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| 1 | Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?显示文摘 | Richard J. Johnson Duk-Hee Kang Daniel Feig Salah Kivlighn John Kanellis Susumu Watanabe Katherine R. Tuttle Bernardo Rodriguez-Iturbe Jaime Herrera-Acosta Marilda Mazzali | 2003 | Hypertension: Journal of the American Heart Association2003，，6： | 4 |
| 2 | Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma显示文摘AIM: To study the implication of prokineticin 1 (PK1/EG- VEGF) and prokineticin 2 (PK2/Bv8) in hepatocellular carcinoma angiogenesis. METHODS: The gene induction of PK1/EG-VEGF and PK2/Bv8 was investigated in 10 normal, 28 fibrotic and 28 tumoral livers by using real time PCR. Their expression was compared to the expression of VEGF (an angiogenesis marker), vWF (an endothelial cell marker) and to CD68 (a monocyte/macrophage marker). Furthermore, the mRNA levels of PK1/EG-VEGF, PK2/Bv8, prokineticin receptor 1 and 2 were evaluated by real time PCR in isolated liver cell populations. Finally, PK2/Bv8 protein was detected in normal liver paraffin sections and in isolated liver cells by immunohistochemistry and immunocytochemistry. RESULTS: PK2/Bv8 mRNA but not PK1/EG-VEGF was expressed in all types of normal liver samples examined. In the context of liver tumor development, we reported that PK2/Bv8 correlates only with CD68 and showed a significant decrease in expression as the pathology evolves towards cancer. Whereas, VEGF and vWF mRNA were significantly upregulated in both fibrosis and HCC,as expected. In addition, out of all isolated liver cells examined, only Kupffer cells (liver resident macrophages) express significant levels of PK2/Bv8 and its receptors, prokineticin receptor 1 and 2. CONCLUSION: In normal liver PK2/Bv8 and its receptors were specifically expressed by Kupffer cells. PK2/Bv8 expression decreased as the liver evolves towards cancer and did not correlate with HCC angiogenesis. | Justin Monnier Claire Piquet-Pellorce Jean-Jacques Feige Orlando Musso Bruno Clément Bruno Turlin Nathalie Théret Michel Samson | 2008 | World Journal of Gastroenterology2008，14，8： | 4 |
| 3 | Human disturbance of B ewick’s S wans is reflected in giving‐up net energy intake rate, but not in giving‐up food density显示文摘 | Abel Gyimesi Marycha S. Franken Nicole Feige Bart A. Nolet | 2012 | Ibis2012，，： | 3 |
| 4 | Impacts of landscape structure on surface urban heat islands: A case study of Shanghai, China显示文摘 | Junxiang Li Conghe Song Lu Cao Feige Zhu Xianlei Meng Jianguo Wu | 2011 | Remote Sensing of Environment2011，，12： | 2 |
| 5 | Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression显示文摘 | Fieke E.M. Froeling Christine Feig Claude Chelala Richard Dobson Charles E. Mein David A. Tuveson Hans Clevers Ian R. Hart Hemant M. Kocher | 2011 | Gastroenterology2011，，4： | 2 |
| 6 | Clinical Significance of Acellular Mucin in Rectal Adenocarcinoma Patients With a Pathologic Complete Response to Preoperative Chemoradiation显示文摘 | Kerrington D. Smith Dongfeng Tan Prajnan Das George J. Chang Kiran Kattepogu Barry W. Feig John M. Skibber Miguel A. Rodriguez-Bigas | 2010 | Annals of Surgery2010，，2： | 2 |
| 7 | Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand显示文摘 | Kong YY Feige U Sarosi I | | 0，，： | 2 |
| 8 | Transfer of glyburlde and glipzide into breast milk显示文摘 | Feig DS Briggs GG Kraerner JM | 2005 | Diabetes Care2005，28，： | 1 |
| 9 | Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? 显示文摘 | Johnson RJ Kang DH Feig D | 2003 | Hypertension2003，41，： | 1 |
| 10 | A Pilot Study of preoperative chemoradiotherapy for resectable gastric cancer 显示文摘 | LDWY A M FEIG B W JANJAN N | 2001 | Ann Surg Oncol2001，8，6： | 1 |
| 11 | Amercian college of radiology guideline for breast cancer screening 显示文摘 | Feig SA D'Orsi CJ Hendrick KE | 1998 | AJR1998，171，1： | 1 |
| 12 | Rapid regression of atherosclemsis: insights from the clinical and experimental literature 显示文摘 | Williams K J Feig JE Fisher EA | 2008 | Nature Clinical Practice Cardiovascular Medicine2008，5，2： | 1 |
| 13 | Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice显示文摘 | TROGAN E FEIG J E DOGAN S | 2006 | Proc Natl Acad Sci U S A2006，103，10： | 1 |
| 14 | Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial显示文摘 | Feig DI Soletsky B Johnson RJ | 2008 | JAMA2008，300，8： | 1 |
| 15 | Uric acid and hypertension显示文摘 | Feig D I | 2011 | Semin Nephrol2011，31，5： | 1 |
| 16 | AMPK regulates energy expenditure by modulating NAD+metabolism and SIRT1 activity显示文摘 | Canto C Gerhart-Hines Z Feige JN | | 0，，7241： | 1 |
| 17 | Transfer of insulin lispro across the human placenta: in vitro perfusion studies显示文摘 | Boskovic R Feig DS Derewlany L | 2003 | Diabetes Care2003，26，5： | 1 |
| 18 | Impact of MRI-eval- uates neoadjuvant chemotherapy response on change of surgical recommendation in breast cancer显示文摘 | CHEN JH FEIG BA HSIANG DJB | 2009 | Ann Surg2009，249，3： | 1 |
| 19 | Ral-GTPases: approaching their 15 minutes of fame 显示文摘 | Feig LA | 2003 | Trends CellBiol2003，13，8： | 1 |
| 20 | Hyperuricemia in childhood primary hypertension显示文摘 | Feig DI Johnson RJ | 2003 | Hypertension2003，42，3： | 1 |
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