bemelmans WJE Broer J Feskens EJM | 2002 | Am J Clin Nutr2002，75，2： | 1 |
| 20 | Stress inactivation of foreign genes in transgenic plant 显示文摘 | BROER I | 1996 | Field Crop Research1996，45，： | 1 |
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