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| 1 | Evolving spectrum of diabetic nephropathy显示文摘Diabetes remains an important health issue as more patients with chronic and uncontrolled diabetes develop diabetic nephropathy(DN), which classically presents with proteinuria followed by a progressive decrease in renal function.However, an increasing proportion of DN patients have a decline in kidney function and vascular complications without proteinuria, known as nonproteinuric DN(NP-DN). Despite the increased incidence of NP-DN, few clinical or experimental studies have thoroughly investigated the pathophysiological mechanisms and targeted treatment for this form of DN. In this review, we will examine the differences between conventional DN and NP-DN and consider potential pathophysiological mechanisms, diagnostic markers, and treatment for both DN and NP-DN. The investigation of the pathophysiology of NP-DN should provide additional insight into the cardiovascular factors influencing renal function and disease and provide novel treatments for the vascular complications seen in diabetic patients. | Jonathan Kopel Camilo Pena-Hernandez Kenneth Nugent | 2019 | World Journal of Diabetes2019，10，5： | 18 |
| 2 | Transhiatal versus transthoracic esophagectomy for esophageal cancer显示文摘Esophageal cancer continues to represent a formidable challenge for both patients and clinicians. Relative 5-year survival rates for patients have improved over the past three decades, probably linked to a combination of improved surgical outcomes, progress in systemic chemotherapy and radiotherapy, and the increasing acceptance of multimodality treatment. Surgical treatment remains a fundamental component of the treatment of localized esophageal adenocarcinoma. Multiple approaches have been described for esophagectomy, which can be thematically grouped under two major categories: either transthoracic or transhiatal. The main controversy rests on whether a more extended resection through thoracotomy provides superior oncological outcomes as opposed to resection with relatively limited morbidity and mortality through a transhiatal approach. After numerous trials have addressed these issues, neither approach has consistently proven to be superior to the other one, and both can provide excellent short-term results in the hands of experienced surgeons. Moreover, the available literature suggests that experience of the surgeonand hospital in the surgical management of esophageal cancer is an important factor for operative morbidity and mortality rates, which could supersede the type of approach selected. Oncological outcomes appear to be similar after both procedures. | J Camilo Barreto Mitchell C Posner | 2010 | World Journal of Gastroenterology2010，16，30： | 16 |
| 3 | Effects of loadinge-unloading and wettinge-drying cycles on geomechanical behaviors of mudrocks in the Colombian Andes显示文摘The mudrocks in the Colombian Andes,particularly those exhibiting low cementation(bonding),are susceptible to degradation when the environmental conditions change,which are challenging issues for engineering works.In this paper,the changes in physico-mechanical properties of mudrocks were monitored in laboratory,and some influential factors on the mechanical competence of geomaterials were studied.The geotechnical characteristics and experimental designs were developed from physical,chemical,mechanical and compositional points of view.In the tests,the techniques such as vapor equilibrium technique(VET)were employed to apply wettingedrying cycles and to control relative humidity(suctioncontrolled)and loadingeunloading cycles through ultrasonic wave velocities technique.The results show that the main failure mechanisms for the laminated mudrocks start on the microscopic scale by fissures coalescence,exhibiting physico-chemical degradation as well;the global geomechanical behavior presents a state between a ductile,like rock,and a fragile,like soil.The obtained results can provide engineering values according to monitoring laboratory set,when compared with in situ conditions. | Mario Camilo Torres-Suarez Adolfo Alarcon-Guzman Rafael Berdugo-De Moya | 2014 | Journal of Rock Mechanics and Geotechnical Engineering2014，6，3： | 10 |
| 4 | NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling显示文摘The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated comorbidities.We aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)remodeling.Samples obtained from 98 subjects were used in a case-control study.The expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were analyzed.The impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was evaluated.We demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.We also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and IL18.We showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral adipocytes.We revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture medium.Furthermore,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation. | Xabier Unamuno Javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva Javier Salvador Gema Fruhbeck Victoria Catalan | 2021 | Cellular & Molecular Immunology2021，18，4： | 9 |
| 5 | 地理信息系统技术在伤寒发热监测中应用显示文摘目的运用地理信息系统(GIS)技术,了解各居民点发热流行率和评价以医疗机构为哨点的伤寒发热监测系统的敏感性。方法收集医学人口普查数据、疾病监测系统信息数据、现场采集居民居住点全球卫星定位数据等资料,建立GIS系统和以人口为基数的发热监测系统;对所有发热就诊病人进行身份和居住地址确认,并制作各居民点年发热就诊率GIS分布图。结果共采集3776个居民居住的全球定位系统(GPS)定位点,人群发热就诊率为1.11‰,发热就诊人次占总门诊人次的16.3%,监测区内的发热就诊病人占所有发热就诊病人的83.5%。在3种类型的医疗机构中,门诊量以个体门诊类最多,但其发热就诊人次占总门诊人次的比率最低(12.6%)。监测区内发热1d或以上的病人地址和身份(ADDRESS-ID)确认率达到95%。根据居民点年发热就诊率GIS分布图,发热就诊率最高的居民点达到17.81‰,最低为0;发热就诊率高的居民点多集中在城市。结论利用GIS技术可直观准确的了解疾病流行率的分布,可迅速直观的寻找出监测系统中的薄弱环节和推断出可能存在的问题。 | 杨进 董柏青 张杰 廖和壮 梁大斌 吴兴华 司国爱 杨宏徽 Jin Kyung Park R Leon Ochiai Camilo J Acosta Moharmmad Ali John D Clemens | 2007 | 中国公共卫生2007，23，9： | 8 |
| 6 | 5~60岁人群伤寒Vi多糖疫苗和A群脑膜炎球菌多糖疫苗大规模接种结果分析显示文摘为考核国产伤寒Vi多糖疫苗在现场试验的效果 ,以A群脑膜炎球菌多糖疫苗为对照 ,对广西壮族自治区河池市城市和农村的 5~ 6 0岁居民进行了一次大规模接种。结果显示 :应接种对象 1180 71人 ,实际接种 92 4 76人 ,接种率为 78 32 % ,其中伤寒Vi多糖疫苗为 76 87% ,A群脑膜炎球菌多糖疫苗为 79 6 9% ;接种率最高的组群接种率为 92 4 8% ,最低为 6 5 2 0 %。按城乡划分 ,城区的接种率为 77 2 9% ,农村的接种率为 80 5 8% ,组群接种率的高低分布无明显的地理性差异。 5~ 9岁接种率最高为 89 6 5 % ,2 0~ 2 9岁接种率最低为 6 9 0 7% ;男女接种率分别为79 0 7%和 82 11%。有 6 6人被观察到或报告出现不良反应 ,不良反应发生率为 71 37/ 10万。表明两种疫苗的安全性好。在大规模疫苗接种中 ,充分发挥当地干部的宣传组织作用 ,并把接种的有关信息提前通知当地居民 ,对于提高接种率十分重要。补漏接种能使接种率低的组群得到显著的提高。在大规模疫苗接种中必须严格遵守安全注射操作程序 ,避免发生不安全注射事故。两种疫苗的平均接种率、年龄别接种率、性别接种率、组群接种率的地理分布均达到了较好均衡性 ,是可比的 。 | 杨进 司国爱 曾竣 张杰 梁贵臣 梁大斌 廖和壮 李翠云 黄焕新 董柏青 杨宏徽 Rion Leon Ochiai Carolina Danovaro Ali Mohammad Camilo J Acosta | 2004 | 中国计划免疫2004，10，4： | 6 |
| 7 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 8 | Identification of ta-siRNAs and Cis-nat-siRNAs in Cassava and Their Roles in Response to Cassava Bacterial Blight显示文摘Trans-acting small interfering RNAs (ta-siRNAs) and natural cis-antisense siRNAs (cis-nat-siRNAs) are recently discovered small RNAs (sRNAs) involved in post-transcriptional gene silencing. ta-siRNAs are transcribed from genomic loci and require processing by microRNAs (miRNAs). cis-nat-siRNAs are derived from antisense RNAs produced by the simultaneous transcription of overlapping antisense genes. Their roles in many plant processes, including pathogen response, are mostly unknown. In this work, we employed a bioinformatic approach to identify ta-siRNAs and cis-nat-siRNAs in cassava from two sRNA libraries, one constructed from healthy cassava plants and one from plants inoculated with the bacterium Xanthomonas axonopodis pv.manihotis (Xam). A total of 54 possible ta-siRNA loci were identified in cassava, including a homolog of TAS3, the best studied plant ta-siRNA. Fifteen of these loci were induced, while 39 were repressed in response to Xam infection. In addition, 15 possible cis-natural antisense transcript (cis-NAT) loci producing siRNAs were identified from overlapping antisense regions in the genome,and were found to be differentially expressed upon Xam infection. Roles of sRNAs were predicted by sequence complementarity and our results showed that many sRNAs identified in this work might be directed against various transcription factors. This work represents a significant step toward understanding the roles of sRNAs in the immune response of cassava. | Andrés Quintero Alvaro L. Pérez-Quintero Camilo López | 2013 | Genomics, Proteomics & Bioinformatics2013，11，3： | 4 |
| 9 | 针灸疗法的证据:亟需在临床实践和卫生政策中得到充分利用显示文摘许能贵教授及其同事呼吁推动针灸确证证据的传播和加大对有潜力针灸疗法的研究投入。针灸作为起源于2000年前的中医疗法,目前在世界范围内得到了医生和患者的广泛应用1.传统中医理论将针灸的疗效归因于通过刺激经络(“气”流动的通道)上特定的身体区域(穴位)来调节身体,现代科学也为针灸的疗效提供了越来越多的生物学证据2。 | 陆丽明 张誉清 汤小荣 葛淑琦 文豪 曾婧纯 王莱 曾召 Gabriel Rada Camila Avila Camilo Vergara 汤煜媛 张培铭 陈柔皓 董昱 魏晓菁 骆文 王琳 Gordon Guyatt 唐纯志 许能贵 吴一凡 | 2022 | 英国医学杂志中文版2022，25，6： | 4 |
| 10 | 以人口为基数的伤寒发热监测结果分析显示文摘目的及时了解、掌握伤寒高发区流行情况。方法在广西河池市的金城江辖区内的金城江镇、东江镇建立以人口为基数的监测系统开展伤寒监测,监测内容包括对发热疑似病人进行病原学、血清学检测;对就诊发热病例进行登记。监测区内的各级医疗机构及大部分的个体诊所均作为监测点。以病原学为确诊依据,肥达试验作为辅助诊断依据。结果监测区内4年的伤寒副伤寒发病数为99例,年均年龄段发病率为20.6/10万。病原学监测9049份标本,分离出伤寒、副伤寒菌99株,其中甲型副伤寒沙门氏菌占70.1%,伤寒沙门氏菌仅占29.9%;伤寒副伤寒症状相似,以发热头痛为主要症状。结论监测区内以散发病例为主要流行趋势,监测的发病率低于以往的常规疫情报告,甲型副伤寒沙门菌是优势菌型;肥达试验在常规监测中的诊断意义较差,确诊伤寒、副伤寒病例的肥达试验诊断符合率低。 | 张杰 董柏青 杨进 王鸣柳 梁贵臣 司国爱 曾竣 谭冬梅 廖和壮 梁大斌 李翠云 吴兴华 RLeon Ochiai Jin-kyung Park Ali Mohammad Camilo J Acosta J.D.Clemens | 2006 | 应用预防医学2006，12，6： | 4 |
| 11 | Treatment of Displaced Calcaneus Fractures Using a Minimally Invasive Sinus Tarsi Approach显示文摘 | Hospodar Paul Guzman Camilo Johnson Paul Uhl Richard | 2008 | Orthopedics (Online)2008，，11： | 3 |
| 12 | Iron homeostasis and H63D mutations in alcoholics with and without liver disease显示文摘AIM: To evaluate the prevalence of HFE gene mutation and indices of disturbed iron homeostasis in alcoholics with and without liver disease.METHODS: One hundred and fifty-three heavy drinkers (defined as alcohol consumption > 80 g/d for at least 5 years) were included in the study. These comprised 78 patients with liver disease [liver disease alcoholics (LDA)] in whom the presence of liver disease was confirmed by liver biopsy or clinical evidence of hepatic decompensation, and 75 subjects with no evidence of liver disease, determined by normal liver tests on two occasions [non-liver disease alcoholics (NLDA)], were consecutively enrolled. Serum markers of iron status and HFE C282Y and H63D mutations were determined. HFE genotyping was compared with data obtained in healthy blood donors from the same geographical area.RESULTS: Gender ratio was similar in both study groups. LDA patients were older than NLDA patients (52 ± 10 years vs 48 ± 11 years, P = 0.03). One third and one fi fth of the study population had serum transferrin saturation (TS) greater than 45% and 60% respectively. Serum iron levels were similar in both groups. However, LDA patients had higher TS (51 ± 27 vs 36 ± 13, P < 0.001) and ferritin levels (559 ± 607 ng/mL vs 159 ± 122 ng/mL, P < 0.001), and lower total iron binding capacity (TIBC) (241 ± 88 μg/dL vs 279 ± 40 μg/dL, P = 0.001). The odds ratio for having liver disease with TS greater than 45% was 2.20 (95% confi dence interval (CI): 1.37-3.54). There was no difference in C282Y allelic frequency between the two groups. However, H63D was more frequent in LDA patients (0.25 vs 0.16, P = 0.03). LDA patients had a greater probability of carrying at least one HFE mutation than NLDA patients (49.5% vs 31.6%, P = 0.02). The odds ratio for LDA in patients with H63D mutation was 1.57 (95% CI: 1.02-2.40).CONCLUSION: The present study confirms the presence of iron overload in alcoholics, which was more severe in the subset of subjects with liver disease, in parallel with an increased frequency of H63D HFE mutation. | Mariana Verdelho Machado Paula Ravasco Alexandra Martins Maria Rosário Almeida Maria Ermelinda Camilo Helena Cortez-Pinto | 2009 | World Journal of Gastroenterology2009，15，1： | 3 |
| 13 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 14 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 15 | 口头尸检对河池市5~60岁死亡病例进行死因评估结果分析显示文摘目的分析河池市5~60岁居民死亡主要原因,分析口头尸检(VerbalAutopsy,VA)进行死因调查的效果。方法建立死亡监测系统,对所有报告的监测区内5~60岁死亡个案进行口头尸检调查。结果2002年7月—2003年6月金城江镇、东江镇共死亡624人,全人口总粗死亡率为4.67‰,标化死亡率为5.34‰,男女之比为1.71∶1;5~60岁死亡病例248例,粗死亡率为2.10‰;导致5~60岁居民主要死亡原因为意外死亡、恶性肿瘤、心脑血管疾病、消化系统疾病等,其中意外死亡占死亡构成比的1/3;通过VA进行死因调查,使3.00%的错误死因定义得到更正、5.00%的不明死因得到诊断;无因伤寒导致的死亡。结论交通事故成为当地5~60岁居民死亡的主要因素;随着社会经济发展,伤寒等肠道传染病已不是导致死亡的重要因素;使用VA对于死因的判定比一般的监测系统报告更为准确。 | 杨进 韦士良 刘莉莉 黄兰森 温贤莲 张杰 曾竣 董柏青 吴兴华 RLeon Ochiai Ali Mohammad Camilo J Acosta | 2004 | 中国初级卫生保健2004，18，6： | 3 |
| 16 | The first pulsar discovered by FAST显示文摘To assist with the commissioning [1] of the Five-hundredmeter Aperture Spherical radio Telescope (FAST), we performed a pulsar search, with the primary goal of developing and testing the pulsar data acquisition and processing pipelines. We tested and used three pipelines, two (Pl and P2 hereafter) searched for the periodic signature of pulsars whereas the other one was used to search for bright single pulses (P3 hereafter). | Lei Qian ZhiChen Pan Di Li George Hobbs WeiWei Zhu Pei Wang ZhiJie Liu YouLing Yue Yan Zhu HongFei Liu DongJun Yu JingHai Sun Peng Jiang GaoFeng Pan Hui Li HengQian Gan Rui Yao XiaoYao Xie Fernando Camilo Andrew Cameron Lei Zhang Shen Wang FAST Collaboration | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 3 |
| 17 | 组群随机试验在伤寒疫苗效果观察中的应用研究显示文摘目的 用组群随机试验实现伤寒Vi疫苗效果观察的研究设计和实施应用。方法 采用组群随机试验方法确定试验组和对照组所需样本量 ,并组织实施大规模疫苗接种 ,在试验组接种伤寒Vi疫苗、对照组接种流脑疫苗。结果 根据组群随机试验方法计算共需要观察对象为 96 12 1人 ,分为 10 8个组群。根据组群大小、地理位置 (城乡 )及性质 (学校、机关、厂矿、人口特征 )分层配对 ,确定试验组分为 5 3个组群共 4 4 0 5 4人 ,对照组为 5 4个组群共 4 84 2 2人。对两组间各主要混杂因子 (年龄、性别、居住地点、主要人群的经济收入、受教育程度、主要职业 )等进行分析 ,发现两组之间总体相差不大 ,具有较好的均衡性与可比性。结论 组群随机抽样法应用于大规模疫苗效果观察试验 ,能较好地控制组间混杂因子 ,使干预的实际效果得到科学的评价 ;实施也比较简单 ,被干预对象容易接受 ,可行性高。 | 董柏青 杨进 唐振柱 杨宏徽 曾竣 张杰 王鸣柳 梁贵臣 司国爱 李翠云 梁大斌 廖和壮 Rion Leo nOchiai Ali Mohammad Camilo J Acosta John Clemens | 2005 | 中华流行病学杂志2005，26，2： | 3 |
| 18 | Impact of dietary L-arginine supply during early gestation on myofiber development in newborn pigs exposed to intra-uterine crowding显示文摘Background: Intra-uterine crowding(IUC) observed in hyperprolific sows impairs myofiber hyperplasia and overall fetal growth. Arginine supplementation(ARG) in gestation diets has been shown to positively affect litter and muscle development. The study objective was to assess whether the effect of ARG on offspring characteristics, with special emphasis on myofiber hyperplasia, differs under IUC conditions from these responses,because in that situation growth retardation is particularly prevalent due to reduced fetal nutrient supply.Unilateral oviduct ligation(OL) was used as a model for an uncrowded and hyperprolificacy(IN) as a model for a crowded intra-uterine environment.Methods: Five OL and five IN sows were fed a diet supplemented daily with either 43 g L-alanine(Ctrl) or 25 g L-arginine from d 14 to 28 of gestation in a cross-over design(two periods: 5^( th) and 6^( th) parity). At farrowing, two male and two female offspring, respectively, with a low and intermediate birth weight(BtW) were selected. After euthanization, the Semitendinosus muscle(STM) was removed and weighed, and the light and dark portions(STM_d and STM_l) were prepared for myofiber histochemistry using ATPase staining and the entire STM for gene expression analysis of myogenesis-related genes using RT-qPCR. In addition, various organs were removed and weighed. Data were analyzed using the MIXED model in SYSTAT.Results: No effect of either IUC or dietary treatment was found in litter characteristics. Offspring of ARG sows displayed a greater muscle area in STM(P < 0.01) as a result of the greater myofiber hyperplasia(P < 0.01). The increase was more distinct in the STM_l(P < 0.05) than in the STM_d(P = 0.131). Offspring of OL sows were heavier at birth(P < 0.01), had a heavier STM(P < 0.05), liver(P < 0.01) and kidney(P < 0.05), but when expressed relative to birth weight, these differences were absent. In addition, IUC had an effect(P < 0.05) on the expression of one of the myogenesis-related genes investigated.Conclusions: Independent from the extent of IUC, ARG improved Bt W, muscle and organ weights and myofiber hyperplasia in offspring. | Johannes Gulmann Madsen Camilo Pardo Michael Kreuzer Giuseppe Bee | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 3 |
| 19 | Cadmium neurotoxicity显示文摘 | Marisela Méndez-Armenta Camilo Ríos | 2006 | Environmental Toxicology and Pharmacology2006，，3： | 3 |
| 20 | Arabidopsis Heterotrimeric G-protein Regulates Cell Wall Defense and Resistance to Necrotrophic Fungi显示文摘Arabidopsis heterotrimeric G 蛋白质控制防卫回答到 necrotrophic 和脉管的真菌。在 G 子单元显示损害的 agb1 异种提高了危险性到这些病原体。G/AGB1 形式一与任何一个一 Arabidopsis G 子单元(1/AGG1 和 2/AGG2 ) 更暗淡的 obligate。因此,我们现在证明 agg1 agg2 加倍异种象到 necrotrophic 真菌 Plectosphaerella cucumerina 的 agb1 植物一样易受影响。阐明 heterotrimeric G-protein-mediated 抵抗的分子的基础,我们与 P 在接种之上执行了 agb1-1 异种和野类型的植物的比较 transcriptomic 分析。cucumerina。和 metabolomic 研究,这分析证明 G-protein-mediated 抵抗独立于为抵抗要求到 necrotrophic 真菌的防御小径,例如发信号的水杨酸酸, jasmonic 酸,乙烯, abscisic 酸,和导出色氨酸的代谢物,当这些小径没在 agb1 和 agg1 agg2 异种被损害。尤其是,在 agb1 植物的许多调整 mis 的基因与房间墙功能被联系,它也是在 agg1 agg2 异种的盒子。生物化学的分析和 Fourier 变换红外线(FTIR ) 从 G 蛋白质异种的房间墙的光谱学比在野类型的植物,和那异种墙有类似的 FTIR spectratypes 的表明木糖内容在 agb1 和 agg1 agg2 异种是更低的,它不同于野类型的植物的。这里介绍的数据在 Arabidopsis 有免疫力的回答和房间墙作文的规定的控制建议 G 和 G1/2 子单元的正规功能。 | Magdalena Delgado-Cerezo Clara Sanchez-Rodriguez Viviana Escudero Eva Miedes Paula Virginia Fernandez Lucia Jorda Camilo Hernandez-Blanco Andrea Sanchez-Vallet Pawel Bednarek Paul Schulze-Lefert Shauna Somervilleg Jose Manuel Estevez Staffan Persson Antonio Molina | 2012 | Molecular Plant2012，5，1： | 3 |
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