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| 1 | 综合性卒中中心医疗质量的度量标准:对脑卒中联盟综合性卒中中心推荐意见的详细随访美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘背景卒中是一种主要的残疾和死亡原因。脑卒巾联盟提议,建立初级卒中中心(primary stroke center,PSC)和综合性卒中中心(comprehensive stroke center,csc)以分别为需要基本或高级下预的卒中患者提供适当的医疗服务。从2003年开始,美国医疗卫生机构认证联合委员会和各州已指定了一些PSC,目前正在考虑CSC的指定工作。为了推进该过程,我们提出了一套CSC应追踪监测医疗质量并促进质量改进的标准和相关数据。方法和结果我们分析了现有指南、综述和其他文献,以识别区分CSC与PSC的主要特征;起草了一套标准和相关数据元素,以评价这些卒中医疗方面的关键部分;然后通过反复修改达成共识。我们提出的这套标准和相关数据元素,涵盖了CSC内缺血性脯血管病、非外伤性蛛网膜下腔出血和腩出血患者专、№医疗的主要方面。结论我们提出这套标准,旨在为CSC的标准化数据采集提供一个框架,以促进当地医疗质量改进,并允许对来自不同CSC的数据进行合并分析。这将有助于将来CSC国家执行标准的制定。 | 何晟(译) 蔡可夫(译) 张元媛(译) 胡旻婧(译) 倪耀辉(译) 芮瑛(译) 柯开富(译) Dana Leifer Dawn M. Bravata J.J. (Buddy) Connors Ⅲ Judith A. Hinchey Edward C. Jauch S. Claibome Johnston Richard Latchaw William kikosky Christopher Ogilvy Adrian I. Qureshi Debbie Summers Gene Y. Sung Linda S. Williams Richard Zorowitz | 2011 | 国际脑血管病杂志2011，19，3： | 21 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | Telbivudine Improves Renal Function in Patients With Chronic Hepatitis B显示文摘 | Edward J. Gane Gilbert Deray Yun-Fan Liaw Seng Gee Lim Ching-Lung Lai Jens Rasenack Yuming Wang George Papatheodoridis Adrian Di Bisceglie Maria Buti Didier Samuel Alkaz Uddin Sophie Bosset Aldo Trylesinski | 2014 | Gastroenterology2014，，1： | 2 |
| 4 | Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors显示文摘 | Edward Sausville Patricia LoRusso Michael Carducci Judith Carter Mary F. Quinn Lisa Malburg Nilofer Azad David Cosgrove Richard Knight Peter Barker Sonya Zabludoff Felix Agbo Patricia Oakes Adrian Senderowicz | 2014 | Cancer Chemotherapy and Pharmacology2014，，3： | 1 |
| 5 | 'Doing prescribing':how doctors can be more effective显示文摘 | Glyn Elwyn Adrian Edwards Nicky Brittem | 2003 | BMJ2003，327，7419： | 1 |
| 6 | A Prospective Study of Common Bile Duct Calculi in Patients Undergoing Laparoscopic Cholecystectomy: Natural History of Choledocholithiasis Revisited显示文摘 | Chris Collins Donal Maguire Adrian Ireland Edward Fitzgerald Gerald C. O'Sullivan | 2004 | Annals of Surgery2004，，1： | 1 |
| 7 | Efficacy and safety of sitagliptin added to ongoing metformin and rosiglitazone combination therapy in a randomized placebo‐controlled 54‐week trial in patients with type 2 diabetes (一项为期54周的对持续使用二甲双胍与罗格列酮联合治疗的2型糖尿病患者加用西格列汀治疗的有效性与安全性的随机安慰剂对照研究)*显示文摘 | Adrian S. DOBS Barry J. GOLDSTEIN Pablo ASCHNER Edward S. HORTON Guillermo E. UMPIERREZ Lorraine DURAN Julie S. HILL Yu CHEN Gregory T. GOLM Ronald B. LANGDON Debora E. WILLIAMS‐HERMAN Keith D. KAUFMAN John M. AMATRUDA Juan Camilo ARJONA FERREIRA | 2013 | Journal of Diabetes2013，，1： | 1 |
| 8 | Dissolution of jarosite at pH 2 and 8: Insights from batch experiments and computational modeling 显示文摘 | Adrian M L Smith Karen A Hudson - Edwards William E Dubbin | 2006 | Geochimica et Cosmochimica Acta2006，70，3： | 1 |
| 9 | Environmental Policy and Techno- logical Innovation: Why do firms adopt or reject new technolo- gies? 显示文摘 | ADRIAN SMITH CARLOS MONTALVO CORRAL EDWARD ELGAR CHELTENHAM | 2003 | Journal of Economic Psychology2003，24，4： | 1 |
| 10 | Baseline characteristics and early on-treatment response predict the outcomes of 2<ce:hsp sp='0.25'/>years of telbivudine treatment of chronic hepatitis B显示文摘 | Stefan Zeuzem Edward Gane Yun-Fan Liaw Seng G. Lim Adrian DiBisceglie Maria Buti Anuchit Chutaputti Jens Rasenack Jinlin Hou Christopher O’Brien Tuan T. Nguyen Jidong Jia Thierry Poynard Bruce Belanger Weibin Bao Nikolai V. Naoumov | 2009 | Journal of Hepatology2009，，1： | 1 |
| 11 | Comparison of supports for fhe direct synthesis of hydrogen peroxide from H2 and O2 using Au-Pd catalysts显示文摘 | Jennifer K Edwards Adrian Thomas Benjamin E Solosona | 2007 | Catalysis Today2007，122，： | 1 |
| 12 | Baseline characteristics and early on-treatment response predict the outcomes of 2years of telbivudine treatment of chronic hepatitis B显示文摘 | Stefan Zeuzem Edward Gane Yun-Fan Liaw Seng G. Lim Adrian DiBisceglie Maria Buti Anuchit Chutaputti Jens Rasenack Jinlin Hou Christopher O’Brien Tuan T. Nguyen Jidong Jia Thierry Poynard Bruce Belanger Weibin Bao Nikolai V. Naoumov | 2009 | Journal of Hepatology2009，，1： | 1 |
| 13 | A Prospective Study of Common Bile Duct Calculi in Patients Undergoing Laparoscopic Cholecystectomy: Natural History of Choledocholithiasis Revisited显示文摘 | Chris Collins Donal Maguire Adrian Ireland Edward Fitzgerald Gerald C. O’Sullivan | 2004 | Annals of Surgery2004，，1： | 1 |
| 14 | Comparison of supports for the direct synthesis of hydrogen peroxide from H2 and O2 using Au-Pd catalysts 显示文摘 | Jennifer K Edwards Adrian Thomas Benjamin E Solosona | 2007 | Catalysis Today2007，122，： | 1 |
| 15 | Au-Pd supported nanocrystals as catalysts for the direct synthesis of hydrogen peroxide from H2 and O2显示文摘 | Edwards Jennifer K Thomas Adrian Carley Albert F | 2008 | Green Chemistry2008，10，： | 1 |
| 16 | Long-term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients显示文摘 | Mark Bonnen Christopher Crane Jean-Nicolas Vauthey John Skibber Marc E. Delclos Miguel Rodriguez-Bigas Paulo M. Hoff Edward Lin Cathy Eng Adrian Wong Nora A. Janjan Barry W. Feig | 2004 | International Journal of Radiation Oncology Biology Physics2004，，4： | 1 |
| 17 | Impact of segmental grafts on pediatric liver transplantation—A review of the United Network for Organ Sharing Scientific registry data (1990–1996)显示文摘 | Rakesh Sindhi John Rosendale Dale Mundy Sarah Taranto Prabhaker Baliga Adrian Reuben P.R Rajagopalan Andre Hebra Edward Tagge H.Biemann Othersen | 1999 | Journal of Pediatric Surgery1999，，1： | 1 |
| 18 | Kinetics of the Formation of Organic Molecular Nanocrystals显示文摘 | Edward Van Keuren Elena Oeorgieva Jack Adrian | 2001 | Nano Lett2001，1，3： | 1 |
| 19 | IFN-γ^(+) cytotoxic CD4^(+) T lymphocytes are involved in thepathogenesis of colitis induced by IL-23 and the foodcolorant Red 40显示文摘The food colorant Red 40 is an environmental risk factor for colitis development in mice with increased expression of interleukin(IL)-23.This immune response is mediated by CD4^(+)T cells,but mechanistic insights into how these CD4^(+)T cells trigger andperpetuate colitis have remained elusive.Here,using single-cell transcriptomic analysis,we found that several CD4^(+)T-cell subsetsare present in the intestines of colitic mice,including an interferon(IFN)-γ-producing subset.In vivo challenge of primed mice withRed 40 promoted rapid activation of CD4^(+)T cells and caused marked intestinal epithelial cell(IEC)apoptosis that was attenuated bydepletion of CD4^(+)cells and blockade of IFN-γ.Ex vivo experiments showed that intestinal CD4^(+)T cells from colitic mice directlypromoted apoptosis of IECs and intestinal enteroids.CD4^(+)T cell-mediated cytotoxicity was contact-dependent and required FasL,which promoted caspase-dependent cell death in target IECs.Genetic ablation of IFN-γconstrained IL-23-and Red 40-inducedcolitis development,and blockade of IFN-γinhibited epithelial cell death in vivo.These results advance the understanding of themechanisms regulating colitis development caused by IL-23 and food colorants and identify IFN-γ^(+)cytotoxic CD4^(+)T cells as a newpotential therapeutic target for colitis. | Lili Chen Zhengxiang He Bernardo S.Reis Jesse D.Gelles Jerry Edward Chipuk Adrian T.Ting Julie A.Spicer Joseph A.Trapani Glaucia C.Furtado Sergio A.Lira | 2022 | Cellular & Molecular Immunology2022，19，7： | 1 |
| 20 | Gamma Interferon Regulates Contraction of the Influenza Virus-Specific CD8 T Cell Response and Limits the Size of the Memory Population显示文摘 | Nayana Prabhu Adrian W. Ho Kenneth H. S. Wong Paul Edward Hutchinson Yen Leong Chua Matheswaran Kandasamy Debbie C. P. Lee Baalasubramanian Sivasankar David Michael Kemeny | 2013 | Journal of Virology2013，，23： | 1 |
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