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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘 | M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie | 2000 | Journal of Hepatology2000，，5： | 2 |
| 4 | Solubility of carbon dioxide in acetone and propionic acid at temperatures between 298 K and 333 K显示文摘 | Adrian T Maurer G | 1997 | J Chen Eng Data1997，42，： | 2 |
| 5 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
| 6 | Analysis and interpretation of instantaneous turbulent velocity fields 显示文摘 | ADRIAN J CHRISTENSEN K T LIU Z | 2000 | Experiments in Fluids2000，29，3： | 1 |
| 7 | Stock returns and volatility: Pricing the short-run and long-run components of market risk显示文摘 | Adrian T Rosenberg J | 2008 | Journal of Finance2008，83，6： | 1 |
| 8 | System identification of nonlinear state - space models 显示文摘 | T B Schon Adrian Wills Brett Ninness | 2011 | Automatica2011，47，： | 1 |
| 9 | Bombesin receptor subtype mediation of gastroenteropancreatic hormone seere-tion in rats 显示文摘 | Varga G Adrian T E Coy D H | 1994 | Peptides1994，15，4： | 1 |
| 10 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 11 | A Two-Phase Cinematic PIV Method for Bubbly Flows 显示文摘 | Oakley T R Loth E Adrian R J | 1997 | Journal of Fluids Engineering1997，，119： | 1 |
| 12 | Tumor necrosis factor stimulates amylin secretion but inhibits insulin from islet β-cells by independent pathways显示文摘 | Ding X Z Flatt P R Adrian T E | 1996 | Regulatory Peptides1996，64，3： | 1 |
| 13 | The Novel ATP-Competitive Inhibitor of the MET Hepatocyte Growth Factor Receptor EMD1214063 Displays Inhibitory Activity against Selected MET-Mutated Variants显示文摘 | Michaela Medová Beno?t Pochon Bruno Streit Wieslawa Blank-Liss Paola Francica Deborah Stroka Adrian Keogh Daniel M. Aebersold Andree Blaukat Friedhelm Bladt Yitzhak Zimmer | 2013 | Molecular Cancer Therapeutics2013，，11： | 1 |
| 14 | Flexible active power control of distributed power generation systems during grid faults显示文摘 | Pedro R Adrian V T Remus T | 2007 | IEEE Transactions on Industrial Electronics2007，54，5： | 1 |
| 15 | Prevalence and Predictors of Acute Stress Disorder and PTSD Following Road Traffic Accidents:Thought Control Strategies and Social Support:Special Series:On Understanding the Persistence of Depressive and Anxious Thinking显示文摘 | Vassiliki H Nicholas T Adrian W | 2001 | Behav Ther(S0005-7894)2001，32，1： | 1 |
| 16 | Particle dispersion in isotropic turbulence under Stokes drag and Basset force with gravitational setting显示文摘 | MEI R W ADRIAN R J HANRATTY T J | 1991 | J Fluid Mech1991，225，： | 1 |
| 17 | Minimal gradient encoding for robust estimation of diffusion anisotropy☆显示文摘 | Nikolaos G Papadakis Chris D Murrills Laurance D Hall Christopher L.-H Huang T Adrian Carpenter | 2000 | Magnetic Resonance Imaging2000，，： | 1 |
| 18 | Allosteric inhibitors of Bcrabl-dependent cell proliferation显示文摘 | Adrian F J Ding Q Sim T | 2006 | Nat Chem Biol2006，2，2： | 1 |
| 19 | 3D structure of Alzheimer's amyloid-β(1-42) fibrils显示文摘 | L(U)HRS T RITTER C ADRIAN M | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 20 | Group key agreement efficient in communication 显示文摘 | Yongdae K Adrian P Gene T | 2004 | IEEE Transactions on Computers2004，53，7： | 1 |
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